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The map label for this gene is aceA [C]

Identifier: 85373887

GI number: 85373887

Start: 1094387

End: 1095985

Strand: Reverse

Name: aceA [C]

Synonym: ELI_05300

Alternate gene names: 85373887

Gene position: 1095985-1094387 (Counterclockwise)

Preceding gene: 85373895

Following gene: 85373886

Centisome position: 35.91

GC content: 59.97

Gene sequence:

>1599_bases
ATGACCTACCAGCAAACCATCGCGAAGATGAACGAAACGATCGCCAGCAACGGCGCACCTTGGGATGCCATCGATGCCGA
AGCGGCAGCCCGGATGCAGATCCAGAACCGGTTTCCCACCGGCCTCGATATCGCGCGTTATACCGCGAAGATCATGCGCG
ATGACATGAAGGCCTATGACAACGACCCTGCCAATTACACCCAGTCGCTGGGCTGCTGGCACGGGTTCATCGCGCAACAA
AAGATGATCAGCATCAAGAAGCATTTCGGCAGCACCAAGCGCCGTTATCTCTATCTGTCGGGCTGGATGGTCGCTGCATT
GCGGAGCGAATTCGGACCCCTGCCCGACCAGTCGATGCATGAGAAGACCAGCGTTCCGGCCTTGATCGAGGAGCTCTACA
CTTTCCTCAAACAGGCCGATGCCCGCGAACTGGGCGGCCTGTTCCGTGAACTCGACGCGGCGAAGGAAGCCAGCGACGCA
GTGAATATCCACCGCCTGCAACGCAAGATCGAAGAGCACCAGACCCATGTCGTCCCGATCATTGCCGATATCGATGCCGG
CTTCGGCAATGCCGAGGCGACCTACCTGCTCGCCAAGAAGATGATCGAAGCCGGTGCCTGCGCGCTGCAGATCGAAAACC
AGGTTTCGGACGAGAAGCAGTGCGGCCACCAGGATGGAAAGGTCACTGTCCCGCACGAGGACTTCCACCAGAAGATCCGC
GCGATCCGCTACGCCTTCCTCGAACTGGGCGTTCCGGACGGCATCATCGTTGCACGTACCGACTCGCTCGGCGCGGGCCT
CACCAAGCAGATCGCCTACACGACGGAAGAAGGCGATCTCGGCGACCAGTACAACGCATTCCTCGACTGCGAAGAAGTCT
CGCCCGAAGACATGAAGAATGGTGATGTGTTCCTGAGCCGCGAAGGCAAGCTGCTGCGTCCCAAACGTCTACCGTCGAAC
CTGTTCCAGTTCCGTGAAGGGACGGGCGAAGATCGCTGCGTCCTCGACGGCATCACCAGCCTGCAGGCCGGCGCCGACCT
GCTGTGGATCGAAACCGAGAAGCCGCATATCGGCCAGATCGGCGGTATGGTGAAGCGCATCCGCGAAGTGATTCCGAATG
CCAAGCTCGTCTATAACAATTCGCCGAGCTTTAACTGGACGCTCAACTTCCGCCAGCAGGTTTTCGATGCCTGGAAGGAA
GAAGGCCGCGATCTCACCAATTACGACCGCGCCCGTCTCATGGACGCAGAGTACGACGAGACCGAGCTCGCCGCTGAAGC
CGATGCGCGCATCCAGACCTTCCAGGCCGATGCGGCGCGCGAGGCGGGCATCTTCCACCACCTGATCACCCTGCCGACCT
ATCACACGGCAGCGCTGAGCACGGATAACCTCGCCAAGCGCTACTTCGGTGACGAAGGCATGCTGGGCTACGTCAAGAAC
GTTCAGCGCGAGGAGATCCGCCAGGGCATCGCCTGCGTGAAGCACCAGAACATGGCCGGTTCGGACATCGGTGACGATCA
CAAGGAGTATTTTGCCGGTGAAGCTGCCCTGAAGGCGGGCGGCGCAGATAACACCATGAACCAGTTCGAAGCCGCCTGA

Upstream 100 bases:

>100_bases
CGCTCGATAAACAAGATTTCCTGTAAGAATTTCTATCACTTTAGCAAATTGGATGCGAAAAGCTGCTCCAACACATCTTT
CCCCGGACAGGAGATCCGCC

Downstream 100 bases:

>100_bases
TCGGGCAGCGAGAAGAAGGAGAGGAACGATGACCGACACCGAAGCCAAAAAGGAACCGGGACGGGCGCGCGCCCTGCTCT
CGACTGCGGATTTCAAGCTG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MTYQQTIAKMNETIASNGAPWDAIDAEAAARMQIQNRFPTGLDIARYTAKIMRDDMKAYDNDPANYTQSLGCWHGFIAQQ
KMISIKKHFGSTKRRYLYLSGWMVAALRSEFGPLPDQSMHEKTSVPALIEELYTFLKQADARELGGLFRELDAAKEASDA
VNIHRLQRKIEEHQTHVVPIIADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQDGKVTVPHEDFHQKIR
AIRYAFLELGVPDGIIVARTDSLGAGLTKQIAYTTEEGDLGDQYNAFLDCEEVSPEDMKNGDVFLSREGKLLRPKRLPSN
LFQFREGTGEDRCVLDGITSLQAGADLLWIETEKPHIGQIGGMVKRIREVIPNAKLVYNNSPSFNWTLNFRQQVFDAWKE
EGRDLTNYDRARLMDAEYDETELAAEADARIQTFQADAAREAGIFHHLITLPTYHTAALSTDNLAKRYFGDEGMLGYVKN
VQREEIRQGIACVKHQNMAGSDIGDDHKEYFAGEAALKAGGADNTMNQFEAA

Sequences:

>Translated_532_residues
MTYQQTIAKMNETIASNGAPWDAIDAEAAARMQIQNRFPTGLDIARYTAKIMRDDMKAYDNDPANYTQSLGCWHGFIAQQ
KMISIKKHFGSTKRRYLYLSGWMVAALRSEFGPLPDQSMHEKTSVPALIEELYTFLKQADARELGGLFRELDAAKEASDA
VNIHRLQRKIEEHQTHVVPIIADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQDGKVTVPHEDFHQKIR
AIRYAFLELGVPDGIIVARTDSLGAGLTKQIAYTTEEGDLGDQYNAFLDCEEVSPEDMKNGDVFLSREGKLLRPKRLPSN
LFQFREGTGEDRCVLDGITSLQAGADLLWIETEKPHIGQIGGMVKRIREVIPNAKLVYNNSPSFNWTLNFRQQVFDAWKE
EGRDLTNYDRARLMDAEYDETELAAEADARIQTFQADAAREAGIFHHLITLPTYHTAALSTDNLAKRYFGDEGMLGYVKN
VQREEIRQGIACVKHQNMAGSDIGDDHKEYFAGEAALKAGGADNTMNQFEAA
>Mature_531_residues
TYQQTIAKMNETIASNGAPWDAIDAEAAARMQIQNRFPTGLDIARYTAKIMRDDMKAYDNDPANYTQSLGCWHGFIAQQK
MISIKKHFGSTKRRYLYLSGWMVAALRSEFGPLPDQSMHEKTSVPALIEELYTFLKQADARELGGLFRELDAAKEASDAV
NIHRLQRKIEEHQTHVVPIIADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQDGKVTVPHEDFHQKIRA
IRYAFLELGVPDGIIVARTDSLGAGLTKQIAYTTEEGDLGDQYNAFLDCEEVSPEDMKNGDVFLSREGKLLRPKRLPSNL
FQFREGTGEDRCVLDGITSLQAGADLLWIETEKPHIGQIGGMVKRIREVIPNAKLVYNNSPSFNWTLNFRQQVFDAWKEE
GRDLTNYDRARLMDAEYDETELAAEADARIQTFQADAAREAGIFHHLITLPTYHTAALSTDNLAKRYFGDEGMLGYVKNV
QREEIRQGIACVKHQNMAGSDIGDDHKEYFAGEAALKAGGADNTMNQFEAA

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=413, Percent_Identity=28.3292978208232, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71982926, Length=433, Percent_Identity=27.0207852193995, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17561814, Length=433, Percent_Identity=27.0207852193995, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6320908, Length=175, Percent_Identity=30.8571428571429, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 59530; Mature: 59398

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYQQTIAKMNETIASNGAPWDAIDAEAAARMQIQNRFPTGLDIARYTAKIMRDDMKAYD
CCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
NDPANYTQSLGCWHGFIAQQKMISIKKHFGSTKRRYLYLSGWMVAALRSEFGPLPDQSMH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHCCCCCCCHHH
EKTSVPALIEELYTFLKQADARELGGLFRELDAAKEASDAVNIHRLQRKIEEHQTHVVPI
HHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
IADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQDGKVTVPHEDFHQKIR
EEECCCCCCCCHHHHHHHHHHHHCCCCEEEECHHCCHHHHCCCCCCEEECCHHHHHHHHH
AIRYAFLELGVPDGIIVARTDSLGAGLTKQIAYTTEEGDLGDQYNAFLDCEEVSPEDMKN
HHHHHHHHCCCCCCEEEEECCCCCCCCHHHHEEECCCCCCCCCHHCEEECCCCCCCCCCC
GDVFLSREGKLLRPKRLPSNLFQFREGTGEDRCVLDGITSLQAGADLLWIETEKPHIGQI
CCEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHH
GGMVKRIREVIPNAKLVYNNSPSFNWTLNFRQQVFDAWKEEGRDLTNYDRARLMDAEYDE
HHHHHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCH
TELAAEADARIQTFQADAAREAGIFHHLITLPTYHTAALSTDNLAKRYFGDEGMLGYVKN
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHCCCCCCHHHHHH
VQREEIRQGIACVKHQNMAGSDIGDDHKEYFAGEAALKAGGADNTMNQFEAA
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCHHHHHCCCCCCCHHHHCCC
>Mature Secondary Structure 
TYQQTIAKMNETIASNGAPWDAIDAEAAARMQIQNRFPTGLDIARYTAKIMRDDMKAYD
CHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
NDPANYTQSLGCWHGFIAQQKMISIKKHFGSTKRRYLYLSGWMVAALRSEFGPLPDQSMH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHCCCCCCCHHH
EKTSVPALIEELYTFLKQADARELGGLFRELDAAKEASDAVNIHRLQRKIEEHQTHVVPI
HHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
IADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQDGKVTVPHEDFHQKIR
EEECCCCCCCCHHHHHHHHHHHHCCCCEEEECHHCCHHHHCCCCCCEEECCHHHHHHHHH
AIRYAFLELGVPDGIIVARTDSLGAGLTKQIAYTTEEGDLGDQYNAFLDCEEVSPEDMKN
HHHHHHHHCCCCCCEEEEECCCCCCCCHHHHEEECCCCCCCCCHHCEEECCCCCCCCCCC
GDVFLSREGKLLRPKRLPSNLFQFREGTGEDRCVLDGITSLQAGADLLWIETEKPHIGQI
CCEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHH
GGMVKRIREVIPNAKLVYNNSPSFNWTLNFRQQVFDAWKEEGRDLTNYDRARLMDAEYDE
HHHHHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCH
TELAAEADARIQTFQADAAREAGIFHHLITLPTYHTAALSTDNLAKRYFGDEGMLGYVKN
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHCCCCCCHHHHHH
VQREEIRQGIACVKHQNMAGSDIGDDHKEYFAGEAALKAGGADNTMNQFEAA
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCHHHHHCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]