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The map label for this gene is phbA [H]

Identifier: 85375234

GI number: 85375234

Start: 2426811

End: 2428049

Strand: Direct

Name: phbA [H]

Synonym: ELI_12035

Alternate gene names: 85375234

Gene position: 2426811-2428049 (Clockwise)

Preceding gene: 85375233

Following gene: 85375235

Centisome position: 79.51

GC content: 66.34

Gene sequence:

>1239_bases
ATGATCGAGATGACCAAACGCCGCGTAGCCATCTGTACCCCGCTTCGCACGCCCGTCGGGCGCTTTGGCGGCACGCTTGC
CCCGCTCGATGCGGGCAAGCTCGGGGCCGTCATCCTCAAGGCCCTGATCGAGCGCAGCGGAATCGATCCGACGCGGGTGG
ACGATGTCGTTTTCAGCCAGGGCTATGGCAATGCCGAGGCCCCGGCGATCGGTCACTGGAGCTGGCTGGCGGCAGACCTG
CCGATGGAAGTGCCCGGCTTTCAGCTCGATCGTCGCTGCGGCTCGGGCGTGCAGGCGGTCGCCACTGCGGCGATGATGGT
CGAAACGGGCATGGCTGACATGGTCGTCGCGGGCGGGTGCGAGAGCATGTCCAATGTCGAGCACTATACGACCGACCTGC
GCGGCGGGGTGAGGATGGGCGACATGACGCTGCATGACCGGCTGACGCGCGGCCGGTTGATGAGCCAGCCGATCGAGCGC
TTCGGCGTCATCACCGGCATGATCGAGACGGCGGAAAACCTCGCCAAGGATTACGACATCACCCGCGACCAGGCCGATGC
CTATGCCGTGCGCTCGCACCGGAACGCGGCGAAGGCGTGGGAAGAGGGCAAGTTCGCCGATCACCTCGTGCCGGTGGAGG
TGCCACAACGCCGCGCCGACCCTGTCACCTTCGACCATGACGAGGGCTACCGTGCCGATGCCAGCATGGAGAGCCTGGGC
AAGCTGCGCGCAATCGATCTCAAGCGCGATCCAGAAGCCATCGTCACCGCAGGCAATGCCAGCCAGCAGAACGATGCGGC
AGCGGCGTGCCTGGTCGTGGCGGAAGACAAGCTGGAAGAAATGGGCCTGACCCCTTCGCTCTGGTTCCATAGCTGGGCAC
CCGCCGGCTGCGATCCCAGCCGCATGGGGATCGGCCCCGTGCCGGCGTTAGAGCGCCTGTTCGCGCGCACCGGAATGGGC
TGGGACGATATCGGGCTGGTCGAGCTCAACGAAGCCTTCGCCCCGCAGGTTCTGGCCGTGCTCAAGGGCTGGGGCTGGAG
CGAGGACGACTCGCGCCTCGACATGCTCAACGTCAACGGCTCGGGAATTTCCCTGGGCCACCCGATCGGTGCAACGGGCG
GGCGCATCCTCGCAGACATGGCCGCCGAAATGCACCGCCGCGAAGTGCGCTATGGCCTCGAAACCATGTGCATAGGAGGC
GGACAGGGCATTGCCGCGATCTTCGAGCGTGCGGCCTGA

Upstream 100 bases:

>100_bases
TTCGGGCTGAGCTTGTCGAAGCCCTGCACTTTCTTCTAGCGCCCGGCACAAAGTGAAGAACGGCCCTTCGACAGGCTCAG
GGCGAACGGGATTGAGAGGA

Downstream 100 bases:

>100_bases
TGAGCAAATGGGACGCCTGGATCGGTCGGACGCAGGCGCAGTCCGACACGCTCGATGCGGCGCTGGCGCGGCGCTGGTGC
GCGACATTCGACCTCGAGGT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MIEMTKRRVAICTPLRTPVGRFGGTLAPLDAGKLGAVILKALIERSGIDPTRVDDVVFSQGYGNAEAPAIGHWSWLAADL
PMEVPGFQLDRRCGSGVQAVATAAMMVETGMADMVVAGGCESMSNVEHYTTDLRGGVRMGDMTLHDRLTRGRLMSQPIER
FGVITGMIETAENLAKDYDITRDQADAYAVRSHRNAAKAWEEGKFADHLVPVEVPQRRADPVTFDHDEGYRADASMESLG
KLRAIDLKRDPEAIVTAGNASQQNDAAAACLVVAEDKLEEMGLTPSLWFHSWAPAGCDPSRMGIGPVPALERLFARTGMG
WDDIGLVELNEAFAPQVLAVLKGWGWSEDDSRLDMLNVNGSGISLGHPIGATGGRILADMAAEMHRREVRYGLETMCIGG
GQGIAAIFERAA

Sequences:

>Translated_412_residues
MIEMTKRRVAICTPLRTPVGRFGGTLAPLDAGKLGAVILKALIERSGIDPTRVDDVVFSQGYGNAEAPAIGHWSWLAADL
PMEVPGFQLDRRCGSGVQAVATAAMMVETGMADMVVAGGCESMSNVEHYTTDLRGGVRMGDMTLHDRLTRGRLMSQPIER
FGVITGMIETAENLAKDYDITRDQADAYAVRSHRNAAKAWEEGKFADHLVPVEVPQRRADPVTFDHDEGYRADASMESLG
KLRAIDLKRDPEAIVTAGNASQQNDAAAACLVVAEDKLEEMGLTPSLWFHSWAPAGCDPSRMGIGPVPALERLFARTGMG
WDDIGLVELNEAFAPQVLAVLKGWGWSEDDSRLDMLNVNGSGISLGHPIGATGGRILADMAAEMHRREVRYGLETMCIGG
GQGIAAIFERAA
>Mature_412_residues
MIEMTKRRVAICTPLRTPVGRFGGTLAPLDAGKLGAVILKALIERSGIDPTRVDDVVFSQGYGNAEAPAIGHWSWLAADL
PMEVPGFQLDRRCGSGVQAVATAAMMVETGMADMVVAGGCESMSNVEHYTTDLRGGVRMGDMTLHDRLTRGRLMSQPIER
FGVITGMIETAENLAKDYDITRDQADAYAVRSHRNAAKAWEEGKFADHLVPVEVPQRRADPVTFDHDEGYRADASMESLG
KLRAIDLKRDPEAIVTAGNASQQNDAAAACLVVAEDKLEEMGLTPSLWFHSWAPAGCDPSRMGIGPVPALERLFARTGMG
WDDIGLVELNEAFAPQVLAVLKGWGWSEDDSRLDMLNVNGSGISLGHPIGATGGRILADMAAEMHRREVRYGLETMCIGG
GQGIAAIFERAA

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=408, Percent_Identity=36.0294117647059, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI148539872, Length=405, Percent_Identity=34.320987654321, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI4557237, Length=410, Percent_Identity=34.390243902439, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI4501853, Length=417, Percent_Identity=33.0935251798561, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI4504327, Length=427, Percent_Identity=30.2107728337237, Blast_Score=169, Evalue=5e-42,
Organism=Escherichia coli, GI87082165, Length=407, Percent_Identity=41.5233415233415, Blast_Score=267, Evalue=8e-73,
Organism=Escherichia coli, GI1788554, Length=410, Percent_Identity=41.9512195121951, Blast_Score=267, Evalue=9e-73,
Organism=Escherichia coli, GI1787663, Length=410, Percent_Identity=38.0487804878049, Blast_Score=255, Evalue=3e-69,
Organism=Escherichia coli, GI48994986, Length=414, Percent_Identity=35.5072463768116, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1788683, Length=416, Percent_Identity=31.0096153846154, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI133906874, Length=412, Percent_Identity=37.621359223301, Blast_Score=253, Evalue=9e-68,
Organism=Caenorhabditis elegans, GI17535921, Length=414, Percent_Identity=33.0917874396135, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI25147385, Length=409, Percent_Identity=28.8508557457213, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17551802, Length=427, Percent_Identity=27.1662763466042, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6325229, Length=413, Percent_Identity=32.4455205811138, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6322031, Length=414, Percent_Identity=30.9178743961353, Blast_Score=172, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=39.1089108910891, Blast_Score=264, Evalue=7e-71,
Organism=Drosophila melanogaster, GI17648125, Length=408, Percent_Identity=34.0686274509804, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI24640423, Length=410, Percent_Identity=34.6341463414634, Blast_Score=211, Evalue=5e-55,
Organism=Drosophila melanogaster, GI17137578, Length=435, Percent_Identity=30.1149425287356, Blast_Score=171, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 44377; Mature: 44377

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEMTKRRVAICTPLRTPVGRFGGTLAPLDAGKLGAVILKALIERSGIDPTRVDDVVFSQ
CCCCCCCCEEEECCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCC
GYGNAEAPAIGHWSWLAADLPMEVPGFQLDRRCGSGVQAVATAAMMVETGMADMVVAGGC
CCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCHHHEEECCC
ESMSNVEHYTTDLRGGVRMGDMTLHDRLTRGRLMSQPIERFGVITGMIETAENLAKDYDI
HHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TRDQADAYAVRSHRNAAKAWEEGKFADHLVPVEVPQRRADPVTFDHDEGYRADASMESLG
CCCHHHHHHHHHCCHHHHHHHCCCCHHCCCCCCCCCCCCCCCEECCCCCCCCCCCHHHHC
KLRAIDLKRDPEAIVTAGNASQQNDAAAACLVVAEDKLEEMGLTPSLWFHSWAPAGCDPS
CEEEECCCCCCCCEEEECCCCCCCCHHHEEEEEEHHHHHHCCCCHHHHHCCCCCCCCCCC
RMGIGPVPALERLFARTGMGWDDIGLVELNEAFAPQVLAVLKGWGWSEDDSRLDMLNVNG
CCCCCCHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCCCCCEEEEECCC
SGISLGHPIGATGGRILADMAAEMHRREVRYGLETMCIGGGQGIAAIFERAA
CCEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHEEECCCCHHHHHHHHCC
>Mature Secondary Structure
MIEMTKRRVAICTPLRTPVGRFGGTLAPLDAGKLGAVILKALIERSGIDPTRVDDVVFSQ
CCCCCCCCEEEECCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCC
GYGNAEAPAIGHWSWLAADLPMEVPGFQLDRRCGSGVQAVATAAMMVETGMADMVVAGGC
CCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCHHHEEECCC
ESMSNVEHYTTDLRGGVRMGDMTLHDRLTRGRLMSQPIERFGVITGMIETAENLAKDYDI
HHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TRDQADAYAVRSHRNAAKAWEEGKFADHLVPVEVPQRRADPVTFDHDEGYRADASMESLG
CCCHHHHHHHHHCCHHHHHHHCCCCHHCCCCCCCCCCCCCCCEECCCCCCCCCCCHHHHC
KLRAIDLKRDPEAIVTAGNASQQNDAAAACLVVAEDKLEEMGLTPSLWFHSWAPAGCDPS
CEEEECCCCCCCCEEEECCCCCCCCHHHEEEEEEHHHHHHCCCCHHHHHCCCCCCCCCCC
RMGIGPVPALERLFARTGMGWDDIGLVELNEAFAPQVLAVLKGWGWSEDDSRLDMLNVNG
CCCCCCHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCCCCCEEEEECCC
SGISLGHPIGATGGRILADMAAEMHRREVRYGLETMCIGGGQGIAAIFERAA
CCEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7763384 [H]