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The map label for this gene is lpxP [H]

Identifier: 85858704

GI number: 85858704

Start: 886490

End: 887368

Strand: Direct

Name: lpxP [H]

Synonym: SYN_00133

Alternate gene names: 85858704

Gene position: 886490-887368 (Clockwise)

Preceding gene: 85858703

Following gene: 85858709

Centisome position: 27.88

GC content: 51.19

Gene sequence:

>879_bases
ATGAAGAAGTTACAGTCTCACACCGTTGTTTTGCTTATATTAAAATCGATTCCGCTGTCGGTGAGAAGATTCTTATTCAC
CGGCATTGCCCTTCTTGTTTACTGCCTGGTACCGAAAAGACGCCTGATCGCCCTTTATAATCTGCATCGCGCCTTTCCGG
AAAAATCCATGGACGAACTTGTCCGGATTGCAAAGGGGGTTTACCGGAACGTCGGCATCCTGGCAGCCGAATTTGTGGAC
ATTCCCTCTCTGAACGCAAGCCGGATCAATGAATTCATGGAAGTCCGGGGGCTGGAAAATTACTGGAAAGCCAAGGCAAA
AAATAAAGGGGTGGTCCTGGTGACGGCTCACTTCGGTAACTGGGAATTGATGGCAGCGGCTTTTGCCGTCATCGGGGAGC
CCATCATGATCCTCTATCGACCCTTTGATAACCCCCTGCTGGAAAACATCGTTTCCACAGTGAGGACGTCGACAGGCAAT
ACGGTCACTCCCGCGAACCGAGCCATGCGCGGAATATTGCGGCGCCTGAGAGATAAAAAAACCGTGGGGCTGCTGATCGA
TCAGAATGTTTCACCGCCGGAAGGCCGTTTTGTCCAGTTTTTCAACAGGCCTGCCTGTACGTCGCCGGGATTGGCGCATA
TCGCTCTTCTTACAGACGCTCCGGTCGTACCTGCCTTTCTCATTCGAAAAGAGGATGGAAAATATATTCTGGAGATTGGC
GCCGAAAGAGAGTTGATCAAATCCGGAGACGATGACCGGGATATTATTCTGAACACGCAGCGTTACACCCGAGCTATCGA
GGATGTCGTCAGGCAGCATCCGGAACAGTGGTTCTGGGTCCATCACCGCTGGAAAGCACAACCGCTTCCTCATCAATAA

Upstream 100 bases:

>100_bases
AGAACCGGGTTTTAGAAAGTTGTAACCCAAGAAACATCCCCTGTAATATGAAAGAAATCATTTCAACTATGTATCGTTGA
ATTTTCCAAAATAACAATAG

Downstream 100 bases:

>100_bases
TAAAAAATAAGTTGAATTATTTTTTCTGCGCAGGAGACAGGCTTTCAGCTTTGCGACGAGCTTCTTCTGCCTGTTCCGGG
AGGTTCAGCTTTTCATAGGA

Product: lipid A biosynthesis lauroyl acyltransferase

Products: KDO2-(palmitoleoyl)-lipid IVA [C]

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MKKLQSHTVVLLILKSIPLSVRRFLFTGIALLVYCLVPKRRLIALYNLHRAFPEKSMDELVRIAKGVYRNVGILAAEFVD
IPSLNASRINEFMEVRGLENYWKAKAKNKGVVLVTAHFGNWELMAAAFAVIGEPIMILYRPFDNPLLENIVSTVRTSTGN
TVTPANRAMRGILRRLRDKKTVGLLIDQNVSPPEGRFVQFFNRPACTSPGLAHIALLTDAPVVPAFLIRKEDGKYILEIG
AERELIKSGDDDRDIILNTQRYTRAIEDVVRQHPEQWFWVHHRWKAQPLPHQ

Sequences:

>Translated_292_residues
MKKLQSHTVVLLILKSIPLSVRRFLFTGIALLVYCLVPKRRLIALYNLHRAFPEKSMDELVRIAKGVYRNVGILAAEFVD
IPSLNASRINEFMEVRGLENYWKAKAKNKGVVLVTAHFGNWELMAAAFAVIGEPIMILYRPFDNPLLENIVSTVRTSTGN
TVTPANRAMRGILRRLRDKKTVGLLIDQNVSPPEGRFVQFFNRPACTSPGLAHIALLTDAPVVPAFLIRKEDGKYILEIG
AERELIKSGDDDRDIILNTQRYTRAIEDVVRQHPEQWFWVHHRWKAQPLPHQ
>Mature_292_residues
MKKLQSHTVVLLILKSIPLSVRRFLFTGIALLVYCLVPKRRLIALYNLHRAFPEKSMDELVRIAKGVYRNVGILAAEFVD
IPSLNASRINEFMEVRGLENYWKAKAKNKGVVLVTAHFGNWELMAAAFAVIGEPIMILYRPFDNPLLENIVSTVRTSTGN
TVTPANRAMRGILRRLRDKKTVGLLIDQNVSPPEGRFVQFFNRPACTSPGLAHIALLTDAPVVPAFLIRKEDGKYILEIG
AERELIKSGDDDRDIILNTQRYTRAIEDVVRQHPEQWFWVHHRWKAQPLPHQ

Specific function: Unknown

COG id: COG1560

COG function: function code M; Lauroyl/myristoyl acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the htrB/msbB family [H]

Homologues:

Organism=Escherichia coli, GI87082094, Length=282, Percent_Identity=27.6595744680851, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1787292, Length=280, Percent_Identity=27.8571428571429, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788161, Length=238, Percent_Identity=24.7899159663866, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004960
- InterPro:   IPR011920 [H]

Pfam domain/function: PF03279 Lip_A_acyltrans [H]

EC number: NA

Molecular weight: Translated: 33308; Mature: 33308

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLQSHTVVLLILKSIPLSVRRFLFTGIALLVYCLVPKRRLIALYNLHRAFPEKSMDEL
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHH
VRIAKGVYRNVGILAAEFVDIPSLNASRINEFMEVRGLENYWKAKAKNKGVVLVTAHFGN
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEEECCC
WELMAAAFAVIGEPIMILYRPFDNPLLENIVSTVRTSTGNTVTPANRAMRGILRRLRDKK
HHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHCCC
TVGLLIDQNVSPPEGRFVQFFNRPACTSPGLAHIALLTDAPVVPAFLIRKEDGKYILEIG
CEEEEEECCCCCCCCHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCEEEEEC
AERELIKSGDDDRDIILNTQRYTRAIEDVVRQHPEQWFWVHHRWKAQPLPHQ
CCHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCC
>Mature Secondary Structure
MKKLQSHTVVLLILKSIPLSVRRFLFTGIALLVYCLVPKRRLIALYNLHRAFPEKSMDEL
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHH
VRIAKGVYRNVGILAAEFVDIPSLNASRINEFMEVRGLENYWKAKAKNKGVVLVTAHFGN
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEEECCC
WELMAAAFAVIGEPIMILYRPFDNPLLENIVSTVRTSTGNTVTPANRAMRGILRRLRDKK
HHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHCCC
TVGLLIDQNVSPPEGRFVQFFNRPACTSPGLAHIALLTDAPVVPAFLIRKEDGKYILEIG
CEEEEEECCCCCCCCHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCEEEEEC
AERELIKSGDDDRDIILNTQRYTRAIEDVVRQHPEQWFWVHHRWKAQPLPHQ
CCHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: KDO2-lipid IVA; palmitoleoyl-ACP [C]

Specific reaction: KDO2-lipid IVA + palmitoleoyl-ACP = KDO2-(palmitoleoyl)-lipid IVA + [acyl carrier protein] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]