BacMap

Definition	Erythrobacter litoralis HTCC2594 chromosome, complete genome.
Accession	NC_007722
Length	3,052,398

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The map label for this gene is ppi [H]

Identifier: 85374533

GI number: 85374533

Start: 1745616

End: 1746077

Strand: Reverse

Name: ppi [H]

Synonym: ELI_08530

Alternate gene names: 85374533

Gene position: 1746077-1745616 (Counterclockwise)

Preceding gene: 85374535

Following gene: 85374532

Centisome position: 57.2

GC content: 64.94

Gene sequence:

>462_bases
ATGGCCGATACCCTCACCCTCACGCTCGACACCGGCGACGGCGAAGGCAAGGACGTCACGATCAAGCTGCGCCCGGACCT
CGCGCCGGACCACGTCGAACGCATTACCGAGCTGGCAGGTGAAGGCTTCTACGATGACGTGGTGTTTCACCGCGTGATCC
CCGGCTTCATGGCGCAGGGCGGCGACCCGACCGGCACCGGCATGGGCGGCAGCGAGAAGCCCGACCTGAAGGCCGAGTTC
AACGCCGAGCCGCATGTCGAAGGCACGTGCTCGATGGCACGCGCGCAAAATCCGGACAGCGCCAATTCGCAGTTCTTCAT
CTGCTTCGAGGACGCGCATTTCCTCGACGGGCAGTACACCGTCTGGGGCCAGGTGACTTCCGGCATGGAGCATGTCCACG
CTTTGCCCAAGGGCGAGCCGCCGGCGAACCCGGGGAAGATCGTGAAAGCGACCGTTTCCTGA

Upstream 100 bases:

>100_bases
AAGCAAGCCGTGACACATGCGCACGGGCTGCTAGAGAAGCGCGCAATCCATCACCGCCCGCGATCAGGGCGAGCAAGAAC
CAGGCAAACGGAGAATACCC

Downstream 100 bases:

>100_bases
TCCAGCGGGAGCCTTGAGGTGACGCTGTCCCGGGTCGCACCGAAGCTGCTGGCGGCATTTGCGCTGCTGACCTTGAGCGG
CTGCGTCACCTATCCCGACA

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MADTLTLTLDTGDGEGKDVTIKLRPDLAPDHVERITELAGEGFYDDVVFHRVIPGFMAQGGDPTGTGMGGSEKPDLKAEF
NAEPHVEGTCSMARAQNPDSANSQFFICFEDAHFLDGQYTVWGQVTSGMEHVHALPKGEPPANPGKIVKATVS

Sequences:

>Translated_153_residues
MADTLTLTLDTGDGEGKDVTIKLRPDLAPDHVERITELAGEGFYDDVVFHRVIPGFMAQGGDPTGTGMGGSEKPDLKAEF
NAEPHVEGTCSMARAQNPDSANSQFFICFEDAHFLDGQYTVWGQVTSGMEHVHALPKGEPPANPGKIVKATVS
>Mature_152_residues
ADTLTLTLDTGDGEGKDVTIKLRPDLAPDHVERITELAGEGFYDDVVFHRVIPGFMAQGGDPTGTGMGGSEKPDLKAEFN
AEPHVEGTCSMARAQNPDSANSQFFICFEDAHFLDGQYTVWGQVTSGMEHVHALPKGEPPANPGKIVKATVS

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=144, Percent_Identity=36.1111111111111, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI24308049, Length=147, Percent_Identity=39.4557823129252, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI19557636, Length=138, Percent_Identity=36.9565217391304, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI64276486, Length=140, Percent_Identity=36.4285714285714, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI310129267, Length=125, Percent_Identity=40.8, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI310120620, Length=125, Percent_Identity=40.8, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI10863927, Length=126, Percent_Identity=41.2698412698413, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI5031987, Length=135, Percent_Identity=37.7777777777778, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI256017253, Length=147, Percent_Identity=37.4149659863946, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI221139811, Length=147, Percent_Identity=37.4149659863946, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI256017251, Length=147, Percent_Identity=37.4149659863946, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI310110104, Length=125, Percent_Identity=40, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI4505991, Length=133, Percent_Identity=39.0977443609023, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310127646, Length=127, Percent_Identity=38.5826771653543, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI310114371, Length=127, Percent_Identity=38.5826771653543, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI310119221, Length=127, Percent_Identity=38.5826771653543, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI178057341, Length=128, Percent_Identity=38.28125, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI22547212, Length=146, Percent_Identity=39.7260273972603, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI7657473, Length=146, Percent_Identity=39.7260273972603, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1789763, Length=150, Percent_Identity=36.6666666666667, Blast_Score=84, Evalue=3e-18,
Organism=Escherichia coli, GI1786736, Length=128, Percent_Identity=37.5, Blast_Score=80, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17539496, Length=130, Percent_Identity=36.1538461538462, Blast_Score=83, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17506311, Length=122, Percent_Identity=39.344262295082, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17539498, Length=143, Percent_Identity=39.8601398601399, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71980594, Length=129, Percent_Identity=36.4341085271318, Blast_Score=76, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=129, Percent_Identity=36.4341085271318, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17532641, Length=116, Percent_Identity=35.3448275862069, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17565860, Length=145, Percent_Identity=38.6206896551724, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=149, Percent_Identity=35.5704697986577, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71997782, Length=134, Percent_Identity=37.3134328358209, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17551282, Length=102, Percent_Identity=43.1372549019608, Blast_Score=63, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17551284, Length=102, Percent_Identity=43.1372549019608, Blast_Score=63, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17559074, Length=93, Percent_Identity=44.0860215053763, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321848, Length=129, Percent_Identity=37.984496124031, Blast_Score=66, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=127, Percent_Identity=38.5826771653543, Blast_Score=63, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=143, Percent_Identity=39.1608391608392, Blast_Score=62, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17986117, Length=157, Percent_Identity=40.7643312101911, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19922376, Length=121, Percent_Identity=33.0578512396694, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17647301, Length=136, Percent_Identity=35.2941176470588, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45549139, Length=126, Percent_Identity=38.8888888888889, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24652460, Length=144, Percent_Identity=34.7222222222222, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20130249, Length=125, Percent_Identity=39.2, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24664125, Length=126, Percent_Identity=38.8888888888889, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21357783, Length=126, Percent_Identity=38.8888888888889, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19922912, Length=152, Percent_Identity=38.1578947368421, Blast_Score=63, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16358; Mature: 16227

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTLTLTLDTGDGEGKDVTIKLRPDLAPDHVERITELAGEGFYDDVVFHRVIPGFMAQG
CCCEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
GDPTGTGMGGSEKPDLKAEFNAEPHVEGTCSMARAQNPDSANSQFFICFEDAHFLDGQYT
CCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHCCCCCCCCCEEEEEECCCEEECCCEE
VWGQVTSGMEHVHALPKGEPPANPGKIVKATVS
EEEEHHCCHHHHHCCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure 
ADTLTLTLDTGDGEGKDVTIKLRPDLAPDHVERITELAGEGFYDDVVFHRVIPGFMAQG
CCEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
GDPTGTGMGGSEKPDLKAEFNAEPHVEGTCSMARAQNPDSANSQFFICFEDAHFLDGQYT
CCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHCCCCCCCCCEEEEEECCCEEECCCEE
VWGQVTSGMEHVHALPKGEPPANPGKIVKATVS
EEEEHHCCHHHHHCCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA