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The map label for this gene is bsaA [H]

Identifier: 85374225

GI number: 85374225

Start: 1450986

End: 1451465

Strand: Reverse

Name: bsaA [H]

Synonym: ELI_06990

Alternate gene names: 85374225

Gene position: 1451465-1450986 (Counterclockwise)

Preceding gene: 85374226

Following gene: 85374224

Centisome position: 47.55

GC content: 58.33

Gene sequence:

>480_bases
ATGACCACCATTGCCGATTTCACCGTCACCACCAATCGCGGCGAAGAGCTCGATCTCGCCGAGAAGAAGGGCAAGGTGCT
GTTGGTGGTGAACACCGCCAGCAAATGCGGTTTCACCCCGCAATATGACGGTCTCGAAGAGCTCTACCAGCAATACAAAA
ACCAGGGCTTCGAAGTGCTCGGCTTCCCCTGCAACCAGTTCGGGGCGCAAGAGCCGGGCAGCGCCGACGAGATCGCAGAG
TTCTGCAAAGTCAATTTCGGTGTCACCTTCCCGCTGATGGAAAAGGTCGAAGTCAATGGCCCCGACGCCTCGCCGGTGTT
CGACTGGATGAAGGGGGAGGCGGAAGGCCTGATGGGCTCGACCGGGATCAAGTGGAACTTCACCAAGTTCCTGATCGATC
GCGAAGGCAATGTCGTGAAGCGCTTCGCCCCGCAGGATTCGCCAAGCTCGATCGCCAGGCATGTCGAGAAGCTGCTGTAA

Upstream 100 bases:

>100_bases
ACGATGGCAGTGTCCGCCAGCACGGAGAATCCTCGACGGACCATGGGCTTTCGTGGCAGACGTCCTTCGATCTCCTGTAT
CGACCGAAAGCGACTCCCGA

Downstream 100 bases:

>100_bases
CCTTGGGGGTGCGCGATCCGAACAACGGGCATATTCAGATGGGGATTTGAGCCATGCTCGAAGCAATCAACGAATGGATC
CTGGCGCAAGGCGCGCAGTA

Product: glutathione peroxidase

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MTTIADFTVTTNRGEELDLAEKKGKVLLVVNTASKCGFTPQYDGLEELYQQYKNQGFEVLGFPCNQFGAQEPGSADEIAE
FCKVNFGVTFPLMEKVEVNGPDASPVFDWMKGEAEGLMGSTGIKWNFTKFLIDREGNVVKRFAPQDSPSSIARHVEKLL

Sequences:

>Translated_159_residues
MTTIADFTVTTNRGEELDLAEKKGKVLLVVNTASKCGFTPQYDGLEELYQQYKNQGFEVLGFPCNQFGAQEPGSADEIAE
FCKVNFGVTFPLMEKVEVNGPDASPVFDWMKGEAEGLMGSTGIKWNFTKFLIDREGNVVKRFAPQDSPSSIARHVEKLL
>Mature_158_residues
TTIADFTVTTNRGEELDLAEKKGKVLLVVNTASKCGFTPQYDGLEELYQQYKNQGFEVLGFPCNQFGAQEPGSADEIAEF
CKVNFGVTFPLMEKVEVNGPDASPVFDWMKGEAEGLMGSTGIKWNFTKFLIDREGNVVKRFAPQDSPSSIARHVEKLL

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI75709200, Length=154, Percent_Identity=42.8571428571429, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI90903240, Length=154, Percent_Identity=42.8571428571429, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI192455698, Length=154, Percent_Identity=37.6623376623377, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI15618997, Length=155, Percent_Identity=38.0645161290323, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI90903238, Length=131, Percent_Identity=41.9847328244275, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI4557629, Length=169, Percent_Identity=37.2781065088757, Blast_Score=95, Evalue=3e-20,
Organism=Homo sapiens, GI33186887, Length=177, Percent_Identity=35.0282485875706, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI41406084, Length=170, Percent_Identity=34.7058823529412, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI6006001, Length=169, Percent_Identity=33.7278106508876, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI32967607, Length=181, Percent_Identity=30.939226519337, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI1788003, Length=154, Percent_Identity=44.1558441558442, Blast_Score=130, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17506887, Length=160, Percent_Identity=43.125, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17535473, Length=160, Percent_Identity=42.5, Blast_Score=139, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI193210707, Length=162, Percent_Identity=41.358024691358, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71993584, Length=158, Percent_Identity=36.0759493670886, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI193209493, Length=163, Percent_Identity=35.5828220858896, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17550320, Length=163, Percent_Identity=34.9693251533742, Blast_Score=101, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71999642, Length=76, Percent_Identity=39.4736842105263, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71993573, Length=96, Percent_Identity=35.4166666666667, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319721, Length=158, Percent_Identity=53.1645569620253, Blast_Score=195, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6322228, Length=159, Percent_Identity=50.314465408805, Blast_Score=188, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6322826, Length=159, Percent_Identity=42.1383647798742, Blast_Score=143, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24656772, Length=163, Percent_Identity=46.0122699386503, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24656767, Length=164, Percent_Identity=45.7317073170732, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24656777, Length=163, Percent_Identity=46.0122699386503, Blast_Score=140, Evalue=5e-34,
Organism=Drosophila melanogaster, GI85726443, Length=159, Percent_Identity=38.3647798742138, Blast_Score=113, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: NA

Molecular weight: Translated: 17624; Mature: 17493

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1 ; PS00763 GLUTATHIONE_PEROXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIADFTVTTNRGEELDLAEKKGKVLLVVNTASKCGFTPQYDGLEELYQQYKNQGFEVL
CCEEEEEEEECCCCCCCCHHCCCCCEEEEEECCHHCCCCCCCCCHHHHHHHHHHCCCEEE
GFPCNQFGAQEPGSADEIAEFCKVNFGVTFPLMEKVEVNGPDASPVFDWMKGEAEGLMGS
ECCHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHCCCCCCCCCC
TGIKWNFTKFLIDREGNVVKRFAPQDSPSSIARHVEKLL
CCCCEEHEEEEEECCCCEEEECCCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
TTIADFTVTTNRGEELDLAEKKGKVLLVVNTASKCGFTPQYDGLEELYQQYKNQGFEVL
CEEEEEEEECCCCCCCCHHCCCCCEEEEEECCHHCCCCCCCCCHHHHHHHHHHCCCEEE
GFPCNQFGAQEPGSADEIAEFCKVNFGVTFPLMEKVEVNGPDASPVFDWMKGEAEGLMGS
ECCHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHCCCCCCCCCC
TGIKWNFTKFLIDREGNVVKRFAPQDSPSSIARHVEKLL
CCCCEEHEEEEEECCCCEEEECCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]