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The map label for this gene is ispA [H]

Identifier: 85373942

GI number: 85373942

Start: 1155895

End: 1156812

Strand: Direct

Name: ispA [H]

Synonym: ELI_05575

Alternate gene names: 85373942

Gene position: 1155895-1156812 (Clockwise)

Preceding gene: 85373941

Following gene: 85373943

Centisome position: 37.87

GC content: 63.94

Gene sequence:

>918_bases
GTGGGCAAGATGGAACTCGTCGACAGTGACGGCGCGAAACTTTCTTCCGCGCTGAACCGCATCGCGCGCGATATCGATGC
GGTCTTCGATGTGCTGCTGCCCGTGCCGGACGATACCCGTGCCCCGCTGGTGGAGGCGATGCGCTATTCGGCCATGGACG
GTGGCAAACGGGTTCGCCCACTGCTGGTCGTTGCGACAGCGGAAATGCTGGGCGTCAGCCGCGATCCTGCGCTCAGGGTC
GGCTGTGCGGTCGAGGCGATCCATGTCTATTCGCTGATTCATGACGACTTGCCGTGCATGGACGATGACGAGCTTCGTCG
CGGCAAGGCAACGCTGCACAAGGCCTATGACGAAGCCACGGCAGTTCTGGCCGGGGATTCGCTGCATGCGCTGGCCTTCG
AGATCCTCACCGATGACGAGACAACGCCCGATCCTTTCACGCAGGCCGAACTTGTCCGCACGCTGGCTGCGGCGAGCGGC
ATGGCAGGAATGGCTGGCGGCCAGATGATGGATATGGCGGCGGAAAGTGCCGATTACGATCTCCACACCATCACCCGGCT
GCAACAGCTCAAGACCGGCGCGTTGCTGGCAGCCTCGGTCGAGATGGGCGCTATCCTCGCCAAGATCCCGCGCGAAGGCC
GCAGCCATTTGCGCGCCTATGCCCGCGACATCGGGCTCGCCTTCCAGATCGCCGACGACCTGCTCGATGCCGAAGGCGAT
GAGGAAAAGGCCGGCAAGGCGCTGCGCAAGGATGACGAGCAAGGAAAGCAGACCTTCGTGACACTGATGGGGGTCGAAGG
GGCGCGCAACCAGGCCCGCGCACTGGTGGACCACGCGGTCGGCCACCTCGGGCAATATGGAGAAGATGCTGCGGTGCTGC
GGGCACTCGCGCGCTACATCGTCGAGAGGGACCGATAA

Upstream 100 bases:

>100_bases
GGCACGGCTCGACGCGGCGCAGGCCAAGATCGAAGCGATCGTGCAGGATGCAAGCGGCGCGGCGACCGGCACCAAACCCT
TCGACAGCGACGGCTGACCG

Downstream 100 bases:

>100_bases
TGAACGAGCGCATCGGGGTCTATCCCGGCACATTCGACCCGATCACGCGAGGCCACCGCGACATCATCCGGCGCGGGGCC
AAGCTGGTCGATACCCTCAT

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MGKMELVDSDGAKLSSALNRIARDIDAVFDVLLPVPDDTRAPLVEAMRYSAMDGGKRVRPLLVVATAEMLGVSRDPALRV
GCAVEAIHVYSLIHDDLPCMDDDELRRGKATLHKAYDEATAVLAGDSLHALAFEILTDDETTPDPFTQAELVRTLAAASG
MAGMAGGQMMDMAAESADYDLHTITRLQQLKTGALLAASVEMGAILAKIPREGRSHLRAYARDIGLAFQIADDLLDAEGD
EEKAGKALRKDDEQGKQTFVTLMGVEGARNQARALVDHAVGHLGQYGEDAAVLRALARYIVERDR

Sequences:

>Translated_305_residues
MGKMELVDSDGAKLSSALNRIARDIDAVFDVLLPVPDDTRAPLVEAMRYSAMDGGKRVRPLLVVATAEMLGVSRDPALRV
GCAVEAIHVYSLIHDDLPCMDDDELRRGKATLHKAYDEATAVLAGDSLHALAFEILTDDETTPDPFTQAELVRTLAAASG
MAGMAGGQMMDMAAESADYDLHTITRLQQLKTGALLAASVEMGAILAKIPREGRSHLRAYARDIGLAFQIADDLLDAEGD
EEKAGKALRKDDEQGKQTFVTLMGVEGARNQARALVDHAVGHLGQYGEDAAVLRALARYIVERDR
>Mature_304_residues
GKMELVDSDGAKLSSALNRIARDIDAVFDVLLPVPDDTRAPLVEAMRYSAMDGGKRVRPLLVVATAEMLGVSRDPALRVG
CAVEAIHVYSLIHDDLPCMDDDELRRGKATLHKAYDEATAVLAGDSLHALAFEILTDDETTPDPFTQAELVRTLAAASGM
AGMAGGQMMDMAAESADYDLHTITRLQQLKTGALLAASVEMGAILAKIPREGRSHLRAYARDIGLAFQIADDLLDAEGDE
EKAGKALRKDDEQGKQTFVTLMGVEGARNQARALVDHAVGHLGQYGEDAAVLRALARYIVERDR

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=237, Percent_Identity=27.0042194092827, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1786623, Length=277, Percent_Identity=46.9314079422383, Blast_Score=197, Evalue=5e-52,
Organism=Escherichia coli, GI1789578, Length=214, Percent_Identity=32.2429906542056, Blast_Score=105, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17505681, Length=194, Percent_Identity=29.8969072164948, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24651612, Length=252, Percent_Identity=23.8095238095238, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32854; Mature: 32723

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKMELVDSDGAKLSSALNRIARDIDAVFDVLLPVPDDTRAPLVEAMRYSAMDGGKRVRP
CCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCH
LLVVATAEMLGVSRDPALRVGCAVEAIHVYSLIHDDLPCMDDDELRRGKATLHKAYDEAT
HHEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
AVLAGDSLHALAFEILTDDETTPDPFTQAELVRTLAAASGMAGMAGGQMMDMAAESADYD
HEEECCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCH
LHTITRLQQLKTGALLAASVEMGAILAKIPREGRSHLRAYARDIGLAFQIADDLLDAEGD
HHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EEKAGKALRKDDEQGKQTFVTLMGVEGARNQARALVDHAVGHLGQYGEDAAVLRALARYI
HHHHHHHHHCCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VERDR
HHCCC
>Mature Secondary Structure 
GKMELVDSDGAKLSSALNRIARDIDAVFDVLLPVPDDTRAPLVEAMRYSAMDGGKRVRP
CCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCH
LLVVATAEMLGVSRDPALRVGCAVEAIHVYSLIHDDLPCMDDDELRRGKATLHKAYDEAT
HHEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
AVLAGDSLHALAFEILTDDETTPDPFTQAELVRTLAAASGMAGMAGGQMMDMAAESADYD
HEEECCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCH
LHTITRLQQLKTGALLAASVEMGAILAKIPREGRSHLRAYARDIGLAFQIADDLLDAEGD
HHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EEKAGKALRKDDEQGKQTFVTLMGVEGARNQARALVDHAVGHLGQYGEDAAVLRALARYI
HHHHHHHHHCCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VERDR
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]