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The map label for this gene is hemH [H]

Identifier: 85375090

GI number: 85375090

Start: 2287196

End: 2288188

Strand: Reverse

Name: hemH [H]

Synonym: ELI_11315

Alternate gene names: 85375090

Gene position: 2288188-2287196 (Counterclockwise)

Preceding gene: 85375091

Following gene: 85375089

Centisome position: 74.96

GC content: 65.76

Gene sequence:

>993_bases
ATGAACAGCGGCAAGGTCGGCGTGCTGCTCGTCAATCTCGGCACGCCGGCGGCGCCGGACACGGGATCGGTGCGGACCTA
TCTGGCGGAATTCCTCAGCGACAAGCGCGTGGTCGAAATCCCGAGCCTCATCTGGCAGCCGATCCTGCGCGGGATCATTC
TCAATACGCGGCCCAAGAAGAGCGCTGCCGCCTATAAGAAGGTCTGGGGAGAAGCCGGCTCGCCGCTGGCAGCGATTACT
GAACGGCAGGCGAAGGCTTTGCAGGTGCGGCTGGGCGATGCGGTGCAGGTCGACTGGGCCATGCGTTACGGCAAACCGTC
GATTGCCGAGCGGATGCAGGCAATGATGGATGCCGGTTGCGAACGGATCCTGTTTGCGCCGCTCTATCCGCAATATTCCG
GCGCGACCACGGCGACGGCGGTCGACAAGGTCGCCGACGTGCTGCGCGCCATGCGCTGGCAAGCGAGCCTGCGCACGCTG
CCGCCCTATCACGACCACCCCTCCTATATCGACGCGCTGGCAGCAGATACCATGCGACAGCTCGACGCGCTCGATTTCGT
GCCCGAAGTGCTGCTCTTGAGCTTTCATGGCATGCCGTTGCGGACGCTCGAACTGGGCGATCCCTATCACTGCCACTGCC
ACAAGACCGCGCGGCTGCTGGGCGAGCGCCTGCACGCTTCGGACAAATGGCGGGACTTGCGCCTCGTCACGTCGTTCCAG
AGCCGCTTCGGCCGGGCCAAGTGGCTCGAGCCCGCCACAGACGAGACGATCGAAGCCGAAGCGCATGCGGGGACGAAGCG
GATGGCGGTCGCCATGCCGGGGTTCTCCGCCGACTGCCTCGAAACGCTCGAGGAAATCGCCATGGAGGGGCGCGGCACTT
TCCTCGCAGCGGGCGGCGAGCACTATGCCGCGCTCGCCTGCCTCAACGACGGCGCGACCGGCATGGACATGATCGAAGCG
CTGGTGCGGCAGGAACTCGCGGGCTGGGTGTGA

Upstream 100 bases:

>100_bases
TGTTCTCGGGACTATAGGGCACCTTGACGGCCCCCGCGCATTAGGGTTGGCGGAAGCGATGACCTGGCAAGCCCAATCTC
TTCCGGCAGACCATCCGCCC

Downstream 100 bases:

>100_bases
TTCGCTGGATTTGAAGGATCGATTAACTTACAAGGGGGTAAGTAGCGTTTCGATACCGAAGGACCACCGATGGCCACCCT
AGCCACCCCCCACCAGCCCG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MNSGKVGVLLVNLGTPAAPDTGSVRTYLAEFLSDKRVVEIPSLIWQPILRGIILNTRPKKSAAAYKKVWGEAGSPLAAIT
ERQAKALQVRLGDAVQVDWAMRYGKPSIAERMQAMMDAGCERILFAPLYPQYSGATTATAVDKVADVLRAMRWQASLRTL
PPYHDHPSYIDALAADTMRQLDALDFVPEVLLLSFHGMPLRTLELGDPYHCHCHKTARLLGERLHASDKWRDLRLVTSFQ
SRFGRAKWLEPATDETIEAEAHAGTKRMAVAMPGFSADCLETLEEIAMEGRGTFLAAGGEHYAALACLNDGATGMDMIEA
LVRQELAGWV

Sequences:

>Translated_330_residues
MNSGKVGVLLVNLGTPAAPDTGSVRTYLAEFLSDKRVVEIPSLIWQPILRGIILNTRPKKSAAAYKKVWGEAGSPLAAIT
ERQAKALQVRLGDAVQVDWAMRYGKPSIAERMQAMMDAGCERILFAPLYPQYSGATTATAVDKVADVLRAMRWQASLRTL
PPYHDHPSYIDALAADTMRQLDALDFVPEVLLLSFHGMPLRTLELGDPYHCHCHKTARLLGERLHASDKWRDLRLVTSFQ
SRFGRAKWLEPATDETIEAEAHAGTKRMAVAMPGFSADCLETLEEIAMEGRGTFLAAGGEHYAALACLNDGATGMDMIEA
LVRQELAGWV
>Mature_330_residues
MNSGKVGVLLVNLGTPAAPDTGSVRTYLAEFLSDKRVVEIPSLIWQPILRGIILNTRPKKSAAAYKKVWGEAGSPLAAIT
ERQAKALQVRLGDAVQVDWAMRYGKPSIAERMQAMMDAGCERILFAPLYPQYSGATTATAVDKVADVLRAMRWQASLRTL
PPYHDHPSYIDALAADTMRQLDALDFVPEVLLLSFHGMPLRTLELGDPYHCHCHKTARLLGERLHASDKWRDLRLVTSFQ
SRFGRAKWLEPATDETIEAEAHAGTKRMAVAMPGFSADCLETLEEIAMEGRGTFLAAGGEHYAALACLNDGATGMDMIEA
LVRQELAGWV

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=297, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI60499025, Length=297, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1786681, Length=322, Percent_Identity=40.6832298136646, Blast_Score=222, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6324750, Length=338, Percent_Identity=24.5562130177515, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17864156, Length=335, Percent_Identity=23.8805970149254, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24651774, Length=267, Percent_Identity=23.9700374531835, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 36247; Mature: 36247

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSGKVGVLLVNLGTPAAPDTGSVRTYLAEFLSDKRVVEIPSLIWQPILRGIILNTRPKK
CCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCCCCCCH
SAAAYKKVWGEAGSPLAAITERQAKALQVRLGDAVQVDWAMRYGKPSIAERMQAMMDAGC
HHHHHHHHHCCCCCCHHHHHHHHHHHHHEECCCCEEEHHHHHCCCHHHHHHHHHHHHCCC
ERILFAPLYPQYSGATTATAVDKVADVLRAMRWQASLRTLPPYHDHPSYIDALAADTMRQ
CEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
LDALDFVPEVLLLSFHGMPLRTLELGDPYHCHCHKTARLLGERLHASDKWRDLRLVTSFQ
HHHHHHHHHHHHHHCCCCCEEEEECCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
SRFGRAKWLEPATDETIEAEAHAGTKRMAVAMPGFSADCLETLEEIAMEGRGTFLAAGGE
HHCCCCCCCCCCCCCCEEHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCC
HYAALACLNDGATGMDMIEALVRQELAGWV
CEEEEEEECCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNSGKVGVLLVNLGTPAAPDTGSVRTYLAEFLSDKRVVEIPSLIWQPILRGIILNTRPKK
CCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCCCCCCH
SAAAYKKVWGEAGSPLAAITERQAKALQVRLGDAVQVDWAMRYGKPSIAERMQAMMDAGC
HHHHHHHHHCCCCCCHHHHHHHHHHHHHEECCCCEEEHHHHHCCCHHHHHHHHHHHHCCC
ERILFAPLYPQYSGATTATAVDKVADVLRAMRWQASLRTLPPYHDHPSYIDALAADTMRQ
CEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
LDALDFVPEVLLLSFHGMPLRTLELGDPYHCHCHKTARLLGERLHASDKWRDLRLVTSFQ
HHHHHHHHHHHHHHCCCCCEEEEECCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
SRFGRAKWLEPATDETIEAEAHAGTKRMAVAMPGFSADCLETLEEIAMEGRGTFLAAGGE
HHCCCCCCCCCCCCCCEEHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCC
HYAALACLNDGATGMDMIEALVRQELAGWV
CEEEEEEECCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA