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The map label for this gene is 85373949

Identifier: 85373949

GI number: 85373949

Start: 1162167

End: 1164149

Strand: Direct

Name: 85373949

Synonym: ELI_05610

Alternate gene names: NA

Gene position: 1162167-1164149 (Clockwise)

Preceding gene: 85373948

Following gene: 85373952

Centisome position: 38.07

GC content: 61.47

Gene sequence:

>1983_bases
ATGAAATACTGCTCGTCACTTGCTGCGCTTGCCGCGGCTGCTTTCGCTGCACCACTCGCGGCTCAAACGCTGGCAGAGGA
CGCGTCGGCGTTCGGCGCTCGCCAATCGGTCGAAAACCTCAGTATTTCTCCATCCGGAGACAGGCTGCTCTACATCCAGC
CGGGTGCGCAATCGGACGAGACGATCTACGTCGTCGACCTTGCCAATGGCGGCGCGCCAACGCCGATCATCACCATGAAC
GAGGCGCAGGCGCGCTTGAATTGGTGTCAGTGGGCAACCGAAGAACGCATCGTCTGCGAGATTTTCGGAATGCAGGATTC
CGGCGGGGTCCTGCTTAATTTCACGCGCGTCATGGCGATTAGTGCAGACGGATCGGATACCGAAATGCTGACTCCGTCCA
GCAGCTACAAGACGATGGGCGTCCTCCAGGACGGGGGCGATGTGCTCGCGCTCGACGTGGAGGGGCAGGACAGCAAGATC
CTGATGACCAAGCGCTATATCAAGGAGCGCTGCGAAAAGACCCGTCTATGCAACGATAAGGAAGGGCTGGGGGTCGACGC
AGTCGATGTCGAGAACGGACGCGCACGGCCTGTCGAGGACGCCGCGTTGCGAGCCGTTTCCTATATGGCGGATGGCAGTG
GGCAGGTCCGCGTGATGCTCGCCGGCGATACCGCGGCCAGTGGTTATGACGGCAGCGACTATCGCTATCTCTACCGCCGG
AAGGGTGAGAGCAAATGGTATCCGCTTTCCAGTGTCGACGCAGGTGGGCCGCTGTCGGTGGGATTCCGCCCGGTCGGCAT
CGATAGCGAGAAGGACGTCGTTTACGGGCTCGAGCGCAAGAACGGCTACGACGCCCTGTATGCCTTCGCGCTCGATGGTT
CGGAATCCAAGACGCTCGTCATGGCGCTCGACGATGTGGACGTGGACGGCGTCGCGCGTATCGGTCGCCAGCGCCGCGTG
GTCGGCGCCAATTTTGCGACTGAACGGGCTTACACCAAATATTTCGATCCCCAACTTGAGAAACTCGCCGACGCCTTCGC
CAAGGCTCTGCCGGGCAACCCCTCGATCACCATCGCCGATGCCAGCGCCGACGAGAACGAACTAATCCTTATCGCCTCGA
GCGATACCGATCCCGGCAAGGCCTATCTGTTTGAAAAGGACACCCGTTCACTGAGTGAGCTCCTGTCGCTGCGCATGCCG
CTCGACAGTCGCTCTATGGGCAAGATGAAACCCGTCACCTATCCGGCGGCGGACGGAACCCAGGTCCCCGGCTATCTGAC
CCTGCCACCGGGTAGCGACGGCAAGAACCTGCCTGCCATCGTCATGCCGCATGGCGGGCCGGGCTCACGCGATGTGTGGG
GTTTCGACTGGCTCGTGCAGTTCTTCGCCGCCCGTGGTTACGCCGTGCTCCAGCCCAATTTTCGCGGCTCGTCCGGCTAT
GGCTCGGCGTGGTTCGGCAAAAATGGTTTTCAGGCTTGGGAAACGGCAATCGGAGACATCAACGATGCCGGACGCTGGCT
CGTGTCTCAGGGCATTGCCGATGCGACGAAACTCGCCACGGTGGGTTGGTCCTACGGCGGCTATGCCGCGCTGCAATCGC
AAGTGGTCGATCCCGATCTGTTCAAGGCGGTGGTCGCCATTGCGCCGGTGACGGACCTTGATCTGCTCCGCGAGGAAAAC
CGGCGCTATACCAGCTACACCGCTTATGACCGGATGATCGGTAACGGCGCGCATGTGCAGAATGGGTCGCCCGCGCGCCA
CGCGGCGAACTTCAAGGCACCCGTGCTGCTAGTGCACGGAACGCTGGACCAGAATGTCACCGCGGCCCAATCGAAACTGA
TGGAAAATCGGTTGCAGTCCGCCGGGAAATCGGTCGACTACCTAGAGTTCAAGGGGCTCGACCACGGGCTGGTCCACAGC
CAGGCGCGCGGGATCATGCTGAAAAGGATCGGCGAGTTTCTCGAGGCCAACCTCGCGTTCTGA

Upstream 100 bases:

>100_bases
GGCGCGACTACCTGGGCGGCGGCGACACTGCATAATCCCTCTTTTCAAATGCTTGGTCCCAGCTAAACTGGGCCAGCTTA
ACGGGGAACAGGGTCTGTTT

Downstream 100 bases:

>100_bases
AGAACCACATCGAGACACAGAAAAAGGGCGGCCACAATGGGCCGCCCTTTTCGTATTCGGTATCGCGTGTGTCTTAGCGC
GAGTAGAACTCGACCACGAG

Product: prolyl oligopeptidase family protein

Products: NA

Alternate protein names: AARE; Acyl-peptide hydrolase; APH; Acylaminoacyl-peptidase [H]

Number of amino acids: Translated: 660; Mature: 660

Protein sequence:

>660_residues
MKYCSSLAALAAAAFAAPLAAQTLAEDASAFGARQSVENLSISPSGDRLLYIQPGAQSDETIYVVDLANGGAPTPIITMN
EAQARLNWCQWATEERIVCEIFGMQDSGGVLLNFTRVMAISADGSDTEMLTPSSSYKTMGVLQDGGDVLALDVEGQDSKI
LMTKRYIKERCEKTRLCNDKEGLGVDAVDVENGRARPVEDAALRAVSYMADGSGQVRVMLAGDTAASGYDGSDYRYLYRR
KGESKWYPLSSVDAGGPLSVGFRPVGIDSEKDVVYGLERKNGYDALYAFALDGSESKTLVMALDDVDVDGVARIGRQRRV
VGANFATERAYTKYFDPQLEKLADAFAKALPGNPSITIADASADENELILIASSDTDPGKAYLFEKDTRSLSELLSLRMP
LDSRSMGKMKPVTYPAADGTQVPGYLTLPPGSDGKNLPAIVMPHGGPGSRDVWGFDWLVQFFAARGYAVLQPNFRGSSGY
GSAWFGKNGFQAWETAIGDINDAGRWLVSQGIADATKLATVGWSYGGYAALQSQVVDPDLFKAVVAIAPVTDLDLLREEN
RRYTSYTAYDRMIGNGAHVQNGSPARHAANFKAPVLLVHGTLDQNVTAAQSKLMENRLQSAGKSVDYLEFKGLDHGLVHS
QARGIMLKRIGEFLEANLAF

Sequences:

>Translated_660_residues
MKYCSSLAALAAAAFAAPLAAQTLAEDASAFGARQSVENLSISPSGDRLLYIQPGAQSDETIYVVDLANGGAPTPIITMN
EAQARLNWCQWATEERIVCEIFGMQDSGGVLLNFTRVMAISADGSDTEMLTPSSSYKTMGVLQDGGDVLALDVEGQDSKI
LMTKRYIKERCEKTRLCNDKEGLGVDAVDVENGRARPVEDAALRAVSYMADGSGQVRVMLAGDTAASGYDGSDYRYLYRR
KGESKWYPLSSVDAGGPLSVGFRPVGIDSEKDVVYGLERKNGYDALYAFALDGSESKTLVMALDDVDVDGVARIGRQRRV
VGANFATERAYTKYFDPQLEKLADAFAKALPGNPSITIADASADENELILIASSDTDPGKAYLFEKDTRSLSELLSLRMP
LDSRSMGKMKPVTYPAADGTQVPGYLTLPPGSDGKNLPAIVMPHGGPGSRDVWGFDWLVQFFAARGYAVLQPNFRGSSGY
GSAWFGKNGFQAWETAIGDINDAGRWLVSQGIADATKLATVGWSYGGYAALQSQVVDPDLFKAVVAIAPVTDLDLLREEN
RRYTSYTAYDRMIGNGAHVQNGSPARHAANFKAPVLLVHGTLDQNVTAAQSKLMENRLQSAGKSVDYLEFKGLDHGLVHS
QARGIMLKRIGEFLEANLAF
>Mature_660_residues
MKYCSSLAALAAAAFAAPLAAQTLAEDASAFGARQSVENLSISPSGDRLLYIQPGAQSDETIYVVDLANGGAPTPIITMN
EAQARLNWCQWATEERIVCEIFGMQDSGGVLLNFTRVMAISADGSDTEMLTPSSSYKTMGVLQDGGDVLALDVEGQDSKI
LMTKRYIKERCEKTRLCNDKEGLGVDAVDVENGRARPVEDAALRAVSYMADGSGQVRVMLAGDTAASGYDGSDYRYLYRR
KGESKWYPLSSVDAGGPLSVGFRPVGIDSEKDVVYGLERKNGYDALYAFALDGSESKTLVMALDDVDVDGVARIGRQRRV
VGANFATERAYTKYFDPQLEKLADAFAKALPGNPSITIADASADENELILIASSDTDPGKAYLFEKDTRSLSELLSLRMP
LDSRSMGKMKPVTYPAADGTQVPGYLTLPPGSDGKNLPAIVMPHGGPGSRDVWGFDWLVQFFAARGYAVLQPNFRGSSGY
GSAWFGKNGFQAWETAIGDINDAGRWLVSQGIADATKLATVGWSYGGYAALQSQVVDPDLFKAVVAIAPVTDLDLLREEN
RRYTSYTAYDRMIGNGAHVQNGSPARHAANFKAPVLLVHGTLDQNVTAAQSKLMENRLQSAGKSVDYLEFKGLDHGLVHS
QARGIMLKRIGEFLEANLAF

Specific function: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9C family [H]

Homologues:

Organism=Homo sapiens, GI16933540, Length=337, Percent_Identity=24.3323442136499, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI18765694, Length=283, Percent_Identity=25.0883392226148, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI18450280, Length=206, Percent_Identity=30.5825242718447, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI37577089, Length=206, Percent_Identity=30.5825242718447, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI23510451, Length=229, Percent_Identity=27.5109170305677, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI194394146, Length=200, Percent_Identity=30.5, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25144540, Length=437, Percent_Identity=26.3157894736842, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25144537, Length=334, Percent_Identity=28.4431137724551, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25144543, Length=221, Percent_Identity=32.1266968325792, Blast_Score=99, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17552908, Length=229, Percent_Identity=29.2576419213974, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17564632, Length=212, Percent_Identity=30.6603773584906, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17564634, Length=212, Percent_Identity=30.6603773584906, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17550672, Length=330, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25149159, Length=239, Percent_Identity=27.1966527196653, Blast_Score=65, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6324793, Length=291, Percent_Identity=26.4604810996564, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24582257, Length=234, Percent_Identity=24.7863247863248, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45550825, Length=233, Percent_Identity=27.8969957081545, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45553511, Length=233, Percent_Identity=27.8969957081545, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45551969, Length=233, Percent_Identity=27.8969957081545, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17933704, Length=333, Percent_Identity=26.4264264264264, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221331178, Length=333, Percent_Identity=26.4264264264264, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161083744, Length=333, Percent_Identity=26.4264264264264, Blast_Score=70, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR001375
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9 [H]

EC number: =3.4.19.1 [H]

Molecular weight: Translated: 71133; Mature: 71133

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYCSSLAALAAAAFAAPLAAQTLAEDASAFGARQSVENLSISPSGDRLLYIQPGAQSDE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
TIYVVDLANGGAPTPIITMNEAQARLNWCQWATEERIVCEIFGMQDSGGVLLNFTRVMAI
EEEEEEECCCCCCCCEEEECCHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEEEEEEE
SADGSDTEMLTPSSSYKTMGVLQDGGDVLALDVEGQDSKILMTKRYIKERCEKTRLCNDK
ECCCCCCEEECCCCCCCEEEEEECCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCC
EGLGVDAVDVENGRARPVEDAALRAVSYMADGSGQVRVMLAGDTAASGYDGSDYRYLYRR
CCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEEEE
KGESKWYPLSSVDAGGPLSVGFRPVGIDSEKDVVYGLERKNGYDALYAFALDGSESKTLV
CCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCEEE
MALDDVDVDGVARIGRQRRVVGANFATERAYTKYFDPQLEKLADAFAKALPGNPSITIAD
EEECCCCCHHHHHHCCCCEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEE
ASADENELILIASSDTDPGKAYLFEKDTRSLSELLSLRMPLDSRSMGKMKPVTYPAADGT
CCCCCCCEEEEECCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCC
QVPGYLTLPPGSDGKNLPAIVMPHGGPGSRDVWGFDWLVQFFAARGYAVLQPNFRGSSGY
CCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCC
GSAWFGKNGFQAWETAIGDINDAGRWLVSQGIADATKLATVGWSYGGYAALQSQVVDPDL
CCCCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCHHHHHEEECCCCCCHHHHHHHCCCHHH
FKAVVAIAPVTDLDLLREENRRYTSYTAYDRMIGNGAHVQNGSPARHAANFKAPVLLVHG
HHHHHHHCCCCHHHHHHHCCCCEEEEHHHHHHHCCCCCCCCCCCHHHCCCCCCCEEEEEC
TLDQNVTAAQSKLMENRLQSAGKSVDYLEFKGLDHGLVHSQARGIMLKRIGEFLEANLAF
CCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKYCSSLAALAAAAFAAPLAAQTLAEDASAFGARQSVENLSISPSGDRLLYIQPGAQSDE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
TIYVVDLANGGAPTPIITMNEAQARLNWCQWATEERIVCEIFGMQDSGGVLLNFTRVMAI
EEEEEEECCCCCCCCEEEECCHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEEEEEEE
SADGSDTEMLTPSSSYKTMGVLQDGGDVLALDVEGQDSKILMTKRYIKERCEKTRLCNDK
ECCCCCCEEECCCCCCCEEEEEECCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCC
EGLGVDAVDVENGRARPVEDAALRAVSYMADGSGQVRVMLAGDTAASGYDGSDYRYLYRR
CCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEEEE
KGESKWYPLSSVDAGGPLSVGFRPVGIDSEKDVVYGLERKNGYDALYAFALDGSESKTLV
CCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCEEE
MALDDVDVDGVARIGRQRRVVGANFATERAYTKYFDPQLEKLADAFAKALPGNPSITIAD
EEECCCCCHHHHHHCCCCEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEE
ASADENELILIASSDTDPGKAYLFEKDTRSLSELLSLRMPLDSRSMGKMKPVTYPAADGT
CCCCCCCEEEEECCCCCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCC
QVPGYLTLPPGSDGKNLPAIVMPHGGPGSRDVWGFDWLVQFFAARGYAVLQPNFRGSSGY
CCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCC
GSAWFGKNGFQAWETAIGDINDAGRWLVSQGIADATKLATVGWSYGGYAALQSQVVDPDL
CCCCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCHHHHHEEECCCCCCHHHHHHHCCCHHH
FKAVVAIAPVTDLDLLREENRRYTSYTAYDRMIGNGAHVQNGSPARHAANFKAPVLLVHG
HHHHHHHCCCCHHHHHHHCCCCEEEEHHHHHHHCCCCCCCCCCCHHHCCCCCCCEEEEEC
TLDQNVTAAQSKLMENRLQSAGKSVDYLEFKGLDHGLVHSQARGIMLKRIGEFLEANLAF
CCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966; 12037315 [H]