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The map label for this gene is mdmC [H]

Identifier: 85373815

GI number: 85373815

Start: 1019087

End: 1019767

Strand: Direct

Name: mdmC [H]

Synonym: ELI_04940

Alternate gene names: 85373815

Gene position: 1019087-1019767 (Clockwise)

Preceding gene: 85373814

Following gene: 85373816

Centisome position: 33.39

GC content: 61.67

Gene sequence:

>681_bases
ATGTCCGGCGTCGCCGGATGGAAGGCGGTTAATCCGCTCTGGTCGGCTGTCGACGACATGATCGGCGAGGCTTTGCTCGA
AGACGGTCCAGTCCTCGCCGACTGTGCAGCGCGCAATGCCGAGCGCGGTCTTCCCGACATCGCCGTTTCGCCCGCTCAAG
GACGCTTCCTGCAAATGGTGTGCGAAATCATGGGCGCTCGGCGCGCGCTTGAGATCGGGACGCTAGGCGGCTTTTCGACC
CTTTTCCTCGCCCGCGGCGTCGGTGAGACCGGTCGCGTGGTGACCCTTGAGGCGAAGAAAACCTACGCCAGTGTCGCGCG
GAAGAACTTCGATGAGTCGGGCATCGGAGATCGCATCGAGATGAAAGTGGCTGCAGCTCTGGAATCGCTCGCAACGCTTG
AAGGCCCTTTCGATCTGACGTTCATCGATGCCGACAAGCCCAACAACGTCAACTATGTCGAACACGCCCTGCGACTCTCG
CGGCCAGGCGCGCTGATTATCGTCGACAACGTGGTCCGCGAGGGGAACATTCTCGAGCCGGACGAAGACGATGAATCGGC
CAAGGGCACCCGCGCGCTGTACGAACATGTGAACAATCATCCGCGCCTCGAGGCTACGGCGCTGCAAACCGTCGGGGCCA
AGGGCTGGGACGGGATGATGTTCCTCAGAGTGAGAGACTGA

Upstream 100 bases:

>100_bases
AACATCCTTCGCGCCGAAAAACAGGCGACGGTGGCCAAGGTCAACGCTGGGGAAGGCGATAGCCTCGCCGTGGATGCGGT
GATCTTGGAGCTGGAATAGC

Downstream 100 bases:

>100_bases
TGCACCTGACCCACGCGCCCGATGCACCGGCAGCCGACCAGATCGACTTCGACCATTTTCTCGGCGTCGATATTCGCATC
GGAACGATCGTGGCAGCCGA

Product: O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MSGVAGWKAVNPLWSAVDDMIGEALLEDGPVLADCAARNAERGLPDIAVSPAQGRFLQMVCEIMGARRALEIGTLGGFST
LFLARGVGETGRVVTLEAKKTYASVARKNFDESGIGDRIEMKVAAALESLATLEGPFDLTFIDADKPNNVNYVEHALRLS
RPGALIIVDNVVREGNILEPDEDDESAKGTRALYEHVNNHPRLEATALQTVGAKGWDGMMFLRVRD

Sequences:

>Translated_226_residues
MSGVAGWKAVNPLWSAVDDMIGEALLEDGPVLADCAARNAERGLPDIAVSPAQGRFLQMVCEIMGARRALEIGTLGGFST
LFLARGVGETGRVVTLEAKKTYASVARKNFDESGIGDRIEMKVAAALESLATLEGPFDLTFIDADKPNNVNYVEHALRLS
RPGALIIVDNVVREGNILEPDEDDESAKGTRALYEHVNNHPRLEATALQTVGAKGWDGMMFLRVRD
>Mature_225_residues
SGVAGWKAVNPLWSAVDDMIGEALLEDGPVLADCAARNAERGLPDIAVSPAQGRFLQMVCEIMGARRALEIGTLGGFSTL
FLARGVGETGRVVTLEAKKTYASVARKNFDESGIGDRIEMKVAAALESLATLEGPFDLTFIDADKPNNVNYVEHALRLSR
PGALIIVDNVVREGNILEPDEDDESAKGTRALYEHVNNHPRLEATALQTVGAKGWDGMMFLRVRD

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=188, Percent_Identity=29.7872340425532, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25148771, Length=162, Percent_Identity=30.2469135802469, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 24380; Mature: 24249

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGVAGWKAVNPLWSAVDDMIGEALLEDGPVLADCAARNAERGLPDIAVSPAQGRFLQMV
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCCEEECCCCCHHHHHH
CEIMGARRALEIGTLGGFSTLFLARGVGETGRVVTLEAKKTYASVARKNFDESGIGDRIE
HHHHCCHHEEEECCCCCHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCHHH
MKVAAALESLATLEGPFDLTFIDADKPNNVNYVEHALRLSRPGALIIVDNVVREGNILEP
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECHHCCCCCCCC
DEDDESAKGTRALYEHVNNHPRLEATALQTVGAKGWDGMMFLRVRD
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEECC
>Mature Secondary Structure 
SGVAGWKAVNPLWSAVDDMIGEALLEDGPVLADCAARNAERGLPDIAVSPAQGRFLQMV
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCCEEECCCCCHHHHHH
CEIMGARRALEIGTLGGFSTLFLARGVGETGRVVTLEAKKTYASVARKNFDESGIGDRIE
HHHHCCHHEEEECCCCCHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCHHH
MKVAAALESLATLEGPFDLTFIDADKPNNVNYVEHALRLSRPGALIIVDNVVREGNILEP
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECHHCCCCCCCC
DEDDESAKGTRALYEHVNNHPRLEATALQTVGAKGWDGMMFLRVRD
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]