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The map label for this gene is accD [C]

Identifier: 85859805

GI number: 85859805

Start: 2044299

End: 2045870

Strand: Direct

Name: accD [C]

Synonym: SYN_01398

Alternate gene names: 85859805

Gene position: 2044299-2045870 (Clockwise)

Preceding gene: 85859804

Following gene: 85859807

Centisome position: 64.3

GC content: 53.94

Gene sequence:

>1572_bases
ATGAACACGGAAAATTACGAGGGCATGACAGCGGGAAAAATTCGGGAATTTGAAAAAAGGAAAGAAGCCCTGATGCTTAT
GGGCGGCGACGAGATGATCAGAAAACAGCACGAACTCGGCAAACTGACCGCAAGGGAACGGCTGGATCTGCTTTTCGACA
ATGGGTCTTTCCAGGAAGTCCAGCTCTTTACAAAACATCGTTCCACACTTTTCGGCCTCGACAAGAAGGAAATTCCCGCG
GATGGCGTCATTACCGGATTCGGCGAGGTAAACGGCCGTGTCGTCTTTGCGGCGGCTCAGGATTTCACCTGCTCCGGCGG
CAGTCTTGGGGAAATGCAGGCAAAGAAGATCTGGAAGGTGATGGATATGGCCATCGCAGCGGGGAAACCCTTTGTTTCCC
TGAACGACTCCGGAGGAGCGCGCATTCAGGAAGGCGTCCCCGCTCTTGAAGGATATGGAGGAATTTTCTACCGGAATACC
CTCGCCTCCGGGTATATCCCCCAGATTACCGCGACCATGGGGCCGACCGCCGGCGGGGCCGTTTATTCACCGGCATTGAC
GGACTGGATATTCATGGTCAAGAAAAGCAGTTACATGTGCATCACGGGCCCGGATGTCATCAAGGCCGTTATCGGTGAAG
AAGTCACCACCGAAGCCCTGGGAGGCGCCGTCGTTCATTCCACCAAAAGCGGCGTATGTCATTTCGCCACAAATGACGAC
CAGGACTGTATCAATAAAATTCGAACCCTGTTGTCTTATCTCCCGGACAGTTGTCACAGTCCCCTTCCTCTTCTGCCAAC
GTCTGACACCCCGGATCGCGAATGCCTCGAACTGGACGAAATCATTCCTGATAAACCTTCAAAAGGCTATGACATGAAAA
AGGTTATCCTGGAAATCGCCGATAATGCAGAAATGATGGAACCTCATGCCGGATGGGCCAGGAACATCATCGTCGCATTT
ATTCGCATCATGGGGCGTCCTGTAGGGGTCATCGCGAACAACCCCAGTTTCGGCGCCGGCGTACTCGATGTGAATGCTTC
AGACAAGGCGGCGCGCTTCATCCGTTTCTGTGACGCCTTCAACATCCCCCTGCTGACGCTTGCCGATGTCCCCGGTTACC
TTCCCGGCACACGTCAGGAATGGGCGGGAATCATCACACATGGAGCCAAAATGCTCCATGCCTATTCCGAAGCCACAGTG
CCCAAACTGACGGTCGTCATCCGCAAGGATTACGGCGGCGCCTACATCGGCATGTGCAGCAAACAGCTCGGCGCGGATTA
CGTCATGGCCTGGCCTTCCGCGGAAATTGCCGTCATGGGAGCGGATGGCGCTTGTAACATTGTGTATCGCAAGGAAATCC
AGACGGCGCCGGACCCCGCGGCCAAGCGGAAGGAACTGGCCTCCGCTTACGAAACTCAGTTCAACAATCCTTACTTTGCC
GCCGGACTGGGAATTGTGGATGAAATCATCCTGCCCAGAGAGACCCGTAAGCGAGTCGCCTTCCTGTTAGAAACCTTTAA
GGAAAAGAAGGAAACCCGGGTGACAAAAAAGCACAACAATATTCCGCTTTAA

Upstream 100 bases:

>100_bases
ATAAATGGTCAATTCAAAAAAGACATCATGATGGGGTATTATGAGATATTAAAACCCTGTTCCCCTTTTAAAATCAAGAA
AAAGCATTTTGTGGAGGAGT

Downstream 100 bases:

>100_bases
ACAGGCTGCAAGATGCGTTTCAGATGAAGCGGAAGATATTTTATGGAAGACGCAAACGCGTTATTCCGATTTTGATTTTC
TATGAGAGTTATCTGACCAG

Product: methylmalonyl-CoA decarboxylase subunit alpha

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MNTENYEGMTAGKIREFEKRKEALMLMGGDEMIRKQHELGKLTARERLDLLFDNGSFQEVQLFTKHRSTLFGLDKKEIPA
DGVITGFGEVNGRVVFAAAQDFTCSGGSLGEMQAKKIWKVMDMAIAAGKPFVSLNDSGGARIQEGVPALEGYGGIFYRNT
LASGYIPQITATMGPTAGGAVYSPALTDWIFMVKKSSYMCITGPDVIKAVIGEEVTTEALGGAVVHSTKSGVCHFATNDD
QDCINKIRTLLSYLPDSCHSPLPLLPTSDTPDRECLELDEIIPDKPSKGYDMKKVILEIADNAEMMEPHAGWARNIIVAF
IRIMGRPVGVIANNPSFGAGVLDVNASDKAARFIRFCDAFNIPLLTLADVPGYLPGTRQEWAGIITHGAKMLHAYSEATV
PKLTVVIRKDYGGAYIGMCSKQLGADYVMAWPSAEIAVMGADGACNIVYRKEIQTAPDPAAKRKELASAYETQFNNPYFA
AGLGIVDEIILPRETRKRVAFLLETFKEKKETRVTKKHNNIPL

Sequences:

>Translated_523_residues
MNTENYEGMTAGKIREFEKRKEALMLMGGDEMIRKQHELGKLTARERLDLLFDNGSFQEVQLFTKHRSTLFGLDKKEIPA
DGVITGFGEVNGRVVFAAAQDFTCSGGSLGEMQAKKIWKVMDMAIAAGKPFVSLNDSGGARIQEGVPALEGYGGIFYRNT
LASGYIPQITATMGPTAGGAVYSPALTDWIFMVKKSSYMCITGPDVIKAVIGEEVTTEALGGAVVHSTKSGVCHFATNDD
QDCINKIRTLLSYLPDSCHSPLPLLPTSDTPDRECLELDEIIPDKPSKGYDMKKVILEIADNAEMMEPHAGWARNIIVAF
IRIMGRPVGVIANNPSFGAGVLDVNASDKAARFIRFCDAFNIPLLTLADVPGYLPGTRQEWAGIITHGAKMLHAYSEATV
PKLTVVIRKDYGGAYIGMCSKQLGADYVMAWPSAEIAVMGADGACNIVYRKEIQTAPDPAAKRKELASAYETQFNNPYFA
AGLGIVDEIILPRETRKRVAFLLETFKEKKETRVTKKHNNIPL
>Mature_523_residues
MNTENYEGMTAGKIREFEKRKEALMLMGGDEMIRKQHELGKLTARERLDLLFDNGSFQEVQLFTKHRSTLFGLDKKEIPA
DGVITGFGEVNGRVVFAAAQDFTCSGGSLGEMQAKKIWKVMDMAIAAGKPFVSLNDSGGARIQEGVPALEGYGGIFYRNT
LASGYIPQITATMGPTAGGAVYSPALTDWIFMVKKSSYMCITGPDVIKAVIGEEVTTEALGGAVVHSTKSGVCHFATNDD
QDCINKIRTLLSYLPDSCHSPLPLLPTSDTPDRECLELDEIIPDKPSKGYDMKKVILEIADNAEMMEPHAGWARNIIVAF
IRIMGRPVGVIANNPSFGAGVLDVNASDKAARFIRFCDAFNIPLLTLADVPGYLPGTRQEWAGIITHGAKMLHAYSEATV
PKLTVVIRKDYGGAYIGMCSKQLGADYVMAWPSAEIAVMGADGACNIVYRKEIQTAPDPAAKRKELASAYETQFNNPYFA
AGLGIVDEIILPRETRKRVAFLLETFKEKKETRVTKKHNNIPL

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=511, Percent_Identity=52.0547945205479, Blast_Score=524, Evalue=1e-149,
Organism=Homo sapiens, GI295821216, Length=531, Percent_Identity=50.0941619585687, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI11545863, Length=511, Percent_Identity=32.8767123287671, Blast_Score=236, Evalue=5e-62,
Organism=Homo sapiens, GI134142062, Length=346, Percent_Identity=25.7225433526012, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI38679960, Length=301, Percent_Identity=26.2458471760797, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38679971, Length=301, Percent_Identity=26.2458471760797, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38679977, Length=301, Percent_Identity=26.2458471760797, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38679967, Length=301, Percent_Identity=26.2458471760797, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38679974, Length=301, Percent_Identity=26.2458471760797, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788655, Length=188, Percent_Identity=25.531914893617, Blast_Score=63, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI25147359, Length=509, Percent_Identity=50.4911591355599, Blast_Score=525, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI25147362, Length=509, Percent_Identity=50.4911591355599, Blast_Score=525, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17552936, Length=495, Percent_Identity=32.3232323232323, Blast_Score=255, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI71997163, Length=311, Percent_Identity=23.7942122186495, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323863, Length=349, Percent_Identity=26.3610315186246, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6324343, Length=346, Percent_Identity=24.2774566473988, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24586065, Length=523, Percent_Identity=31.9311663479924, Blast_Score=230, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 57124; Mature: 57124

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTENYEGMTAGKIREFEKRKEALMLMGGDEMIRKQHELGKLTARERLDLLFDNGSFQEV
CCCCCCCCCCHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHEEEECCCCCHHH
QLFTKHRSTLFGLDKKEIPADGVITGFGEVNGRVVFAAAQDFTCSGGSLGEMQAKKIWKV
HHHHHHHHHHCCCCHHCCCCCCEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHH
MDMAIAAGKPFVSLNDSGGARIQEGVPALEGYGGIFYRNTLASGYIPQITATMGPTAGGA
HHHHHHCCCCEEEECCCCCCCHHCCCCCHHCCCCEEEEHHHCCCCCCEEEECCCCCCCCC
VYSPALTDWIFMVKKSSYMCITGPDVIKAVIGEEVTTEALGGAVVHSTKSGVCHFATNDD
EECHHHHHHHHHEECCCEEEEECHHHHHHHHCCHHHHHHHCCCEEECCCCCEEEECCCCC
QDCINKIRTLLSYLPDSCHSPLPLLPTSDTPDRECLELDEIIPDKPSKGYDMKKVILEIA
HHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHH
DNAEMMEPHAGWARNIIVAFIRIMGRPVGVIANNPSFGAGVLDVNASDKAARFIRFCDAF
CCCHHCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHCC
NIPLLTLADVPGYLPGTRQEWAGIITHGAKMLHAYSEATVPKLTVVIRKDYGGAYIGMCS
CCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEHHH
KQLGADYVMAWPSAEIAVMGADGACNIVYRKEIQTAPDPAAKRKELASAYETQFNNPYFA
HHHCCCEEEECCCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEE
AGLGIVDEIILPRETRKRVAFLLETFKEKKETRVTKKHNNIPL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNTENYEGMTAGKIREFEKRKEALMLMGGDEMIRKQHELGKLTARERLDLLFDNGSFQEV
CCCCCCCCCCHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHEEEECCCCCHHH
QLFTKHRSTLFGLDKKEIPADGVITGFGEVNGRVVFAAAQDFTCSGGSLGEMQAKKIWKV
HHHHHHHHHHCCCCHHCCCCCCEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHH
MDMAIAAGKPFVSLNDSGGARIQEGVPALEGYGGIFYRNTLASGYIPQITATMGPTAGGA
HHHHHHCCCCEEEECCCCCCCHHCCCCCHHCCCCEEEEHHHCCCCCCEEEECCCCCCCCC
VYSPALTDWIFMVKKSSYMCITGPDVIKAVIGEEVTTEALGGAVVHSTKSGVCHFATNDD
EECHHHHHHHHHEECCCEEEEECHHHHHHHHCCHHHHHHHCCCEEECCCCCEEEECCCCC
QDCINKIRTLLSYLPDSCHSPLPLLPTSDTPDRECLELDEIIPDKPSKGYDMKKVILEIA
HHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHH
DNAEMMEPHAGWARNIIVAFIRIMGRPVGVIANNPSFGAGVLDVNASDKAARFIRFCDAF
CCCHHCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHCC
NIPLLTLADVPGYLPGTRQEWAGIITHGAKMLHAYSEATVPKLTVVIRKDYGGAYIGMCS
CCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEHHH
KQLGADYVMAWPSAEIAVMGADGACNIVYRKEIQTAPDPAAKRKELASAYETQFNNPYFA
HHHCCCEEEECCCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEE
AGLGIVDEIILPRETRKRVAFLLETFKEKKETRVTKKHNNIPL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]