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The map label for this gene is kbl [C]

Identifier: 85858958

GI number: 85858958

Start: 1138960

End: 1140213

Strand: Direct

Name: kbl [C]

Synonym: SYN_00565

Alternate gene names: 85858958

Gene position: 1138960-1140213 (Clockwise)

Preceding gene: 85858957

Following gene: 85858959

Centisome position: 35.82

GC content: 60.77

Gene sequence:

>1254_bases
TTGAACATCTTGCATTCAAACTGGGAAAAGCGGGGGAGGATCGACATGGCGCAGGATAAACTGAAACGCCTGCTGGTGGA
GAAGCTGGATGCGATGGAACGAAACGGCGTCCGCAAGGGGAAAGAAAGAATCATCACCGGCCGCCGGCCGCCCCGCGACG
GCTTCGGTCCGAGATATTTTCTCAAGAGCTGTGGGGGGCGGGCTTTTCTACGTATGAATGCCAATGCCTACCTCGGCCTC
AACACCCACCCTCGCGTGGTGGAAGCGGAAGAAACTGCCGTCCGGCGCTACGGCGCGGGACCCGGTGCGGTACGCTTCAT
CAGCGGCACCTTCGAACCCCACATCAAGCTGGAAGAGCGCCTGGCCTCTTTCCACGGGCGGGAAGCGGGAATGCTGTTCA
GTGCCGCCTACGCAGCAGTCATGGGCGTGCTGCCGCAGCTTGTCACCGGGGAGACCCTGGTGGTGAGCGACGCCCTCAAC
CATAACTGCATCATCAACGCCGTCCGTCTGGCCCAGCCCGCCGCCAGAGCGGTTTATGAACACCTGGACACCGCCCGGCT
GGAAGGCCTCCTGGAGCAGTATCTGGGAAAGGCCAAGAGGGTCGTTGTCGTCACCGACGGTGTCTTCAGCATGCGCGGCG
ACTACGCCCCCCTGGACGTAATCTGTGCGATCTGCAGGCGTTATTCCGAGCTTTTTGAGGAAGGGGTGATTTCCGTTGTT
GATGACTCTCACGGCGTCGGCGCCTTCGGAGAGACCGGCAGGGGAAGCGAGGAAAAAACGGCGGCGCGGGCCGACATCCT
CATTGCCACGCTGGGCAAGGCGCTCGGCGTCAACGGTGGCTATGTGGTGTCTGACAGGACGGTCATCGACTACCTGCGGG
AAACCGCTCCCTTCTACATTTACTCCAATCCGATTACTCCTTCGGAAGCGGCCGCCGCCCTTGCGGCGCTGGAAATACTC
GACAGCGGCGAGGGAATCGGTCTGCTGAAAAAAATCCGGGACCTTGCCGCCTCCCTGCGCCGGGGTTTTCGGGATTGCGG
CCGCGAAACCCTGGACGGCGAACACCCCATCGTTCCCCTCCTGATTCGGGATACCGCAAAAACCAGGGAACTGGTTCAGC
GGCTTTATGATCGCGACGTTCTGGCGACAGGTCTCGGTTATCCCGTCGTGCCCAGAGGGGATGAGGAACTCCGGTTCCAG
ATCTCCGCGGAGCATACCGAAAGAGACATCGGTTATCTGCTGGATGTTTTGTGA

Upstream 100 bases:

>100_bases
ATTGCCGATTCCTGGCCCCGGCACATGGATGACAGCGCGGCGCGTACGGAATGGGGCTGGCAGCCCCGTTACGACCTTGC
CGCCACGACATCGGAAATGA

Downstream 100 bases:

>100_bases
AAGAGAAAACTCGATGAGCGAGGAGTTCGAAAACCGGGAACAATTGCTGGACGAGATTTCATCGCTGCGTCAGCGCGTTA
AGGAACTTGAAGTATCCGTT

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MNILHSNWEKRGRIDMAQDKLKRLLVEKLDAMERNGVRKGKERIITGRRPPRDGFGPRYFLKSCGGRAFLRMNANAYLGL
NTHPRVVEAEETAVRRYGAGPGAVRFISGTFEPHIKLEERLASFHGREAGMLFSAAYAAVMGVLPQLVTGETLVVSDALN
HNCIINAVRLAQPAARAVYEHLDTARLEGLLEQYLGKAKRVVVVTDGVFSMRGDYAPLDVICAICRRYSELFEEGVISVV
DDSHGVGAFGETGRGSEEKTAARADILIATLGKALGVNGGYVVSDRTVIDYLRETAPFYIYSNPITPSEAAAALAALEIL
DSGEGIGLLKKIRDLAASLRRGFRDCGRETLDGEHPIVPLLIRDTAKTRELVQRLYDRDVLATGLGYPVVPRGDEELRFQ
ISAEHTERDIGYLLDVL

Sequences:

>Translated_417_residues
MNILHSNWEKRGRIDMAQDKLKRLLVEKLDAMERNGVRKGKERIITGRRPPRDGFGPRYFLKSCGGRAFLRMNANAYLGL
NTHPRVVEAEETAVRRYGAGPGAVRFISGTFEPHIKLEERLASFHGREAGMLFSAAYAAVMGVLPQLVTGETLVVSDALN
HNCIINAVRLAQPAARAVYEHLDTARLEGLLEQYLGKAKRVVVVTDGVFSMRGDYAPLDVICAICRRYSELFEEGVISVV
DDSHGVGAFGETGRGSEEKTAARADILIATLGKALGVNGGYVVSDRTVIDYLRETAPFYIYSNPITPSEAAAALAALEIL
DSGEGIGLLKKIRDLAASLRRGFRDCGRETLDGEHPIVPLLIRDTAKTRELVQRLYDRDVLATGLGYPVVPRGDEELRFQ
ISAEHTERDIGYLLDVL
>Mature_417_residues
MNILHSNWEKRGRIDMAQDKLKRLLVEKLDAMERNGVRKGKERIITGRRPPRDGFGPRYFLKSCGGRAFLRMNANAYLGL
NTHPRVVEAEETAVRRYGAGPGAVRFISGTFEPHIKLEERLASFHGREAGMLFSAAYAAVMGVLPQLVTGETLVVSDALN
HNCIINAVRLAQPAARAVYEHLDTARLEGLLEQYLGKAKRVVVVTDGVFSMRGDYAPLDVICAICRRYSELFEEGVISVV
DDSHGVGAFGETGRGSEEKTAARADILIATLGKALGVNGGYVVSDRTVIDYLRETAPFYIYSNPITPSEAAAALAALEIL
DSGEGIGLLKKIRDLAASLRRGFRDCGRETLDGEHPIVPLLIRDTAKTRELVQRLYDRDVLATGLGYPVVPRGDEELRFQ
ISAEHTERDIGYLLDVL

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=411, Percent_Identity=36.7396593673966, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI284448556, Length=430, Percent_Identity=35.8139534883721, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI4502025, Length=350, Percent_Identity=32.2857142857143, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI40316939, Length=350, Percent_Identity=32.2857142857143, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI83977442, Length=341, Percent_Identity=31.9648093841642, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI83977444, Length=341, Percent_Identity=31.9648093841642, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI83977440, Length=341, Percent_Identity=31.9648093841642, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI119220554, Length=365, Percent_Identity=26.8493150684932, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI4758668, Length=358, Percent_Identity=27.3743016759777, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI5454084, Length=345, Percent_Identity=26.3768115942029, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1790046, Length=394, Percent_Identity=35.5329949238579, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1786993, Length=351, Percent_Identity=33.3333333333333, Blast_Score=181, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI71994529, Length=398, Percent_Identity=34.9246231155779, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI32566772, Length=370, Percent_Identity=27.5675675675676, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17560912, Length=323, Percent_Identity=27.2445820433437, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17560914, Length=323, Percent_Identity=27.2445820433437, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71982625, Length=366, Percent_Identity=25.6830601092896, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71982617, Length=366, Percent_Identity=25.6830601092896, Blast_Score=98, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320438, Length=361, Percent_Identity=29.0858725761773, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320267, Length=373, Percent_Identity=28.4182305630027, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323954, Length=287, Percent_Identity=27.1777003484321, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24662918, Length=398, Percent_Identity=35.1758793969849, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI17137420, Length=339, Percent_Identity=31.2684365781711, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI17136286, Length=367, Percent_Identity=29.4277929155313, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24653280, Length=348, Percent_Identity=24.7126436781609, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24653276, Length=348, Percent_Identity=24.7126436781609, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24653278, Length=348, Percent_Identity=24.7126436781609, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 45908; Mature: 45908

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILHSNWEKRGRIDMAQDKLKRLLVEKLDAMERNGVRKGKERIITGRRPPRDGFGPRYF
CCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHEECCCCCCCCCCCHHHH
LKSCGGRAFLRMNANAYLGLNTHPRVVEAEETAVRRYGAGPGAVRFISGTFEPHIKLEER
HHHCCCCEEEEECCCEEEECCCCCCEEEHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHH
LASFHGREAGMLFSAAYAAVMGVLPQLVTGETLVVSDALNHNCIINAVRLAQPAARAVYE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
HLDTARLEGLLEQYLGKAKRVVVVTDGVFSMRGDYAPLDVICAICRRYSELFEEGVISVV
HHHHHHHHHHHHHHHCCCCEEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEE
DDSHGVGAFGETGRGSEEKTAARADILIATLGKALGVNGGYVVSDRTVIDYLRETAPFYI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCEEE
YSNPITPSEAAAALAALEILDSGEGIGLLKKIRDLAASLRRGFRDCGRETLDGEHPIVPL
EECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCEEEE
LIRDTAKTRELVQRLYDRDVLATGLGYPVVPRGDEELRFQISAEHTERDIGYLLDVL
EECCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHEEEEEECCHHHHHHHHHHHCC
>Mature Secondary Structure
MNILHSNWEKRGRIDMAQDKLKRLLVEKLDAMERNGVRKGKERIITGRRPPRDGFGPRYF
CCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHEECCCCCCCCCCCHHHH
LKSCGGRAFLRMNANAYLGLNTHPRVVEAEETAVRRYGAGPGAVRFISGTFEPHIKLEER
HHHCCCCEEEEECCCEEEECCCCCCEEEHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHH
LASFHGREAGMLFSAAYAAVMGVLPQLVTGETLVVSDALNHNCIINAVRLAQPAARAVYE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
HLDTARLEGLLEQYLGKAKRVVVVTDGVFSMRGDYAPLDVICAICRRYSELFEEGVISVV
HHHHHHHHHHHHHHHCCCCEEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEE
DDSHGVGAFGETGRGSEEKTAARADILIATLGKALGVNGGYVVSDRTVIDYLRETAPFYI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCEEE
YSNPITPSEAAAALAALEILDSGEGIGLLKKIRDLAASLRRGFRDCGRETLDGEHPIVPL
EECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCEEEE
LIRDTAKTRELVQRLYDRDVLATGLGYPVVPRGDEELRFQISAEHTERDIGYLLDVL
EECCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHEEEEEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA