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The map label for this gene is fur [H]

Identifier: 85374524

GI number: 85374524

Start: 1738083

End: 1738505

Strand: Direct

Name: fur [H]

Synonym: ELI_08485

Alternate gene names: 85374524

Gene position: 1738083-1738505 (Clockwise)

Preceding gene: 85374523

Following gene: 85374525

Centisome position: 56.94

GC content: 60.99

Gene sequence:

>423_bases
TTGCCCGAACGGATCGATCTCGAACAATTGTGTGCCGACAAGGGCCTGCGCATCACCGAGCAGCGCCGCGTCATCGCAAA
GGTGCTGTCGGAAAGCGACGATCATCCCGATGTCGAGCTGCTGCACGAACGCGCCAGTGCGGTCGATCCGAAGATCTCCA
TTGCGACCGTCTATCGCACCGTGCGCCTGTTCGAAGAGGCCGGCATTCTCGACCGGCACGATTTCGGCGATGGCCGCGCC
CGCTACGAGCCCGCTCCCGAAGCGCATCACGATCACCTGATCGATGTGGAAAGCGGAAAGGTCGTCGAATTCGTCGACCC
CGAACTCGAAGCGTTGCAGAAACAGATCGCCGAAAAGCTCGGCTATCGCCTGGTCGACCACCGCATGGAATTGTACGGCG
TGCGGATAGGCCGTGACGACTGA

Upstream 100 bases:

>100_bases
CCTGACCTGTTGATCCGATGAGAGTGGGTGAAAGCGCCCGCTTGAGTGCAACGCCCCGGCCCTCTAAGGGTTCGGGGCGT
TTCATTACCGGAGAGACGGG

Downstream 100 bases:

>100_bases
GACAAAGACCGTGGCAGGAACCGGCCAAGGCAAAGTGAAGCGCCGTCACGACCCCTTGCGCAACGAATGGCGACACCGCG
CCGCGGCAGCCAAAGGTGTG

Product: Fe2+/Zn2+ uptake regulation protein

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MPERIDLEQLCADKGLRITEQRRVIAKVLSESDDHPDVELLHERASAVDPKISIATVYRTVRLFEEAGILDRHDFGDGRA
RYEPAPEAHHDHLIDVESGKVVEFVDPELEALQKQIAEKLGYRLVDHRMELYGVRIGRDD

Sequences:

>Translated_140_residues
MPERIDLEQLCADKGLRITEQRRVIAKVLSESDDHPDVELLHERASAVDPKISIATVYRTVRLFEEAGILDRHDFGDGRA
RYEPAPEAHHDHLIDVESGKVVEFVDPELEALQKQIAEKLGYRLVDHRMELYGVRIGRDD
>Mature_139_residues
PERIDLEQLCADKGLRITEQRRVIAKVLSESDDHPDVELLHERASAVDPKISIATVYRTVRLFEEAGILDRHDFGDGRAR
YEPAPEAHHDHLIDVESGKVVEFVDPELEALQKQIAEKLGYRLVDHRMELYGVRIGRDD

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=120, Percent_Identity=44.1666666666667, Blast_Score=102, Evalue=1e-23,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 16050; Mature: 15919

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPERIDLEQLCADKGLRITEQRRVIAKVLSESDDHPDVELLHERASAVDPKISIATVYRT
CCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHH
VRLFEEAGILDRHDFGDGRARYEPAPEAHHDHLIDVESGKVVEFVDPELEALQKQIAEKL
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCHHHHHHHHHHHHHH
GYRLVDHRMELYGVRIGRDD
HHHHHHHHHHHHEEECCCCC
>Mature Secondary Structure 
PERIDLEQLCADKGLRITEQRRVIAKVLSESDDHPDVELLHERASAVDPKISIATVYRT
CCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHH
VRLFEEAGILDRHDFGDGRARYEPAPEAHHDHLIDVESGKVVEFVDPELEALQKQIAEKL
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCHHHHHHHHHHHHHH
GYRLVDHRMELYGVRIGRDD
HHHHHHHHHHHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9835040 [H]