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The map label for this gene is phoR [H]

Identifier: 85373912

GI number: 85373912

Start: 1127597

End: 1128853

Strand: Reverse

Name: phoR [H]

Synonym: ELI_05425

Alternate gene names: 85373912

Gene position: 1128853-1127597 (Counterclockwise)

Preceding gene: 85373913

Following gene: 85373911

Centisome position: 36.98

GC content: 64.2

Gene sequence:

>1257_bases
GTGGATTCGCAGCCGACATTTCCCTGGCCCGGTCTTCTGATTGCGGTCGCGACGACGACAGTCCTGTCGCTCACCGGTCT
CGAATGGCCGCTGGCGCTGGCGCTGTTCGTCGTCTGGTGCGGCACCTTGCTGCTCGGCGCGCAGCGCGAAGAAAGCCTGC
CGCCGGAACCGCAGGATCCTGTCTTCTCGAAAGAGGGCATGGCGACGATGATCGAACATTCGGCCACGCCGCTCATGCTC
AGCGAACGCAACCGCATCATCATCGCCAACCGCGCCGCACGCAGCGTTCTCGGTAGCCATGTCGTCGGTCAGGATGTGCG
GGTCGCATTCCGGCACCCGGAAGCCATCGCCTTGATGGATCGCAATGAGCCTGGCCAAGCTATTGTCACAGGGCTGGCGC
GACCCAAGGACATCTGGAGCGTCAACCGTTACCAGATGAACGAGGAGCTGGCAGTGATCGAGCTCGCCAACAGGACCGCC
GAAGCCGATATCAGTCGCGCGCACACCGATTTCGTCGCCAATGCCAGCCACGAGTTGCGCACACCGCTGGCCTCGATCAT
CGGTTACGCCGAAACGCTGAGCGACACGCCCGACCAGATCGACACGCCCACAGCGCAGAAATTCATCGACACGATCTATC
GCGAGGCCCGCCGTTTGCAGAGCCTCGTCAGCGATCTGATGTCGCTGTCGCGGATCGAGGCGGAAAAGCACGAACAACCG
GTCGAGCGCGTCGATCTCAGTGCGGTGGTCGAGCGGGCCGCACGCGATGCCGCCAACCTGGGCGACCGCGCCGAGCGCCT
CGTGATCGATATACACGGCCAATACGCGGTCGGCGGCGACGCGCAGCAACTCGAACAACTGGTCCGCAACCTCGTCGACA
ACGCCTTCAAATATGGCAGCAAGGATGCGCCGGTAACCGTCCGGCTGTCGCAAGCGGCCAGCGGCGACGCCAGGCTGGAC
GTGGTCGACCAGGGCGAAGGCATACCGCGCGAACACCTGCCGCACCTGACCCGGCGGTTCTACCGCACCGATCCTGGCCG
CAGCCTCGCCTCTGGCGGGACCGGCCTCGGCCTCGCCATCGTCAAGCATATCGTCCAGCGTCACCGCGGCCGGCTCGACA
TCGATAGCGAGATGGGCGTCGGCACAACGATCACTGTGCGCATCCCACTCTGGCGCGAAATGGATGCACCCGAGATGGGC
GGAGACGAGACCGCTAATGAGGTGGATAGCGGCGACAATGCAGGTGCCTTGTCATGA

Upstream 100 bases:

>100_bases
GGGTCACCACCCGGAGGCGCAATTTCCCCTCATGCACCAGATATCCACTGCCGTTCGTGCGACGGTGGCGGGACGTGCGT
TTCCCCTCTAAGGCCGCAGC

Downstream 100 bases:

>100_bases
ATTTGCCATATGGAGCCACCATCGCATTTCTGACCCGGGGGCAGGCGCAGACTCGCGTCCCGCCAATTGTGCTCGATCAG
ATCTCACGCATCCTTGATCG

Product: two-component signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MDSQPTFPWPGLLIAVATTTVLSLTGLEWPLALALFVVWCGTLLLGAQREESLPPEPQDPVFSKEGMATMIEHSATPLML
SERNRIIIANRAARSVLGSHVVGQDVRVAFRHPEAIALMDRNEPGQAIVTGLARPKDIWSVNRYQMNEELAVIELANRTA
EADISRAHTDFVANASHELRTPLASIIGYAETLSDTPDQIDTPTAQKFIDTIYREARRLQSLVSDLMSLSRIEAEKHEQP
VERVDLSAVVERAARDAANLGDRAERLVIDIHGQYAVGGDAQQLEQLVRNLVDNAFKYGSKDAPVTVRLSQAASGDARLD
VVDQGEGIPREHLPHLTRRFYRTDPGRSLASGGTGLGLAIVKHIVQRHRGRLDIDSEMGVGTTITVRIPLWREMDAPEMG
GDETANEVDSGDNAGALS

Sequences:

>Translated_418_residues
MDSQPTFPWPGLLIAVATTTVLSLTGLEWPLALALFVVWCGTLLLGAQREESLPPEPQDPVFSKEGMATMIEHSATPLML
SERNRIIIANRAARSVLGSHVVGQDVRVAFRHPEAIALMDRNEPGQAIVTGLARPKDIWSVNRYQMNEELAVIELANRTA
EADISRAHTDFVANASHELRTPLASIIGYAETLSDTPDQIDTPTAQKFIDTIYREARRLQSLVSDLMSLSRIEAEKHEQP
VERVDLSAVVERAARDAANLGDRAERLVIDIHGQYAVGGDAQQLEQLVRNLVDNAFKYGSKDAPVTVRLSQAASGDARLD
VVDQGEGIPREHLPHLTRRFYRTDPGRSLASGGTGLGLAIVKHIVQRHRGRLDIDSEMGVGTTITVRIPLWREMDAPEMG
GDETANEVDSGDNAGALS
>Mature_418_residues
MDSQPTFPWPGLLIAVATTTVLSLTGLEWPLALALFVVWCGTLLLGAQREESLPPEPQDPVFSKEGMATMIEHSATPLML
SERNRIIIANRAARSVLGSHVVGQDVRVAFRHPEAIALMDRNEPGQAIVTGLARPKDIWSVNRYQMNEELAVIELANRTA
EADISRAHTDFVANASHELRTPLASIIGYAETLSDTPDQIDTPTAQKFIDTIYREARRLQSLVSDLMSLSRIEAEKHEQP
VERVDLSAVVERAARDAANLGDRAERLVIDIHGQYAVGGDAQQLEQLVRNLVDNAFKYGSKDAPVTVRLSQAASGDARLD
VVDQGEGIPREHLPHLTRRFYRTDPGRSLASGGTGLGLAIVKHIVQRHRGRLDIDSEMGVGTTITVRIPLWREMDAPEMG
GDETANEVDSGDNAGALS

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=317, Percent_Identity=33.4384858044164, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1788393, Length=228, Percent_Identity=33.7719298245614, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788713, Length=241, Percent_Identity=26.9709543568465, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI145693157, Length=256, Percent_Identity=30.859375, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1789149, Length=255, Percent_Identity=31.7647058823529, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI48994928, Length=229, Percent_Identity=31.4410480349345, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1790346, Length=242, Percent_Identity=31.404958677686, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786783, Length=238, Percent_Identity=30.2521008403361, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082128, Length=220, Percent_Identity=28.6363636363636, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787894, Length=222, Percent_Identity=31.5315315315315, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788549, Length=239, Percent_Identity=25.5230125523013, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790861, Length=221, Percent_Identity=28.9592760180996, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1790436, Length=261, Percent_Identity=25.6704980842912, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081816, Length=249, Percent_Identity=30.1204819277108, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790551, Length=205, Percent_Identity=31.219512195122, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789808, Length=222, Percent_Identity=29.7297297297297, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790300, Length=277, Percent_Identity=27.7978339350181, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789403, Length=204, Percent_Identity=32.3529411764706, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786912, Length=236, Percent_Identity=27.1186440677966, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788279, Length=203, Percent_Identity=26.1083743842365, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 45702; Mature: 45702

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSQPTFPWPGLLIAVATTTVLSLTGLEWPLALALFVVWCGTLLLGAQREESLPPEPQDP
CCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCC
VFSKEGMATMIEHSATPLMLSERNRIIIANRAARSVLGSHVVGQDVRVAFRHPEAIALMD
CCCCCCHHHHHHCCCCCEEEECCCEEEEECHHHHHHHHHHHCCCCCEEEEECCCEEEEEC
RNEPGQAIVTGLARPKDIWSVNRYQMNEELAVIELANRTAEADISRAHTDFVANASHELR
CCCCCHHHHHHCCCCHHHHCCHHHHCCCCEEEEEHHCCHHHHHHHHHHHHHHHCCCHHHH
TPLASIIGYAETLSDTPDQIDTPTAQKFIDTIYREARRLQSLVSDLMSLSRIEAEKHEQP
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
VERVDLSAVVERAARDAANLGDRAERLVIDIHGQYAVGGDAQQLEQLVRNLVDNAFKYGS
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHCCC
KDAPVTVRLSQAASGDARLDVVDQGEGIPREHLPHLTRRFYRTDPGRSLASGGTGLGLAI
CCCCEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHH
VKHIVQRHRGRLDIDSEMGVGTTITVRIPLWREMDAPEMGGDETANEVDSGDNAGALS
HHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHCCCCCCCCCCC
>Mature Secondary Structure
MDSQPTFPWPGLLIAVATTTVLSLTGLEWPLALALFVVWCGTLLLGAQREESLPPEPQDP
CCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCC
VFSKEGMATMIEHSATPLMLSERNRIIIANRAARSVLGSHVVGQDVRVAFRHPEAIALMD
CCCCCCHHHHHHCCCCCEEEECCCEEEEECHHHHHHHHHHHCCCCCEEEEECCCEEEEEC
RNEPGQAIVTGLARPKDIWSVNRYQMNEELAVIELANRTAEADISRAHTDFVANASHELR
CCCCCHHHHHHCCCCHHHHCCHHHHCCCCEEEEEHHCCHHHHHHHHHHHHHHHCCCHHHH
TPLASIIGYAETLSDTPDQIDTPTAQKFIDTIYREARRLQSLVSDLMSLSRIEAEKHEQP
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
VERVDLSAVVERAARDAANLGDRAERLVIDIHGQYAVGGDAQQLEQLVRNLVDNAFKYGS
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHCCC
KDAPVTVRLSQAASGDARLDVVDQGEGIPREHLPHLTRRFYRTDPGRSLASGGTGLGLAI
CCCCEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHH
VKHIVQRHRGRLDIDSEMGVGTTITVRIPLWREMDAPEMGGDETANEVDSGDNAGALS
HHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3550103; 9278503; 2187152; 8391104 [H]