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The map label for this gene is glmU

Identifier: 85374590

GI number: 85374590

Start: 1795452

End: 1796855

Strand: Reverse

Name: glmU

Synonym: ELI_08815

Alternate gene names: 85374590

Gene position: 1796855-1795452 (Counterclockwise)

Preceding gene: 85374593

Following gene: 85374589

Centisome position: 58.87

GC content: 64.46

Gene sequence:

>1404_bases
ATGGAAACTGCAACAATTTGCTGGCAGGGCACGCGCATGAGCACCCAACGAGATTTCGCCGCCGTCATCCTTGCCGCGGG
CAAGGGCACCCGCATGAAGAGCGACCTGCACAAGGTCCTGCACCCGATCGCGGGGCGCGCCATGCTCGACCACCTGATGG
CCTCGGTCGACGCGCTTGCGCCGAGCGAGAAAGTGGTCGTGGTCGGGGCCGGACGCGAGCAGCTCGAAGCGGCGGTCGAA
GGCCGCGCCAAGACCTGCTTGCAGGAGCCGCAACATGGCACCGGGCACGCTGTGCAGCAGGCCGAGAGCGATTTAGCTGG
ATACGAAGGCGATGTGCTCATCCTGTATGGCGACGTGCCCTTCGTGCGCAGCTCGACGATGGAAATGATGCTCGACCGGC
TCCACGAGCAGGATGCGCCGGCGGTAGTCGTGCTGGGCTTCGAACCCGACGATGCGCTGCAATATGGCCGGGTAATCGCC
AATGCTGATGGCCACATCGAAAAGATGGTCGAGTTCAAGGATGCGAGCGAACAAGAGCGCGCGTGTACCCTGTGCAATTC
GGGCCTGATGGCGGTGAAGGGCGCGGACCTGTTCGACCTCTTGCGCCGGGTTGGCAACGATAACGCCCAAGGCGAATACT
ACCTGGTCGACATCGTCAACATCGCCCGCGGGGATGGTCGCCACAGCGCGGTCGTGGTGACGGACGATCCGGGCGAAGTC
GCCGGGATCAACTCCCGCGCCGAACTCGCCGCTGCCGAAGCGCAGTGGCAGGAGCTGAAGCGGGAGGAGGCGATGGCGGC
GGGCGTGTCGCTCAAGGCGCCGGAAACCGTATTCTTCAGCTGGGACACCGAATTGGGCCGCGATGTCACCGTCGAACCCA
ATGTCGTGTTCGGCCCCGGCGTGAAAGTCGCCGACGGCGCGCATATCAAGAGCTTCAGCCACTTGGAGGGCGCGACGGTC
GGCCCCAACTGCCAGGTCGGTCCTTACGCCCGCCTGCGCCCCGGCGCGGTGATGGAGGAAGACAGCTTCATCGGCAATTT
CGTCGAGATGAAGAAAACGACCCTCGGGCCCGGGGCCAAGGCCAGCCACCTGACCTATCTCGGCGACGCTACCGTCGGCG
CGAAGGCCAATATCGGCGCGGGCACCATCACCTGCAACTACGATGGCTATTTCAAATACCAGACCGTGATCGGCGAGCGT
GCCTTCATCGGCTCCAACAGCGCGCTGGTCGCGCCGGTGACGATCGGTGCCGATGCGATCGTGGCTGCGGGCAGCACCGT
CACCCGCGATGTCGCGGACGGCGAGCTACGCATGGAGCGCGCCGAGCAATCGGTGAAGCCGGGCTGGGCCGACCGCTTCC
ACGACACGATGAAAAAGAAGAAAGCGGCGGAGCCCAAAAAGTAA

Upstream 100 bases:

>100_bases
GCTCCGAGATCGCGGAAGGTGTCGAGCAGCGTGCCGTCGAGGTCGAAACCCACGGCGTCGAAAGCAAAATCGGCCATGCG
CCCTGCGATGCCGCTATGCT

Downstream 100 bases:

>100_bases
ATGTGATTGACCCGGCTCACCTGCGCGGCAATCCCTTGAACACAAGATGAGCCGACACGACAGTCGGTCTTCTTTTGTAA
TGGGGGAGCGTGCGGTCTTG

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
METATICWQGTRMSTQRDFAAVILAAGKGTRMKSDLHKVLHPIAGRAMLDHLMASVDALAPSEKVVVVGAGREQLEAAVE
GRAKTCLQEPQHGTGHAVQQAESDLAGYEGDVLILYGDVPFVRSSTMEMMLDRLHEQDAPAVVVLGFEPDDALQYGRVIA
NADGHIEKMVEFKDASEQERACTLCNSGLMAVKGADLFDLLRRVGNDNAQGEYYLVDIVNIARGDGRHSAVVVTDDPGEV
AGINSRAELAAAEAQWQELKREEAMAAGVSLKAPETVFFSWDTELGRDVTVEPNVVFGPGVKVADGAHIKSFSHLEGATV
GPNCQVGPYARLRPGAVMEEDSFIGNFVEMKKTTLGPGAKASHLTYLGDATVGAKANIGAGTITCNYDGYFKYQTVIGER
AFIGSNSALVAPVTIGADAIVAAGSTVTRDVADGELRMERAEQSVKPGWADRFHDTMKKKKAAEPKK

Sequences:

>Translated_467_residues
METATICWQGTRMSTQRDFAAVILAAGKGTRMKSDLHKVLHPIAGRAMLDHLMASVDALAPSEKVVVVGAGREQLEAAVE
GRAKTCLQEPQHGTGHAVQQAESDLAGYEGDVLILYGDVPFVRSSTMEMMLDRLHEQDAPAVVVLGFEPDDALQYGRVIA
NADGHIEKMVEFKDASEQERACTLCNSGLMAVKGADLFDLLRRVGNDNAQGEYYLVDIVNIARGDGRHSAVVVTDDPGEV
AGINSRAELAAAEAQWQELKREEAMAAGVSLKAPETVFFSWDTELGRDVTVEPNVVFGPGVKVADGAHIKSFSHLEGATV
GPNCQVGPYARLRPGAVMEEDSFIGNFVEMKKTTLGPGAKASHLTYLGDATVGAKANIGAGTITCNYDGYFKYQTVIGER
AFIGSNSALVAPVTIGADAIVAAGSTVTRDVADGELRMERAEQSVKPGWADRFHDTMKKKKAAEPKK
>Mature_467_residues
METATICWQGTRMSTQRDFAAVILAAGKGTRMKSDLHKVLHPIAGRAMLDHLMASVDALAPSEKVVVVGAGREQLEAAVE
GRAKTCLQEPQHGTGHAVQQAESDLAGYEGDVLILYGDVPFVRSSTMEMMLDRLHEQDAPAVVVLGFEPDDALQYGRVIA
NADGHIEKMVEFKDASEQERACTLCNSGLMAVKGADLFDLLRRVGNDNAQGEYYLVDIVNIARGDGRHSAVVVTDDPGEV
AGINSRAELAAAEAQWQELKREEAMAAGVSLKAPETVFFSWDTELGRDVTVEPNVVFGPGVKVADGAHIKSFSHLEGATV
GPNCQVGPYARLRPGAVMEEDSFIGNFVEMKKTTLGPGAKASHLTYLGDATVGAKANIGAGTITCNYDGYFKYQTVIGER
AFIGSNSALVAPVTIGADAIVAAGSTVTRDVADGELRMERAEQSVKPGWADRFHDTMKKKKAAEPKK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=449, Percent_Identity=42.3162583518931, Blast_Score=339, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR001228
- InterPro:   IPR011004 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 49934; Mature: 49934

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METATICWQGTRMSTQRDFAAVILAAGKGTRMKSDLHKVLHPIAGRAMLDHLMASVDALA
CCCEEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PSEKVVVVGAGREQLEAAVEGRAKTCLQEPQHGTGHAVQQAESDLAGYEGDVLILYGDVP
CCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCC
FVRSSTMEMMLDRLHEQDAPAVVVLGFEPDDALQYGRVIANADGHIEKMVEFKDASEQER
CHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHCCEEECCCCHHHHHHHHCCCCCHHH
ACTLCNSGLMAVKGADLFDLLRRVGNDNAQGEYYLVDIVNIARGDGRHSAVVVTDDPGEV
HHHHHCCCEEEECCCCHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCEEEEEECCCCCE
AGINSRAELAAAEAQWQELKREEAMAAGVSLKAPETVFFSWDTELGRDVTVEPNVVFGPG
ECCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEEECCCCCCEEEECCCEEECCC
VKVADGAHIKSFSHLEGATVGPNCQVGPYARLRPGAVMEEDSFIGNFVEMKKTTLGPGAK
CEECCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
ASHLTYLGDATVGAKANIGAGTITCNYDGYFKYQTVIGERAFIGSNSALVAPVTIGADAI
CCEEEEECCCCCCCCCCCCCCEEEECCCCEEEEEEEECCEEEECCCCCEEEEEEECCCCE
VAAGSTVTRDVADGELRMERAEQSVKPGWADRFHDTMKKKKAAEPKK
EECCCHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
METATICWQGTRMSTQRDFAAVILAAGKGTRMKSDLHKVLHPIAGRAMLDHLMASVDALA
CCCEEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PSEKVVVVGAGREQLEAAVEGRAKTCLQEPQHGTGHAVQQAESDLAGYEGDVLILYGDVP
CCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCC
FVRSSTMEMMLDRLHEQDAPAVVVLGFEPDDALQYGRVIANADGHIEKMVEFKDASEQER
CHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHCCEEECCCCHHHHHHHHCCCCCHHH
ACTLCNSGLMAVKGADLFDLLRRVGNDNAQGEYYLVDIVNIARGDGRHSAVVVTDDPGEV
HHHHHCCCEEEECCCCHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCEEEEEECCCCCE
AGINSRAELAAAEAQWQELKREEAMAAGVSLKAPETVFFSWDTELGRDVTVEPNVVFGPG
ECCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEEECCCCCCEEEECCCEEECCC
VKVADGAHIKSFSHLEGATVGPNCQVGPYARLRPGAVMEEDSFIGNFVEMKKTTLGPGAK
CEECCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
ASHLTYLGDATVGAKANIGAGTITCNYDGYFKYQTVIGERAFIGSNSALVAPVTIGADAI
CCEEEEECCCCCCCCCCCCCCEEEECCCCEEEEEEEECCEEEECCCCCEEEEEEECCCCE
VAAGSTVTRDVADGELRMERAEQSVKPGWADRFHDTMKKKKAAEPKK
EECCCHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA