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The map label for this gene is phr [H]

Identifier: 85858841

GI number: 85858841

Start: 1030703

End: 1032085

Strand: Direct

Name: phr [H]

Synonym: SYN_00402

Alternate gene names: 85858841

Gene position: 1030703-1032085 (Clockwise)

Preceding gene: 85858839

Following gene: 85858845

Centisome position: 32.42

GC content: 44.97

Gene sequence:

>1383_bases
ATGATTCAGAAGGAAAGAGTTAAATCGCTGAATAAGGCAGAGTTGAAAAAAGGAAAGTATGTCCTGTATTGGATGCAGGC
CTCTCAGAGAGAGACATGTAATCACGCTCTGGAATACGCAATCCGAAAAGCCAATGCGCTTTGCCAACCTGTAGTTGTTT
TTTTCGGTATTGTCGACGATTTCCCAGAAGCTAATGAACGGCACTACTTTTTTATGCTGGAGGGCCTTTGTGATGCGAAG
CGCACCCTTGAGAAAAGAGGTATTCAACTTGTAATTCAACACTGCTCACCGGAACTTGGAGTTGTAATGATGAGCCGGGA
TGCTTCTCTGGTAGTTGTGGACAGAGGGTATCTTCGAATACAAAAAGCTTGGAGAAACGTCGCGGCTGCTTCCATGGATT
GTCCTCTAATTCAGGTTGAAAGTGATGTGGTAGTTCCTATTGAAGAAACTTCGTCCAAGGAGGAATATTCTGCAGCAACA
ATCCGAAAAAAAATCCACCAAAAATTGAATCAGTACCTGATTTCTCTGGAAGAAACCAAACCAATGGCCGATTCTCTTTC
TCTCGATTTTGAATCTTTTCCCATCGATGATGTGGAAAGAGCCATCTTGCGCCTCGATATTGACCGGAGCGTTAAATGTG
TCAGCTTTTTTCGAGGAGGCTTTGAGGAGGGCAGGAAGCATCTTGATGTGTTCATTGATCAGAAACTGGAGCATTATGCT
GAACACAGAAATGACCCAACTCTGGACTGTCTCTCCCTCATGAGCCCCTATCTTCATTTCGGACAGATATCACCTCTGTA
CATCGCGCTGAGGATCTTGAACTCTGGCAGAACCAGCAGTGAGGCCTATCTTGAGGAACTCATTGTCAGACGAGAGTTGG
GCATCAACTTCGTATTCTACAATACACATTATGATACATTTGAATGCCTCCCAGGCTGGGCGAAAAAAAGTCTGAGGACT
CATGAGAAGGACCAACGGCCCTATCATTACTCTCGCAAGGAATTAGAGGATGGGAAAACACATGATCCGTATTGGAACGC
CGCGCAGAAAGAGATGGTGTTGAAGGGAAAGATGCACGGTTATATGAGAATGTATTGGGGAAAAAAAATTATCGAGTGGT
GTGAGACTCCTGAAGAAGCTTTCCATACCGCGATATATCTCAACAACAAGTACGAGTTGGATGGAAGGGAGCCCAATGGT
TTTATGGGCGTTGCATGGTGTTTCGGGAAGCATGACCGCCCCTGGAGGGAACGAAACATTTTCGGTAACGTCAGATACAT
GAATGACAGGGGGCTAAAGAGAAAATTTGATGCCGACGGGTACGTGAAACTAAGCGCGCAATGGGAAGACCAAGGTGCTT
TAATTCCCAATCAGTTAGAATAA

Upstream 100 bases:

>100_bases
ACGCCTTCTTTCTATTCTGTCCACAACGTTGGCTTATCTCTCGTTGGGAAAAAGCAAAGGCCGCTGTGAAATGTAGTTAT
TACCATCTGAAAGGATCATC

Downstream 100 bases:

>100_bases
TTTACGTTGAGATGAACCACAGGAGGCAATAATATTGAACTAAGCGAATACTTTGAGCAGACAAAAGTTGCTTCCATCAT
CCACGGAGGCAATCCGGATG

Product: deoxyribodipyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MIQKERVKSLNKAELKKGKYVLYWMQASQRETCNHALEYAIRKANALCQPVVVFFGIVDDFPEANERHYFFMLEGLCDAK
RTLEKRGIQLVIQHCSPELGVVMMSRDASLVVVDRGYLRIQKAWRNVAAASMDCPLIQVESDVVVPIEETSSKEEYSAAT
IRKKIHQKLNQYLISLEETKPMADSLSLDFESFPIDDVERAILRLDIDRSVKCVSFFRGGFEEGRKHLDVFIDQKLEHYA
EHRNDPTLDCLSLMSPYLHFGQISPLYIALRILNSGRTSSEAYLEELIVRRELGINFVFYNTHYDTFECLPGWAKKSLRT
HEKDQRPYHYSRKELEDGKTHDPYWNAAQKEMVLKGKMHGYMRMYWGKKIIEWCETPEEAFHTAIYLNNKYELDGREPNG
FMGVAWCFGKHDRPWRERNIFGNVRYMNDRGLKRKFDADGYVKLSAQWEDQGALIPNQLE

Sequences:

>Translated_460_residues
MIQKERVKSLNKAELKKGKYVLYWMQASQRETCNHALEYAIRKANALCQPVVVFFGIVDDFPEANERHYFFMLEGLCDAK
RTLEKRGIQLVIQHCSPELGVVMMSRDASLVVVDRGYLRIQKAWRNVAAASMDCPLIQVESDVVVPIEETSSKEEYSAAT
IRKKIHQKLNQYLISLEETKPMADSLSLDFESFPIDDVERAILRLDIDRSVKCVSFFRGGFEEGRKHLDVFIDQKLEHYA
EHRNDPTLDCLSLMSPYLHFGQISPLYIALRILNSGRTSSEAYLEELIVRRELGINFVFYNTHYDTFECLPGWAKKSLRT
HEKDQRPYHYSRKELEDGKTHDPYWNAAQKEMVLKGKMHGYMRMYWGKKIIEWCETPEEAFHTAIYLNNKYELDGREPNG
FMGVAWCFGKHDRPWRERNIFGNVRYMNDRGLKRKFDADGYVKLSAQWEDQGALIPNQLE
>Mature_460_residues
MIQKERVKSLNKAELKKGKYVLYWMQASQRETCNHALEYAIRKANALCQPVVVFFGIVDDFPEANERHYFFMLEGLCDAK
RTLEKRGIQLVIQHCSPELGVVMMSRDASLVVVDRGYLRIQKAWRNVAAASMDCPLIQVESDVVVPIEETSSKEEYSAAT
IRKKIHQKLNQYLISLEETKPMADSLSLDFESFPIDDVERAILRLDIDRSVKCVSFFRGGFEEGRKHLDVFIDQKLEHYA
EHRNDPTLDCLSLMSPYLHFGQISPLYIALRILNSGRTSSEAYLEELIVRRELGINFVFYNTHYDTFECLPGWAKKSLRT
HEKDQRPYHYSRKELEDGKTHDPYWNAAQKEMVLKGKMHGYMRMYWGKKIIEWCETPEEAFHTAIYLNNKYELDGREPNG
FMGVAWCFGKHDRPWRERNIFGNVRYMNDRGLKRKFDADGYVKLSAQWEDQGALIPNQLE

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Drosophila melanogaster, GI24586396, Length=452, Percent_Identity=40.929203539823, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24586398, Length=452, Percent_Identity=40.929203539823, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24586404, Length=148, Percent_Identity=54.7297297297297, Blast_Score=177, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008148
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 53773; Mature: 53773

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQKERVKSLNKAELKKGKYVLYWMQASQRETCNHALEYAIRKANALCQPVVVFFGIVDD
CCCHHHHHCCCHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FPEANERHYFFMLEGLCDAKRTLEKRGIQLVIQHCSPELGVVMMSRDASLVVVDRGYLRI
CCCCCCCEEEEEECCHHHHHHHHHHCCHHHHHHHCCCCCCEEEEECCCEEEEEECCHHHH
QKAWRNVAAASMDCPLIQVESDVVVPIEETSSKEEYSAATIRKKIHQKLNQYLISLEETK
HHHHHHHHHHCCCCCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PMADSLSLDFESFPIDDVERAILRLDIDRSVKCVSFFRGGFEEGRKHLDVFIDQKLEHYA
CCHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
EHRNDPTLDCLSLMSPYLHFGQISPLYIALRILNSGRTSSEAYLEELIVRRELGINFVFY
HHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEEE
NTHYDTFECLPGWAKKSLRTHEKDQRPYHYSRKELEDGKTHDPYWNAAQKEMVLKGKMHG
ECCCCHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
YMRMYWGKKIIEWCETPEEAFHTAIYLNNKYELDGREPNGFMGVAWCFGKHDRPWRERNI
HHHHHHHHHHHHHHCCHHHHHEEEEEECCEEEECCCCCCCCEEEEEEECCCCCCHHHCCC
FGNVRYMNDRGLKRKFDADGYVKLSAQWEDQGALIPNQLE
EECEEEECCCCCCEECCCCCEEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MIQKERVKSLNKAELKKGKYVLYWMQASQRETCNHALEYAIRKANALCQPVVVFFGIVDD
CCCHHHHHCCCHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FPEANERHYFFMLEGLCDAKRTLEKRGIQLVIQHCSPELGVVMMSRDASLVVVDRGYLRI
CCCCCCCEEEEEECCHHHHHHHHHHCCHHHHHHHCCCCCCEEEEECCCEEEEEECCHHHH
QKAWRNVAAASMDCPLIQVESDVVVPIEETSSKEEYSAATIRKKIHQKLNQYLISLEETK
HHHHHHHHHHCCCCCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PMADSLSLDFESFPIDDVERAILRLDIDRSVKCVSFFRGGFEEGRKHLDVFIDQKLEHYA
CCHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
EHRNDPTLDCLSLMSPYLHFGQISPLYIALRILNSGRTSSEAYLEELIVRRELGINFVFY
HHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEEE
NTHYDTFECLPGWAKKSLRTHEKDQRPYHYSRKELEDGKTHDPYWNAAQKEMVLKGKMHG
ECCCCHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
YMRMYWGKKIIEWCETPEEAFHTAIYLNNKYELDGREPNGFMGVAWCFGKHDRPWRERNI
HHHHHHHHHHHHHHCCHHHHHEEEEEECCEEEECCCCCCCCEEEEEEECCCCCCHHHCCC
FGNVRYMNDRGLKRKFDADGYVKLSAQWEDQGALIPNQLE
EECEEEECCCCCCEECCCCCEEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2668276 [H]