Click here to switch to the map view.

The map label for this gene is groEL

Identifier: 85859566

GI number: 85859566

Start: 1789319

End: 1790947

Strand: Direct

Name: groEL

Synonym: SYN_01909

Alternate gene names: 85859566

Gene position: 1789319-1790947 (Clockwise)

Preceding gene: 85859565

Following gene: 85859567

Centisome position: 56.28

GC content: 56.05

Gene sequence:

>1629_bases
ATGCCTGCAAAGGAAATAAAATATGATATGCAAGCCCGCGAAAAAATAATGAAGGGCGTTGATACGTTGGCCAATGCGGT
AAAAGTCACCCTGGGACCCAAAGGACGGAATGTGGCTATCGCCAAATCCTGGGGCGCCCCTCAGGTCACAAAGGACGGCG
TTACCGTGGCCAAAGAGATTGAGTTGGAAGACAAATTCGAAAACATGGGGGCGCAGATGGTCAAAGAAGTTGCCTCCAAG
ACTTCGGATAAGGCGGGCGACGGCACCACGACGGCTACCGTGCTCGCCCAGGCGATTTATCGTGAAGGATCCAAGCTTGT
CGTCTCCGGTATGAACCCCATGTCGCTGAAGCGAGGGATCGACAAGGGGGTGGCTCTCGTTGTGGATGAACTGAAGAAGC
GCAGTAAGACCATCAGCGACAAGAAGGAGATTGCCCAGATTGGCACCATTTCGGCAAACAACGATGCGACTATTGGAAAC
ATCATCTCCGAAGCAATGGAGAAAGTCGGCAAGGATGGGGTGATCACCGTTGAAGAAGCCAAGGGAATGGAAACCGAATT
GGAGATCGTTGAAGGGATGCAGTTCGATCGGGGCTATGTCTCGCCCTACTTTGTCACCGATGCGGAGAAAATGGAGGTCC
GCCTGGATGATCCCTATATCCTGCTCCATGAAAAGAAGATCAGCGCCATGAAAGACATGGTTCCTCTTCTGGAGCAGATC
GCCAAGACGGGCAAGCCGCTCCTGCTCGTCGCGGAAGATATCGAGGGAGAGGCTTTGGCCACCCTGGTCGTCAACAAGAT
GCGCGGGACCCTCAAATGCGTGGCAGTCAAGGCACCTGGCTTCGGAGACCGCCGCAAGGCCATGCTCCAGGATATCGCCG
TTCTGACGGGAGGAAATCTTATTTCCGAGGACGTGGGAATAAAGTTAGAGAACGTCACGCTTCAGGATCTGGGCACTTGC
AAGAAGGTCACTGTTGACAAGGACAATACCACCATCGTGGACGGCGCCGGCAACCGCGCTGACATCGAAGGGCGCGTGAA
GCAGATCCGGGCGGAGATCGAGGAGACAAAATCGGACTATGACCGGGAGAAGCTCCAGGAGCGGCTGGCCAAGATCGTCG
GGGGCGTGGCGGTTATCAGAGTTGGCGCCGCCACGGAGATCGAGATGAAAGAGAAGAAAGCGCGGGTCGAGGATGCCTTG
CATGCCACGCGAGCCGCTGTTGAAGAGGGCATTGTTCCGGGCGGCGGCGTGGCATTCATCCGCTCCATCGGTGCATTGGC
GGATGCAAAATTGCCCGATGAGGAGCAACAGGGATTGAACATCGTCCGGCGCGCCTTGGAAGAGCCGTTACGTCAGATCG
CCGCCAACGCAGGCTGCGAAGGCTCCATTGTAGTGGAAAAGGTGAAGGAGTCAAACGGGACTCATGGTTTCGACGCCGAA
ACTGAGCAGTACGTTGACATGCTGAAGGCCGGGATCATCGATCCCACGAAGGTCGCCCGCTTTGCCCTCCAGAACGCCGC
GTCGGTTGCTTCGCTCCTATTGACCACCGAGGCGATGATCGCGGAAAAGCCGAAGAAGAAAGAACCGCCCATGCCTGCCA
TGCCGTCGGACATGGGGGATTATGACTAA

Upstream 100 bases:

>100_bases
GGCCGGCACGGAGTTCAAGCTTGACGGTCAGGAGCATATGATCATGAAAGAGGACGATATCCTCGGCATTATTGAATCAT
AATACAAGGAGGTAGGAACC

Downstream 100 bases:

>100_bases
CCCCTCCTGAAGCCGCCCTCCCGCTTCCGGGAAACCGGGGCGGGGGCGGTCCCTCCCTTTGTTCGCGCAATGAGAAGTTC
ATATCAAACCATACCGAAAT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 3; Protein Cpn60 3

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MPAKEIKYDMQAREKIMKGVDTLANAVKVTLGPKGRNVAIAKSWGAPQVTKDGVTVAKEIELEDKFENMGAQMVKEVASK
TSDKAGDGTTTATVLAQAIYREGSKLVVSGMNPMSLKRGIDKGVALVVDELKKRSKTISDKKEIAQIGTISANNDATIGN
IISEAMEKVGKDGVITVEEAKGMETELEIVEGMQFDRGYVSPYFVTDAEKMEVRLDDPYILLHEKKISAMKDMVPLLEQI
AKTGKPLLLVAEDIEGEALATLVVNKMRGTLKCVAVKAPGFGDRRKAMLQDIAVLTGGNLISEDVGIKLENVTLQDLGTC
KKVTVDKDNTTIVDGAGNRADIEGRVKQIRAEIEETKSDYDREKLQERLAKIVGGVAVIRVGAATEIEMKEKKARVEDAL
HATRAAVEEGIVPGGGVAFIRSIGALADAKLPDEEQQGLNIVRRALEEPLRQIAANAGCEGSIVVEKVKESNGTHGFDAE
TEQYVDMLKAGIIDPTKVARFALQNAASVASLLLTTEAMIAEKPKKKEPPMPAMPSDMGDYD

Sequences:

>Translated_542_residues
MPAKEIKYDMQAREKIMKGVDTLANAVKVTLGPKGRNVAIAKSWGAPQVTKDGVTVAKEIELEDKFENMGAQMVKEVASK
TSDKAGDGTTTATVLAQAIYREGSKLVVSGMNPMSLKRGIDKGVALVVDELKKRSKTISDKKEIAQIGTISANNDATIGN
IISEAMEKVGKDGVITVEEAKGMETELEIVEGMQFDRGYVSPYFVTDAEKMEVRLDDPYILLHEKKISAMKDMVPLLEQI
AKTGKPLLLVAEDIEGEALATLVVNKMRGTLKCVAVKAPGFGDRRKAMLQDIAVLTGGNLISEDVGIKLENVTLQDLGTC
KKVTVDKDNTTIVDGAGNRADIEGRVKQIRAEIEETKSDYDREKLQERLAKIVGGVAVIRVGAATEIEMKEKKARVEDAL
HATRAAVEEGIVPGGGVAFIRSIGALADAKLPDEEQQGLNIVRRALEEPLRQIAANAGCEGSIVVEKVKESNGTHGFDAE
TEQYVDMLKAGIIDPTKVARFALQNAASVASLLLTTEAMIAEKPKKKEPPMPAMPSDMGDYD
>Mature_541_residues
PAKEIKYDMQAREKIMKGVDTLANAVKVTLGPKGRNVAIAKSWGAPQVTKDGVTVAKEIELEDKFENMGAQMVKEVASKT
SDKAGDGTTTATVLAQAIYREGSKLVVSGMNPMSLKRGIDKGVALVVDELKKRSKTISDKKEIAQIGTISANNDATIGNI
ISEAMEKVGKDGVITVEEAKGMETELEIVEGMQFDRGYVSPYFVTDAEKMEVRLDDPYILLHEKKISAMKDMVPLLEQIA
KTGKPLLLVAEDIEGEALATLVVNKMRGTLKCVAVKAPGFGDRRKAMLQDIAVLTGGNLISEDVGIKLENVTLQDLGTCK
KVTVDKDNTTIVDGAGNRADIEGRVKQIRAEIEETKSDYDREKLQERLAKIVGGVAVIRVGAATEIEMKEKKARVEDALH
ATRAAVEEGIVPGGGVAFIRSIGALADAKLPDEEQQGLNIVRRALEEPLRQIAANAGCEGSIVVEKVKESNGTHGFDAET
EQYVDMLKAGIIDPTKVARFALQNAASVASLLLTTEAMIAEKPKKKEPPMPAMPSDMGDYD

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=531, Percent_Identity=51.9774011299435, Blast_Score=538, Evalue=1e-153,
Organism=Homo sapiens, GI31542947, Length=531, Percent_Identity=51.9774011299435, Blast_Score=538, Evalue=1e-153,
Organism=Homo sapiens, GI24307939, Length=521, Percent_Identity=22.8406909788868, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI38455427, Length=301, Percent_Identity=24.5847176079734, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1790586, Length=526, Percent_Identity=65.3992395437262, Blast_Score=690, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=52.2727272727273, Blast_Score=556, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI193210679, Length=209, Percent_Identity=54.5454545454545, Blast_Score=221, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=51.7175572519084, Blast_Score=544, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6322350, Length=535, Percent_Identity=23.1775700934579, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322524, Length=136, Percent_Identity=25.7352941176471, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=52.2813688212928, Blast_Score=550, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=52.2813688212928, Blast_Score=550, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=50.381679389313, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=50.381679389313, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=50.381679389313, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI17864606, Length=525, Percent_Identity=44.1904761904762, Blast_Score=450, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24584129, Length=540, Percent_Identity=35.9259259259259, Blast_Score=337, Evalue=2e-92,
Organism=Drosophila melanogaster, GI19921262, Length=540, Percent_Identity=35.9259259259259, Blast_Score=337, Evalue=2e-92,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH603_SYNAS (Q2LU42)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_461768.1
- HSSP:   P0A6F5
- ProteinModelPortal:   Q2LU42
- SMR:   Q2LU42
- STRING:   Q2LU42
- GeneID:   3883938
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_01909
- NMPDR:   fig|56780.10.peg.1705
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   EDYVDMV
- PhylomeDB:   Q2LU42
- ProtClustDB:   PRK12849
- BioCyc:   SACI56780:SYN_01909-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 58418; Mature: 58287

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAKEIKYDMQAREKIMKGVDTLANAVKVTLGPKGRNVAIAKSWGAPQVTKDGVTVAKEI
CCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHC
ELEDKFENMGAQMVKEVASKTSDKAGDGTTTATVLAQAIYREGSKLVVSGMNPMSLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHH
DKGVALVVDELKKRSKTISDKKEIAQIGTISANNDATIGNIISEAMEKVGKDGVITVEEA
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KGMETELEIVEGMQFDRGYVSPYFVTDAEKMEVRLDDPYILLHEKKISAMKDMVPLLEQI
CCCHHHHHHHHCCCCCCCCCCCEEEECHHHEEEEECCCEEEEECHHHHHHHHHHHHHHHH
AKTGKPLLLVAEDIEGEALATLVVNKMRGTLKCVAVKAPGFGDRRKAMLQDIAVLTGGNL
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCE
ISEDVGIKLENVTLQDLGTCKKVTVDKDNTTIVDGAGNRADIEGRVKQIRAEIEETKSDY
ECCCCCCEEECEEHHHCCCCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
DREKLQERLAKIVGGVAVIRVGAATEIEMKEKKARVEDALHATRAAVEEGIVPGGGVAFI
CHHHHHHHHHHHHCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RSIGALADAKLPDEEQQGLNIVRRALEEPLRQIAANAGCEGSIVVEKVKESNGTHGFDAE
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCC
TEQYVDMLKAGIIDPTKVARFALQNAASVASLLLTTEAMIAEKPKKKEPPMPAMPSDMGD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
YD
CC
>Mature Secondary Structure 
PAKEIKYDMQAREKIMKGVDTLANAVKVTLGPKGRNVAIAKSWGAPQVTKDGVTVAKEI
CCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHC
ELEDKFENMGAQMVKEVASKTSDKAGDGTTTATVLAQAIYREGSKLVVSGMNPMSLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHH
DKGVALVVDELKKRSKTISDKKEIAQIGTISANNDATIGNIISEAMEKVGKDGVITVEEA
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KGMETELEIVEGMQFDRGYVSPYFVTDAEKMEVRLDDPYILLHEKKISAMKDMVPLLEQI
CCCHHHHHHHHCCCCCCCCCCCEEEECHHHEEEEECCCEEEEECHHHHHHHHHHHHHHHH
AKTGKPLLLVAEDIEGEALATLVVNKMRGTLKCVAVKAPGFGDRRKAMLQDIAVLTGGNL
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCE
ISEDVGIKLENVTLQDLGTCKKVTVDKDNTTIVDGAGNRADIEGRVKQIRAEIEETKSDY
ECCCCCCEEECEEHHHCCCCCEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
DREKLQERLAKIVGGVAVIRVGAATEIEMKEKKARVEDALHATRAAVEEGIVPGGGVAFI
CHHHHHHHHHHHHCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RSIGALADAKLPDEEQQGLNIVRRALEEPLRQIAANAGCEGSIVVEKVKESNGTHGFDAE
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCC
TEQYVDMLKAGIIDPTKVARFALQNAASVASLLLTTEAMIAEKPKKKEPPMPAMPSDMGD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
YD
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA