Click here to switch to the map view.

The map label for this gene is grx [H]

Identifier: 85374117

GI number: 85374117

Start: 1339246

End: 1339509

Strand: Reverse

Name: grx [H]

Synonym: ELI_06450

Alternate gene names: 85374117

Gene position: 1339509-1339246 (Counterclockwise)

Preceding gene: 85374119

Following gene: 85374116

Centisome position: 43.88

GC content: 60.23

Gene sequence:

>264_bases
ATGTCTGAACCCAAGGTCGACATCTACACTAAATTCGGTTGCGGTTACTGCGTCCGCGCCAAGCGCCTGCTCGACGAAAA
AGGCGTCGACTACGAGGAATTCGACATCACCATGGGCGGCCCGAAACGGGACGAAATGCGCGAGCGCGCGCCCGGTGCGA
TGACGGTGCCGCAAATCTTCATCGGCGATACGCATGTCGGCGGTTCCGACGAGCTTCACGCGTTGGAGCGTGAAGGCAAA
CTCGATCCGCTGCTGGCAGGCTGA

Upstream 100 bases:

>100_bases
CAAATGACACGATCCGATATGGCATCGCGCCAAACCTGAATATAAGTCGGATAAAATGGCTTTCAAGCCCTGCCAAGCGT
CGGAAAAACAAGGATTTTCA

Downstream 100 bases:

>100_bases
GGGCAGTCAGGTCGATGCCTAGGATAGCCGTCCTGCAAATGACCTCGGGGATCGATCCTGAGGCCAATTTCGCCGCGATT
GAGCAGGCGGCGCGGGAAGC

Product: glutaredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 87; Mature: 86

Protein sequence:

>87_residues
MSEPKVDIYTKFGCGYCVRAKRLLDEKGVDYEEFDITMGGPKRDEMRERAPGAMTVPQIFIGDTHVGGSDELHALEREGK
LDPLLAG

Sequences:

>Translated_87_residues
MSEPKVDIYTKFGCGYCVRAKRLLDEKGVDYEEFDITMGGPKRDEMRERAPGAMTVPQIFIGDTHVGGSDELHALEREGK
LDPLLAG
>Mature_86_residues
SEPKVDIYTKFGCGYCVRAKRLLDEKGVDYEEFDITMGGPKRDEMRERAPGAMTVPQIFIGDTHVGGSDELHALEREGKL
DPLLAG

Specific function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins [H]

COG id: COG0695

COG function: function code O; Glutaredoxin and related proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI37537704, Length=87, Percent_Identity=36.7816091954023, Blast_Score=66, Evalue=8e-12,
Organism=Homo sapiens, GI21361507, Length=87, Percent_Identity=36.7816091954023, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790039, Length=81, Percent_Identity=54.320987654321, Blast_Score=85, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR014025
- InterPro:   IPR011900
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 9659; Mature: 9528

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPKVDIYTKFGCGYCVRAKRLLDEKGVDYEEFDITMGGPKRDEMRERAPGAMTVPQIF
CCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHCCCCCCCCEEE
IGDTHVGGSDELHALEREGKLDPLLAG
ECCCCCCCCCCHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SEPKVDIYTKFGCGYCVRAKRLLDEKGVDYEEFDITMGGPKRDEMRERAPGAMTVPQIF
CCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHCCCCCCCCEEE
IGDTHVGGSDELHALEREGKLDPLLAG
ECCCCCCCCCCHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]