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The map label for this gene is ndk

Identifier: 85374599

GI number: 85374599

Start: 1804407

End: 1804829

Strand: Reverse

Name: ndk

Synonym: ELI_08860

Alternate gene names: 85374599

Gene position: 1804829-1804407 (Counterclockwise)

Preceding gene: 85374600

Following gene: 85374596

Centisome position: 59.13

GC content: 61.23

Gene sequence:

>423_bases
ATGGCGGTCACCCGCACCTTTTCGATCATCAAACCCGATGCCACCAAGCGCAACCTGACCGGCGCCGTCACCAAGATGCT
GGAAGAGGCCGGCCTGCGCGTCGTCGCTTCGAAGCGCATCCGCATGTCCCGCGAACAGGCCGAAGGCTTCTACGCGGTTC
ACAAGGAACGTCCTTTCTTCGGTGAACTCGTCGACTTCATGATGAGCGAGCCGGTGGTCGTGCAGGTGCTCGAGGGCGAA
GACGCCGTGAAGCGCAATCGCGACGTTATGGGCGCGACCAACCCGGCCGAAGCCGCCGAAGGCACGATCCGCAAGGAATA
CGCCCTGTCGATCGGCGAAAACACCGTCCACGGCTCGGATAGCGAAGAGAACGCGAAAATCGAGATCGACTTCTTCTTCG
ACGAGGACGAGATCGTCGGCTGA

Upstream 100 bases:

>100_bases
GCGCTACGCCGCTTCGGCAAGGCTTGCCCGTCGTGCGCGGCGGCGCTAAGGGCGCGCGCAACCAATTTCGCCCCCGACAA
TTCGACTGAAGGAAATTCCC

Downstream 100 bases:

>100_bases
GCCTCGCGCTCAAGCGAATTCAAAGAGGGCCGCTCCGATCGGGGCGGCCTTTTTTGTGTCGCGAATTGGGTGGGAAGCGG
ACGTTAGCTCTGCACTCGAA

Product: nucleoside diphosphate kinase protein

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MAVTRTFSIIKPDATKRNLTGAVTKMLEEAGLRVVASKRIRMSREQAEGFYAVHKERPFFGELVDFMMSEPVVVQVLEGE
DAVKRNRDVMGATNPAEAAEGTIRKEYALSIGENTVHGSDSEENAKIEIDFFFDEDEIVG

Sequences:

>Translated_140_residues
MAVTRTFSIIKPDATKRNLTGAVTKMLEEAGLRVVASKRIRMSREQAEGFYAVHKERPFFGELVDFMMSEPVVVQVLEGE
DAVKRNRDVMGATNPAEAAEGTIRKEYALSIGENTVHGSDSEENAKIEIDFFFDEDEIVG
>Mature_139_residues
AVTRTFSIIKPDATKRNLTGAVTKMLEEAGLRVVASKRIRMSREQAEGFYAVHKERPFFGELVDFMMSEPVVVQVLEGED
AVKRNRDVMGATNPAEAAEGTIRKEYALSIGENTVHGSDSEENAKIEIDFFFDEDEIVG

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=44.4444444444444, Blast_Score=130, Evalue=4e-31,
Organism=Homo sapiens, GI66392203, Length=135, Percent_Identity=45.1851851851852, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI66392227, Length=135, Percent_Identity=45.1851851851852, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI66392205, Length=135, Percent_Identity=45.1851851851852, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI4505409, Length=135, Percent_Identity=45.1851851851852, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI66392192, Length=135, Percent_Identity=45.1851851851852, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=43.7037037037037, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=43.7037037037037, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI4826862, Length=135, Percent_Identity=37.037037037037, Blast_Score=100, Evalue=4e-22,
Organism=Homo sapiens, GI37574614, Length=132, Percent_Identity=30.3030303030303, Blast_Score=76, Evalue=8e-15,
Organism=Homo sapiens, GI7019465, Length=132, Percent_Identity=30.3030303030303, Blast_Score=76, Evalue=8e-15,
Organism=Homo sapiens, GI5031951, Length=138, Percent_Identity=34.0579710144928, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=29.4117647058824, Blast_Score=64, Evalue=3e-11,
Organism=Homo sapiens, GI148839372, Length=135, Percent_Identity=29.6296296296296, Blast_Score=63, Evalue=7e-11,
Organism=Escherichia coli, GI1788866, Length=139, Percent_Identity=53.9568345323741, Blast_Score=158, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17506807, Length=134, Percent_Identity=42.5373134328358, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=40, Blast_Score=120, Evalue=8e-29,
Organism=Drosophila melanogaster, GI45549037, Length=135, Percent_Identity=44.4444444444444, Blast_Score=126, Evalue=4e-30,
Organism=Drosophila melanogaster, GI18860097, Length=139, Percent_Identity=31.6546762589928, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_ERYLH (Q2N8X7)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_458661.1
- HSSP:   P22887
- ProteinModelPortal:   Q2N8X7
- SMR:   Q2N8X7
- STRING:   Q2N8X7
- GeneID:   3870174
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_08860
- NMPDR:   fig|314225.3.peg.1270
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q2N8X7
- BioCyc:   ELIT314225:ELI_08860-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15587; Mature: 15456

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTRTFSIIKPDATKRNLTGAVTKMLEEAGLRVVASKRIRMSREQAEGFYAVHKERPFF
CCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCEEEEECCCCCH
GELVDFMMSEPVVVQVLEGEDAVKRNRDVMGATNPAEAAEGTIRKEYALSIGENTVHGSD
HHHHHHHCCCCEEEEEECCCHHHHHCCCCCCCCCCHHHHCCHHHHHHEEECCCCCCCCCC
SEENAKIEIDFFFDEDEIVG
CCCCCEEEEEEEECCCCCCC
>Mature Secondary Structure 
AVTRTFSIIKPDATKRNLTGAVTKMLEEAGLRVVASKRIRMSREQAEGFYAVHKERPFF
CCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCEEEEECCCCCH
GELVDFMMSEPVVVQVLEGEDAVKRNRDVMGATNPAEAAEGTIRKEYALSIGENTVHGSD
HHHHHHHCCCCEEEEEECCCHHHHHCCCCCCCCCCHHHHCCHHHHHHEEECCCCCCCCCC
SEENAKIEIDFFFDEDEIVG
CCCCCEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA