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The map label for this gene is lpxC

Identifier: 85860023

GI number: 85860023

Start: 2239057

End: 2240004

Strand: Direct

Name: lpxC

Synonym: SYN_00756

Alternate gene names: 85860023

Gene position: 2239057-2240004 (Clockwise)

Preceding gene: 85860022

Following gene: 85860030

Centisome position: 70.43

GC content: 46.41

Gene sequence:

>948_bases
ATGTATTTTCAAAGGACTTTGAAAAGCGATCTGTCCTGTCAGAGTGTGGGGTTGCATTCAGGCAGGAAAGTTAATATGCG
AATCAGACCTGCGTCCTCCGACGAAGGCATCATTCTCGTGCGCACGGACACCCGATACAGACAGATGATCAGGGTTTGTC
TTGAAAATGTTACGGATACAACATTGGCAACAACAATTGGCAGTAGCGGAGCCGCGATTTCTACTGTTGAACACATCCTC
TCGGCGTTAAGTGGGATGGGTGTAGATAACGCGATCATCGAGGTTGATGCGCCTGAAATTCCAATCATGGATGGAAGCGC
ATTGCCGTTTGTCAACATGTTGAAGCTTGTGGGTATCCGCACCCAGGAAAAATTGAAAAAATACCTGGTCGTTAAAAAGC
CTGTTTCCGTATCGGAAGGGGAAAGTTTCGCAATGCTGGCGCCTTCCAGTTCCTTCGAAATCACATATAAAATTGAGTTT
GACCACCCCCTTATCAAGGAACAGAGCTATCATCTCAAATTGTCCGACGAAACTTATGAAAAGGAAATCTGCAGTTCTCG
TACTTTCGGTTTTTTAAAAGATGTCGAATACCTCCAGGCCAAAGGACTGGCCCTCGGCGGTTCTCTTAAAAATGCCGTCA
TCCTTGACGAAAAGAGAATCATCAACAAGGAGGGACTGAGAAGCCACAATGAATTTGTGAAGCACAAAATACTGGATGCA
ATCGGAGATCTTTCCCTGATAGGGATGCCGATCGTCGGGCATTTTATTGCCTACAAATCCGGTCACAAATTGAATTCCAT
GCTGGTAAAGGCATTACTGGAACAGCAGGAAAACTGGACGACAGCCAGTTTTTTGAATTGTCAGGACGCCCACGGGCAGA
ATACCCGCGAAAAATTCAGCATACGGGACATTCCTGCCCGGAAAATTCTGGGCGCCATCCACGCATGA

Upstream 100 bases:

>100_bases
ATAATATTAATGGGTACGCATCTTATTTTTTTAAAGAATCGAGGAAAATAATGGAACGCATTTTGCTTAAATAGGCTTTA
ACTTAATAAGGATTGAATTT

Downstream 100 bases:

>100_bases
AAATCTGTAATCTGCACGCTTCTGGAAACAGGAGCGTGCAGATTTAACTTTGGCAGGATTTTTTAGACCTGTTTAACAGT
CCGTCGTCGTGAAGGATTTC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MYFQRTLKSDLSCQSVGLHSGRKVNMRIRPASSDEGIILVRTDTRYRQMIRVCLENVTDTTLATTIGSSGAAISTVEHIL
SALSGMGVDNAIIEVDAPEIPIMDGSALPFVNMLKLVGIRTQEKLKKYLVVKKPVSVSEGESFAMLAPSSSFEITYKIEF
DHPLIKEQSYHLKLSDETYEKEICSSRTFGFLKDVEYLQAKGLALGGSLKNAVILDEKRIINKEGLRSHNEFVKHKILDA
IGDLSLIGMPIVGHFIAYKSGHKLNSMLVKALLEQQENWTTASFLNCQDAHGQNTREKFSIRDIPARKILGAIHA

Sequences:

>Translated_315_residues
MYFQRTLKSDLSCQSVGLHSGRKVNMRIRPASSDEGIILVRTDTRYRQMIRVCLENVTDTTLATTIGSSGAAISTVEHIL
SALSGMGVDNAIIEVDAPEIPIMDGSALPFVNMLKLVGIRTQEKLKKYLVVKKPVSVSEGESFAMLAPSSSFEITYKIEF
DHPLIKEQSYHLKLSDETYEKEICSSRTFGFLKDVEYLQAKGLALGGSLKNAVILDEKRIINKEGLRSHNEFVKHKILDA
IGDLSLIGMPIVGHFIAYKSGHKLNSMLVKALLEQQENWTTASFLNCQDAHGQNTREKFSIRDIPARKILGAIHA
>Mature_315_residues
MYFQRTLKSDLSCQSVGLHSGRKVNMRIRPASSDEGIILVRTDTRYRQMIRVCLENVTDTTLATTIGSSGAAISTVEHIL
SALSGMGVDNAIIEVDAPEIPIMDGSALPFVNMLKLVGIRTQEKLKKYLVVKKPVSVSEGESFAMLAPSSSFEITYKIEF
DHPLIKEQSYHLKLSDETYEKEICSSRTFGFLKDVEYLQAKGLALGGSLKNAVILDEKRIINKEGLRSHNEFVKHKILDA
IGDLSLIGMPIVGHFIAYKSGHKLNSMLVKALLEQQENWTTASFLNCQDAHGQNTREKFSIRDIPARKILGAIHA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=287, Percent_Identity=45.2961672473868, Blast_Score=268, Evalue=3e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_SYNAS (Q2LVE4)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_462225.1
- ProteinModelPortal:   Q2LVE4
- SMR:   Q2LVE4
- STRING:   Q2LVE4
- GeneID:   3884171
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_00756
- NMPDR:   fig|56780.10.peg.2158
- eggNOG:   COG0774
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- PhylomeDB:   Q2LVE4
- ProtClustDB:   PRK13186
- BioCyc:   SACI56780:SYN_00756-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 34981; Mature: 34981

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYFQRTLKSDLSCQSVGLHSGRKVNMRIRPASSDEGIILVRTDTRYRQMIRVCLENVTDT
CCCHHHHHCCCCCHHCCCCCCCEEEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHCCCH
TLATTIGSSGAAISTVEHILSALSGMGVDNAIIEVDAPEIPIMDGSALPFVNMLKLVGIR
HHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCC
TQEKLKKYLVVKKPVSVSEGESFAMLAPSSSFEITYKIEFDHPLIKEQSYHLKLSDETYE
CHHHHHHHHEEECCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCCEEEEECCCHHH
KEICSSRTFGFLKDVEYLQAKGLALGGSLKNAVILDEKRIINKEGLRSHNEFVKHKILDA
HHHHCCCCCHHHHHHHHHHHCCEEECCCCCCEEEECHHHHHCHHHCHHHHHHHHHHHHHH
IGDLSLIGMPIVGHFIAYKSGHKLNSMLVKALLEQQENWTTASFLNCQDAHGQNTREKFS
HCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCHHHCC
IRDIPARKILGAIHA
CCCCCHHHHHHHHCC
>Mature Secondary Structure
MYFQRTLKSDLSCQSVGLHSGRKVNMRIRPASSDEGIILVRTDTRYRQMIRVCLENVTDT
CCCHHHHHCCCCCHHCCCCCCCEEEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHCCCH
TLATTIGSSGAAISTVEHILSALSGMGVDNAIIEVDAPEIPIMDGSALPFVNMLKLVGIR
HHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCC
TQEKLKKYLVVKKPVSVSEGESFAMLAPSSSFEITYKIEFDHPLIKEQSYHLKLSDETYE
CHHHHHHHHEEECCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCCEEEEECCCHHH
KEICSSRTFGFLKDVEYLQAKGLALGGSLKNAVILDEKRIINKEGLRSHNEFVKHKILDA
HHHHCCCCCHHHHHHHHHHHCCEEECCCCCCEEEECHHHHHCHHHCHHHHHHHHHHHHHH
IGDLSLIGMPIVGHFIAYKSGHKLNSMLVKALLEQQENWTTASFLNCQDAHGQNTREKFS
HCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCHHHCC
IRDIPARKILGAIHA
CCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA