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The map label for this gene is trxA [C]

Identifier: 85373842

GI number: 85373842

Start: 1048186

End: 1048506

Strand: Direct

Name: trxA [C]

Synonym: ELI_05075

Alternate gene names: 85373842

Gene position: 1048186-1048506 (Clockwise)

Preceding gene: 85373841

Following gene: 85373845

Centisome position: 34.34

GC content: 60.12

Gene sequence:

>321_bases
ATGGCCACCGTCAACGTCACCGATGCCAGCTTCAAGGCCGATGTCCTCGAATCCGACAAGCCCGTGCTGGTCGATTTCTG
GGCCGAATGGTGCGGTCCCTGCAAGATGATCGCCCCCGCGTTGGAGGAAATCAGCGAGGAACTGGGCGAGCAGGTCACCA
TCGCCAAGATGGACATCATGGAAAATACCGACACCGCGAGCGAGATGGGTGTGCAGTCGATCCCGCTGATGGTGCTGTTC
AAGAACGGCGAAGCGGTCGCCCGCAAGGTCGGCGCTGCGCCCAAGAGCCAGCTCAAGGACTGGATCGAAAGCGAAATCTG
A

Upstream 100 bases:

>100_bases
AAGAGGCATTGCAGGGTTAGTGGGAAAGCTTTGTCACCGATCCCTTTGATCGGGCGAACAGCCACCCTAGATTGAACCCA
ATCAACAGGAGATTGCCGTT

Downstream 100 bases:

>100_bases
TCCGGTGCGGTTTCTGACCCGGGTGATCTAGCCGCCCGGGCGGAAGCCCAAGGTCTCGAGCCGCGCGACGAATTCGTCCC
ACAAGCCCTGGCTGGCGGCG

Product: thiol-disulfide isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MATVNVTDASFKADVLESDKPVLVDFWAEWCGPCKMIAPALEEISEELGEQVTIAKMDIMENTDTASEMGVQSIPLMVLF
KNGEAVARKVGAAPKSQLKDWIESEI

Sequences:

>Translated_106_residues
MATVNVTDASFKADVLESDKPVLVDFWAEWCGPCKMIAPALEEISEELGEQVTIAKMDIMENTDTASEMGVQSIPLMVLF
KNGEAVARKVGAAPKSQLKDWIESEI
>Mature_105_residues
ATVNVTDASFKADVLESDKPVLVDFWAEWCGPCKMIAPALEEISEELGEQVTIAKMDIMENTDTASEMGVQSIPLMVLFK
NGEAVARKVGAAPKSQLKDWIESEI

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=107, Percent_Identity=38.3177570093458, Blast_Score=84, Evalue=2e-17,
Organism=Homo sapiens, GI20070125, Length=80, Percent_Identity=36.25, Blast_Score=65, Evalue=9e-12,
Organism=Homo sapiens, GI5031973, Length=99, Percent_Identity=32.3232323232323, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=52.4271844660194, Blast_Score=125, Evalue=7e-31,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=36.9565217391304, Blast_Score=86, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=38.7096774193548, Blast_Score=78, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17510299, Length=98, Percent_Identity=40.8163265306122, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=101, Percent_Identity=31.6831683168317, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI25144092, Length=105, Percent_Identity=30.4761904761905, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=79, Percent_Identity=49.3670886075949, Blast_Score=82, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321648, Length=88, Percent_Identity=43.1818181818182, Blast_Score=79, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319925, Length=90, Percent_Identity=36.6666666666667, Blast_Score=66, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=39, Blast_Score=86, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24639826, Length=77, Percent_Identity=41.5584415584416, Blast_Score=79, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17648013, Length=89, Percent_Identity=43.8202247191011, Blast_Score=78, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24583090, Length=89, Percent_Identity=43.8202247191011, Blast_Score=78, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=35.4166666666667, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664269, Length=75, Percent_Identity=38.6666666666667, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11589; Mature: 11458

Theoretical pI: Translated: 4.01; Mature: 4.01

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVNVTDASFKADVLESDKPVLVDFWAEWCGPCKMIAPALEEISEELGEQVTIAKMDIM
CCEECCCCCCHHHHHHCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHCCEEEHHHHHHH
ENTDTASEMGVQSIPLMVLFKNGEAVARKVGAAPKSQLKDWIESEI
CCCCCHHHCCCCCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ATVNVTDASFKADVLESDKPVLVDFWAEWCGPCKMIAPALEEISEELGEQVTIAKMDIM
CEECCCCCCHHHHHHCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHCCEEEHHHHHHH
ENTDTASEMGVQSIPLMVLFKNGEAVARKVGAAPKSQLKDWIESEI
CCCCCHHHCCCCCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7021558 [H]