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The map label for this gene is mco [H]

Identifier: 85373730

GI number: 85373730

Start: 936907

End: 938415

Strand: Direct

Name: mco [H]

Synonym: ELI_04515

Alternate gene names: 85373730

Gene position: 936907-938415 (Clockwise)

Preceding gene: 85373729

Following gene: 85373731

Centisome position: 30.69

GC content: 60.37

Gene sequence:

>1509_bases
GTGGACCGCCGCACACTGATCAAAAGCGCTGGTTTTGCTGCTGCAGGCTTTGCCGCGTTCCCGCTTGCGGGATGCAAAGC
GCAAGACGCATCGATGCTGGACAGCACTGACGGATCCAATTTGCTCGCTATACCGCCCTTGCAGCGTGGCGAGATTGAGC
AGGGCGCACGGGTTTTCCGCTTGTCTTTGACCCCAGGCCAGAAGGAATTCGTCACCGGTGTTGCTTCGCCCACCATCGGC
ATCGACGCACCCTATCTGGGACCGACGCTGGAAATGCGCCGGGGCGAGTGGGTGCAGTTCCATATCGACAACAAGCTGGC
CGAAGGCGCTACGGTCCATTGGCATGGTTTCGAACTTCCTGCCGCAGCCGATGGCGGACCGCATCAGTTGATCCGTCCCG
GCGAACGCTGGAGGCCTTCTTTCCAAGTTCGCCAGCGGGCTTCGCTCTACTGGTATCATTCACACTTGGAGCGCGGAGCC
GGGCCGCAGGTCTATGCCGGGCTCGCCGCGCCGATCTATGTTCGCGACGACGAGGAAGAGCGCCTCGACTTGCCGAGCGA
CTATGGCGTCGACGACATTCCGCTGATCGTGCAGGACCGCGTGATCGATGGATCCGGCCGCTTGGTGTACCCGCTGAGTA
TGCACGCGCGGATGATGGGCGTGCGCGGGAGCCGGATATTCGTCAACGGCACTGAAAACGCTGTGTTCGACGCACAGACA
GGCCAATTGCGGCTGCGCATCCTCAATGGATCGAACGCCCGCCTTTACGATTTTTCGCTCGAAGGTGATCGTTCGATGCA
ACTGATCGCGAGCGATGGCGGCTTGCTCGATCGTTCGCACATCGTCCGCTCGGTCAGGCTCGCCCCGGGGGAGCGCGCGC
AGGTAATTATCGATCTCTCGGAAGGACGCCCGCTTCGCCTTCTTGCCAGCAGTCCCGAAAACGCCATGGGCATGATGGGC
GGACGCGGAATGATGGGCGGCGGGATGATGGGGCGCGGCGATAGCGGCGATGCTTCCGCAGACGTGTTTCAAATCCTCGA
TATCAGGCCGGCAAGTTCGGCCCAGCGCATCAGGGTGCCGACACAACTGGCATCGCTTGCTCCAACCGACCCGTCGTCAG
CCGTCCGAACCCGGCGTTTCGTTCTCGACATGGGCATGATGGGCGGCGGAATGTCCATTAACGGTGCTGCGATGGACATG
AATGTGATCAACGAACGTGTGCCAGTCGGCCAATGGGAAATCTGGGAGATCGCCAACGCTTCGATGATGGCCCACCCGTT
TCATATCCATAACGTCCAGTTTCGTGTGATCGACCGCGATGGCCGAGCGCCCCCACCATTGGAAACCAGTTTGAAGGATA
CCGTGATCGTCAACCCGCGCGAGCAGGTACGCCTTCTCCTGCGTTTTGAAGAACACACCGACCCAGACCTGCCCTACATG
TATCACTGCCACATTCTCGAACACGAGGATGCAGGCATGATGGGGCAGTTCGTAGTCGTGAAGAGCTAG

Upstream 100 bases:

>100_bases
AGGAGTAAATCGGTTGGGCGGTGCCAGGCAAATCTGGTGCCGCCCATCGCGAAACAGGAGGAGCATGATCCGGACACCCC
GCATAACCCAGGCATTCCCC

Downstream 100 bases:

>100_bases
GAAGGACAGGCGATGAGCAAGGACCAGAGTGTGATCGAGGGTACCGCGATCGACCCGGTATGCGGCATGAGCGTTGCAAT
CGACGGGGCTCAGCATATCG

Product: putative oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MDRRTLIKSAGFAAAGFAAFPLAGCKAQDASMLDSTDGSNLLAIPPLQRGEIEQGARVFRLSLTPGQKEFVTGVASPTIG
IDAPYLGPTLEMRRGEWVQFHIDNKLAEGATVHWHGFELPAAADGGPHQLIRPGERWRPSFQVRQRASLYWYHSHLERGA
GPQVYAGLAAPIYVRDDEEERLDLPSDYGVDDIPLIVQDRVIDGSGRLVYPLSMHARMMGVRGSRIFVNGTENAVFDAQT
GQLRLRILNGSNARLYDFSLEGDRSMQLIASDGGLLDRSHIVRSVRLAPGERAQVIIDLSEGRPLRLLASSPENAMGMMG
GRGMMGGGMMGRGDSGDASADVFQILDIRPASSAQRIRVPTQLASLAPTDPSSAVRTRRFVLDMGMMGGGMSINGAAMDM
NVINERVPVGQWEIWEIANASMMAHPFHIHNVQFRVIDRDGRAPPPLETSLKDTVIVNPREQVRLLLRFEEHTDPDLPYM
YHCHILEHEDAGMMGQFVVVKS

Sequences:

>Translated_502_residues
MDRRTLIKSAGFAAAGFAAFPLAGCKAQDASMLDSTDGSNLLAIPPLQRGEIEQGARVFRLSLTPGQKEFVTGVASPTIG
IDAPYLGPTLEMRRGEWVQFHIDNKLAEGATVHWHGFELPAAADGGPHQLIRPGERWRPSFQVRQRASLYWYHSHLERGA
GPQVYAGLAAPIYVRDDEEERLDLPSDYGVDDIPLIVQDRVIDGSGRLVYPLSMHARMMGVRGSRIFVNGTENAVFDAQT
GQLRLRILNGSNARLYDFSLEGDRSMQLIASDGGLLDRSHIVRSVRLAPGERAQVIIDLSEGRPLRLLASSPENAMGMMG
GRGMMGGGMMGRGDSGDASADVFQILDIRPASSAQRIRVPTQLASLAPTDPSSAVRTRRFVLDMGMMGGGMSINGAAMDM
NVINERVPVGQWEIWEIANASMMAHPFHIHNVQFRVIDRDGRAPPPLETSLKDTVIVNPREQVRLLLRFEEHTDPDLPYM
YHCHILEHEDAGMMGQFVVVKS
>Mature_502_residues
MDRRTLIKSAGFAAAGFAAFPLAGCKAQDASMLDSTDGSNLLAIPPLQRGEIEQGARVFRLSLTPGQKEFVTGVASPTIG
IDAPYLGPTLEMRRGEWVQFHIDNKLAEGATVHWHGFELPAAADGGPHQLIRPGERWRPSFQVRQRASLYWYHSHLERGA
GPQVYAGLAAPIYVRDDEEERLDLPSDYGVDDIPLIVQDRVIDGSGRLVYPLSMHARMMGVRGSRIFVNGTENAVFDAQT
GQLRLRILNGSNARLYDFSLEGDRSMQLIASDGGLLDRSHIVRSVRLAPGERAQVIIDLSEGRPLRLLASSPENAMGMMG
GRGMMGGGMMGRGDSGDASADVFQILDIRPASSAQRIRVPTQLASLAPTDPSSAVRTRRFVLDMGMMGGGMSINGAAMDM
NVINERVPVGQWEIWEIANASMMAHPFHIHNVQFRVIDRDGRAPPPLETSLKDTVIVNPREQVRLLLRFEEHTDPDLPYM
YHCHILEHEDAGMMGQFVVVKS

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=489, Percent_Identity=32.9243353783231, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI1789394, Length=507, Percent_Identity=28.9940828402367, Blast_Score=204, Evalue=1e-53,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 55167; Mature: 55167

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRRTLIKSAGFAAAGFAAFPLAGCKAQDASMLDSTDGSNLLAIPPLQRGEIEQGARVFR
CCCHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHCCCCCCCEEEECCCCCCCCCCCCEEEE
LSLTPGQKEFVTGVASPTIGIDAPYLGPTLEMRRGEWVQFHIDNKLAEGATVHWHGFELP
EEECCCCHHHHEECCCCCCCCCCCCCCCCEEECCCCEEEEEECCCCCCCCEEEEECEECC
AAADGGPHQLIRPGERWRPSFQVRQRASLYWYHSHLERGAGPQVYAGLAAPIYVRDDEEE
CCCCCCCHHHCCCCHHCCCCHHHHHCCEEEEEEHHHHCCCCCEEEECCEEEEEEECCCHH
RLDLPSDYGVDDIPLIVQDRVIDGSGRLVYPLSMHARMMGVRGSRIFVNGTENAVFDAQT
HCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCEEEECCCCCEEEEECCCCEEEECCC
GQLRLRILNGSNARLYDFSLEGDRSMQLIASDGGLLDRSHIVRSVRLAPGERAQVIIDLS
CEEEEEEEECCCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHEEECCCCCCEEEEEECC
EGRPLRLLASSPENAMGMMGGRGMMGGGMMGRGDSGDASADVFQILDIRPASSAQRIRVP
CCCEEEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEECC
TQLASLAPTDPSSAVRTRRFVLDMGMMGGGMSINGAAMDMNVINERVPVGQWEIWEIANA
HHHHHCCCCCCHHHHHHHHEEEECCCCCCCCEECCEEEEHHHHHCCCCCCCEEEEEECCC
SMMAHPFHIHNVQFRVIDRDGRAPPPLETSLKDTVIVNPREQVRLLLRFEEHTDPDLPYM
CEEECCEEEEEEEEEEEECCCCCCCCCCCCCCCEEEECCHHHEEEEEEECCCCCCCCCEE
YHCHILEHEDAGMMGQFVVVKS
EEEEEEEECCCCCCEEEEEEEC
>Mature Secondary Structure
MDRRTLIKSAGFAAAGFAAFPLAGCKAQDASMLDSTDGSNLLAIPPLQRGEIEQGARVFR
CCCHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHCCCCCCCEEEECCCCCCCCCCCCEEEE
LSLTPGQKEFVTGVASPTIGIDAPYLGPTLEMRRGEWVQFHIDNKLAEGATVHWHGFELP
EEECCCCHHHHEECCCCCCCCCCCCCCCCEEECCCCEEEEEECCCCCCCCEEEEECEECC
AAADGGPHQLIRPGERWRPSFQVRQRASLYWYHSHLERGAGPQVYAGLAAPIYVRDDEEE
CCCCCCCHHHCCCCHHCCCCHHHHHCCEEEEEEHHHHCCCCCEEEECCEEEEEEECCCHH
RLDLPSDYGVDDIPLIVQDRVIDGSGRLVYPLSMHARMMGVRGSRIFVNGTENAVFDAQT
HCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCEEEECCCCCEEEEECCCCEEEECCC
GQLRLRILNGSNARLYDFSLEGDRSMQLIASDGGLLDRSHIVRSVRLAPGERAQVIIDLS
CEEEEEEEECCCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHEEECCCCCCEEEEEECC
EGRPLRLLASSPENAMGMMGGRGMMGGGMMGRGDSGDASADVFQILDIRPASSAQRIRVP
CCCEEEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEECC
TQLASLAPTDPSSAVRTRRFVLDMGMMGGGMSINGAAMDMNVINERVPVGQWEIWEIANA
HHHHHCCCCCCHHHHHHHHEEEECCCCCCCCEECCEEEEHHHHHCCCCCCCEEEEEECCC
SMMAHPFHIHNVQFRVIDRDGRAPPPLETSLKDTVIVNPREQVRLLLRFEEHTDPDLPYM
CEEECCEEEEEEEEEEEECCCCCCCCCCCCCCCEEEECCHHHEEEEEEECCCCCCCCCEE
YHCHILEHEDAGMMGQFVVVKS
EEEEEEEECCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA