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The map label for this gene is purL

Identifier: 85373938

GI number: 85373938

Start: 1152244

End: 1154478

Strand: Reverse

Name: purL

Synonym: ELI_05555

Alternate gene names: 85373938

Gene position: 1154478-1152244 (Counterclockwise)

Preceding gene: 85373939

Following gene: 85373937

Centisome position: 37.82

GC content: 63.0

Gene sequence:

>2235_bases
ATGTCTGAAATCACGCCAGAAGTGGTCGAGTCGCACGGCCTCTCGTCCGAAGAATACGATGTCATCCTCAAGGCGCTGGG
GCGCGAACCCAACCTTGTCGAGCTCGGTATCTTTTCGGTCATGTGGAGCGAGCATTGCTCCTACAAGTCCTCGCGCCTGC
ACCTGAAGAAGCTCCCGACCGAGGCACCGTGGGTGATCTGCGGCCCGGGCGAGAATGCCGGCGTGATCGATATCGGCGAT
GGTCATGCAGCCATCTTCAAGATGGAGAGTCACAACCACCCCAGCTACATCGAACCCTATCAAGGCGCGGCAACGGGTGT
CGGCGGGATCCTGCGCGATGTCTTCACCATGGGCGCGCGGCCGGTGGCGAACGCCAACGCGCTGCGCTTCGGGCGGCCTG
AGCACCCGAAGATGAAGCACTTGGTGCAGGGCGTGGTCGCGGGGATCGGCGGCTACGGCAATTGCGTCGGCGTGCCGACC
GTCTGCGGCGAAACAAATTTCCACCCGGCCTATGACGGCAACATCCTGGTCAACGCGATGACCGTGGGCGTCGCCGATAC
CGACAAGATATTCTACTCGGCTGCGACGGGCGTCGGCAATCCGATCGTCTATGTCGGCTCCAAGACCGGGCGCGACGGCA
TCCATGGCGCGACCATGGCTTCGACCGATTTCGAGGAAGACAGCGATGCCAAGCGCCCCACGGTGCAGGTTGGCGACCCG
TTCACCGAAAAGCTGCTGATCGAAGCCTGCCTCGAACTGATGGCGACCGATGCCATCGTCGCGATCCAGGACATGGGCGC
GGCGGGCCTGACCTCTTCCAGCGTCGAAATGGCGACCAATGGCAAAACCGGCATCCGGCTCGATATGGACAAGGTGCCGT
GCCGGGAAGAAGGCATGACGCCGTACGAAATGATGCTGAGCGAGAGCCAGGAGCGCATGCTCATGGTGCTCAAGCCCGGA
AAAGAGGAGATGGCCGCCGAAATCTTCAAGAAATGGGAGCTCGATTTCGCGGTCATCGGCGAAGTCACCGATACCCAGCG
CATGGTGCTGGAGTTCGGCGGCGAGGTTGTGTGCGACATCCCGCTCGGCCCGCTGGCCGACGAGGCTCCGCTCTACGATC
GCCCGACCATCAGCCTCGAGGAATACAAGGCCTGGGCCAAGATCGCACCGATCACCGATGCTCCCGACAGCGCCGATCCG
GGGGCGGACCTGCTCAAGCTGATGGCCTCCCCCAACCTCGCCTCGCGCGCCTGGATCGCCGAGCAGTATGACAGCCAGGT
CGGGGCCGATACGCTGCAGACCGGCGGCGATGCTGGTGTGGTGCGTGTGCATGGGACGAAGAAGGCTCTCGCCATCAGTA
CCGACTGCACTCCGCGCTATTGCTATGCCGATCCTTACGAGGGTGGCAAACAGGCTATCGCCGAAGCCTATCGCAATTTG
TGTGCTGTCGGTGCGCGGCCGCTGGCGGTTACCAACTGCCTGAACTTCGCCAACCCCCAGCGCCCGGAAATCATGACGCA
GCTCGTCGAGGCCCTGCGCGGCATGGGCGATGCCTGCCGCATGCTCGATTTTCCCATCGTGAGCGGCAACGTCAGTCTCT
ACAACGAGAGCAAGGCCACCGGCGGCGGCTCGGCGATCCTGCCCACCCCTGCCATCGGCGGGGTCGGCATCATCGACGAT
TACGAACGCATGATGACGATGGGCTTCAAGAACGCTGGCGATACGATCTACCTAGTAGGCCCCGAATTCTGGGCCACGCC
CGATCCGACCCGGTCGCATCTCGGCAAGTCGCTGTGGCTCGATGTCGTCCATGGCCGCGACGAAGGCCGTACTCCGCCGA
CCGACCTCGTGGTCGAGCGCAACGCGGGCAAGATTATCCACGAACTGATCGACGATGGCTTGGTCAACGCGGTGCATGAC
GTGTCCGACGGCGGCTTGGCGGTGGCGCTGGCGGAAATGGCATTGTCTGGCGGCACAGGAGCCGATGTCGAGCAAAACTC
CGAATACACCGCGGCGCAGTGGTGGTTCGGCGAAGACCAGGGCCGCTATGTCGTGACCGTGCCCGATACCGAAGCGCTTA
ACGAAGCGCTGTCGAAGGGCACCGAGAACGCGGAAACAGCACAGATAGGTTTCCGGCGCATCGGCACCGTCGGCGGCGAT
GGCCTGTTGGGCGTCTCACTTGCCGATCTGCGCGAAGCCCATGCGAGCTTCTTCCGCGAGTGGATGGAAGTTTGA

Upstream 100 bases:

>100_bases
GGTCTGCCGACGCTGATCGCTGCGTGGGTCGGCTCGACAAGGTGGCATAAACGGGAGGTCGGGCTAGCGGTCCCCACCAT
GCATCGCTAAGGGCGCTGCC

Downstream 100 bases:

>100_bases
TCATCGCGCGTCCCTGCGAAGGTGGGGACCTCAGGCACTCTCGTGCTAAATCGACTGAGGCTCCCGCCTTCGCGGGAGTG
CGGTAATTGTGATAATCCTC

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 744; Mature: 743

Protein sequence:

>744_residues
MSEITPEVVESHGLSSEEYDVILKALGREPNLVELGIFSVMWSEHCSYKSSRLHLKKLPTEAPWVICGPGENAGVIDIGD
GHAAIFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVANANALRFGRPEHPKMKHLVQGVVAGIGGYGNCVGVPT
VCGETNFHPAYDGNILVNAMTVGVADTDKIFYSAATGVGNPIVYVGSKTGRDGIHGATMASTDFEEDSDAKRPTVQVGDP
FTEKLLIEACLELMATDAIVAIQDMGAAGLTSSSVEMATNGKTGIRLDMDKVPCREEGMTPYEMMLSESQERMLMVLKPG
KEEMAAEIFKKWELDFAVIGEVTDTQRMVLEFGGEVVCDIPLGPLADEAPLYDRPTISLEEYKAWAKIAPITDAPDSADP
GADLLKLMASPNLASRAWIAEQYDSQVGADTLQTGGDAGVVRVHGTKKALAISTDCTPRYCYADPYEGGKQAIAEAYRNL
CAVGARPLAVTNCLNFANPQRPEIMTQLVEALRGMGDACRMLDFPIVSGNVSLYNESKATGGGSAILPTPAIGGVGIIDD
YERMMTMGFKNAGDTIYLVGPEFWATPDPTRSHLGKSLWLDVVHGRDEGRTPPTDLVVERNAGKIIHELIDDGLVNAVHD
VSDGGLAVALAEMALSGGTGADVEQNSEYTAAQWWFGEDQGRYVVTVPDTEALNEALSKGTENAETAQIGFRRIGTVGGD
GLLGVSLADLREAHASFFREWMEV

Sequences:

>Translated_744_residues
MSEITPEVVESHGLSSEEYDVILKALGREPNLVELGIFSVMWSEHCSYKSSRLHLKKLPTEAPWVICGPGENAGVIDIGD
GHAAIFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVANANALRFGRPEHPKMKHLVQGVVAGIGGYGNCVGVPT
VCGETNFHPAYDGNILVNAMTVGVADTDKIFYSAATGVGNPIVYVGSKTGRDGIHGATMASTDFEEDSDAKRPTVQVGDP
FTEKLLIEACLELMATDAIVAIQDMGAAGLTSSSVEMATNGKTGIRLDMDKVPCREEGMTPYEMMLSESQERMLMVLKPG
KEEMAAEIFKKWELDFAVIGEVTDTQRMVLEFGGEVVCDIPLGPLADEAPLYDRPTISLEEYKAWAKIAPITDAPDSADP
GADLLKLMASPNLASRAWIAEQYDSQVGADTLQTGGDAGVVRVHGTKKALAISTDCTPRYCYADPYEGGKQAIAEAYRNL
CAVGARPLAVTNCLNFANPQRPEIMTQLVEALRGMGDACRMLDFPIVSGNVSLYNESKATGGGSAILPTPAIGGVGIIDD
YERMMTMGFKNAGDTIYLVGPEFWATPDPTRSHLGKSLWLDVVHGRDEGRTPPTDLVVERNAGKIIHELIDDGLVNAVHD
VSDGGLAVALAEMALSGGTGADVEQNSEYTAAQWWFGEDQGRYVVTVPDTEALNEALSKGTENAETAQIGFRRIGTVGGD
GLLGVSLADLREAHASFFREWMEV
>Mature_743_residues
SEITPEVVESHGLSSEEYDVILKALGREPNLVELGIFSVMWSEHCSYKSSRLHLKKLPTEAPWVICGPGENAGVIDIGDG
HAAIFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVANANALRFGRPEHPKMKHLVQGVVAGIGGYGNCVGVPTV
CGETNFHPAYDGNILVNAMTVGVADTDKIFYSAATGVGNPIVYVGSKTGRDGIHGATMASTDFEEDSDAKRPTVQVGDPF
TEKLLIEACLELMATDAIVAIQDMGAAGLTSSSVEMATNGKTGIRLDMDKVPCREEGMTPYEMMLSESQERMLMVLKPGK
EEMAAEIFKKWELDFAVIGEVTDTQRMVLEFGGEVVCDIPLGPLADEAPLYDRPTISLEEYKAWAKIAPITDAPDSADPG
ADLLKLMASPNLASRAWIAEQYDSQVGADTLQTGGDAGVVRVHGTKKALAISTDCTPRYCYADPYEGGKQAIAEAYRNLC
AVGARPLAVTNCLNFANPQRPEIMTQLVEALRGMGDACRMLDFPIVSGNVSLYNESKATGGGSAILPTPAIGGVGIIDDY
ERMMTMGFKNAGDTIYLVGPEFWATPDPTRSHLGKSLWLDVVHGRDEGRTPPTDLVVERNAGKIIHELIDDGLVNAVHDV
SDGGLAVALAEMALSGGTGADVEQNSEYTAAQWWFGEDQGRYVVTVPDTEALNEALSKGTENAETAQIGFRRIGTVGGDG
LLGVSLADLREAHASFFREWMEV

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Escherichia coli, GI48994899, Length=443, Percent_Identity=27.0880361173815, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17553022, Length=659, Percent_Identity=20.9408194233687, Blast_Score=86, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6321498, Length=745, Percent_Identity=23.2214765100671, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24582111, Length=651, Percent_Identity=23.6559139784946, Blast_Score=94, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24582109, Length=651, Percent_Identity=23.6559139784946, Blast_Score=94, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17137292, Length=651, Percent_Identity=23.6559139784946, Blast_Score=94, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_ERYLH (Q2NAT8)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_458000.1
- HSSP:   Q9X0X3
- ProteinModelPortal:   Q2NAT8
- STRING:   Q2NAT8
- GeneID:   3870508
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_05555
- NMPDR:   fig|314225.3.peg.1953
- eggNOG:   COG0046
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- PhylomeDB:   Q2NAT8
- ProtClustDB:   PRK01213
- BioCyc:   ELIT314225:ELI_05555-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 79674; Mature: 79543

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEITPEVVESHGLSSEEYDVILKALGREPNLVELGIFSVMWSEHCSYKSSRLHLKKLPT
CCCCCHHHHHHCCCCCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCCHHHHCCC
EAPWVICGPGENAGVIDIGDGHAAIFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGAR
CCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
PVANANALRFGRPEHPKMKHLVQGVVAGIGGYGNCVGVPTVCGETNFHPAYDGNILVNAM
CCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
TVGVADTDKIFYSAATGVGNPIVYVGSKTGRDGIHGATMASTDFEEDSDAKRPTVQVGDP
EECCCCCCHHEEEECCCCCCCEEEECCCCCCCCCCCCEECCCCCCCCCCCCCCEEECCCC
FTEKLLIEACLELMATDAIVAIQDMGAAGLTSSSVEMATNGKTGIRLDMDKVPCREEGMT
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCCCCCEEEECCCCCCCCCCCC
PYEMMLSESQERMLMVLKPGKEEMAAEIFKKWELDFAVIGEVTDTQRMVLEFGGEVVCDI
HHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCEEEEC
PLGPLADEAPLYDRPTISLEEYKAWAKIAPITDAPDSADPGADLLKLMASPNLASRAWIA
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHH
EQYDSQVGADTLQTGGDAGVVRVHGTKKALAISTDCTPRYCYADPYEGGKQAIAEAYRNL
HHHHHHCCCHHHHCCCCCCEEEEECCCEEEEEECCCCCCEEECCCCCCHHHHHHHHHHHH
CAVGARPLAVTNCLNFANPQRPEIMTQLVEALRGMGDACRMLDFPIVSGNVSLYNESKAT
HHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHCCEEEECCEEEEECCCCC
GGGSAILPTPAIGGVGIIDDYERMMTMGFKNAGDTIYLVGPEFWATPDPTRSHLGKSLWL
CCCCEECCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHCCHHEEE
DVVHGRDEGRTPPTDLVVERNAGKIIHELIDDGLVNAVHDVSDGGLAVALAEMALSGGTG
EEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
ADVEQNSEYTAAQWWFGEDQGRYVVTVPDTEALNEALSKGTENAETAQIGFRRIGTVGGD
CCCCCCCCEEEEEEECCCCCCCEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
GLLGVSLADLREAHASFFREWMEV
CEECCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEITPEVVESHGLSSEEYDVILKALGREPNLVELGIFSVMWSEHCSYKSSRLHLKKLPT
CCCCHHHHHHCCCCCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCCHHHHCCC
EAPWVICGPGENAGVIDIGDGHAAIFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGAR
CCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
PVANANALRFGRPEHPKMKHLVQGVVAGIGGYGNCVGVPTVCGETNFHPAYDGNILVNAM
CCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
TVGVADTDKIFYSAATGVGNPIVYVGSKTGRDGIHGATMASTDFEEDSDAKRPTVQVGDP
EECCCCCCHHEEEECCCCCCCEEEECCCCCCCCCCCCEECCCCCCCCCCCCCCEEECCCC
FTEKLLIEACLELMATDAIVAIQDMGAAGLTSSSVEMATNGKTGIRLDMDKVPCREEGMT
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCCCCCEEEECCCCCCCCCCCC
PYEMMLSESQERMLMVLKPGKEEMAAEIFKKWELDFAVIGEVTDTQRMVLEFGGEVVCDI
HHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCEEEEC
PLGPLADEAPLYDRPTISLEEYKAWAKIAPITDAPDSADPGADLLKLMASPNLASRAWIA
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHH
EQYDSQVGADTLQTGGDAGVVRVHGTKKALAISTDCTPRYCYADPYEGGKQAIAEAYRNL
HHHHHHCCCHHHHCCCCCCEEEEECCCEEEEEECCCCCCEEECCCCCCHHHHHHHHHHHH
CAVGARPLAVTNCLNFANPQRPEIMTQLVEALRGMGDACRMLDFPIVSGNVSLYNESKAT
HHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHCCEEEECCEEEEECCCCC
GGGSAILPTPAIGGVGIIDDYERMMTMGFKNAGDTIYLVGPEFWATPDPTRSHLGKSLWL
CCCCEECCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHCCHHEEE
DVVHGRDEGRTPPTDLVVERNAGKIIHELIDDGLVNAVHDVSDGGLAVALAEMALSGGTG
EEEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
ADVEQNSEYTAAQWWFGEDQGRYVVTVPDTEALNEALSKGTENAETAQIGFRRIGTVGGD
CCCCCCCCEEEEEEECCCCCCCEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
GLLGVSLADLREAHASFFREWMEV
CEECCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA