Click here to switch to the map view.

The map label for this gene is yhcV [H]

Identifier: 85373724

GI number: 85373724

Start: 929475

End: 929918

Strand: Direct

Name: yhcV [H]

Synonym: ELI_04485

Alternate gene names: 85373724

Gene position: 929475-929918 (Clockwise)

Preceding gene: 85373723

Following gene: 85373725

Centisome position: 30.45

GC content: 52.7

Gene sequence:

>444_bases
ATGGAAGCCAAGAATGTGATGACCTCGAATCCTGCATGCTGCAATCCTTCGACCAGTGTACGGGAGGCCGCTAATCTCAT
GGTGAAAAACGACTGCGGCGAAATTCCGGTTGTAGATGATTCCGGCACACTTGTCGGTGTGATTACCGATCGTGACATTG
CTTGTCGCTGCGTTGCAGACGGCAAGTCTTCTGACACGTCGGTAGAAGACGTGATGACAAGCTCTCCGATTACTGTGACA
CCCGACACGAGTGTCGATGATTGTCGCAGCAAAATGGAGGACAACAAAGTTCGGCGGCTTCCTGTTGTGGACGAGAGTGG
CAAATGTTGCGGCATCGTTTCACAAGCCGACATTGCTCGGCATGCGAACGAAAAAGAGACCGGCGATCTGGTGCGTGAGG
TATCGGAACCCACCGAGGAAGCGTCAAAGTCAGGTTGCTGTTAG

Upstream 100 bases:

>100_bases
ATCGATTTCATCCGGAAATGCGAGAGGAACATTATCCGGCGCCTCGCCGTTGCAATGGTACGCAAATATTCAGGTATTTA
ATAGAAATTGGAGACATATC

Downstream 100 bases:

>100_bases
GCAAATTTGGGCAATAGGTTTGGGCTTCGGGTTTGCTGAAGCGAAAACATAAATCTGGCCTTTGTCTTCAGCCTGATAAC
CGACTTGCACGTCGTATGCG

Product: CBS

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 147; Mature: 147

Protein sequence:

>147_residues
MEAKNVMTSNPACCNPSTSVREAANLMVKNDCGEIPVVDDSGTLVGVITDRDIACRCVADGKSSDTSVEDVMTSSPITVT
PDTSVDDCRSKMEDNKVRRLPVVDESGKCCGIVSQADIARHANEKETGDLVREVSEPTEEASKSGCC

Sequences:

>Translated_147_residues
MEAKNVMTSNPACCNPSTSVREAANLMVKNDCGEIPVVDDSGTLVGVITDRDIACRCVADGKSSDTSVEDVMTSSPITVT
PDTSVDDCRSKMEDNKVRRLPVVDESGKCCGIVSQADIARHANEKETGDLVREVSEPTEEASKSGCC
>Mature_147_residues
MEAKNVMTSNPACCNPSTSVREAANLMVKNDCGEIPVVDDSGTLVGVITDRDIACRCVADGKSSDTSVEDVMTSSPITVT
PDTSVDDCRSKMEDNKVRRLPVVDESGKCCGIVSQADIARHANEKETGDLVREVSEPTEEASKSGCC

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0517

COG function: function code R; FOG: CBS domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

None

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644 [H]

Pfam domain/function: PF00571 CBS [H]

EC number: 1.1.1.205

Molecular weight: Translated: 15588; Mature: 15588

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

6.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
10.2 %Cys+Met (Translated Protein)
6.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
10.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAKNVMTSNPACCNPSTSVREAANLMVKNDCGEIPVVDDSGTLVGVITDRDIACRCVAD
CCCCCCCCCCCCCCCCCCHHHHHHHEEECCCCCCCCEECCCCCEEEEEECCCEEEEEEEC
GKSSDTSVEDVMTSSPITVTPDTSVDDCRSKMEDNKVRRLPVVDESGKCCGIVSQADIAR
CCCCCCCHHHHHCCCCEEECCCCCHHHHHHHHHCCCEEECCCCCCCCCEEEECCHHHHHH
HANEKETGDLVREVSEPTEEASKSGCC
HCCCCHHHHHHHHHHCHHHHHHCCCCC
>Mature Secondary Structure
MEAKNVMTSNPACCNPSTSVREAANLMVKNDCGEIPVVDDSGTLVGVITDRDIACRCVAD
CCCCCCCCCCCCCCCCCCHHHHHHHEEECCCCCCCCEECCCCCEEEEEECCCEEEEEEEC
GKSSDTSVEDVMTSSPITVTPDTSVDDCRSKMEDNKVRRLPVVDESGKCCGIVSQADIAR
CCCCCCCHHHHHCCCCEEECCCCCHHHHHHHHHCCCEEECCCCCCCCCEEEECCHHHHHH
HANEKETGDLVREVSEPTEEASKSGCC
HCCCCHHHHHHHHHHCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969498; 9384377 [H]