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The map label for this gene is czcD [H]

Identifier: 85373709

GI number: 85373709

Start: 910103

End: 911056

Strand: Reverse

Name: czcD [H]

Synonym: ELI_04410

Alternate gene names: 85373709

Gene position: 911056-910103 (Counterclockwise)

Preceding gene: 85373710

Following gene: 85373708

Centisome position: 29.85

GC content: 58.07

Gene sequence:

>954_bases
ATGGCGCACTCGCACGATCAAGCTGGCCACAGTCACGGCGAGGAAAACCTTAGCGATCGTCAGCTGATCCTCGCGGTCGC
GATCAATGTCCTCCTGACCCTTGCCCAGATTGTCGGCGGCATCCTTTCAGGGTCACTGGCGCTTATCGCGGATGCATTGC
ACAACTTCAGCGATGCGGCCTCTCTTGGTCTTGCGTGGTTTGCGCGACGCATAGGCCGGCGTCCGGCGGACAAGCTGATG
ACCTTCGGCTACGCCCAGGGAGAAGTGGTCGCCGCACTCATCAATCTGACGACCTTGCTGATCATCGGATTCTATCTGAT
CGTTGAGGCGATCAACCGTTTCGCCGCGCCGCAGCCGGTCGAAGGCTGGACCGTGATCTGGGTTGCCGGGATCGCACTTG
TCATCGATCTCGTCACCGCATTCATTGTCTATCGCGGCGCGCATGACAGCATTAACATGAAGGCTGCCTTCCTTCATAAC
GTTTCGGACGCGCTGGCCTCGATCGGTGTGATCGTCGCCGGAGTGCTAATTATTCTATACGATCTCGTCGTCGCCGATCT
CATCATCACTCTCATCATCGCGGCCTATGTCATCTGGCAGGGCGCGACGCTCCTACCGCGAACCGTTCGTCTGCTGATGG
GAGCAGTGCCGGACGAGGTGGAATTTGATCAGATGGTTGAAAACCTGCGCGCGCTTGGCGGCGTGCAGGATATTCACCAC
GTCCATGTCTGGAATCTGGGAGAACATCACCGGGCGCTCGAAGCCCATCTCACTCTTGTTGATTACTCCCAAACAGCATT
CGAGGGAGTCAAGCGACGCGCGCGGGCGATGCTGGAAAAGGATTTCGGCATCGCACATGTCACTTTCGAGCCCTGCCTCG
CTACGGACTGCGATGATGCGCTGATCCCTGCCCACCCGGCACCCAACAACGGGAAAAACACGGTCGGTGATTAA

Upstream 100 bases:

>100_bases
TCGGATTTAACGCCGCGATCGGAGCAATCGATAATTCCGATGCGATCCTTCAGCATCCGGATACCGCCGGCAACAAAATC
GCAAATAGCGGAGAAAAGTG

Downstream 100 bases:

>100_bases
GCTTTCGCTGGCCTGTTCCTGCCCGGCCGTTCGCAGACCCTGAGCCCTCATCGCGCGCCGGTCGCGGACGGTATTGCAGT
CCAGAACCGATGCACCGCGA

Product: cation efflux system protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MAHSHDQAGHSHGEENLSDRQLILAVAINVLLTLAQIVGGILSGSLALIADALHNFSDAASLGLAWFARRIGRRPADKLM
TFGYAQGEVVAALINLTTLLIIGFYLIVEAINRFAAPQPVEGWTVIWVAGIALVIDLVTAFIVYRGAHDSINMKAAFLHN
VSDALASIGVIVAGVLIILYDLVVADLIITLIIAAYVIWQGATLLPRTVRLLMGAVPDEVEFDQMVENLRALGGVQDIHH
VHVWNLGEHHRALEAHLTLVDYSQTAFEGVKRRARAMLEKDFGIAHVTFEPCLATDCDDALIPAHPAPNNGKNTVGD

Sequences:

>Translated_317_residues
MAHSHDQAGHSHGEENLSDRQLILAVAINVLLTLAQIVGGILSGSLALIADALHNFSDAASLGLAWFARRIGRRPADKLM
TFGYAQGEVVAALINLTTLLIIGFYLIVEAINRFAAPQPVEGWTVIWVAGIALVIDLVTAFIVYRGAHDSINMKAAFLHN
VSDALASIGVIVAGVLIILYDLVVADLIITLIIAAYVIWQGATLLPRTVRLLMGAVPDEVEFDQMVENLRALGGVQDIHH
VHVWNLGEHHRALEAHLTLVDYSQTAFEGVKRRARAMLEKDFGIAHVTFEPCLATDCDDALIPAHPAPNNGKNTVGD
>Mature_316_residues
AHSHDQAGHSHGEENLSDRQLILAVAINVLLTLAQIVGGILSGSLALIADALHNFSDAASLGLAWFARRIGRRPADKLMT
FGYAQGEVVAALINLTTLLIIGFYLIVEAINRFAAPQPVEGWTVIWVAGIALVIDLVTAFIVYRGAHDSINMKAAFLHNV
SDALASIGVIVAGVLIILYDLVVADLIITLIIAAYVIWQGATLLPRTVRLLMGAVPDEVEFDQMVENLRALGGVQDIHHV
HVWNLGEHHRALEAHLTLVDYSQTAFEGVKRRARAMLEKDFGIAHVTFEPCLATDCDDALIPAHPAPNNGKNTVGD

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=304, Percent_Identity=26.9736842105263, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI21361112, Length=297, Percent_Identity=27.9461279461279, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI289803013, Length=321, Percent_Identity=26.1682242990654, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI289803009, Length=321, Percent_Identity=26.1682242990654, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI289803007, Length=321, Percent_Identity=26.1682242990654, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI289803003, Length=321, Percent_Identity=26.1682242990654, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI21359890, Length=311, Percent_Identity=24.1157556270096, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI64762489, Length=321, Percent_Identity=26.1682242990654, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI20070323, Length=273, Percent_Identity=24.1758241758242, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI14210520, Length=216, Percent_Identity=22.6851851851852, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI52351208, Length=124, Percent_Identity=33.0645161290323, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786966, Length=289, Percent_Identity=30.7958477508651, Blast_Score=117, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI193210990, Length=311, Percent_Identity=29.5819935691318, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17555794, Length=307, Percent_Identity=29.3159609120521, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17555796, Length=309, Percent_Identity=29.4498381877023, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI32564488, Length=300, Percent_Identity=22.6666666666667, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323899, Length=134, Percent_Identity=30.5970149253731, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324892, Length=149, Percent_Identity=30.2013422818792, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320411, Length=170, Percent_Identity=32.3529411764706, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24583858, Length=369, Percent_Identity=22.7642276422764, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24585900, Length=125, Percent_Identity=33.6, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585898, Length=125, Percent_Identity=33.6, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585896, Length=125, Percent_Identity=33.6, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921672, Length=125, Percent_Identity=33.6, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24584409, Length=135, Percent_Identity=31.1111111111111, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574430, Length=135, Percent_Identity=31.1111111111111, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34226; Mature: 34095

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AHSHDQAGHSHGEENLSDRQLILAVAINVLLTLAQIVGGILSGSLALIADALHNFSDAA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLGLAWFARRIGRRPADKLMTFGYAQGEVVAALINLTTLLIIGFYLIVEAINRFAAPQPV
HHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EGWTVIWVAGIALVIDLVTAFIVYRGAHDSINMKAAFLHNVSDALASIGVIVAGVLIILY
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLVVADLIITLIIAAYVIWQGATLLPRTVRLLMGAVPDEVEFDQMVENLRALGGVQDIHH
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHH
VHVWNLGEHHRALEAHLTLVDYSQTAFEGVKRRARAMLEKDFGIAHVTFEPCLATDCDDA
EEEECCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHCCCCCCC
LIPAHPAPNNGKNTVGD
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]