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The map label for this gene is ldc [H]

Identifier: 85373776

GI number: 85373776

Start: 980304

End: 981506

Strand: Direct

Name: ldc [H]

Synonym: ELI_04745

Alternate gene names: 85373776

Gene position: 980304-981506 (Clockwise)

Preceding gene: 85373775

Following gene: 85373777

Centisome position: 32.12

GC content: 63.59

Gene sequence:

>1203_bases
TTGCACACCTTTCCCGACGCCAAGTCCGTAATCCGCGCCCTTGCGCCGGACGAGCCTGTCATCCTCAACCGCCCGCACGC
CGCCCAGCGCGCCGCCCGCTTCTTCGTCGAGAAGTTTCCGGGCAAGGTGCTCTATGCGGTGAAGGCCAATCCTTCGCCGG
ATCTGCTCCAGATCCTGCGGGCGAGCGGCGTGACGCATTATGATGTCGCCAGCATCGCCGAAGTGCGGCTGGTGCGCGAT
GCGCTGCCGGACGCCGTGTTATGCTTCATGCACCCGGTGAAGACCCCGCGCGCGATCGCCGAGGCTTACCACCAGCACGG
CGTGCGCACTTTCAGCCTCGATACCGAGGAAGAGCTGGCCAAGATCGTCGAGGCTTGCAGCGACGCGCAGGGCAATCCGG
CGAAAGATCTGAAGCTTTGCGTCCGTATCCGCGTCTCGTCCGACTATTCCGAGCTCTCGCTCGCCAGCAAGTTCGGCTGC
GACCTGACCGAAGCGCCGGCCCTGCTGCAACTTGCGCGCCAGCATTGCGACTGGCTGGGCGTGTGCTTCCATGTCGGCAG
CCAGGCGATGACGCCCTTCGCCTATGTCCAGGCGATCGAGCGTGTGCGCGCAGCCATCGCCGATGCCTCCGTGGTGATCG
ACATGATCGACGTCGGAGGAGGCTTCCCAAGCGTCTATCCGGGCATGGAGCCGCCGCCGCTGGAAGATTACTTCGCGATC
ATCCACAAGCATTTCGAAGCGCTGCCCATCGCCTACAATGCCGAGCTGTGGTGCGAGCCGGGCAGGGCGCTGTGTGCGGA
ATATTCCTCGCTGACCGTGCGCGTCGACAAACGCCGTGGTGAGGAACTGTACATCAATGACGGCGCGTATGGCGCGCTCT
ATGATGCCGCGCATGTCGGATGGAAATTCCCCGTCCGCGCGCTTGAGGACGACCTCATCAAGCCGGACATGCCCTTCGCC
TTCTACGGCCCGACCTGCGACGATGCCGACTACATGGAAGGGCCGTTCAACCTGCCCGAAGACATCCAGGCCGGTGATTA
TATCGAAGTGGGCATGCTCGGCGCTTACGGAGCGGCGATGAAGACCGGCTTCAACGGCTTCGGCAATGCCGAGCAGATCG
TGGTGGAGGACGAACCTATGGCCAGCCTGTACCGCGGCGATCGCGAACTGCCGGTCAGCGACAACGTAGTGAGCCTGCGC
TGA

Upstream 100 bases:

>100_bases
CAGACCCCTCATAACCCTAGGGCGCGCGTTCCGCTGCCCCAGGGGGTCCTTAACCGCAAGGCAGCCTTGTTCAGAACTTA
CCTTCTGGGGGTCCCTTGAG

Downstream 100 bases:

>100_bases
TGCGCTTCCCGGCATTGTCGCTGGCGACTTCTTTCCTGTTCACGATCATCTCGCCAGCCGCAGCGGCCGCGGCACCGGTC
ATCTCCACGGACCATACAGT

Product: diaminopimelate/ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MHTFPDAKSVIRALAPDEPVILNRPHAAQRAARFFVEKFPGKVLYAVKANPSPDLLQILRASGVTHYDVASIAEVRLVRD
ALPDAVLCFMHPVKTPRAIAEAYHQHGVRTFSLDTEEELAKIVEACSDAQGNPAKDLKLCVRIRVSSDYSELSLASKFGC
DLTEAPALLQLARQHCDWLGVCFHVGSQAMTPFAYVQAIERVRAAIADASVVIDMIDVGGGFPSVYPGMEPPPLEDYFAI
IHKHFEALPIAYNAELWCEPGRALCAEYSSLTVRVDKRRGEELYINDGAYGALYDAAHVGWKFPVRALEDDLIKPDMPFA
FYGPTCDDADYMEGPFNLPEDIQAGDYIEVGMLGAYGAAMKTGFNGFGNAEQIVVEDEPMASLYRGDRELPVSDNVVSLR

Sequences:

>Translated_400_residues
MHTFPDAKSVIRALAPDEPVILNRPHAAQRAARFFVEKFPGKVLYAVKANPSPDLLQILRASGVTHYDVASIAEVRLVRD
ALPDAVLCFMHPVKTPRAIAEAYHQHGVRTFSLDTEEELAKIVEACSDAQGNPAKDLKLCVRIRVSSDYSELSLASKFGC
DLTEAPALLQLARQHCDWLGVCFHVGSQAMTPFAYVQAIERVRAAIADASVVIDMIDVGGGFPSVYPGMEPPPLEDYFAI
IHKHFEALPIAYNAELWCEPGRALCAEYSSLTVRVDKRRGEELYINDGAYGALYDAAHVGWKFPVRALEDDLIKPDMPFA
FYGPTCDDADYMEGPFNLPEDIQAGDYIEVGMLGAYGAAMKTGFNGFGNAEQIVVEDEPMASLYRGDRELPVSDNVVSLR
>Mature_400_residues
MHTFPDAKSVIRALAPDEPVILNRPHAAQRAARFFVEKFPGKVLYAVKANPSPDLLQILRASGVTHYDVASIAEVRLVRD
ALPDAVLCFMHPVKTPRAIAEAYHQHGVRTFSLDTEEELAKIVEACSDAQGNPAKDLKLCVRIRVSSDYSELSLASKFGC
DLTEAPALLQLARQHCDWLGVCFHVGSQAMTPFAYVQAIERVRAAIADASVVIDMIDVGGGFPSVYPGMEPPPLEDYFAI
IHKHFEALPIAYNAELWCEPGRALCAEYSSLTVRVDKRRGEELYINDGAYGALYDAAHVGWKFPVRALEDDLIKPDMPFA
FYGPTCDDADYMEGPFNLPEDIQAGDYIEVGMLGAYGAAMKTGFNGFGNAEQIVVEDEPMASLYRGDRELPVSDNVVSLR

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=363, Percent_Identity=31.129476584022, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI16506287, Length=360, Percent_Identity=27.7777777777778, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI22538418, Length=359, Percent_Identity=25.9052924791086, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI21361583, Length=359, Percent_Identity=25.9052924791086, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562780, Length=370, Percent_Identity=30, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322664, Length=388, Percent_Identity=27.0618556701031, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24586472, Length=363, Percent_Identity=27.5482093663912, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24586474, Length=341, Percent_Identity=26.6862170087977, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 43988; Mature: 43988

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTFPDAKSVIRALAPDEPVILNRPHAAQRAARFFVEKFPGKVLYAVKANPSPDLLQILR
CCCCCCHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHH
ASGVTHYDVASIAEVRLVRDALPDAVLCFMHPVKTPRAIAEAYHQHGVRTFSLDTEEELA
HCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCCHHHHH
KIVEACSDAQGNPAKDLKLCVRIRVSSDYSELSLASKFGCDLTEAPALLQLARQHCDWLG
HHHHHHCCCCCCCHHHEEEEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
VCFHVGSQAMTPFAYVQAIERVRAAIADASVVIDMIDVGGGFPSVYPGMEPPPLEDYFAI
HHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCCCCHHHHHHH
IHKHFEALPIAYNAELWCEPGRALCAEYSSLTVRVDKRRGEELYINDGAYGALYDAAHVG
HHHHHHHCCEEECCCEEECCCHHHHHCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHCC
WKFPVRALEDDLIKPDMPFAFYGPTCDDADYMEGPFNLPEDIQAGDYIEVGMLGAYGAAM
CCCCHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHH
KTGFNGFGNAEQIVVEDEPMASLYRGDRELPVSDNVVSLR
HCCCCCCCCCCEEEECCCCHHHHHCCCCCCCCCCCCEECC
>Mature Secondary Structure
MHTFPDAKSVIRALAPDEPVILNRPHAAQRAARFFVEKFPGKVLYAVKANPSPDLLQILR
CCCCCCHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHH
ASGVTHYDVASIAEVRLVRDALPDAVLCFMHPVKTPRAIAEAYHQHGVRTFSLDTEEELA
HCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCCHHHHH
KIVEACSDAQGNPAKDLKLCVRIRVSSDYSELSLASKFGCDLTEAPALLQLARQHCDWLG
HHHHHHCCCCCCCHHHEEEEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
VCFHVGSQAMTPFAYVQAIERVRAAIADASVVIDMIDVGGGFPSVYPGMEPPPLEDYFAI
HHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCCCCHHHHHHH
IHKHFEALPIAYNAELWCEPGRALCAEYSSLTVRVDKRRGEELYINDGAYGALYDAAHVG
HHHHHHHCCEEECCCEEECCCHHHHHCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHCC
WKFPVRALEDDLIKPDMPFAFYGPTCDDADYMEGPFNLPEDIQAGDYIEVGMLGAYGAAM
CCCCHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHH
KTGFNGFGNAEQIVVEDEPMASLYRGDRELPVSDNVVSLR
HCCCCCCCCCCEEEECCCCHHHHHCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]