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The map label for this gene is hemE

Identifier: 85375428

GI number: 85375428

Start: 2618441

End: 2619466

Strand: Direct

Name: hemE

Synonym: ELI_13005

Alternate gene names: 85375428

Gene position: 2618441-2619466 (Clockwise)

Preceding gene: 85375417

Following gene: 85375429

Centisome position: 85.78

GC content: 65.79

Gene sequence:

>1026_bases
ATGCCCGGTCTTCTTCTCGACACGCTGAACAGAACGCGAAGCGATCGCGTGCCGCTGTGGCTCATGCGCCAGGCCGGGCG
TTACCTGCCGGAATATCGCGAGCTGCGGGCGCGGAAGGGCGGCTTTCTCGAGCTGGTCTATGACAGCGAAGCGGCCCGCG
AAGTCACGCTGCAGCCGATCCGCCGCTTCGGCTTCGACGGGGCGATCCTGTTTTCCGATATCCTGATCGTGCCTCATGCG
CTGGGCCAGAAGCTCGAATTCCTGGCCGGTGAAGGTCCGCATCTCTCGCCGCGGCTGGCCGATGCCGAGCTGGAGGCACT
CAGCACGGTCCCTGAGCGTCTGGATGCGATCTACGAGACGGTGCGCCAGGTCCGTGCGGCCCTCGATCCCGAGACCACTT
TGCTGGGCTTTGCAGGCAGCCCCTGGACCGTCGCGACCTACATGGTGGCGGGCGAGGGCAGCCGCGACCAGCAGGCTGCG
CGTTCGATGGCCTATACCGATCCGGGCAAATTGCAGGCGATCGTCGATGCGATCATCGACCTCACCGTCGAGTATCTTGT
CGGCCAGATCGATGCCGGAGCCGAGGCCGTGCAGCTGTTCGACAGCTGGGCTGGGAGCCTCGCCCCCGACCAGTTCGAGC
GCTGGGTGATCGCGCCCAATGCCGCAATCGTGCGCCGCCTGAAGGAAGCGCGGCCCGATGCGCTGGTGATCGGCTTTCCC
AAGGGGGCAGGGGCCAAGCTCTCGGCTTATGCCGCCGGGACCGGCGTCGATGCCATCGCGCTCGACGAGACGATCGATCC
GGCCTGGGCGCATACGGTATTGCCCGATGGCATGCCGGTGCAGGGCAATCTCGATCCGCTCCAGATCCTTGCCGGCGGCG
ATGCCATGGTCGAGCGGACTAAGGCTATCCTCGGCGCGCTGGCCGACCGGCCGCATGTCTTCAATCTGGGTCACGGGATC
GACAAGCACACGCCCATCGGACACGTCGAACGGCTGGTGGATACAGTTCGCAATTGGCAGCGCTGA

Upstream 100 bases:

>100_bases
GGGAGAATTCGGGCAGGCGCCGCTTGTGCCCGCTTTCCACAGGGCCAACAGACTCCATCATCTCTTTATAAATACTATTT
ATTGATTGGATTCTTTCCCG

Downstream 100 bases:

>100_bases
CCGCGCTCGCTAGGTGGGGCCCATGCAGGAATTCCTTTCGATGACCTATTACTGGCTCAAGGCCGGGCACATCATCTTCA
TGATCTTCTGGATGGCAGGC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MPGLLLDTLNRTRSDRVPLWLMRQAGRYLPEYRELRARKGGFLELVYDSEAAREVTLQPIRRFGFDGAILFSDILIVPHA
LGQKLEFLAGEGPHLSPRLADAELEALSTVPERLDAIYETVRQVRAALDPETTLLGFAGSPWTVATYMVAGEGSRDQQAA
RSMAYTDPGKLQAIVDAIIDLTVEYLVGQIDAGAEAVQLFDSWAGSLAPDQFERWVIAPNAAIVRRLKEARPDALVIGFP
KGAGAKLSAYAAGTGVDAIALDETIDPAWAHTVLPDGMPVQGNLDPLQILAGGDAMVERTKAILGALADRPHVFNLGHGI
DKHTPIGHVERLVDTVRNWQR

Sequences:

>Translated_341_residues
MPGLLLDTLNRTRSDRVPLWLMRQAGRYLPEYRELRARKGGFLELVYDSEAAREVTLQPIRRFGFDGAILFSDILIVPHA
LGQKLEFLAGEGPHLSPRLADAELEALSTVPERLDAIYETVRQVRAALDPETTLLGFAGSPWTVATYMVAGEGSRDQQAA
RSMAYTDPGKLQAIVDAIIDLTVEYLVGQIDAGAEAVQLFDSWAGSLAPDQFERWVIAPNAAIVRRLKEARPDALVIGFP
KGAGAKLSAYAAGTGVDAIALDETIDPAWAHTVLPDGMPVQGNLDPLQILAGGDAMVERTKAILGALADRPHVFNLGHGI
DKHTPIGHVERLVDTVRNWQR
>Mature_340_residues
PGLLLDTLNRTRSDRVPLWLMRQAGRYLPEYRELRARKGGFLELVYDSEAAREVTLQPIRRFGFDGAILFSDILIVPHAL
GQKLEFLAGEGPHLSPRLADAELEALSTVPERLDAIYETVRQVRAALDPETTLLGFAGSPWTVATYMVAGEGSRDQQAAR
SMAYTDPGKLQAIVDAIIDLTVEYLVGQIDAGAEAVQLFDSWAGSLAPDQFERWVIAPNAAIVRRLKEARPDALVIGFPK
GAGAKLSAYAAGTGVDAIALDETIDPAWAHTVLPDGMPVQGNLDPLQILAGGDAMVERTKAILGALADRPHVFNLGHGID
KHTPIGHVERLVDTVRNWQR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=353, Percent_Identity=36.2606232294618, Blast_Score=205, Evalue=6e-53,
Organism=Escherichia coli, GI2367337, Length=340, Percent_Identity=41.7647058823529, Blast_Score=229, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6320252, Length=330, Percent_Identity=34.2424242424242, Blast_Score=194, Evalue=1e-50,
Organism=Drosophila melanogaster, GI19921920, Length=332, Percent_Identity=37.0481927710843, Blast_Score=211, Evalue=5e-55,
Organism=Drosophila melanogaster, GI221330099, Length=332, Percent_Identity=37.0481927710843, Blast_Score=211, Evalue=5e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_ERYLH (Q2N6J8)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_459490.1
- ProteinModelPortal:   Q2N6J8
- SMR:   Q2N6J8
- STRING:   Q2N6J8
- GeneID:   3870223
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_13005
- NMPDR:   fig|314225.3.peg.423
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q2N6J8
- ProtClustDB:   PRK00115
- BioCyc:   ELIT314225:ELI_13005-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37124; Mature: 36993

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 73-73 BINDING 147-147 BINDING 202-202 BINDING 318-318

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGLLLDTLNRTRSDRVPLWLMRQAGRYLPEYRELRARKGGFLELVYDSEAAREVTLQPI
CCCHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHH
RRFGFDGAILFSDILIVPHALGQKLEFLAGEGPHLSPRLADAELEALSTVPERLDAIYET
HHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VRQVRAALDPETTLLGFAGSPWTVATYMVAGEGSRDQQAARSMAYTDPGKLQAIVDAIID
HHHHHHHCCCCCEEEECCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHH
LTVEYLVGQIDAGAEAVQLFDSWAGSLAPDQFERWVIAPNAAIVRRLKEARPDALVIGFP
HHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHCCEEECCCHHHHHHHHHCCCCEEEEECC
KGAGAKLSAYAAGTGVDAIALDETIDPAWAHTVLPDGMPVQGNLDPLQILAGGDAMVERT
CCCCCEEEEEECCCCCCEEEECCCCCCHHHHHCCCCCCCCCCCCCCEEEEECCHHHHHHH
KAILGALADRPHVFNLGHGIDKHTPIGHVERLVDTVRNWQR
HHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PGLLLDTLNRTRSDRVPLWLMRQAGRYLPEYRELRARKGGFLELVYDSEAAREVTLQPI
CCHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHH
RRFGFDGAILFSDILIVPHALGQKLEFLAGEGPHLSPRLADAELEALSTVPERLDAIYET
HHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VRQVRAALDPETTLLGFAGSPWTVATYMVAGEGSRDQQAARSMAYTDPGKLQAIVDAIID
HHHHHHHCCCCCEEEECCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHH
LTVEYLVGQIDAGAEAVQLFDSWAGSLAPDQFERWVIAPNAAIVRRLKEARPDALVIGFP
HHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHCCEEECCCHHHHHHHHHCCCCEEEEECC
KGAGAKLSAYAAGTGVDAIALDETIDPAWAHTVLPDGMPVQGNLDPLQILAGGDAMVERT
CCCCCEEEEEECCCCCCEEEECCCCCCHHHHHCCCCCCCCCCCCCCEEEEECCHHHHHHH
KAILGALADRPHVFNLGHGIDKHTPIGHVERLVDTVRNWQR
HHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA