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The map label for this gene is degP [H]

Identifier: 85373654

GI number: 85373654

Start: 854769

End: 855767

Strand: Direct

Name: degP [H]

Synonym: ELI_04135

Alternate gene names: 85373654

Gene position: 854769-855767 (Clockwise)

Preceding gene: 85373651

Following gene: 85373660

Centisome position: 28.0

GC content: 60.36

Gene sequence:

>999_bases
ATGGTCACTCCGCGTGGAGACCTAGCTGCAGACGAACGCGCCAATATTGACCTGTTCCGCAATGCCCGAGAGTCCGTCGT
CTTCATATCGACACGGCAGCGAGTTGCCGATTTCTGGACACGTAATGTCTACAGCGTCCCGCGCGGGTCGGGTTCGGGCC
TCGTATGGGATGAGGCTGGCCATATCCTCACCAATTATCATGTCATCGAGGGTGCATCAGAAGCGCAAATACAGCTTGCT
GACGGTCGCCAGTTTTCCGCCACACTGGTGGGTACGAGCCCACAGCACGACCTTGCTGTTTTGAAGATCGGCGGTGCAGG
TTTCACAGCGCCCGCTCGGGTCCCCATAGGCACGAGCAATGATCTGCAAGTCGGGCAGAATGTCTTCGCGATTGGAAACC
CGTTCGGCCTAGACTGGACCCTGACTAAAGGGATCGTCTCGGCACTGGATCGCTCGCTGCCTAACGAGAACGGCCCCGAC
ATTCGCAACCTGATCCAGACCGATGCGGCCATCAACCCAGGCAATTCGGGCGGTCCGCTGCTAGATTCAGCGGGCAGACT
GATCGGGATCAATACCGCAATCTACAGTCCCTCTGGGGCATCGGCAGGCATCGGTTTTGCCGTACCGGTCGACACGGTCA
TGCGGGTTGTGCCGCAACTGATTTCTGAGGGGCGCTATACGCGGCCCAGCCTTGGCCTTGAAAGCGATGACGATATCAAC
GACCGGCTCAAGCGCGCTTCGGGGATCGAAGGGGTTTTTGTCCTGCGGGTCGATCCCGGGTCATCAGCGGATCGCGCCGG
TCTGGTTGCTGCCCAGCGCACGAGGCGCGGCGTCGCTCCAGGGGACATCGTTACCGCTTTGAACGGCAAACCCGTTTCGA
GAGTCGGCGATCTGCTCGCTCGGCTTGACGACTTTCGGGTCGGGCAAAGCGTCGTACTCACGCTGATGCGGGGCGGCGCA
GAGCGAACGGTAAGGCTCGAACTCGAGCCGGGAAGCTGA

Upstream 100 bases:

>100_bases
GCGTCCATGGATAGTGGGTTTGATCATAATGAATGGGCTCCTCTTAGCTGCAACAGTGTCGTTAATCTTCATCCAGTCGG
CTCCAGTGGCCGAGCCACGG

Downstream 100 bases:

>100_bases
TGCACGAAGAAGGGCCGGTCCCATTGGTGAGACCGGCCCTCATGGCTGCCATTAACCGGCGTTTATCGGGAACGTCTTGC
GTCCCTTTGTCGCTTCTGCG

Product: serine protease, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MVTPRGDLAADERANIDLFRNARESVVFISTRQRVADFWTRNVYSVPRGSGSGLVWDEAGHILTNYHVIEGASEAQIQLA
DGRQFSATLVGTSPQHDLAVLKIGGAGFTAPARVPIGTSNDLQVGQNVFAIGNPFGLDWTLTKGIVSALDRSLPNENGPD
IRNLIQTDAAINPGNSGGPLLDSAGRLIGINTAIYSPSGASAGIGFAVPVDTVMRVVPQLISEGRYTRPSLGLESDDDIN
DRLKRASGIEGVFVLRVDPGSSADRAGLVAAQRTRRGVAPGDIVTALNGKPVSRVGDLLARLDDFRVGQSVVLTLMRGGA
ERTVRLELEPGS

Sequences:

>Translated_332_residues
MVTPRGDLAADERANIDLFRNARESVVFISTRQRVADFWTRNVYSVPRGSGSGLVWDEAGHILTNYHVIEGASEAQIQLA
DGRQFSATLVGTSPQHDLAVLKIGGAGFTAPARVPIGTSNDLQVGQNVFAIGNPFGLDWTLTKGIVSALDRSLPNENGPD
IRNLIQTDAAINPGNSGGPLLDSAGRLIGINTAIYSPSGASAGIGFAVPVDTVMRVVPQLISEGRYTRPSLGLESDDDIN
DRLKRASGIEGVFVLRVDPGSSADRAGLVAAQRTRRGVAPGDIVTALNGKPVSRVGDLLARLDDFRVGQSVVLTLMRGGA
ERTVRLELEPGS
>Mature_332_residues
MVTPRGDLAADERANIDLFRNARESVVFISTRQRVADFWTRNVYSVPRGSGSGLVWDEAGHILTNYHVIEGASEAQIQLA
DGRQFSATLVGTSPQHDLAVLKIGGAGFTAPARVPIGTSNDLQVGQNVFAIGNPFGLDWTLTKGIVSALDRSLPNENGPD
IRNLIQTDAAINPGNSGGPLLDSAGRLIGINTAIYSPSGASAGIGFAVPVDTVMRVVPQLISEGRYTRPSLGLESDDDIN
DRLKRASGIEGVFVLRVDPGSSADRAGLVAAQRTRRGVAPGDIVTALNGKPVSRVGDLLARLDDFRVGQSVVLTLMRGGA
ERTVRLELEPGS

Specific function: Serine protease that is required at high temperature. Involved in the degradation of damaged proteins. Shared specificity with hhoA/degQ [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=276, Percent_Identity=34.4202898550725, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4506141, Length=302, Percent_Identity=31.4569536423841, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI24308541, Length=302, Percent_Identity=30.794701986755, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI7019477, Length=347, Percent_Identity=29.3948126801153, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1786356, Length=287, Percent_Identity=42.5087108013937, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI1789629, Length=286, Percent_Identity=42.6573426573427, Blast_Score=187, Evalue=8e-49,
Organism=Escherichia coli, GI1789630, Length=334, Percent_Identity=33.2335329341317, Blast_Score=146, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24646839, Length=337, Percent_Identity=31.7507418397626, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 35070; Mature: 35070

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTPRGDLAADERANIDLFRNARESVVFISTRQRVADFWTRNVYSVPRGSGSGLVWDEAG
CCCCCCCCCCCCCCCHHHHHCCCCCEEEEECHHHHHHHHHCCCEECCCCCCCEEEECCCC
HILTNYHVIEGASEAQIQLADGRQFSATLVGTSPQHDLAVLKIGGAGFTAPARVPIGTSN
CEEEEEEEEECCCCCEEEEECCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCC
DLQVGQNVFAIGNPFGLDWTLTKGIVSALDRSLPNENGPDIRNLIQTDAAINPGNSGGPL
CHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCC
LDSAGRLIGINTAIYSPSGASAGIGFAVPVDTVMRVVPQLISEGRYTRPSLGLESDDDIN
HHCCCCEEEEEEEEECCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
DRLKRASGIEGVFVLRVDPGSSADRAGLVAAQRTRRGVAPGDIVTALNGKPVSRVGDLLA
HHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHH
RLDDFRVGQSVVLTLMRGGAERTVRLELEPGS
HHHHHCCCHHHHHHHHHCCCCEEEEEEECCCC
>Mature Secondary Structure
MVTPRGDLAADERANIDLFRNARESVVFISTRQRVADFWTRNVYSVPRGSGSGLVWDEAG
CCCCCCCCCCCCCCCHHHHHCCCCCEEEEECHHHHHHHHHCCCEECCCCCCCEEEECCCC
HILTNYHVIEGASEAQIQLADGRQFSATLVGTSPQHDLAVLKIGGAGFTAPARVPIGTSN
CEEEEEEEEECCCCCEEEEECCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCC
DLQVGQNVFAIGNPFGLDWTLTKGIVSALDRSLPNENGPDIRNLIQTDAAINPGNSGGPL
CHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCC
LDSAGRLIGINTAIYSPSGASAGIGFAVPVDTVMRVVPQLISEGRYTRPSLGLESDDDIN
HHCCCCEEEEEEEEECCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
DRLKRASGIEGVFVLRVDPGSSADRAGLVAAQRTRRGVAPGDIVTALNGKPVSRVGDLLA
HHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHH
RLDDFRVGQSVVLTLMRGGAERTVRLELEPGS
HHHHHCCCHHHHHHHHHCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1645840; 11677609 [H]