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The map label for this gene is nqo2 [H]

Identifier: 85374160

GI number: 85374160

Start: 1382037

End: 1382705

Strand: Reverse

Name: nqo2 [H]

Synonym: ELI_06665

Alternate gene names: 85374160

Gene position: 1382705-1382037 (Counterclockwise)

Preceding gene: 85374161

Following gene: 85374159

Centisome position: 45.3

GC content: 64.57

Gene sequence:

>669_bases
ATGGCTGATCGTTCTCTCGCCGCCGATACGCCCGAACTGCGCGAGCGCTGGGGCAACTTCGTCTTCACGGCCGCGAACAA
GGCCGAAGCGGACAAGCATATCGCCAAATACCCTGAAGGGCGCCAGCGCAGCGCGGTGATGCCGCTGCTGTTTCTCGCCC
AGGCCCAGGTCGGCGAAGAGACCAACACGCAGGGGTGGCTGCCGCTGCCGGTGATGGAATATGTCGCCGACTATCTCGAC
ATGCCGGTGATCCGCGTGGTCGAGGTCGCGACCTTCTATTTCATGTACAACCTCCAGCCGGTCGGGAAATACCACGTGCA
GGTATGCGGCACGACGCCCTGCATGCTGCGCGGCAGCGACGAGATCATTGCCGCCTGCAAGAAGCGCGGGATGGAGAAGG
GCAGGGTCTCGGCAGATGGCCTCTGGACCCTCACCGAAGTCGAATGCATGGGCAATTGCGCCACCGCGCCGATGGTCCAG
ATCAACGACGACAATTACGAAGACCTGACGCCCGAACGCCTCGATGCCGTGCTCGACGCGCTCGCGGCGGGCGAGCAGCC
GAAGACCGGCACGCAGGAGCCGGGGCGGCACACGTCGGAGCCCCTGGGCGGGCCGACGACGCTCAAGGAAATGGTCGACG
CCAATCACGATTACCGGAGCGAGTGGTGA

Upstream 100 bases:

>100_bases
GTGTTTCACGGGGCGCCGAGCTTCAAGGAAATCACGTCGACGGCGGGTGCCGCTGTCATCGGCCTCTATGTCGGCCGCTA
TCTGCAACACAGGTTGAACC

Downstream 100 bases:

>100_bases
GCGATGGAATTCGTCTCGATCATAGTCGCGCTCGGGCTGGCCTTCATCGCCTACAAGGTGCTGATGGGGCTGGCGCGCGT
GGGCGTGATCATCGTCATTT

Product: NADH:ubiquinone oxidoreductase 41 kD complex I subunit

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 2; NDH-1, chain 2 [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MADRSLAADTPELRERWGNFVFTAANKAEADKHIAKYPEGRQRSAVMPLLFLAQAQVGEETNTQGWLPLPVMEYVADYLD
MPVIRVVEVATFYFMYNLQPVGKYHVQVCGTTPCMLRGSDEIIAACKKRGMEKGRVSADGLWTLTEVECMGNCATAPMVQ
INDDNYEDLTPERLDAVLDALAAGEQPKTGTQEPGRHTSEPLGGPTTLKEMVDANHDYRSEW

Sequences:

>Translated_222_residues
MADRSLAADTPELRERWGNFVFTAANKAEADKHIAKYPEGRQRSAVMPLLFLAQAQVGEETNTQGWLPLPVMEYVADYLD
MPVIRVVEVATFYFMYNLQPVGKYHVQVCGTTPCMLRGSDEIIAACKKRGMEKGRVSADGLWTLTEVECMGNCATAPMVQ
INDDNYEDLTPERLDAVLDALAAGEQPKTGTQEPGRHTSEPLGGPTTLKEMVDANHDYRSEW
>Mature_221_residues
ADRSLAADTPELRERWGNFVFTAANKAEADKHIAKYPEGRQRSAVMPLLFLAQAQVGEETNTQGWLPLPVMEYVADYLDM
PVIRVVEVATFYFMYNLQPVGKYHVQVCGTTPCMLRGSDEIIAACKKRGMEKGRVSADGLWTLTEVECMGNCATAPMVQI
NDDNYEDLTPERLDAVLDALAAGEQPKTGTQEPGRHTSEPLGGPTTLKEMVDANHDYRSEW

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=192, Percent_Identity=51.0416666666667, Blast_Score=192, Evalue=3e-49,
Organism=Escherichia coli, GI1788621, Length=161, Percent_Identity=31.055900621118, Blast_Score=85, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17561328, Length=193, Percent_Identity=49.740932642487, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI18859877, Length=203, Percent_Identity=48.7684729064039, Blast_Score=183, Evalue=9e-47,
Organism=Drosophila melanogaster, GI21355353, Length=192, Percent_Identity=41.1458333333333, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 24674; Mature: 24543

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADRSLAADTPELRERWGNFVFTAANKAEADKHIAKYPEGRQRSAVMPLLFLAQAQVGEE
CCCCCCCCCCHHHHHHHCCEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC
TNTQGWLPLPVMEYVADYLDMPVIRVVEVATFYFMYNLQPVGKYHVQVCGTTPCMLRGSD
CCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEECCH
EIIAACKKRGMEKGRVSADGLWTLTEVECMGNCATAPMVQINDDNYEDLTPERLDAVLDA
HHHHHHHHCCCCCCCCCCCCCEEEHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHH
LAAGEQPKTGTQEPGRHTSEPLGGPTTLKEMVDANHDYRSEW
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
ADRSLAADTPELRERWGNFVFTAANKAEADKHIAKYPEGRQRSAVMPLLFLAQAQVGEE
CCCCCCCCCHHHHHHHCCEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC
TNTQGWLPLPVMEYVADYLDMPVIRVVEVATFYFMYNLQPVGKYHVQVCGTTPCMLRGSD
CCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEECCH
EIIAACKKRGMEKGRVSADGLWTLTEVECMGNCATAPMVQINDDNYEDLTPERLDAVLDA
HHHHHHHHCCCCCCCCCCCCCEEEHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHH
LAAGEQPKTGTQEPGRHTSEPLGGPTTLKEMVDANHDYRSEW
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1909571 [H]