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The map label for this gene is pgi

Identifier: 85373797

GI number: 85373797

Start: 1000152

End: 1001705

Strand: Direct

Name: pgi

Synonym: ELI_04850

Alternate gene names: 85373797

Gene position: 1000152-1001705 (Clockwise)

Preceding gene: 85373793

Following gene: 85373798

Centisome position: 32.77

GC content: 66.28

Gene sequence:

>1554_bases
ATGAGCGATGCTGAAACCAACGCATGGGATGCGATCCACCGGGTGGAAAAGCGCACCCTGCTGGAGCTGTTCGATGCCGA
TAGCGAGCGGGTCAGCAAGCTCAGCCACCGGCTCGCATGGGGCGTTGAAAGTCCCGGGGGGCAGGAGGCTGGCGGCATCC
TGTTCGACTGGTCGAAAACGCACCTGACCGACGAGCTGCTCGACGGGTTCGAAGCGCTCGCCGACGCGATGGATTTTGCG
GGTGCCCGCGAGAAACTGCTGAGCGGCGCAAAGATCAATGTCACCGAAGGCCGCGCCGCCGAACACACCGCGCAGCGCGG
CACGGGCGCGGAGGCGAGCGTCGAGGAAGCCGTGGCGCTGATGGGCCGGATGAAAGCGCTGGTCGACGCGATCCATGGCG
GTGCGATGGGGGAGGTGAAGCACCTGATCCATGTCGGCATCGGCGGCAGCGCGCTCGGGCCCAAACTCGCGCTTGATGCG
CTGACCCGTGACCTGGCGCTGGTCGATGTCCATGTTGTCTCCAATATCGACGGCGTCGCGCTGGAGCAGGCCTTTGCGGC
GTGCGATCCGGCCACCACGCTGATCGCTATTGCCTCCAAGACCTTCACCACGATCGAGACCATGACCAACGCGACAAGCG
CGCTACACTGGCTCAAGACCAATGGCGTGGACGATCCGCATGGCCGGGTGGTGGCACTGACCGCCAATCCGGAAGCGGCA
GTCGAATTCGGCGTCGACGAAACCCGCGTCTTACCTTTCATGGAGAGCGTCGGCGGGCGCTATTCGCTGTGGTCGAGCAT
CGGTTTCCCGGTCGCGCTCGGCGCGGGGTGGGACGAGTTCGAAGGCATGCTGGCGGGCGCGCAGGCAATGGACGAGCATT
TCGCCAGCGCCGATGGCCGCGCCAACCTGCCGCTGCTCGCTGCCTTTGCCGACCTCTACTACACCCGCGTGCGCGGCTGC
CAGGCGCGCGCGTGCTTCGCCTATGACGAGCGGCTCGGCCTGCTGCCCGACTATCTCCAGCAGCTCGAGATGGAGAGCAA
CGGCAAGCGCGTGAAGGCGGACGGCACGCCCGTCGATGGCCCGACCGCGCCGATCACCTGGGGCGGGGTGGGGACGGACG
CACAGCACGCGGTGTTCCAGCTCCTCCACCAGGGCACGCATCTGGTGCCGGTCGATTTCATCGCCAGCATCGCGCCCGGC
GACGATCTCGACCCGGCCCATCACCGCATCCTGCTGACCAATTGCTTCGCGCAAGGAGCGGCGCTGATGGCTGGCGGCAA
TATGGCGGCGGATGAAAAGGACCCCGCTCGCGTCTTCCCCGGCGACCGCCCCAGCGCCACCATGCTGTGCGACGATCTCG
ATGCGGTGACCCTGGGCGCGCTGATCGCCTTCCACGAACACCGCACCTTTGCGAATGCGGTGCTGATGGGCATCAACCCC
TTCGACCAGTTCGGCGTCGAGCTGGGCAAGAAGATGGCGAAGGATATCGAAAGCGGCGGCGCGGAGTTCGATGCGAGTAC
GCAGGCGCTGGTAGGGGCTGCGGGGTTGGCATGA

Upstream 100 bases:

>100_bases
CGCTTCGTGGGCGCATCCGTATTCGTAACAGCTTGGGCCTTTTCATTCATCGCTGGCACCCCTAGGCGCGACGGGAAGGC
TGGCAAGAGGAATTTGCGCG

Downstream 100 bases:

>100_bases
CGGTCTACGCCTTGATCTGACTTGCCATTCTCACAGCGCTCTCCGGGCAGGTTCTTGCTACGAACAAGGCCGCTTGGCGG
AGCTTCTACGTTTGAGTAAC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MSDAETNAWDAIHRVEKRTLLELFDADSERVSKLSHRLAWGVESPGGQEAGGILFDWSKTHLTDELLDGFEALADAMDFA
GAREKLLSGAKINVTEGRAAEHTAQRGTGAEASVEEAVALMGRMKALVDAIHGGAMGEVKHLIHVGIGGSALGPKLALDA
LTRDLALVDVHVVSNIDGVALEQAFAACDPATTLIAIASKTFTTIETMTNATSALHWLKTNGVDDPHGRVVALTANPEAA
VEFGVDETRVLPFMESVGGRYSLWSSIGFPVALGAGWDEFEGMLAGAQAMDEHFASADGRANLPLLAAFADLYYTRVRGC
QARACFAYDERLGLLPDYLQQLEMESNGKRVKADGTPVDGPTAPITWGGVGTDAQHAVFQLLHQGTHLVPVDFIASIAPG
DDLDPAHHRILLTNCFAQGAALMAGGNMAADEKDPARVFPGDRPSATMLCDDLDAVTLGALIAFHEHRTFANAVLMGINP
FDQFGVELGKKMAKDIESGGAEFDASTQALVGAAGLA

Sequences:

>Translated_517_residues
MSDAETNAWDAIHRVEKRTLLELFDADSERVSKLSHRLAWGVESPGGQEAGGILFDWSKTHLTDELLDGFEALADAMDFA
GAREKLLSGAKINVTEGRAAEHTAQRGTGAEASVEEAVALMGRMKALVDAIHGGAMGEVKHLIHVGIGGSALGPKLALDA
LTRDLALVDVHVVSNIDGVALEQAFAACDPATTLIAIASKTFTTIETMTNATSALHWLKTNGVDDPHGRVVALTANPEAA
VEFGVDETRVLPFMESVGGRYSLWSSIGFPVALGAGWDEFEGMLAGAQAMDEHFASADGRANLPLLAAFADLYYTRVRGC
QARACFAYDERLGLLPDYLQQLEMESNGKRVKADGTPVDGPTAPITWGGVGTDAQHAVFQLLHQGTHLVPVDFIASIAPG
DDLDPAHHRILLTNCFAQGAALMAGGNMAADEKDPARVFPGDRPSATMLCDDLDAVTLGALIAFHEHRTFANAVLMGINP
FDQFGVELGKKMAKDIESGGAEFDASTQALVGAAGLA
>Mature_516_residues
SDAETNAWDAIHRVEKRTLLELFDADSERVSKLSHRLAWGVESPGGQEAGGILFDWSKTHLTDELLDGFEALADAMDFAG
AREKLLSGAKINVTEGRAAEHTAQRGTGAEASVEEAVALMGRMKALVDAIHGGAMGEVKHLIHVGIGGSALGPKLALDAL
TRDLALVDVHVVSNIDGVALEQAFAACDPATTLIAIASKTFTTIETMTNATSALHWLKTNGVDDPHGRVVALTANPEAAV
EFGVDETRVLPFMESVGGRYSLWSSIGFPVALGAGWDEFEGMLAGAQAMDEHFASADGRANLPLLAAFADLYYTRVRGCQ
ARACFAYDERLGLLPDYLQQLEMESNGKRVKADGTPVDGPTAPITWGGVGTDAQHAVFQLLHQGTHLVPVDFIASIAPGD
DLDPAHHRILLTNCFAQGAALMAGGNMAADEKDPARVFPGDRPSATMLCDDLDAVTLGALIAFHEHRTFANAVLMGINPF
DQFGVELGKKMAKDIESGGAEFDASTQALVGAAGLA

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=542, Percent_Identity=37.6383763837638, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI296080693, Length=529, Percent_Identity=36.8620037807183, Blast_Score=327, Evalue=2e-89,
Organism=Escherichia coli, GI1790457, Length=551, Percent_Identity=37.7495462794918, Blast_Score=352, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI71996703, Length=530, Percent_Identity=37.7358490566038, Blast_Score=335, Evalue=5e-92,
Organism=Caenorhabditis elegans, GI71996708, Length=531, Percent_Identity=37.8531073446328, Blast_Score=334, Evalue=5e-92,
Organism=Saccharomyces cerevisiae, GI6319673, Length=542, Percent_Identity=36.1623616236162, Blast_Score=342, Evalue=7e-95,
Organism=Drosophila melanogaster, GI24651916, Length=531, Percent_Identity=39.1713747645951, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24651914, Length=531, Percent_Identity=39.1713747645951, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI17737445, Length=531, Percent_Identity=39.1713747645951, Blast_Score=353, Evalue=2e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_ERYLH (Q2NB79)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_457859.1
- HSSP:   Q3TEE7
- ProteinModelPortal:   Q2NB79
- SMR:   Q2NB79
- STRING:   Q2NB79
- GeneID:   3869048
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_04850
- NMPDR:   fig|314225.3.peg.2101
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- PhylomeDB:   Q2NB79
- ProtClustDB:   PRK00179
- BioCyc:   ELIT314225:ELI_04850-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 54607; Mature: 54476

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 345-345 ACT_SITE 376-376 ACT_SITE 490-490

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAETNAWDAIHRVEKRTLLELFDADSERVSKLSHRLAWGVESPGGQEAGGILFDWSKT
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCHH
HLTDELLDGFEALADAMDFAGAREKLLSGAKINVTEGRAAEHTAQRGTGAEASVEEAVAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHCCCCCCHHHHHHHHH
MGRMKALVDAIHGGAMGEVKHLIHVGIGGSALGPKLALDALTRDLALVDVHVVSNIDGVA
HHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHEEEHHHCCCCCHH
LEQAFAACDPATTLIAIASKTFTTIETMTNATSALHWLKTNGVDDPHGRVVALTANPEAA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHH
VEFGVDETRVLPFMESVGGRYSLWSSIGFPVALGAGWDEFEGMLAGAQAMDEHFASADGR
EEECCCCHHHHHHHHHCCCCEEHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCC
ANLPLLAAFADLYYTRVRGCQARACFAYDERLGLLPDYLQQLEMESNGKRVKADGTPVDG
CCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHCCCCHHHHHHHHHCCCCCEEECCCCCCCC
PTAPITWGGVGTDAQHAVFQLLHQGTHLVPVDFIASIAPGDDLDPAHHRILLTNCFAQGA
CCCCEEECCCCCCHHHHHHHHHHCCCCEEEHHHHHHCCCCCCCCHHHCEEEEEHHHHCCC
ALMAGGNMAADEKDPARVFPGDRPSATMLCDDLDAVTLGALIAFHEHRTFANAVLMGINP
EEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCC
FDQFGVELGKKMAKDIESGGAEFDASTQALVGAAGLA
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
SDAETNAWDAIHRVEKRTLLELFDADSERVSKLSHRLAWGVESPGGQEAGGILFDWSKT
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCHH
HLTDELLDGFEALADAMDFAGAREKLLSGAKINVTEGRAAEHTAQRGTGAEASVEEAVAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHCCCCCCHHHHHHHHH
MGRMKALVDAIHGGAMGEVKHLIHVGIGGSALGPKLALDALTRDLALVDVHVVSNIDGVA
HHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHEEEHHHCCCCCHH
LEQAFAACDPATTLIAIASKTFTTIETMTNATSALHWLKTNGVDDPHGRVVALTANPEAA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHH
VEFGVDETRVLPFMESVGGRYSLWSSIGFPVALGAGWDEFEGMLAGAQAMDEHFASADGR
EEECCCCHHHHHHHHHCCCCEEHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCC
ANLPLLAAFADLYYTRVRGCQARACFAYDERLGLLPDYLQQLEMESNGKRVKADGTPVDG
CCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHCCCCHHHHHHHHHCCCCCEEECCCCCCCC
PTAPITWGGVGTDAQHAVFQLLHQGTHLVPVDFIASIAPGDDLDPAHHRILLTNCFAQGA
CCCCEEECCCCCCHHHHHHHHHHCCCCEEEHHHHHHCCCCCCCCHHHCEEEEEHHHHCCC
ALMAGGNMAADEKDPARVFPGDRPSATMLCDDLDAVTLGALIAFHEHRTFANAVLMGINP
EEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCC
FDQFGVELGKKMAKDIESGGAEFDASTQALVGAAGLA
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA