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The map label for this gene is atpB

Identifier: 85374334

GI number: 85374334

Start: 1560548

End: 1561336

Strand: Reverse

Name: atpB

Synonym: ELI_07535

Alternate gene names: 85374334

Gene position: 1561336-1560548 (Counterclockwise)

Preceding gene: 85374335

Following gene: 85374333

Centisome position: 51.15

GC content: 59.57

Gene sequence:

>789_bases
GTGGCGGCCGAATCTGGCAAAGTCGACCCGATGAAGCAGTTCTCCATCGAGCCCATGCTGGGTTCCGAAGGCTGGGAAAT
CGCGGGCTACAACATCGCCTTCACCAACAGTGCGGCATGGATGGCGCTGACCACCGTGCTGCTCGCCGTGTTCGTGTGGG
GCGGCATGAAGGGGCAGCTCGTCCCCGGTCGCTGGCAGATGATGGTCGAAAGCTTCACCAGCTTTATCGATGACATGCTG
GAAGTGAACATCGGCAAGGCCGGGCGCAAATACGTGCCCTACGTCTTCAGCCTGTTCATGTTCATCCTGTTCGGAAATTT
GCTCGGCCTGCTGCCCTTGGGCGTGCTCGGCATCCACCCGTTCACCTTCACCAGCCACTTCACCATCACCGGCGTGCTGG
CGATCATCAGCTTCTCGATCGTCCTGATCGTCGGCTTCTGGAAGCACGGCTTCCATTTCTTCAGCCTGTTCGTGCCCAGC
GGCACCCCGCTGCCGATGATCCCGATCATCTTCCCGATCGAGCTGATCAGCTTCCTCGTTCGCCCTTTCAGCCTCGCGCT
GCGGCTGTTCGTGGCGATGATGGCGGGCCACGTCCTGCTCAAGGTGCTGTCCAGCTTCGTGATCGACGGCATCAATGCCG
GCGCCGGTTTCGGTTTGCTGGTGGGCGCCCCGAGCTTCATTCTGATGATCGGCATTTCCGCGCTGGAAATCCTCGTAGCC
GGTATCCAGGCCTATGTCTTCGCGTTGTTGACCTCGCTGTATATCAACGACGCCGAAAACCTTCACTAA

Upstream 100 bases:

>100_bases
GCCTTCAGGAATGTGTTTCGAATGGCGAATACGCCGCCCGCGGACAGCTCGGACGAGCGCTGACGGGCCGGGTGTTCGCC
AAAACGCGTAAGGATCTCAC

Downstream 100 bases:

>100_bases
GTCTCTGATCAACCAAACAGATTTGTACTCAAGGAGTTATTACAATGGACGCAGAAGCAGCAAAGCTGGTCGGTGCGGGT
CTCGCAGCAATCGGTGCCGG

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MAAESGKVDPMKQFSIEPMLGSEGWEIAGYNIAFTNSAAWMALTTVLLAVFVWGGMKGQLVPGRWQMMVESFTSFIDDML
EVNIGKAGRKYVPYVFSLFMFILFGNLLGLLPLGVLGIHPFTFTSHFTITGVLAIISFSIVLIVGFWKHGFHFFSLFVPS
GTPLPMIPIIFPIELISFLVRPFSLALRLFVAMMAGHVLLKVLSSFVIDGINAGAGFGLLVGAPSFILMIGISALEILVA
GIQAYVFALLTSLYINDAENLH

Sequences:

>Translated_262_residues
MAAESGKVDPMKQFSIEPMLGSEGWEIAGYNIAFTNSAAWMALTTVLLAVFVWGGMKGQLVPGRWQMMVESFTSFIDDML
EVNIGKAGRKYVPYVFSLFMFILFGNLLGLLPLGVLGIHPFTFTSHFTITGVLAIISFSIVLIVGFWKHGFHFFSLFVPS
GTPLPMIPIIFPIELISFLVRPFSLALRLFVAMMAGHVLLKVLSSFVIDGINAGAGFGLLVGAPSFILMIGISALEILVA
GIQAYVFALLTSLYINDAENLH
>Mature_261_residues
AAESGKVDPMKQFSIEPMLGSEGWEIAGYNIAFTNSAAWMALTTVLLAVFVWGGMKGQLVPGRWQMMVESFTSFIDDMLE
VNIGKAGRKYVPYVFSLFMFILFGNLLGLLPLGVLGIHPFTFTSHFTITGVLAIISFSIVLIVGFWKHGFHFFSLFVPSG
TPLPMIPIIFPIELISFLVRPFSLALRLFVAMMAGHVLLKVLSSFVIDGINAGAGFGLLVGAPSFILMIGISALEILVAG
IQAYVFALLTSLYINDAENLH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Homo sapiens, GI251831112, Length=173, Percent_Identity=38.150289017341, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6226527, Length=262, Percent_Identity=33.206106870229, Blast_Score=123, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_ERYLH (Q2N9P2)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_458396.1
- ProteinModelPortal:   Q2N9P2
- STRING:   Q2N9P2
- GeneID:   3871525
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_07535
- NMPDR:   fig|314225.3.peg.1535
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   MDQFIVK
- PhylomeDB:   Q2N9P2
- ProtClustDB:   PRK05815
- BioCyc:   ELIT314225:ELI_07535-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 28566; Mature: 28434

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x14d4206c)-; HASH(0xe7ab9cc)-; HASH(0x13ffac10)-; HASH(0xdd034fc)-; HASH(0xe4db608)-; HASH(0xdd04d00)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure 
AAESGKVDPMKQFSIEPMLGSEGWEIAGYNIAFTNSAAWMALTTVLLAVFVWGGMKGQL
CCCCCCCCCHHHCCCCCCCCCCCCEEECEEEEEECCHHHHHHHHHHHHHHHHCCCCCCC
VPGRWQMMVESFTSFIDDMLEVNIGKAGRKYVPYVFSLFMFILFGNLLGLLPLGVLGIHP
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FTFTSHFTITGVLAIISFSIVLIVGFWKHGFHFFSLFVPSGTPLPMIPIIFPIELISFLV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHH
RPFSLALRLFVAMMAGHVLLKVLSSFVIDGINAGAGFGLLVGAPSFILMIGISALEILVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHH
GIQAYVFALLTSLYINDAENLH
HHHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA