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The map label for this gene is ffh [H]

Identifier: 85374323

GI number: 85374323

Start: 1550129

End: 1551631

Strand: Reverse

Name: ffh [H]

Synonym: ELI_07480

Alternate gene names: 85374323

Gene position: 1551631-1550129 (Counterclockwise)

Preceding gene: 85374324

Following gene: 85374322

Centisome position: 50.83

GC content: 64.34

Gene sequence:

>1503_bases
ATGTTCGACGCACTGTCCGATCGCCTTGGTAGCACGTTCGACCGCCTGCGCGGCCGGGGGGCGCTGCGCGAGCAGGACGT
GCGCGATGCGATGCGCGAAGTACGGATTGCGCTGCTCGAAGCAGACGTGGCGTTGCCGGTTGCCAAGAGCTTTATCGATA
AGGTCACGGAAAAAGCCGTCGGCGAAGATGTCCTCAAATCGGTCACGCCGGGCCAGCAGGTCATCAAGATCGTCAATGAC
GAGCTGGTGGCGATGCTCGGTGGGGACGACGGCGAGCAGGGCCATGTCCCGCTCACGCTCGAAGCCAAGCCGCCGGTCGT
GATCATGATGGTTGGCCTGCAAGGCTCGGGTAAGACCACCACCACCGCCAAGCTTTCGAAATATATCCGCGAGAAGCACG
GCAAGAAGCCGATGATGGCTTCGCTCGACGTCAATCGACCGGCCGCGCAGGAGCAGCTGGCGGTGCTGGGCGAGCAGGTA
GACGTCGCGACTCTGCCGATCGTGCAGGGCCAGCAGCCGGTCGATATCGCCCGCCGCGCGCTCGAAGCCGCGCGCCTGCA
GAATGTCGACGTGCTGCTGCTCGATACCGCAGGCCGCCTGCATGTCGACGAGGCGCTGATGGCGGAGATGAAGGCCGTCG
CCGGTGTTTCCGCGCCGACCGAAGTGCTGCTCGTCGTCGACAGCCTGACCGGGCAGGACGCGGTCAATGTCGCGCAGAAT
TTCTCCGACGAAGTGCCGCTCACCGGCGTGGTTCTCACCCGGATGGATGGCGATGCGCGCGGCGGCGCGGCGCTTTCCAT
GCGCGCGGTCACTGGCAAGCCGATCAAGTTTGCCGGTACCGGCGAAAAGCTCGACGCGATCGAGGCGTTCCATCCGGCGC
GGGTGGCCGATCGCATCCTCGGCATGGGCGATGTCGTCTCGCTGGTCGAGAAAGCCGCCGAGAACATCAAGGTCGAAGAA
GCCGAAGCGCTCGCCAAGCGCATGGAGAAGGGCAAGTTCGACCTCAACGACCTGCGCATGCAGCTCAGGCAGATGCAGAA
CATGGGCGGGATCGGCGCGATTGCCGGCATGATGCCCGGCATGAAGAAGGCCAAGGCGGCGATGGCCGCGGCCGATATGG
ACGACAAGGTGCTGGTCCATATGGACGCGATCATGGGCTCGATGACGCCCAAGGAACGCGCCAATCCGGCCCTCCTCAAT
GCCAAGCGCAAGAAGCGTGTGGCGGCCGGCTCGGGCACTTCGGTTCAGGAAGTGAACAAGGTGATGAAGATGCACCAGGA
AATGAGCCGGGCGATGAAGCAGATCAAGAAGATGGGCGGGCTCAAGGGCCTCGCTTCCATGTTCGGCGGCGGTGGTGGCG
GCCTTGGCGGTCTCGGCGGGATGGGCGGAGGCGGCGGGATGCCGAACCTGCCCGGTCTCGGCGGACCTGGAGGCAAGGGT
CCATCGGTCGATCCCAACACTCTACCGCCCGATCTTCGCGCGATTTTGGACAAAGACAAGTAA

Upstream 100 bases:

>100_bases
AGCCGGAGCAATTGCTTCGCACGCTGGCCGACGAGTTTTCGTCCGCCGGCGTTTTTCGCATTCGGGACCTCCGTAGGTCC
TGCAGGAGTTCGAGTAACGC

Downstream 100 bases:

>100_bases
GCAATTTCAGTGATTTGATTTGGAAAGGTGAGTTAAAATGGCAGTTGCAATCCGTTTGTCGCGCGGTGGCGCGAAGAAGC
GCCCCTATTACCGCATCGTC

Product: signal recognition particle GTPase

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MFDALSDRLGSTFDRLRGRGALREQDVRDAMREVRIALLEADVALPVAKSFIDKVTEKAVGEDVLKSVTPGQQVIKIVND
ELVAMLGGDDGEQGHVPLTLEAKPPVVIMMVGLQGSGKTTTTAKLSKYIREKHGKKPMMASLDVNRPAAQEQLAVLGEQV
DVATLPIVQGQQPVDIARRALEAARLQNVDVLLLDTAGRLHVDEALMAEMKAVAGVSAPTEVLLVVDSLTGQDAVNVAQN
FSDEVPLTGVVLTRMDGDARGGAALSMRAVTGKPIKFAGTGEKLDAIEAFHPARVADRILGMGDVVSLVEKAAENIKVEE
AEALAKRMEKGKFDLNDLRMQLRQMQNMGGIGAIAGMMPGMKKAKAAMAAADMDDKVLVHMDAIMGSMTPKERANPALLN
AKRKKRVAAGSGTSVQEVNKVMKMHQEMSRAMKQIKKMGGLKGLASMFGGGGGGLGGLGGMGGGGGMPNLPGLGGPGGKG
PSVDPNTLPPDLRAILDKDK

Sequences:

>Translated_500_residues
MFDALSDRLGSTFDRLRGRGALREQDVRDAMREVRIALLEADVALPVAKSFIDKVTEKAVGEDVLKSVTPGQQVIKIVND
ELVAMLGGDDGEQGHVPLTLEAKPPVVIMMVGLQGSGKTTTTAKLSKYIREKHGKKPMMASLDVNRPAAQEQLAVLGEQV
DVATLPIVQGQQPVDIARRALEAARLQNVDVLLLDTAGRLHVDEALMAEMKAVAGVSAPTEVLLVVDSLTGQDAVNVAQN
FSDEVPLTGVVLTRMDGDARGGAALSMRAVTGKPIKFAGTGEKLDAIEAFHPARVADRILGMGDVVSLVEKAAENIKVEE
AEALAKRMEKGKFDLNDLRMQLRQMQNMGGIGAIAGMMPGMKKAKAAMAAADMDDKVLVHMDAIMGSMTPKERANPALLN
AKRKKRVAAGSGTSVQEVNKVMKMHQEMSRAMKQIKKMGGLKGLASMFGGGGGGLGGLGGMGGGGGMPNLPGLGGPGGKG
PSVDPNTLPPDLRAILDKDK
>Mature_500_residues
MFDALSDRLGSTFDRLRGRGALREQDVRDAMREVRIALLEADVALPVAKSFIDKVTEKAVGEDVLKSVTPGQQVIKIVND
ELVAMLGGDDGEQGHVPLTLEAKPPVVIMMVGLQGSGKTTTTAKLSKYIREKHGKKPMMASLDVNRPAAQEQLAVLGEQV
DVATLPIVQGQQPVDIARRALEAARLQNVDVLLLDTAGRLHVDEALMAEMKAVAGVSAPTEVLLVVDSLTGQDAVNVAQN
FSDEVPLTGVVLTRMDGDARGGAALSMRAVTGKPIKFAGTGEKLDAIEAFHPARVADRILGMGDVVSLVEKAAENIKVEE
AEALAKRMEKGKFDLNDLRMQLRQMQNMGGIGAIAGMMPGMKKAKAAMAAADMDDKVLVHMDAIMGSMTPKERANPALLN
AKRKKRVAAGSGTSVQEVNKVMKMHQEMSRAMKQIKKMGGLKGLASMFGGGGGGLGGLGGMGGGGGMPNLPGLGGPGGKG
PSVDPNTLPPDLRAILDKDK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=454, Percent_Identity=32.3788546255507, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI226371618, Length=350, Percent_Identity=35.1428571428571, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI89061728, Length=159, Percent_Identity=37.1069182389937, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI295424842, Length=307, Percent_Identity=29.6416938110749, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI23308697, Length=307, Percent_Identity=29.6416938110749, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1788963, Length=431, Percent_Identity=55.6844547563805, Blast_Score=466, Evalue=1e-132,
Organism=Escherichia coli, GI1789874, Length=256, Percent_Identity=36.71875, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17539958, Length=432, Percent_Identity=32.4074074074074, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI193206261, Length=311, Percent_Identity=29.5819935691318, Blast_Score=95, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6325345, Length=461, Percent_Identity=31.0195227765727, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6320498, Length=209, Percent_Identity=30.1435406698565, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17647949, Length=445, Percent_Identity=28.7640449438202, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24641198, Length=323, Percent_Identity=29.1021671826625, Blast_Score=99, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 52608; Mature: 52608

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDALSDRLGSTFDRLRGRGALREQDVRDAMREVRIALLEADVALPVAKSFIDKVTEKAV
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEDVLKSVTPGQQVIKIVNDELVAMLGGDDGEQGHVPLTLEAKPPVVIMMVGLQGSGKTT
HHHHHHHCCCHHHHHHHHHHHHEEEECCCCCCCCCEEEEEECCCCEEEEEEECCCCCCCH
TTAKLSKYIREKHGKKPMMASLDVNRPAAQEQLAVLGEQVDVATLPIVQGQQPVDIARRA
HHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHH
LEAARLQNVDVLLLDTAGRLHVDEALMAEMKAVAGVSAPTEVLLVVDSLTGQDAVNVAQN
HHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHC
FSDEVPLTGVVLTRMDGDARGGAALSMRAVTGKPIKFAGTGEKLDAIEAFHPARVADRIL
CCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCEEECCCCCHHHHHHHHCHHHHHHHHH
GMGDVVSLVEKAAENIKVEEAEALAKRMEKGKFDLNDLRMQLRQMQNMGGIGAIAGMMPG
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCC
MKKAKAAMAAADMDDKVLVHMDAIMGSMTPKERANPALLNAKRKKRVAAGSGTSVQEVNK
HHHHHHHHHHCCCCCHHHEEHHHHHCCCCCHHCCCCHHHHHHHHHHHHCCCCCCHHHHHH
VMKMHQEMSRAMKQIKKMGGLKGLASMFGGGGGGLGGLGGMGGGGGMPNLPGLGGPGGKG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PSVDPNTLPPDLRAILDKDK
CCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MFDALSDRLGSTFDRLRGRGALREQDVRDAMREVRIALLEADVALPVAKSFIDKVTEKAV
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEDVLKSVTPGQQVIKIVNDELVAMLGGDDGEQGHVPLTLEAKPPVVIMMVGLQGSGKTT
HHHHHHHCCCHHHHHHHHHHHHEEEECCCCCCCCCEEEEEECCCCEEEEEEECCCCCCCH
TTAKLSKYIREKHGKKPMMASLDVNRPAAQEQLAVLGEQVDVATLPIVQGQQPVDIARRA
HHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHH
LEAARLQNVDVLLLDTAGRLHVDEALMAEMKAVAGVSAPTEVLLVVDSLTGQDAVNVAQN
HHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHC
FSDEVPLTGVVLTRMDGDARGGAALSMRAVTGKPIKFAGTGEKLDAIEAFHPARVADRIL
CCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCEEECCCCCHHHHHHHHCHHHHHHHHH
GMGDVVSLVEKAAENIKVEEAEALAKRMEKGKFDLNDLRMQLRQMQNMGGIGAIAGMMPG
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCC
MKKAKAAMAAADMDDKVLVHMDAIMGSMTPKERANPALLNAKRKKRVAAGSGTSVQEVNK
HHHHHHHHHHCCCCCHHHEEHHHHHCCCCCHHCCCCHHHHHHHHHHHHCCCCCCHHHHHH
VMKMHQEMSRAMKQIKKMGGLKGLASMFGGGGGGLGGLGGMGGGGGMPNLPGLGGPGGKG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PSVDPNTLPPDLRAILDKDK
CCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]