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The map label for this gene is fdhA [H]

Identifier: 85373998

GI number: 85373998

Start: 1207695

End: 1209794

Strand: Direct

Name: fdhA [H]

Synonym: ELI_05855

Alternate gene names: 85373998

Gene position: 1207695-1209794 (Clockwise)

Preceding gene: 85373987

Following gene: 85373999

Centisome position: 39.57

GC content: 63.71

Gene sequence:

>2100_bases
ATGACCACCGTCCACCACCGCACCTGCCATATCTGCGAAGCCAATTGCGGCGTGCTGGTGGAGATGGAGGGGCGCAAGGT
CGTGTCGATCAAGGGTAATCCCGATCATGTGCTGAGCCGTGGTCATATCTGCCCCAAGGCCACTGCGATAGCCGATTTGC
AGGACGATCCCGATCGCTTGCGCCGTCCGGTGAAGCGCACCGATACTGGCTGGCAGGAACTCGACTGGGACACGGCGTTC
CGCGAGATCGCGCAGAAGGTGGTCGCGCTACAGGATGCCGGGGCGAGGGCGGCTTTCTATCGCGGCAATCCCGGCGCGCA
CGACTATGCCCTGTCGACACAATCGGGCTATCTCCAGCGGGCCGTCGGCGCGCGCGGGACATTTTCCGCTTCGACGCTCG
ACCAGATCCCGCATCACTACACGCAATACCAGATGTACGGTCACGTCAGCCTCGCTGCGGTGCCCGATATTGATCGTTCG
CAGCTGATCGTGATCGTAGGCGGCAATCCCATGGCGTCGAATGGTAGCCTGTGGACGGTGCCGGACTTCAGGAACCGAGT
GAAGGAAATGCAGGCGCGCGGCGGCAGACTGGTGGTGATCGATCCGCGAAACACCGAAACCGCCAAGGTCGCCGATGAGT
GGTATCCGGTAAAACCCGGGACCGATACGGCGCTGCTCGCCGGCATCCTCCAATGCGTGCTGGCCGATGGTGACACGCTT
CGCGACGGACTGGCCGAACTTGTCGATGACAGTTGGGCGCAGGTGAAGCCTGCGGTCGACGCTTTCGATCTCGATACGCT
GGCCAACCACTGCGCCGTGCCTGCCGACACGATCCCCACGCTCGCCGCCGAGCTATCGAGCGGCAAACCCGCCGCGATTT
ATGGGCGCATGGGTGTGTCGGTCTGCGAGTTCGGCGCGCTCAACCAATGGCTGATTCAGCTCATCAACCTCGCCACCGGC
AATCTCGACCGCGAGGGCGGCACGATGTTCCCGCAACCGCTGCTCGATCTCGTCGGGCAGGTCGGCAAGGGCAATATCAA
GACGGTCGAGACCGCCCGCGGCACCCTGCCTTCGGTGATGAGCGAAATCCCCACCATCGCCTTTGCCGACGAGCTCTCGC
GCGACGATGACCAGCGCATCCGCACGCTGTTCGTGATTGCGGGCAATCCCGTCCTCTCCGCGCCCGACGGCGAGCGCACC
GAGGAAGCGTTGGAGAATCTCGACCTGATGGTGAGTATGGACATGCACATCACCGAGACGAGCCGCCATGCGCATTACAT
CCTGCCGCCCTGCGGACCGCTGGAGAAGGATCATTTTACTTTCTTCTTCGGCCCGCTCGCGGTGCGCAATTTCGGGGCAT
ACTCGCCGCCGACACTGGAAATGGAGGAGGGAGCCAAAGCCGACTGGGAAATTGCCGCCGAATTGGCGCAGGCGATCCTG
GCGGAAAAAGGGAAGCCCGCGCCCAATTTCGACACACCGCGCGAGCGACTCGATGCGATGCTCAAGGCGTCGCCAGCCGG
GATGTCGCTGGCGGAGGTGGAAGCACAACCCAACGGCGTCGATCTCGGGCCCCTGGAGCCGTGCCTGAAGAATCGCCTGC
TAACCGCGGACAAGACGCTCCATGCCGCGCCGCCGGAGCTGCTCGAGGAGCTTGGGCGTTTCGCGGGCCGTCTCAATGAG
CACGATGAAGGCGCGCTCAGCCTGATCGGGAGGCGTCATGTCCGCTCCAACAACAGCTGGCTGCACAATTCCAAGCGCCT
CGTAAAAGGACCGGATCGCTGCACGCTGATGATGCATCCAGACGATGCCGCCGAGCGGGGATTGGCGGATGGCGAAATGG
CCAGCGTCGCCAGTCGCGTTGGCGAAGTGGAGATTGCGGTCGAAGTAACCGAGGACATCATGCCCGGCGTCGTCTCGATC
CCGCATGGCTGGGGGCACCACCGCAAGGGCGTGAGCTGGCAGACCGCCGCCGACCACGCCGGGGTCTCGCTCAACGACCT
GACCGATCCCGAGCGTTACGACCGATTGACCGGCAACGCCGTGCTCAACGGGACACCCGTAACGGTCGCCAAAGTGGAGG
CAGCGGTGGCGGCGGAATAA

Upstream 100 bases:

>100_bases
AGCCGAGATCGCGCCATAGTCCCAAGCGCAATCTCCCGCAGAGCGCAGTCTGGCAGGCGAAGCATACTGCTGCTAGTTGC
CTTATCGAGGAGAGCCCAGC

Downstream 100 bases:

>100_bases
TGCTGCCAATATGCTGCACTGCGGCATTGACCCGCTGTAGAGCCTAAGCCAAAGCGCGCGAAAACTTCGATGAGGCTCAT
GGACCGCAATCCGCAAAAAT

Product: oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 699; Mature: 698

Protein sequence:

>699_residues
MTTVHHRTCHICEANCGVLVEMEGRKVVSIKGNPDHVLSRGHICPKATAIADLQDDPDRLRRPVKRTDTGWQELDWDTAF
REIAQKVVALQDAGARAAFYRGNPGAHDYALSTQSGYLQRAVGARGTFSASTLDQIPHHYTQYQMYGHVSLAAVPDIDRS
QLIVIVGGNPMASNGSLWTVPDFRNRVKEMQARGGRLVVIDPRNTETAKVADEWYPVKPGTDTALLAGILQCVLADGDTL
RDGLAELVDDSWAQVKPAVDAFDLDTLANHCAVPADTIPTLAAELSSGKPAAIYGRMGVSVCEFGALNQWLIQLINLATG
NLDREGGTMFPQPLLDLVGQVGKGNIKTVETARGTLPSVMSEIPTIAFADELSRDDDQRIRTLFVIAGNPVLSAPDGERT
EEALENLDLMVSMDMHITETSRHAHYILPPCGPLEKDHFTFFFGPLAVRNFGAYSPPTLEMEEGAKADWEIAAELAQAIL
AEKGKPAPNFDTPRERLDAMLKASPAGMSLAEVEAQPNGVDLGPLEPCLKNRLLTADKTLHAAPPELLEELGRFAGRLNE
HDEGALSLIGRRHVRSNNSWLHNSKRLVKGPDRCTLMMHPDDAAERGLADGEMASVASRVGEVEIAVEVTEDIMPGVVSI
PHGWGHHRKGVSWQTAADHAGVSLNDLTDPERYDRLTGNAVLNGTPVTVAKVEAAVAAE

Sequences:

>Translated_699_residues
MTTVHHRTCHICEANCGVLVEMEGRKVVSIKGNPDHVLSRGHICPKATAIADLQDDPDRLRRPVKRTDTGWQELDWDTAF
REIAQKVVALQDAGARAAFYRGNPGAHDYALSTQSGYLQRAVGARGTFSASTLDQIPHHYTQYQMYGHVSLAAVPDIDRS
QLIVIVGGNPMASNGSLWTVPDFRNRVKEMQARGGRLVVIDPRNTETAKVADEWYPVKPGTDTALLAGILQCVLADGDTL
RDGLAELVDDSWAQVKPAVDAFDLDTLANHCAVPADTIPTLAAELSSGKPAAIYGRMGVSVCEFGALNQWLIQLINLATG
NLDREGGTMFPQPLLDLVGQVGKGNIKTVETARGTLPSVMSEIPTIAFADELSRDDDQRIRTLFVIAGNPVLSAPDGERT
EEALENLDLMVSMDMHITETSRHAHYILPPCGPLEKDHFTFFFGPLAVRNFGAYSPPTLEMEEGAKADWEIAAELAQAIL
AEKGKPAPNFDTPRERLDAMLKASPAGMSLAEVEAQPNGVDLGPLEPCLKNRLLTADKTLHAAPPELLEELGRFAGRLNE
HDEGALSLIGRRHVRSNNSWLHNSKRLVKGPDRCTLMMHPDDAAERGLADGEMASVASRVGEVEIAVEVTEDIMPGVVSI
PHGWGHHRKGVSWQTAADHAGVSLNDLTDPERYDRLTGNAVLNGTPVTVAKVEAAVAAE
>Mature_698_residues
TTVHHRTCHICEANCGVLVEMEGRKVVSIKGNPDHVLSRGHICPKATAIADLQDDPDRLRRPVKRTDTGWQELDWDTAFR
EIAQKVVALQDAGARAAFYRGNPGAHDYALSTQSGYLQRAVGARGTFSASTLDQIPHHYTQYQMYGHVSLAAVPDIDRSQ
LIVIVGGNPMASNGSLWTVPDFRNRVKEMQARGGRLVVIDPRNTETAKVADEWYPVKPGTDTALLAGILQCVLADGDTLR
DGLAELVDDSWAQVKPAVDAFDLDTLANHCAVPADTIPTLAAELSSGKPAAIYGRMGVSVCEFGALNQWLIQLINLATGN
LDREGGTMFPQPLLDLVGQVGKGNIKTVETARGTLPSVMSEIPTIAFADELSRDDDQRIRTLFVIAGNPVLSAPDGERTE
EALENLDLMVSMDMHITETSRHAHYILPPCGPLEKDHFTFFFGPLAVRNFGAYSPPTLEMEEGAKADWEIAAELAQAILA
EKGKPAPNFDTPRERLDAMLKASPAGMSLAEVEAQPNGVDLGPLEPCLKNRLLTADKTLHAAPPELLEELGRFAGRLNEH
DEGALSLIGRRHVRSNNSWLHNSKRLVKGPDRCTLMMHPDDAAERGLADGEMASVASRVGEVEIAVEVTEDIMPGVVSIP
HGWGHHRKGVSWQTAADHAGVSLNDLTDPERYDRLTGNAVLNGTPVTVAKVEAAVAAE

Specific function: Catalyzes the oxidation of formate [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm Face Of The Membrane [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787870, Length=750, Percent_Identity=23.2, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI87081797, Length=734, Percent_Identity=22.7520435967302, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI3868720, Length=397, Percent_Identity=25.6926952141058, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI3868719, Length=251, Percent_Identity=27.0916334661355, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI3868721, Length=503, Percent_Identity=21.0735586481113, Blast_Score=93, Evalue=7e-20,
Organism=Escherichia coli, GI171474008, Length=439, Percent_Identity=25.0569476082005, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006478
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 75729; Mature: 75598

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVHHRTCHICEANCGVLVEMEGRKVVSIKGNPDHVLSRGHICPKATAIADLQDDPDRL
CCCCCCCEEEEEECCCCEEEEECCCEEEEECCCHHHHHHCCCCCCCHHHHCCCCCCHHHH
RRPVKRTDTGWQELDWDTAFREIAQKVVALQDAGARAAFYRGNPGAHDYALSTQSGYLQR
HCCHHHCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEECCCCCHHHH
AVGARGTFSASTLDQIPHHYTQYQMYGHVSLAAVPDIDRSQLIVIVGGNPMASNGSLWTV
HHCCCCCCCHHHHHHCCHHHHHEEEEEEEEEEECCCCCCCCEEEEECCCCCCCCCCEEEC
PDFRNRVKEMQARGGRLVVIDPRNTETAKVADEWYPVKPGTDTALLAGILQCVLADGDTL
HHHHHHHHHHHHCCCEEEEECCCCCCCHHHHCCEECCCCCCCHHHHHHHHHHHHCCCCHH
RDGLAELVDDSWAQVKPAVDAFDLDTLANHCAVPADTIPTLAAELSSGKPAAIYGRMGVS
HHHHHHHHCCCHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEECCCCH
VCEFGALNQWLIQLINLATGNLDREGGTMFPQPLLDLVGQVGKGNIKTVETARGTLPSVM
HHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEHHHCCCHHHHH
SEIPTIAFADELSRDDDQRIRTLFVIAGNPVLSAPDGERTEEALENLDLMVSMDMHITET
HHCCCEEEHHHHCCCCCCEEEEEEEEECCCEEECCCCHHHHHHHHCCEEEEEECCEEEEC
SRHAHYILPPCGPLEKDHFTFFFGPLAVRNFGAYSPPTLEMEEGAKADWEIAAELAQAIL
CCCCEEECCCCCCCCCCCEEEEECHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AEKGKPAPNFDTPRERLDAMLKASPAGMSLAEVEAQPNGVDLGPLEPCLKNRLLTADKTL
HHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHCCEECCCCCC
HAAPPELLEELGRFAGRLNEHDEGALSLIGRRHVRSNNSWLHNSKRLVKGPDRCTLMMHP
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEECCCCHHCCCCCCEEEEECC
DDAAERGLADGEMASVASRVGEVEIAVEVTEDIMPGVVSIPHGWGHHRKGVSWQTAADHA
CHHHHCCCCCCHHHHHHHHCCCEEEEEEEHHHHCCCEEECCCCCCCCCCCCCCCCCCCCC
GVSLNDLTDPERYDRLTGNAVLNGTPVTVAKVEAAVAAE
CCCHHCCCCHHHHHHCCCCEEECCCCEEEEEECHHHCCC
>Mature Secondary Structure 
TTVHHRTCHICEANCGVLVEMEGRKVVSIKGNPDHVLSRGHICPKATAIADLQDDPDRL
CCCCCCEEEEEECCCCEEEEECCCEEEEECCCHHHHHHCCCCCCCHHHHCCCCCCHHHH
RRPVKRTDTGWQELDWDTAFREIAQKVVALQDAGARAAFYRGNPGAHDYALSTQSGYLQR
HCCHHHCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEECCCCCHHHH
AVGARGTFSASTLDQIPHHYTQYQMYGHVSLAAVPDIDRSQLIVIVGGNPMASNGSLWTV
HHCCCCCCCHHHHHHCCHHHHHEEEEEEEEEEECCCCCCCCEEEEECCCCCCCCCCEEEC
PDFRNRVKEMQARGGRLVVIDPRNTETAKVADEWYPVKPGTDTALLAGILQCVLADGDTL
HHHHHHHHHHHHCCCEEEEECCCCCCCHHHHCCEECCCCCCCHHHHHHHHHHHHCCCCHH
RDGLAELVDDSWAQVKPAVDAFDLDTLANHCAVPADTIPTLAAELSSGKPAAIYGRMGVS
HHHHHHHHCCCHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEECCCCH
VCEFGALNQWLIQLINLATGNLDREGGTMFPQPLLDLVGQVGKGNIKTVETARGTLPSVM
HHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEHHHCCCHHHHH
SEIPTIAFADELSRDDDQRIRTLFVIAGNPVLSAPDGERTEEALENLDLMVSMDMHITET
HHCCCEEEHHHHCCCCCCEEEEEEEEECCCEEECCCCHHHHHHHHCCEEEEEECCEEEEC
SRHAHYILPPCGPLEKDHFTFFFGPLAVRNFGAYSPPTLEMEEGAKADWEIAAELAQAIL
CCCCEEECCCCCCCCCCCEEEEECHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AEKGKPAPNFDTPRERLDAMLKASPAGMSLAEVEAQPNGVDLGPLEPCLKNRLLTADKTL
HHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHCCEECCCCCC
HAAPPELLEELGRFAGRLNEHDEGALSLIGRRHVRSNNSWLHNSKRLVKGPDRCTLMMHP
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEECCCCHHCCCCCCEEEEECC
DDAAERGLADGEMASVASRVGEVEIAVEVTEDIMPGVVSIPHGWGHHRKGVSWQTAADHA
CHHHHCCCCCCHHHHHHHHCCCEEEEEEEHHHHCCCEEECCCCCCCCCCCCCCCCCCCCC
GVSLNDLTDPERYDRLTGNAVLNGTPVTVAKVEAAVAAE
CCCHHCCCCHHHHHHCCCCEEECCCCEEEEEECHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]