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The map label for this gene is tkt [H]

Identifier: 85858095

GI number: 85858095

Start: 265446

End: 267515

Strand: Direct

Name: tkt [H]

Synonym: SYN_01447

Alternate gene names: 85858095

Gene position: 265446-267515 (Clockwise)

Preceding gene: 85858094

Following gene: 85858096

Centisome position: 8.35

GC content: 61.5

Gene sequence:

>2070_bases
ATGTCGAAAACGACCGCCTTCGAAGAAAAGTGTATCAACACCATCCGTTTTTTAGCCGCGGATGCCATAGAAAAAGCGAA
ATCGGGACATCCCGGAATGCCGATGGGCGCCGCTGCCGCAGCCCACACCCTCTGGGTCAGTCATCTGAAACATAATCCTG
TGAACCCGCGGTGGGTCGATCGAGACCGCTTCGTTCTTTCCGCGGGACATGCCTCCATGCTTCTGTACGTACTGCTCCAT
CTGACCGGATATGACCTCTCCATGGATGACTTGAAGGCCTTCCGCCAATGGGAAAGCCGGACGCCGGGGCATCCCGAACT
CCACTGTGCGCCGGGAGTGGAAGTGACCACCGGCCCGCTCGGGCAGGGGCTGAGCAATGCCGTGGGCATGGCGATCGCCG
AGGCCCATCTGGCCGCCCGCTTCAACCGTCCGGACTGTGAGGTGGTCGATCATTTTACCTATGTTCTGGCCAGTGACGGC
GACATCATGGAAGGGGTGACGGCGGAATCCTGTTCTCTGGCAGGACATCTGGGATTGGGTAAGCTCATCGTCCTTTATGA
CGACAACCGGGTTTCGCTGGCGGGGACCACGTCCCTGTCTTTTACGGAAGACGTGGGCAGACGGTTTGAGGCTTATGGCT
GGCAGGTTCTCCGGGTTCAGGAAGGCAACCGGCCGGCGGCGATCAATGCGGCCCTGCAGCAGGCGAGGGCGGAAGAGTCG
AAGCCTTCGATTATTTCCGTGCAGACGGTCCTCGGTTACGGCGCTCCTCATAAACAGGGAACGGCGGATGCCCATGGCTC
TCCCCTGGGCCGGGATGAACTGGACGCCGCCAAGAAAAATCTGGGCTGGCCGGTTGACCCCACCTTCTTTGTGCCCGAAG
ATGTTTCAAATTTTTACCGGGAGGCGCTCGATCGGGGGAAAGCCAGGGAAGAGCAATGGCTTCAGACATTTGAACGCTAT
CGCCGGCAGTATCCGGAGCAGGCTGCGGAATTCAGCCGGGTTCTGGCCGGTCGGCTGCCCGACGACTGGGAAGCGGCATT
GCCCGTGTACGGGGAAGGAGCCGCCGATGTGGCCACCCGCAAGGCCGGGGAAACGGTGATGCAGGCCCTTGCCCCGAAGA
TCCCGGAACTGATGGGCGGATCGGCGGATCTCAATCCGTCCACCTTCACCTGGCTCAAAGGGCTGGGCGATTTTCAGCCT
CCGGGATTTTCTCCGGAAGGCGTGCAGGGTCGTGTCGGCGGACCGTGGGGCTATGAAGGCCGCAACATCCATTACGGCGT
CCGGGAACATGCCATGGGGGCCATTTCCGTGGGGATGGCCCTTCATGGGGGCATTCTTCCCTATACGGCCACCTTTCTGA
CCTTTGCCGATTACATGCGGCCGCCCATTCGGCTTTCCGCCCTCATGGGCCTTCGTGTCATCTATGTCTTTACCCACGAC
AGCATCGGCCTGGGCGAGGATGGCCCGACCCATCAACCGATCGAGCACATCATGAATCTGCGGGCCGTTCCCAATCTTAC
CGTGATCCGTCCCGCCGATGCCGGTGAAACCGTGGAAGCCTGGCGGGAGGCGATCAGAAACACGGAGGGGCCGACGACCC
TGATCTTTTCGCGCCAGAATCTTCCCGTGCTGGATCGCGCGAAGCTGGCCCCCGCGACCGGCCTGCGGAAGGGAGGTTAT
ACCCTCTGGGAATCCGGGGAGGGAATCCCCGACATCATCCTGATCGGGACGGGGTCCGAGGTTGTTCCGACTTTGGAAGC
CGGTCACCGTCTGGCGGTGGATGGAGTTGCCGTGCGGGTGGTCTCAATGCCCAGCTGGGAACTCTTTGACCGTCAACCGG
ACGCCTATCGCGAGGCCGTTCTGCCCTCGGCCGTGCGGGCGCGCGTCGCCGTGGAGGCGGGGATCAAACTGGGCTGGGAA
CGTTACGTCGGGCTGGACGGCGCGATTGTCGGGCTGGAAGGTTTCGGAGCCAGTGCGCCGGCCAAAGTCCTTTTTGAAAA
ATTCGGCATTACTGTGGAAAACGTCACGGCAGCAGCCAGGGCGCTCCTGCGGGCCAGAGTGACCTCTTGA

Upstream 100 bases:

>100_bases
GTTTAAGCGGCCGGGTTAGAGTATAAGCGCAGGGTAAAAAGTCGGCAACCAACGGAAACCCCGTTGCAAGTTATGTGATA
TTAAGGAGATAGAAAAACTC

Downstream 100 bases:

>100_bases
TCGGATGACCCTGATTTCTGAATGAATGCTGAGGCATGGGGATGGCGATGGTTCCGTAAACGCATGCCGTTCACCTGCGG
AAAAATAACCGTAAAACCGA

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 689; Mature: 688

Protein sequence:

>689_residues
MSKTTAFEEKCINTIRFLAADAIEKAKSGHPGMPMGAAAAAHTLWVSHLKHNPVNPRWVDRDRFVLSAGHASMLLYVLLH
LTGYDLSMDDLKAFRQWESRTPGHPELHCAPGVEVTTGPLGQGLSNAVGMAIAEAHLAARFNRPDCEVVDHFTYVLASDG
DIMEGVTAESCSLAGHLGLGKLIVLYDDNRVSLAGTTSLSFTEDVGRRFEAYGWQVLRVQEGNRPAAINAALQQARAEES
KPSIISVQTVLGYGAPHKQGTADAHGSPLGRDELDAAKKNLGWPVDPTFFVPEDVSNFYREALDRGKAREEQWLQTFERY
RRQYPEQAAEFSRVLAGRLPDDWEAALPVYGEGAADVATRKAGETVMQALAPKIPELMGGSADLNPSTFTWLKGLGDFQP
PGFSPEGVQGRVGGPWGYEGRNIHYGVREHAMGAISVGMALHGGILPYTATFLTFADYMRPPIRLSALMGLRVIYVFTHD
SIGLGEDGPTHQPIEHIMNLRAVPNLTVIRPADAGETVEAWREAIRNTEGPTTLIFSRQNLPVLDRAKLAPATGLRKGGY
TLWESGEGIPDIILIGTGSEVVPTLEAGHRLAVDGVAVRVVSMPSWELFDRQPDAYREAVLPSAVRARVAVEAGIKLGWE
RYVGLDGAIVGLEGFGASAPAKVLFEKFGITVENVTAAARALLRARVTS

Sequences:

>Translated_689_residues
MSKTTAFEEKCINTIRFLAADAIEKAKSGHPGMPMGAAAAAHTLWVSHLKHNPVNPRWVDRDRFVLSAGHASMLLYVLLH
LTGYDLSMDDLKAFRQWESRTPGHPELHCAPGVEVTTGPLGQGLSNAVGMAIAEAHLAARFNRPDCEVVDHFTYVLASDG
DIMEGVTAESCSLAGHLGLGKLIVLYDDNRVSLAGTTSLSFTEDVGRRFEAYGWQVLRVQEGNRPAAINAALQQARAEES
KPSIISVQTVLGYGAPHKQGTADAHGSPLGRDELDAAKKNLGWPVDPTFFVPEDVSNFYREALDRGKAREEQWLQTFERY
RRQYPEQAAEFSRVLAGRLPDDWEAALPVYGEGAADVATRKAGETVMQALAPKIPELMGGSADLNPSTFTWLKGLGDFQP
PGFSPEGVQGRVGGPWGYEGRNIHYGVREHAMGAISVGMALHGGILPYTATFLTFADYMRPPIRLSALMGLRVIYVFTHD
SIGLGEDGPTHQPIEHIMNLRAVPNLTVIRPADAGETVEAWREAIRNTEGPTTLIFSRQNLPVLDRAKLAPATGLRKGGY
TLWESGEGIPDIILIGTGSEVVPTLEAGHRLAVDGVAVRVVSMPSWELFDRQPDAYREAVLPSAVRARVAVEAGIKLGWE
RYVGLDGAIVGLEGFGASAPAKVLFEKFGITVENVTAAARALLRARVTS
>Mature_688_residues
SKTTAFEEKCINTIRFLAADAIEKAKSGHPGMPMGAAAAAHTLWVSHLKHNPVNPRWVDRDRFVLSAGHASMLLYVLLHL
TGYDLSMDDLKAFRQWESRTPGHPELHCAPGVEVTTGPLGQGLSNAVGMAIAEAHLAARFNRPDCEVVDHFTYVLASDGD
IMEGVTAESCSLAGHLGLGKLIVLYDDNRVSLAGTTSLSFTEDVGRRFEAYGWQVLRVQEGNRPAAINAALQQARAEESK
PSIISVQTVLGYGAPHKQGTADAHGSPLGRDELDAAKKNLGWPVDPTFFVPEDVSNFYREALDRGKAREEQWLQTFERYR
RQYPEQAAEFSRVLAGRLPDDWEAALPVYGEGAADVATRKAGETVMQALAPKIPELMGGSADLNPSTFTWLKGLGDFQPP
GFSPEGVQGRVGGPWGYEGRNIHYGVREHAMGAISVGMALHGGILPYTATFLTFADYMRPPIRLSALMGLRVIYVFTHDS
IGLGEDGPTHQPIEHIMNLRAVPNLTVIRPADAGETVEAWREAIRNTEGPTTLIFSRQNLPVLDRAKLAPATGLRKGGYT
LWESGEGIPDIILIGTGSEVVPTLEAGHRLAVDGVAVRVVSMPSWELFDRQPDAYREAVLPSAVRARVAVEAGIKLGWER
YVGLDGAIVGLEGFGASAPAKVLFEKFGITVENVTAAARALLRARVTS

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=708, Percent_Identity=24.7175141242938, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI205277463, Length=688, Percent_Identity=24.8546511627907, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI4507521, Length=688, Percent_Identity=24.8546511627907, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI225637459, Length=691, Percent_Identity=23.0101302460203, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI225637463, Length=593, Percent_Identity=24.114671163575, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI225637461, Length=593, Percent_Identity=24.114671163575, Blast_Score=113, Evalue=5e-25,
Organism=Escherichia coli, GI48994911, Length=675, Percent_Identity=50.962962962963, Blast_Score=681, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=675, Percent_Identity=51.7037037037037, Blast_Score=676, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=594, Percent_Identity=26.9360269360269, Blast_Score=159, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6325331, Length=686, Percent_Identity=47.5218658892128, Blast_Score=624, Evalue=1e-179,
Organism=Saccharomyces cerevisiae, GI6319593, Length=688, Percent_Identity=44.1860465116279, Blast_Score=572, Evalue=1e-164,
Organism=Drosophila melanogaster, GI45551847, Length=688, Percent_Identity=26.3081395348837, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI45550715, Length=688, Percent_Identity=26.3081395348837, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24645119, Length=660, Percent_Identity=26.2121212121212, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24666278, Length=694, Percent_Identity=24.4956772334294, Blast_Score=150, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 74646; Mature: 74514

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTTAFEEKCINTIRFLAADAIEKAKSGHPGMPMGAAAAAHTLWVSHLKHNPVNPRWVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEC
RDRFVLSAGHASMLLYVLLHLTGYDLSMDDLKAFRQWESRTPGHPELHCAPGVEVTTGPL
CCCEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCEEECCCC
GQGLSNAVGMAIAEAHLAARFNRPDCEVVDHFTYVLASDGDIMEGVTAESCSLAGHLGLG
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEEECCCCHHCCCCCCHHHHHCCCCCC
KLIVLYDDNRVSLAGTTSLSFTEDVGRRFEAYGWQVLRVQEGNRPAAINAALQQARAEES
EEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCC
KPSIISVQTVLGYGAPHKQGTADAHGSPLGRDELDAAKKNLGWPVDPTFFVPEDVSNFYR
CCCEEEEHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEECCHHHHHHHH
EALDRGKAREEQWLQTFERYRRQYPEQAAEFSRVLAGRLPDDWEAALPVYGEGAADVATR
HHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
KAGETVMQALAPKIPELMGGSADLNPSTFTWLKGLGDFQPPGFSPEGVQGRVGGPWGYEG
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
RNIHYGVREHAMGAISVGMALHGGILPYTATFLTFADYMRPPIRLSALMGLRVIYVFTHD
CEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCEEEEEEEECC
SIGLGEDGPTHQPIEHIMNLRAVPNLTVIRPADAGETVEAWREAIRNTEGPTTLIFSRQN
CCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCC
LPVLDRAKLAPATGLRKGGYTLWESGEGIPDIILIGTGSEVVPTLEAGHRLAVDGVAVRV
CCCHHHHHCCCCCCCCCCCEEEECCCCCCCCEEEECCCCCCCCHHHCCCEEEECCEEEEE
VSMPSWELFDRQPDAYREAVLPSAVRARVAVEAGIKLGWERYVGLDGAIVGLEGFGASAP
EECCCHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHCHHHHCCCCCEEEEECCCCCCCH
AKVLFEKFGITVENVTAAARALLRARVTS
HHHHHHHHCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKTTAFEEKCINTIRFLAADAIEKAKSGHPGMPMGAAAAAHTLWVSHLKHNPVNPRWVD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEC
RDRFVLSAGHASMLLYVLLHLTGYDLSMDDLKAFRQWESRTPGHPELHCAPGVEVTTGPL
CCCEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCEEECCCC
GQGLSNAVGMAIAEAHLAARFNRPDCEVVDHFTYVLASDGDIMEGVTAESCSLAGHLGLG
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEEEECCCCHHCCCCCCHHHHHCCCCCC
KLIVLYDDNRVSLAGTTSLSFTEDVGRRFEAYGWQVLRVQEGNRPAAINAALQQARAEES
EEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCC
KPSIISVQTVLGYGAPHKQGTADAHGSPLGRDELDAAKKNLGWPVDPTFFVPEDVSNFYR
CCCEEEEHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEECCHHHHHHHH
EALDRGKAREEQWLQTFERYRRQYPEQAAEFSRVLAGRLPDDWEAALPVYGEGAADVATR
HHHHCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
KAGETVMQALAPKIPELMGGSADLNPSTFTWLKGLGDFQPPGFSPEGVQGRVGGPWGYEG
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
RNIHYGVREHAMGAISVGMALHGGILPYTATFLTFADYMRPPIRLSALMGLRVIYVFTHD
CEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCEEEEEEEECC
SIGLGEDGPTHQPIEHIMNLRAVPNLTVIRPADAGETVEAWREAIRNTEGPTTLIFSRQN
CCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCC
LPVLDRAKLAPATGLRKGGYTLWESGEGIPDIILIGTGSEVVPTLEAGHRLAVDGVAVRV
CCCHHHHHCCCCCCCCCCCEEEECCCCCCCCEEEECCCCCCCCHHHCCCEEEECCEEEEE
VSMPSWELFDRQPDAYREAVLPSAVRARVAVEAGIKLGWERYVGLDGAIVGLEGFGASAP
EECCCHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHCHHHHCCCCCEEEEECCCCCCCH
AKVLFEKFGITVENVTAAARALLRARVTS
HHHHHHHHCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]