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The map label for this gene is msrA2 [H]

Identifier: 85375333

GI number: 85375333

Start: 2535276

End: 2535953

Strand: Reverse

Name: msrA2 [H]

Synonym: ELI_12530

Alternate gene names: 85375333

Gene position: 2535953-2535276 (Counterclockwise)

Preceding gene: 85375334

Following gene: 85375332

Centisome position: 83.08

GC content: 61.8

Gene sequence:

>678_bases
ATGAAGCGCGGATTTCCGCTTTTCGCCGCTGTCGGCCTGGCGCTTGCAGGCTGCGGGCAGGTCGCCCTGGCAAAAGAAAA
CCATGTCCGCGCGCCGGCACCCAAGGTGACCGCCGCCGAGAAAGGCAGCACCCAGACTGCGATCTTTGCCGGTGGATGCT
TCTGGGGAATCGAAGCCATCTTCAGCCATGTGAAGGGCGTAGAAAGCGCCATCTCGGGCTATCACGGCGGCACTGCGCGG
TCGGCGAAATACTCGATCGTCACGTCGGGCGTCACCGACCATGCCGAAAGCGTGAAGGTCGTCTACGATCCGCGCGTCGT
CAGCTATGACGAGCTGGTGCGGATTTTCTTCTCGGTCGGCGCCGATCCGACGCTCAGGAATCGTCAGGGTCCGGATGTCG
GCGCGCATTATCGCGCCGCGCTGATCCCGGTGAACGCGCAACAGCGCAAGGTCGCGGCTGCCTACCTCCGGCAGATGGAG
CGTTCGGACGTCTGGTCGAAGCCGATCATGACCAAAATCGAAAGTTACAAGGCCTTCTACCCGGCCGAGACCTATCATCA
GGACTTCATGGCGAAGAACCCCAACCACGGCTATATCCGCCGCTGGGATGCGCCCAAGGTCCGCGCGCTCAAGCAATTCT
ATCCGGAGCATTTCCGCGCCAGTTTCAAGCGCGGATAG

Upstream 100 bases:

>100_bases
ATTTCGCTATCGGTTTCGCCGTCGGCGCGGTTGCGATCCTCGTCCAGATGTCGCCCGACCAGTTGACGGCTATTCCGCAA
GCTTTCGCGGCGAGCATCCG

Downstream 100 bases:

>100_bases
CGCAGGGGCGCGACTGACTGGAAAGGCGGTCCGCGCCTCGCTATATCGTTCGCCATGACGGCACACGCACATAGGGAACA
TGCGGGCGACGCGCTGGTCG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKRGFPLFAAVGLALAGCGQVALAKENHVRAPAPKVTAAEKGSTQTAIFAGGCFWGIEAIFSHVKGVESAISGYHGGTAR
SAKYSIVTSGVTDHAESVKVVYDPRVVSYDELVRIFFSVGADPTLRNRQGPDVGAHYRAALIPVNAQQRKVAAAYLRQME
RSDVWSKPIMTKIESYKAFYPAETYHQDFMAKNPNHGYIRRWDAPKVRALKQFYPEHFRASFKRG

Sequences:

>Translated_225_residues
MKRGFPLFAAVGLALAGCGQVALAKENHVRAPAPKVTAAEKGSTQTAIFAGGCFWGIEAIFSHVKGVESAISGYHGGTAR
SAKYSIVTSGVTDHAESVKVVYDPRVVSYDELVRIFFSVGADPTLRNRQGPDVGAHYRAALIPVNAQQRKVAAAYLRQME
RSDVWSKPIMTKIESYKAFYPAETYHQDFMAKNPNHGYIRRWDAPKVRALKQFYPEHFRASFKRG
>Mature_225_residues
MKRGFPLFAAVGLALAGCGQVALAKENHVRAPAPKVTAAEKGSTQTAIFAGGCFWGIEAIFSHVKGVESAISGYHGGTAR
SAKYSIVTSGVTDHAESVKVVYDPRVVSYDELVRIFFSVGADPTLRNRQGPDVGAHYRAALIPVNAQQRKVAAAYLRQME
RSDVWSKPIMTKIESYKAFYPAETYHQDFMAKNPNHGYIRRWDAPKVRALKQFYPEHFRASFKRG

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=158, Percent_Identity=42.4050632911392, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI208609995, Length=158, Percent_Identity=42.4050632911392, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI208609993, Length=110, Percent_Identity=41.8181818181818, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=41.1764705882353, Blast_Score=119, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=31.7241379310345, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320881, Length=158, Percent_Identity=36.7088607594937, Blast_Score=92, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24664627, Length=148, Percent_Identity=32.4324324324324, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24664631, Length=148, Percent_Identity=33.1081081081081, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45553131, Length=142, Percent_Identity=31.6901408450704, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 24853; Mature: 24853

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRGFPLFAAVGLALAGCGQVALAKENHVRAPAPKVTAAEKGSTQTAIFAGGCFWGIEAI
CCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHH
FSHVKGVESAISGYHGGTARSAKYSIVTSGVTDHAESVKVVYDPRVVSYDELVRIFFSVG
HHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCEECHHHHHHHHHHHC
ADPTLRNRQGPDVGAHYRAALIPVNAQQRKVAAAYLRQMERSDVWSKPIMTKIESYKAFY
CCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
PAETYHQDFMAKNPNHGYIRRWDAPKVRALKQFYPEHFRASFKRG
CCHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHCHHHHHHHHCCC
>Mature Secondary Structure
MKRGFPLFAAVGLALAGCGQVALAKENHVRAPAPKVTAAEKGSTQTAIFAGGCFWGIEAI
CCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHH
FSHVKGVESAISGYHGGTARSAKYSIVTSGVTDHAESVKVVYDPRVVSYDELVRIFFSVG
HHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCEECHHHHHHHHHHHC
ADPTLRNRQGPDVGAHYRAALIPVNAQQRKVAAAYLRQMERSDVWSKPIMTKIESYKAFY
CCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
PAETYHQDFMAKNPNHGYIRRWDAPKVRALKQFYPEHFRASFKRG
CCHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]