Click here to switch to the map view.

The map label for this gene is nuoD

Identifier: 85374162

GI number: 85374162

Start: 1382877

End: 1384088

Strand: Reverse

Name: nuoD

Synonym: ELI_06675

Alternate gene names: 85374162

Gene position: 1384088-1382877 (Counterclockwise)

Preceding gene: 85374163

Following gene: 85374161

Centisome position: 45.34

GC content: 61.3

Gene sequence:

>1212_bases
ATGAGCGTTCACATCGAAGAAAGCCCCACCACCGACGGGGACGTGATCACCAACTACACGATCAATTTCGGGCCCCAGCA
CCCGGCGGCCCACGGCGTGCTGCGCATGATCATGGAGCTGGACGGCGAAATCATCGAACGCGTCGACCCGCATGTCGGCC
TGCTCCACCGCGGCACCGAGAAGCTGATCGAGCACAAGACCTATCTGCAGGCGCTGCCCTATTTCGACCGGCTCGACTAT
TGTTCGCCTCTTTGCATGGAGCACAGCTACGTGCTCGCGATCGAGAAGCTGCTCAACATCGAAGTGCCCGAGCGGGCGCA
GTACCTTCGCGTGCTGTTCGCCGAATTGACCCGCATTTCCAACCACATGCTCAACCTCGGCGCGCATGTCCTCGATGTCG
GCGCCTTTACGCCGAACCTGTGGATGTTCGAATTGCGCGAAGACTGCATGAATTTCTTCGAGCGGGCTTCGGGCGCGCGT
ATGCATATGGCGTGGTTCCGCCCCGGCGGCGTCCACCAGGACGTGCCGGAAAAGCTGCTGGTCGATATCGGCGAGTGGCT
CGATACGCGCCTGCCCGAACTGTTCGGCGACGCGATGAGCCTCGTGCTCGACAACCGCATCTTCAAGCAGCGCAACGTCG
ATATCGCCGTCGTCAGCAAGGACGATGCGGTTAAATGGGGCTTCTCCGGCCCGATGATCCGTGCGGCGGGCATCCCGTGG
GACCTGCGCAAGTCGCAGCCTTACGACGTCTATGACCGGATGGAATTCGACATCCCCGTCGGCACCAATTCGGATTGCTA
CGACCGCTTCTCCGTGCGCGTGAAGGAAGTTTACGAGAGCGCAAAGATCATCAAGCAGTGCCTTGCGCAAATGCCGCAGG
GCCCGATTGCCAGCACCGACGGTAAAGTCTCGCCCCCGTCGCGCGGCAGGATGAAACAGTCGATGGAAGCGCTGATCCAT
CACTTCAAGCTCTACACCGAGGGCTTCCACGTTCCGGCGGGCGAAGTCTACGTGGCGACGGAAAGCCCCAAGGGCGAATT
CGGCGTCTATCTGGTCGCCGACGGCACCAACAAGCCATATCGCTGCAAGATCCGCCCGACCGCGTTTTCGCACCTGCAAG
CGATGGACTTCATGTCCAAGGGCCACATGCTGCCCGACGCGACCGCCATCCTCGGCGCAATCGACGTGGTGTTCGGGGAG
TGTGACCGGTGA

Upstream 100 bases:

>100_bases
TGGCCCCGACCGCCGGCAACGAAGCGCGCCGCGCCGCCAACATGGTCGTCACCGACAGCGCGGGCACGACACAGAGCTAT
AGCGGCGATTGGATCTGCGG

Downstream 100 bases:

>100_bases
TCCTCCGCGAACTGTTCATCTTCATCGCGGCGTTTGCGGCGTTCGCTTCGGCGATTGCGGCTTATCTTGCCGTGTTTCAC
GGGGCGCCGAGCTTCAAGGA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MSVHIEESPTTDGDVITNYTINFGPQHPAAHGVLRMIMELDGEIIERVDPHVGLLHRGTEKLIEHKTYLQALPYFDRLDY
CSPLCMEHSYVLAIEKLLNIEVPERAQYLRVLFAELTRISNHMLNLGAHVLDVGAFTPNLWMFELREDCMNFFERASGAR
MHMAWFRPGGVHQDVPEKLLVDIGEWLDTRLPELFGDAMSLVLDNRIFKQRNVDIAVVSKDDAVKWGFSGPMIRAAGIPW
DLRKSQPYDVYDRMEFDIPVGTNSDCYDRFSVRVKEVYESAKIIKQCLAQMPQGPIASTDGKVSPPSRGRMKQSMEALIH
HFKLYTEGFHVPAGEVYVATESPKGEFGVYLVADGTNKPYRCKIRPTAFSHLQAMDFMSKGHMLPDATAILGAIDVVFGE
CDR

Sequences:

>Translated_403_residues
MSVHIEESPTTDGDVITNYTINFGPQHPAAHGVLRMIMELDGEIIERVDPHVGLLHRGTEKLIEHKTYLQALPYFDRLDY
CSPLCMEHSYVLAIEKLLNIEVPERAQYLRVLFAELTRISNHMLNLGAHVLDVGAFTPNLWMFELREDCMNFFERASGAR
MHMAWFRPGGVHQDVPEKLLVDIGEWLDTRLPELFGDAMSLVLDNRIFKQRNVDIAVVSKDDAVKWGFSGPMIRAAGIPW
DLRKSQPYDVYDRMEFDIPVGTNSDCYDRFSVRVKEVYESAKIIKQCLAQMPQGPIASTDGKVSPPSRGRMKQSMEALIH
HFKLYTEGFHVPAGEVYVATESPKGEFGVYLVADGTNKPYRCKIRPTAFSHLQAMDFMSKGHMLPDATAILGAIDVVFGE
CDR
>Mature_402_residues
SVHIEESPTTDGDVITNYTINFGPQHPAAHGVLRMIMELDGEIIERVDPHVGLLHRGTEKLIEHKTYLQALPYFDRLDYC
SPLCMEHSYVLAIEKLLNIEVPERAQYLRVLFAELTRISNHMLNLGAHVLDVGAFTPNLWMFELREDCMNFFERASGARM
HMAWFRPGGVHQDVPEKLLVDIGEWLDTRLPELFGDAMSLVLDNRIFKQRNVDIAVVSKDDAVKWGFSGPMIRAAGIPWD
LRKSQPYDVYDRMEFDIPVGTNSDCYDRFSVRVKEVYESAKIIKQCLAQMPQGPIASTDGKVSPPSRGRMKQSMEALIHH
FKLYTEGFHVPAGEVYVATESPKGEFGVYLVADGTNKPYRCKIRPTAFSHLQAMDFMSKGHMLPDATAILGAIDVVFGEC
DR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=407, Percent_Identity=58.2309582309582, Blast_Score=509, Evalue=1e-144,
Organism=Homo sapiens, GI260898743, Length=401, Percent_Identity=57.6059850374065, Blast_Score=496, Evalue=1e-140,
Organism=Escherichia coli, GI145693162, Length=387, Percent_Identity=39.2764857881137, Blast_Score=298, Evalue=3e-82,
Organism=Escherichia coli, GI1789076, Length=408, Percent_Identity=25.7352941176471, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788832, Length=417, Percent_Identity=25.6594724220624, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17555284, Length=388, Percent_Identity=57.2164948453608, Blast_Score=479, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17568379, Length=388, Percent_Identity=55.9278350515464, Blast_Score=473, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24638644, Length=388, Percent_Identity=59.5360824742268, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI221459469, Length=383, Percent_Identity=56.3968668407311, Blast_Score=478, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_ERYLH (Q2NA64)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_458224.1
- HSSP:   Q56220
- STRING:   Q2NA64
- GeneID:   3869267
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_06675
- NMPDR:   fig|314225.3.peg.1716
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   IFYERAC
- PhylomeDB:   Q2NA64
- ProtClustDB:   PRK06075
- BioCyc:   ELIT314225:ELI_06675-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 45651; Mature: 45520

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVHIEESPTTDGDVITNYTINFGPQHPAAHGVLRMIMELDGEIIERVDPHVGLLHRGTE
CEEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHH
KLIEHKTYLQALPYFDRLDYCSPLCMEHSYVLAIEKLLNIEVPERAQYLRVLFAELTRIS
HHHHHHHHHHHCCCHHHHHHCCHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
NHMLNLGAHVLDVGAFTPNLWMFELREDCMNFFERASGARMHMAWFRPGGVHQDVPEKLL
HHHHHHCHHHEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHH
VDIGEWLDTRLPELFGDAMSLVLDNRIFKQRNVDIAVVSKDDAVKWGFSGPMIRAAGIPW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCEEEECCCCC
DLRKSQPYDVYDRMEFDIPVGTNSDCYDRFSVRVKEVYESAKIIKQCLAQMPQGPIASTD
CCCCCCCCCHHHCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GKVSPPSRGRMKQSMEALIHHFKLYTEGFHVPAGEVYVATESPKGEFGVYLVADGTNKPY
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCE
RCKIRPTAFSHLQAMDFMSKGHMLPDATAILGAIDVVFGECDR
EEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SVHIEESPTTDGDVITNYTINFGPQHPAAHGVLRMIMELDGEIIERVDPHVGLLHRGTE
EEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHH
KLIEHKTYLQALPYFDRLDYCSPLCMEHSYVLAIEKLLNIEVPERAQYLRVLFAELTRIS
HHHHHHHHHHHCCCHHHHHHCCHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
NHMLNLGAHVLDVGAFTPNLWMFELREDCMNFFERASGARMHMAWFRPGGVHQDVPEKLL
HHHHHHCHHHEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHH
VDIGEWLDTRLPELFGDAMSLVLDNRIFKQRNVDIAVVSKDDAVKWGFSGPMIRAAGIPW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCEEEECCCCC
DLRKSQPYDVYDRMEFDIPVGTNSDCYDRFSVRVKEVYESAKIIKQCLAQMPQGPIASTD
CCCCCCCCCHHHCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GKVSPPSRGRMKQSMEALIHHFKLYTEGFHVPAGEVYVATESPKGEFGVYLVADGTNKPY
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCE
RCKIRPTAFSHLQAMDFMSKGHMLPDATAILGAIDVVFGECDR
EEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA