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The map label for this gene is relA [H]

Identifier: 85859448

GI number: 85859448

Start: 1653462

End: 1655633

Strand: Direct

Name: relA [H]

Synonym: SYN_00904

Alternate gene names: 85859448

Gene position: 1653462-1655633 (Clockwise)

Preceding gene: 85859447

Following gene: 85859449

Centisome position: 52.01

GC content: 47.47

Gene sequence:

>2172_bases
ATGCTCAGGATTACAGATATCCTCGATAAAACACAGGAATATCTTACTCCCATAGAACAGGAGTTGATTGAAAAGGCCTA
TATCTTTTCGGCATCCGTCCATCAGGGGCAGGTGCGTCTCTCCGGCGAGCCCTATATGACCCATCCCATGGAGGTTGCAG
GCATTCTGTCTGACATGGAACTTGATGCGGCGACTATAGCAACGGGACTTCTGCACGACACCGTGGAAGACACCCTGACA
ACTCTTGAACAGATCGAAGAGCTCTTTGGGAAAGATGTCGCGTTCCTTGTCGACGGACTGACAAAGATCAGCAAGATTAC
CTTCAGCAGTCAGGAAGAACGTCAGGCGGAAAATTTTCGCAAGATGATTCTGGCCATGTCAGCGGATATTAGAATTCTCC
TTGTGCGTCTGGCGGATCGTATCCACAACATGAGAACCCTCGAGTTTCATACACCTGAAAGACAGAAGTATATAGCAAAA
GAAACCATGGAGTTATATGCACCTTTGGCCAATCGTCTGGGCATCTATCGAATGCAGGTTGAACTTGAAGACATTGCGTT
CCGTTACCTGGATTACGAATCATACGCAAATCTGTCTCGGCGCATTGCGTTGAAGCGGGAAAAAAGAGATGAGTATACCG
AGGAAGTCAAAAGCATAATTCAGGCAAAACTCGATGAGTACGGCATGAAAGGCGTCGTTGAAGGAAGGGCAAAGCATTTC
TGGAGTATTCACAAGAAGATGCATGAGCAGAAAATCAATTTTGACGAGGTTTATGATTTGACTGCCTTCCGCATCATTCT
GGATTCCGACAAGGAAAAAGATTGTTACGAAGCCCTCAGCATCGTTCATTCTCTGTGGATCCCGGTACCCAGAAGGTTTA
AGGATTATATCGCCATGCCGAAGGCGAACAACTATCGTTCACTTCATACGACCGTCATCGGCCCCTATGGCCAGCGGGTG
GAAGTCCAAATCCGAACGAGGGAAATGCATGAGTGGGCGGAGGAGGGGATCGCCGCTCATTGGCGATATAAGGAAAAACG
ATCGCTTCCAGGGGATGACGAGGAACAGATTCGAAAACTTCGCGAGTTGCTGGAAGTTCAGCAGGAGTTGAAGAACCCTC
GTGAGTTCATGTCAAATCTCAAACTGGCGTTGTTTCCGGATGAAGTTTATGTTTTTACGCCTGGGGGAGATGTCAGGTCA
TTCCCCAAAGGGGCCACGCCGATTGATTTTGCCTACAGCATCCATACCGATGTGGGACACCAGTGCATCGGTGCGAAGGT
CAATCGGAGTATCGTTCCCCTTAAATATGAACTTAAAAATGGAGATATCGTTGAGATTATCACTCAGGCTGGCCATCATC
CCAGCAAAGACTGGCTGAAGCACACGGTAACCTCCAGGGCAAGATCGAAAATCAAGAACTGGGTCAAGGCGGAAGAAAGC
AAAAAAAGCATCTCCCTTGGAAAGGATCTTCTGGAAAAAGAGTTCAGAAAACATTCACTTAAATTCAGCTCGATCGTCAA
ATCTGATGAAATCCGCGATCTCTATAATGAATTATCTGTCAATTCACTGGATGATCTTCTGGCCCTTGTGGGATACGGCC
GAGTTTCCGCGAAACGGATCGTTAATTATTTTGTCCACGAAGAGATCGGTGTCAGTGAAAAACCTCCTGACGAAACCATA
TCCAGGAAAGGTAAAAGAGACGCCTCTCAAGGGATTTCCATAACCGGTATTGAAGATATCATGGTGCGGTTTGCCAAATG
CTGTGACCCGATCCCCGGTGATGAGATCGTCGGGTACATATCGAGAGGGCGAGGCGTAGCCATTCATACCGTTGATTGTG
AACGGTTGCAGGAACTGGATTCAGAACGGATCATCGATGTCTCCTGGAGTGCAAAAGCCAGTCAGACCTACTCCGTAAAT
ATGGTCGTCACCTGTAAGGACCAGAAAGGTATTCTGGCGGAAATCAGTTCAGCCATTTCATCACTGGATGTCAATATCAG
CTCGGCGAGGGTTGAAACCCGAAAGGATGGTCGAGTCATTTGTTTTTTCCGGATCGATGTGACCGGGTTGAGACAGTTGA
ATGCCCTCACTTCAGCAATCAAACAGCTCAAAGATGTCATTTCTGTGGAGAGGGTTCATCAGACTAAAGAGCAACCCCGG
CCATCCGATTAA

Upstream 100 bases:

>100_bases
AGAAATATTCGATTCCATACATTCCCATACATCAACAATTGATTGTTATATTATGTATCATTGGCAAAACCGGCTTCATC
AGCAATAAAGAAGGGGCTTC

Downstream 100 bases:

>100_bases
TGTCCCCCACTTATTTATTGACAGGTGTTCGTTTTTTGCTGTATGAGAGGCACACCTCATTGAGCATGATACAGGGAAGA
CAATCCGGCATATGGTAAAT

Product: GTP pyrophosphokinase / guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 723; Mature: 723

Protein sequence:

>723_residues
MLRITDILDKTQEYLTPIEQELIEKAYIFSASVHQGQVRLSGEPYMTHPMEVAGILSDMELDAATIATGLLHDTVEDTLT
TLEQIEELFGKDVAFLVDGLTKISKITFSSQEERQAENFRKMILAMSADIRILLVRLADRIHNMRTLEFHTPERQKYIAK
ETMELYAPLANRLGIYRMQVELEDIAFRYLDYESYANLSRRIALKREKRDEYTEEVKSIIQAKLDEYGMKGVVEGRAKHF
WSIHKKMHEQKINFDEVYDLTAFRIILDSDKEKDCYEALSIVHSLWIPVPRRFKDYIAMPKANNYRSLHTTVIGPYGQRV
EVQIRTREMHEWAEEGIAAHWRYKEKRSLPGDDEEQIRKLRELLEVQQELKNPREFMSNLKLALFPDEVYVFTPGGDVRS
FPKGATPIDFAYSIHTDVGHQCIGAKVNRSIVPLKYELKNGDIVEIITQAGHHPSKDWLKHTVTSRARSKIKNWVKAEES
KKSISLGKDLLEKEFRKHSLKFSSIVKSDEIRDLYNELSVNSLDDLLALVGYGRVSAKRIVNYFVHEEIGVSEKPPDETI
SRKGKRDASQGISITGIEDIMVRFAKCCDPIPGDEIVGYISRGRGVAIHTVDCERLQELDSERIIDVSWSAKASQTYSVN
MVVTCKDQKGILAEISSAISSLDVNISSARVETRKDGRVICFFRIDVTGLRQLNALTSAIKQLKDVISVERVHQTKEQPR
PSD

Sequences:

>Translated_723_residues
MLRITDILDKTQEYLTPIEQELIEKAYIFSASVHQGQVRLSGEPYMTHPMEVAGILSDMELDAATIATGLLHDTVEDTLT
TLEQIEELFGKDVAFLVDGLTKISKITFSSQEERQAENFRKMILAMSADIRILLVRLADRIHNMRTLEFHTPERQKYIAK
ETMELYAPLANRLGIYRMQVELEDIAFRYLDYESYANLSRRIALKREKRDEYTEEVKSIIQAKLDEYGMKGVVEGRAKHF
WSIHKKMHEQKINFDEVYDLTAFRIILDSDKEKDCYEALSIVHSLWIPVPRRFKDYIAMPKANNYRSLHTTVIGPYGQRV
EVQIRTREMHEWAEEGIAAHWRYKEKRSLPGDDEEQIRKLRELLEVQQELKNPREFMSNLKLALFPDEVYVFTPGGDVRS
FPKGATPIDFAYSIHTDVGHQCIGAKVNRSIVPLKYELKNGDIVEIITQAGHHPSKDWLKHTVTSRARSKIKNWVKAEES
KKSISLGKDLLEKEFRKHSLKFSSIVKSDEIRDLYNELSVNSLDDLLALVGYGRVSAKRIVNYFVHEEIGVSEKPPDETI
SRKGKRDASQGISITGIEDIMVRFAKCCDPIPGDEIVGYISRGRGVAIHTVDCERLQELDSERIIDVSWSAKASQTYSVN
MVVTCKDQKGILAEISSAISSLDVNISSARVETRKDGRVICFFRIDVTGLRQLNALTSAIKQLKDVISVERVHQTKEQPR
PSD
>Mature_723_residues
MLRITDILDKTQEYLTPIEQELIEKAYIFSASVHQGQVRLSGEPYMTHPMEVAGILSDMELDAATIATGLLHDTVEDTLT
TLEQIEELFGKDVAFLVDGLTKISKITFSSQEERQAENFRKMILAMSADIRILLVRLADRIHNMRTLEFHTPERQKYIAK
ETMELYAPLANRLGIYRMQVELEDIAFRYLDYESYANLSRRIALKREKRDEYTEEVKSIIQAKLDEYGMKGVVEGRAKHF
WSIHKKMHEQKINFDEVYDLTAFRIILDSDKEKDCYEALSIVHSLWIPVPRRFKDYIAMPKANNYRSLHTTVIGPYGQRV
EVQIRTREMHEWAEEGIAAHWRYKEKRSLPGDDEEQIRKLRELLEVQQELKNPREFMSNLKLALFPDEVYVFTPGGDVRS
FPKGATPIDFAYSIHTDVGHQCIGAKVNRSIVPLKYELKNGDIVEIITQAGHHPSKDWLKHTVTSRARSKIKNWVKAEES
KKSISLGKDLLEKEFRKHSLKFSSIVKSDEIRDLYNELSVNSLDDLLALVGYGRVSAKRIVNYFVHEEIGVSEKPPDETI
SRKGKRDASQGISITGIEDIMVRFAKCCDPIPGDEIVGYISRGRGVAIHTVDCERLQELDSERIIDVSWSAKASQTYSVN
MVVTCKDQKGILAEISSAISSLDVNISSARVETRKDGRVICFFRIDVTGLRQLNALTSAIKQLKDVISVERVHQTKEQPR
PSD

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=137, Percent_Identity=37.2262773722628, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1790082, Length=708, Percent_Identity=41.8079096045198, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI1789147, Length=718, Percent_Identity=36.3509749303621, Blast_Score=468, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI25143118, Length=134, Percent_Identity=35.8208955223881, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24650996, Length=128, Percent_Identity=34.375, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 82887; Mature: 82887

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRITDILDKTQEYLTPIEQELIEKAYIFSASVHQGQVRLSGEPYMTHPMEVAGILSDME
CCCHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHCC
LDAATIATGLLHDTVEDTLTTLEQIEELFGKDVAFLVDGLTKISKITFSSQEERQAENFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
KMILAMSADIRILLVRLADRIHNMRTLEFHTPERQKYIAKETMELYAPLANRLGIYRMQV
HHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEE
ELEDIAFRYLDYESYANLSRRIALKREKRDEYTEEVKSIIQAKLDEYGMKGVVEGRAKHF
EHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
WSIHKKMHEQKINFDEVYDLTAFRIILDSDKEKDCYEALSIVHSLWIPVPRRFKDYIAMP
HHHHHHHHHHCCCHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCC
KANNYRSLHTTVIGPYGQRVEVQIRTREMHEWAEEGIAAHWRYKEKRSLPGDDEEQIRKL
CCCCCCEEEEEEECCCCCEEEEEEEHHHHHHHHHCCCHHHCCCHHHCCCCCCCHHHHHHH
RELLEVQQELKNPREFMSNLKLALFPDEVYVFTPGGDVRSFPKGATPIDFAYSIHTDVGH
HHHHHHHHHHCCHHHHHHCCEEEEECCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCC
QCIGAKVNRSIVPLKYELKNGDIVEIITQAGHHPSKDWLKHTVTSRARSKIKNWVKAEES
HHHCCCCCCCEEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KKSISLGKDLLEKEFRKHSLKFSSIVKSDEIRDLYNELSVNSLDDLLALVGYGRVSAKRI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHH
VNYFVHEEIGVSEKPPDETISRKGKRDASQGISITGIEDIMVRFAKCCDPIPGDEIVGYI
HHHHHHHHCCCCCCCCCHHHHHCCCCHHHCCCEEECHHHHHHHHHHHCCCCCCHHHHHHH
SRGRGVAIHTVDCERLQELDSERIIDVSWSAKASQTYSVNMVVTCKDQKGILAEISSAIS
HCCCCEEEEECCHHHHHCCCCCCEEEEECCCCCCCEEEEEEEEEECCCCCHHHHHHHHHH
SLDVNISSARVETRKDGRVICFFRIDVTGLRQLNALTSAIKQLKDVISVERVHQTKEQPR
HHCCCCHHHEEEECCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PSD
CCC
>Mature Secondary Structure
MLRITDILDKTQEYLTPIEQELIEKAYIFSASVHQGQVRLSGEPYMTHPMEVAGILSDME
CCCHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHCC
LDAATIATGLLHDTVEDTLTTLEQIEELFGKDVAFLVDGLTKISKITFSSQEERQAENFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
KMILAMSADIRILLVRLADRIHNMRTLEFHTPERQKYIAKETMELYAPLANRLGIYRMQV
HHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEE
ELEDIAFRYLDYESYANLSRRIALKREKRDEYTEEVKSIIQAKLDEYGMKGVVEGRAKHF
EHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
WSIHKKMHEQKINFDEVYDLTAFRIILDSDKEKDCYEALSIVHSLWIPVPRRFKDYIAMP
HHHHHHHHHHCCCHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCC
KANNYRSLHTTVIGPYGQRVEVQIRTREMHEWAEEGIAAHWRYKEKRSLPGDDEEQIRKL
CCCCCCEEEEEEECCCCCEEEEEEEHHHHHHHHHCCCHHHCCCHHHCCCCCCCHHHHHHH
RELLEVQQELKNPREFMSNLKLALFPDEVYVFTPGGDVRSFPKGATPIDFAYSIHTDVGH
HHHHHHHHHHCCHHHHHHCCEEEEECCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCC
QCIGAKVNRSIVPLKYELKNGDIVEIITQAGHHPSKDWLKHTVTSRARSKIKNWVKAEES
HHHCCCCCCCEEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KKSISLGKDLLEKEFRKHSLKFSSIVKSDEIRDLYNELSVNSLDDLLALVGYGRVSAKRI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHH
VNYFVHEEIGVSEKPPDETISRKGKRDASQGISITGIEDIMVRFAKCCDPIPGDEIVGYI
HHHHHHHHCCCCCCCCCHHHHHCCCCHHHCCCEEECHHHHHHHHHHHCCCCCCHHHHHHH
SRGRGVAIHTVDCERLQELDSERIIDVSWSAKASQTYSVNMVVTCKDQKGILAEISSAIS
HCCCCEEEEECCHHHHHCCCCCCEEEEECCCCCCCEEEEEEEEEECCCCCHHHHHHHHHH
SLDVNISSARVETRKDGRVICFFRIDVTGLRQLNALTSAIKQLKDVISVERVHQTKEQPR
HHCCCCHHHEEEECCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PSD
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA