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The map label for this gene is ribBA [H]

Identifier: 85375222

GI number: 85375222

Start: 2416530

End: 2417567

Strand: Direct

Name: ribBA [H]

Synonym: ELI_11975

Alternate gene names: 85375222

Gene position: 2416530-2417567 (Clockwise)

Preceding gene: 85375221

Following gene: 85375223

Centisome position: 79.17

GC content: 65.22

Gene sequence:

>1038_bases
GTGGCACAGGCGATCGACGGGCTTCGCCACGGCTGGCCGATCGCGCTGGCGAAGGCGGGCACGCTGTTGCCGATCGAAAC
GACACTGGCGCGCGAGGCCACGGCAGACCGGCTGCTGATCTCCGCCGCGCGCGCCGCGACGCTCAAGCTTGCCAACCAGC
TCGAGGCGGCGGTTCCGCATTCGCCGGTGATGATCCGTGGTGCCGAGCCCTTCGATCTCGACCTGGCGACGGCGGTGGCC
GACCCCGCGCTCGACCTGAAGCACCCGCTCAAGGGGCCGTTCAAGGCCGAGCCGATCGCGTGGGAGTCGGACGCTGCCAC
CGCGCTCGAACTGGCGCGGATCGCGGGAATCCTGCCGGCTTTCATGGTCGCACCGGATGCGGCGGGCGAAGCGCAGTCGG
TCTCGCCCGACGATCTTTCAGCATGGGAAGACCCTGCCGCTTTGCACATCGCCACGCGGGCGCAATTGCCGATCGCCGCG
CGAGAAGACAGCGAGATCGTGGTCTTCCGCAAGCCCGATGACATGCGCGAACACTGCGCGCTGATCGTCGGCCGCCAGTC
CGCTGACGCAATCCCGCTCGTGCGGCTGCATTCGGAATGTCTCACCGGCGATATCCTCGGCAGCCTCAAATGCGATTGCG
GCCCACAGCTCGATGCGGCGCTGGCGCGGATGGCGGCGGAAGCGGAAAACGGTGGATACGGGGTATTGCTCTACATGCGC
CAGGAAGGACGCGGCATCGGCCTGGTCAACAAGATGCGGGCCTATCGCCTGCAAGATCAGGGATTTGATACGGTCGAAGC
CAACGAACGGCTCGGCCTGCCCGACGAAAGTCGCGATTTTACAACCGCAGCGCGCATGCTTAGGCTACTCGGCATCGGTG
AGGTTCGGCTTCTCACCAATAACACAAGAAAAGTGGCCGCCCTGGAGGAGGAGAAAATTTCGATCGCAGAGAGGGTGGCC
CATGCGCTGCCCGCCAACCCATTTAACCAGCGTTATCTCGACACCAAGCGTGACCGCGCCGGTCACCTGCTGCCATGA

Upstream 100 bases:

>100_bases
TGCTCGAAGATGCTCGCAGCTGGGAGAAGCCGTCCGATCATATCCCGCTGACGACGGAGTTCACCTTCTGAACGGGGCCG
GGCCTTCTCCTACCCGCCGC

Downstream 100 bases:

>100_bases
AGATCGCCATTCGGCCGGAGCAGCCCGGCGACGAGCGCGCGATCCGCGCACTGACCGATGCTGCCTTTCGCGACATGGTG
CATGCTGACGGCGACGAAGG

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MAQAIDGLRHGWPIALAKAGTLLPIETTLAREATADRLLISAARAATLKLANQLEAAVPHSPVMIRGAEPFDLDLATAVA
DPALDLKHPLKGPFKAEPIAWESDAATALELARIAGILPAFMVAPDAAGEAQSVSPDDLSAWEDPAALHIATRAQLPIAA
REDSEIVVFRKPDDMREHCALIVGRQSADAIPLVRLHSECLTGDILGSLKCDCGPQLDAALARMAAEAENGGYGVLLYMR
QEGRGIGLVNKMRAYRLQDQGFDTVEANERLGLPDESRDFTTAARMLRLLGIGEVRLLTNNTRKVAALEEEKISIAERVA
HALPANPFNQRYLDTKRDRAGHLLP

Sequences:

>Translated_345_residues
MAQAIDGLRHGWPIALAKAGTLLPIETTLAREATADRLLISAARAATLKLANQLEAAVPHSPVMIRGAEPFDLDLATAVA
DPALDLKHPLKGPFKAEPIAWESDAATALELARIAGILPAFMVAPDAAGEAQSVSPDDLSAWEDPAALHIATRAQLPIAA
REDSEIVVFRKPDDMREHCALIVGRQSADAIPLVRLHSECLTGDILGSLKCDCGPQLDAALARMAAEAENGGYGVLLYMR
QEGRGIGLVNKMRAYRLQDQGFDTVEANERLGLPDESRDFTTAARMLRLLGIGEVRLLTNNTRKVAALEEEKISIAERVA
HALPANPFNQRYLDTKRDRAGHLLP
>Mature_344_residues
AQAIDGLRHGWPIALAKAGTLLPIETTLAREATADRLLISAARAATLKLANQLEAAVPHSPVMIRGAEPFDLDLATAVAD
PALDLKHPLKGPFKAEPIAWESDAATALELARIAGILPAFMVAPDAAGEAQSVSPDDLSAWEDPAALHIATRAQLPIAAR
EDSEIVVFRKPDDMREHCALIVGRQSADAIPLVRLHSECLTGDILGSLKCDCGPQLDAALARMAAEAENGGYGVLLYMRQ
EGRGIGLVNKMRAYRLQDQGFDTVEANERLGLPDESRDFTTAARMLRLLGIGEVRLLTNNTRKVAALEEEKISIAERVAH
ALPANPFNQRYLDTKRDRAGHLLP

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=182, Percent_Identity=55.4945054945055, Blast_Score=194, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6319438, Length=170, Percent_Identity=44.7058823529412, Blast_Score=125, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 37167; Mature: 37036

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQAIDGLRHGWPIALAKAGTLLPIETTLAREATADRLLISAARAATLKLANQLEAAVPH
CCCHHHHHHCCCCEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SPVMIRGAEPFDLDLATAVADPALDLKHPLKGPFKAEPIAWESDAATALELARIAGILPA
CCEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
FMVAPDAAGEAQSVSPDDLSAWEDPAALHIATRAQLPIAAREDSEIVVFRKPDDMREHCA
HHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCEEEEECCCCHHHHHE
LIVGRQSADAIPLVRLHSECLTGDILGSLKCDCGPQLDAALARMAAEAENGGYGVLLYMR
EEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEE
QEGRGIGLVNKMRAYRLQDQGFDTVEANERLGLPDESRDFTTAARMLRLLGIGEVRLLTN
CCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEC
NTRKVAALEEEKISIAERVAHALPANPFNQRYLDTKRDRAGHLLP
CCEEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AQAIDGLRHGWPIALAKAGTLLPIETTLAREATADRLLISAARAATLKLANQLEAAVPH
CCHHHHHHCCCCEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SPVMIRGAEPFDLDLATAVADPALDLKHPLKGPFKAEPIAWESDAATALELARIAGILPA
CCEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
FMVAPDAAGEAQSVSPDDLSAWEDPAALHIATRAQLPIAAREDSEIVVFRKPDDMREHCA
HHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCEEEEECCCCHHHHHE
LIVGRQSADAIPLVRLHSECLTGDILGSLKCDCGPQLDAALARMAAEAENGGYGVLLYMR
EEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEE
QEGRGIGLVNKMRAYRLQDQGFDTVEANERLGLPDESRDFTTAARMLRLLGIGEVRLLTN
CCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEC
NTRKVAALEEEKISIAERVAHALPANPFNQRYLDTKRDRAGHLLP
CCEEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA