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The map label for this gene is guaB [H]

Identifier: 85859456

GI number: 85859456

Start: 1660157

End: 1661617

Strand: Direct

Name: guaB [H]

Synonym: SYN_00897

Alternate gene names: 85859456

Gene position: 1660157-1661617 (Clockwise)

Preceding gene: 85859455

Following gene: 85859457

Centisome position: 52.22

GC content: 50.44

Gene sequence:

>1461_bases
ATGTTAGATGATCATGTAAGACAAGCATTCACATTTGATGATTTACTGCTTTTACCGTCGGAATCACAAATACTCCCTCG
TGATGCAGACCTTTCGACGTGGCTTACGAATCGGATAGCCCTGAAAATACCAATCGTTGCGGCTGCAATGGATACGGTCA
CAGAGTCTGCCACAGCCATTTGCCTCGCCCGCGAGGGGGGGATCGGTATTATTCACCGCAATATGAGCATTGAAAGGCAG
GTCCTTGAAGTCGACAAGGTTAAAAAGTCGGAGAGCGGAATGATTGTCGATCCGATTACCATCGAACCCGAACAGAAAGT
CAGTGAAGCCCTTGATTTGATGCATCGCTACAAAATATCCGGTGTCCCCGTGGTTAAAAATAAAAAACTTGTGGGTATTC
TGACAAACCGTGATCTGCGCTTCGAAGAGAATCTGCATCAGCCGGTATCAAACGTCATGACCAGGGAAAATCTGGTGACG
GTGTCCGCCAACATCTCTCTGGAAGAATCCAAAAGACTGCTTCATAAACATCGGATTGAAAAACTTCTGGTGGTTGATGA
ATCCTATAACCTGAAAGGCTTGATAACGATCAAGGATATTGAAAAGATCAAAAAATATCCCAATGCCTGTAAAGATTCCC
TCGGACGGCTGCGAGCGGGGGCAGCCGTAGGAATCCTGGACCGGGAAGCACGGGTTGACGCCCTGTTGAATGCTGGTGTG
GATGTGATTGTAATCGATACCTCTCATGGTCACTCAAAAGGTGTTCTCGACGCAGTGAGGGATACAAAGAGCAATTTCCC
CAATTGTGAACTGGTCGCGGGCAATGTAGCCACCGCAGAGGGAGCGCAGGCCCTGATCGACGCGGGTGTCGATGCCGTGA
AGGTTGGCGTGGGACCCGGATCCATCTGCACGACGCGCATCATCGCCGGTGTAGGGGTTCCTCAAATCACCGCAATCGCG
GACGCATACAGGGTATGTGCCCGCAATAATATCCCGGTTATCGCCGATGGTGGGATAAAATTCTCCGGAGACATCGTTAA
AGCGCTCGCCGCGGGAGCCCATTCCGTCATGATCGGCGGTCTTTTCGCGGGAACCGAAGAAAGTCCCGGAGAAACCATCC
TGTTTCAGGGGAGAAGTTATAAGGTCTATCGCGGCATGGGATCGCTTGAAGCCATGAAAATGGGCAGTCGGGATCGTTAT
TACCAGGACGATATAGAAAGCAACCTGAAGCTCGTTCCTGAAGGCATAGAGGGCAGGGTGCCTTTTCGAGGCTCATTGTC
CGCAAGTATCCACCAATTGAAAGGCGGAGTCCTGGCCGGCATGGGTTATGTGGGATGCCGGACAATAAAGGAACTGAGGG
AGAAAGCGCGCTTCACAAAGATTACATCGGCAGGCCTTCGGGAAAGCCATGTCCATGACGTGATCATTACAAAGGAAGCA
CCTAATTACTGGCTTGATTGA

Upstream 100 bases:

>100_bases
AAAGACGACGAGAGCCGACTGCCATAGTTTATTTTTTCAAATTTGAGCTGCTCAGAAGGGGCTGGAGCCATGAGTCGCTT
TTCCTTCCCGGAGGTTTAAT

Downstream 100 bases:

>100_bases
AAACCAGAACTTTGAAAGTAACATCCGATGAAAATTGAAACGTTTGTTCACCTCCATGTCCATACGCAGTACAGTCTGCT
TGACGGCACCATCCGGATCA

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MLDDHVRQAFTFDDLLLLPSESQILPRDADLSTWLTNRIALKIPIVAAAMDTVTESATAICLAREGGIGIIHRNMSIERQ
VLEVDKVKKSESGMIVDPITIEPEQKVSEALDLMHRYKISGVPVVKNKKLVGILTNRDLRFEENLHQPVSNVMTRENLVT
VSANISLEESKRLLHKHRIEKLLVVDESYNLKGLITIKDIEKIKKYPNACKDSLGRLRAGAAVGILDREARVDALLNAGV
DVIVIDTSHGHSKGVLDAVRDTKSNFPNCELVAGNVATAEGAQALIDAGVDAVKVGVGPGSICTTRIIAGVGVPQITAIA
DAYRVCARNNIPVIADGGIKFSGDIVKALAAGAHSVMIGGLFAGTEESPGETILFQGRSYKVYRGMGSLEAMKMGSRDRY
YQDDIESNLKLVPEGIEGRVPFRGSLSASIHQLKGGVLAGMGYVGCRTIKELREKARFTKITSAGLRESHVHDVIITKEA
PNYWLD

Sequences:

>Translated_486_residues
MLDDHVRQAFTFDDLLLLPSESQILPRDADLSTWLTNRIALKIPIVAAAMDTVTESATAICLAREGGIGIIHRNMSIERQ
VLEVDKVKKSESGMIVDPITIEPEQKVSEALDLMHRYKISGVPVVKNKKLVGILTNRDLRFEENLHQPVSNVMTRENLVT
VSANISLEESKRLLHKHRIEKLLVVDESYNLKGLITIKDIEKIKKYPNACKDSLGRLRAGAAVGILDREARVDALLNAGV
DVIVIDTSHGHSKGVLDAVRDTKSNFPNCELVAGNVATAEGAQALIDAGVDAVKVGVGPGSICTTRIIAGVGVPQITAIA
DAYRVCARNNIPVIADGGIKFSGDIVKALAAGAHSVMIGGLFAGTEESPGETILFQGRSYKVYRGMGSLEAMKMGSRDRY
YQDDIESNLKLVPEGIEGRVPFRGSLSASIHQLKGGVLAGMGYVGCRTIKELREKARFTKITSAGLRESHVHDVIITKEA
PNYWLD
>Mature_486_residues
MLDDHVRQAFTFDDLLLLPSESQILPRDADLSTWLTNRIALKIPIVAAAMDTVTESATAICLAREGGIGIIHRNMSIERQ
VLEVDKVKKSESGMIVDPITIEPEQKVSEALDLMHRYKISGVPVVKNKKLVGILTNRDLRFEENLHQPVSNVMTRENLVT
VSANISLEESKRLLHKHRIEKLLVVDESYNLKGLITIKDIEKIKKYPNACKDSLGRLRAGAAVGILDREARVDALLNAGV
DVIVIDTSHGHSKGVLDAVRDTKSNFPNCELVAGNVATAEGAQALIDAGVDAVKVGVGPGSICTTRIIAGVGVPQITAIA
DAYRVCARNNIPVIADGGIKFSGDIVKALAAGAHSVMIGGLFAGTEESPGETILFQGRSYKVYRGMGSLEAMKMGSRDRY
YQDDIESNLKLVPEGIEGRVPFRGSLSASIHQLKGGVLAGMGYVGCRTIKELREKARFTKITSAGLRESHVHDVIITKEA
PNYWLD

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=480, Percent_Identity=39.375, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI217035146, Length=478, Percent_Identity=39.9581589958159, Blast_Score=322, Evalue=5e-88,
Organism=Homo sapiens, GI34328928, Length=478, Percent_Identity=39.9581589958159, Blast_Score=321, Evalue=9e-88,
Organism=Homo sapiens, GI156616279, Length=478, Percent_Identity=39.9581589958159, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI34328930, Length=478, Percent_Identity=39.9581589958159, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI217035152, Length=484, Percent_Identity=39.8760330578512, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI217035148, Length=478, Percent_Identity=39.1213389121339, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI217035150, Length=478, Percent_Identity=37.0292887029289, Blast_Score=285, Evalue=7e-77,
Organism=Homo sapiens, GI50541954, Length=253, Percent_Identity=37.5494071146245, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI50541952, Length=253, Percent_Identity=37.5494071146245, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI50541948, Length=253, Percent_Identity=37.5494071146245, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI50541956, Length=253, Percent_Identity=37.5494071146245, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI156104880, Length=225, Percent_Identity=36.8888888888889, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1788855, Length=482, Percent_Identity=59.1286307053942, Blast_Score=520, Evalue=1e-149,
Organism=Escherichia coli, GI1786293, Length=346, Percent_Identity=27.7456647398844, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=500, Percent_Identity=35.4, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=36.7298578199052, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17560440, Length=241, Percent_Identity=36.5145228215768, Blast_Score=158, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6322012, Length=494, Percent_Identity=39.8785425101215, Blast_Score=326, Evalue=6e-90,
Organism=Saccharomyces cerevisiae, GI6323585, Length=495, Percent_Identity=38.989898989899, Blast_Score=315, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6323464, Length=494, Percent_Identity=40.080971659919, Blast_Score=311, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6319352, Length=349, Percent_Identity=39.8280802292264, Blast_Score=239, Evalue=5e-64,
Organism=Saccharomyces cerevisiae, GI6319353, Length=141, Percent_Identity=39.0070921985816, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24641071, Length=486, Percent_Identity=39.3004115226337, Blast_Score=322, Evalue=3e-88,
Organism=Drosophila melanogaster, GI24641073, Length=486, Percent_Identity=39.3004115226337, Blast_Score=322, Evalue=3e-88,
Organism=Drosophila melanogaster, GI28571163, Length=444, Percent_Identity=40.0900900900901, Blast_Score=291, Evalue=5e-79,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52743; Mature: 52743

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDDHVRQAFTFDDLLLLPSESQILPRDADLSTWLTNRIALKIPIVAAAMDTVTESATAI
CCCHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHCCEEEEEEHHHHHHHHHHCCCEEE
CLAREGGIGIIHRNMSIERQVLEVDKVKKSESGMIVDPITIEPEQKVSEALDLMHRYKIS
EEEECCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEECEEECCHHHHHHHHHHHHHHHCC
GVPVVKNKKLVGILTNRDLRFEENLHQPVSNVMTRENLVTVSANISLEESKRLLHKHRIE
CCCEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHC
KLLVVDESYNLKGLITIKDIEKIKKYPNACKDSLGRLRAGAAVGILDREARVDALLNAGV
EEEEEECCCCCEEEEEHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCC
DVIVIDTSHGHSKGVLDAVRDTKSNFPNCELVAGNVATAEGAQALIDAGVDAVKVGVGPG
EEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHCCCCEEEECCCCC
SICTTRIIAGVGVPQITAIADAYRVCARNNIPVIADGGIKFSGDIVKALAAGAHSVMIGG
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCEEECHHHHHHHHCCCCCEEEEE
LFAGTEESPGETILFQGRSYKVYRGMGSLEAMKMGSRDRYYQDDIESNLKLVPEGIEGRV
EEECCCCCCCCEEEEECCCEEEEECCCCHHHHHCCCCCCCCHHHHHCCCEEECCCCCCCC
PFRGSLSASIHQLKGGVLAGMGYVGCRTIKELREKARFTKITSAGLRESHVHDVIITKEA
CCCCCCHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECC
PNYWLD
CCCCCC
>Mature Secondary Structure
MLDDHVRQAFTFDDLLLLPSESQILPRDADLSTWLTNRIALKIPIVAAAMDTVTESATAI
CCCHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHCCEEEEEEHHHHHHHHHHCCCEEE
CLAREGGIGIIHRNMSIERQVLEVDKVKKSESGMIVDPITIEPEQKVSEALDLMHRYKIS
EEEECCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEECEEECCHHHHHHHHHHHHHHHCC
GVPVVKNKKLVGILTNRDLRFEENLHQPVSNVMTRENLVTVSANISLEESKRLLHKHRIE
CCCEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHC
KLLVVDESYNLKGLITIKDIEKIKKYPNACKDSLGRLRAGAAVGILDREARVDALLNAGV
EEEEEECCCCCEEEEEHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCC
DVIVIDTSHGHSKGVLDAVRDTKSNFPNCELVAGNVATAEGAQALIDAGVDAVKVGVGPG
EEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHCCCCEEEECCCCC
SICTTRIIAGVGVPQITAIADAYRVCARNNIPVIADGGIKFSGDIVKALAAGAHSVMIGG
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCEEECHHHHHHHHCCCCCEEEEE
LFAGTEESPGETILFQGRSYKVYRGMGSLEAMKMGSRDRYYQDDIESNLKLVPEGIEGRV
EEECCCCCCCCEEEEECCCEEEEECCCCHHHHHCCCCCCCCHHHHHCCCEEECCCCCCCC
PFRGSLSASIHQLKGGVLAGMGYVGCRTIKELREKARFTKITSAGLRESHVHDVIITKEA
CCCCCCHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECC
PNYWLD
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]