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The map label for this gene is intA [H]

Identifier: 85373628

GI number: 85373628

Start: 825653

End: 826906

Strand: Direct

Name: intA [H]

Synonym: ELI_04005

Alternate gene names: 85373628

Gene position: 825653-826906 (Clockwise)

Preceding gene: 85373627

Following gene: 85373630

Centisome position: 27.05

GC content: 55.58

Gene sequence:

>1254_bases
ATGGCCTTGAGTGAGATTCAGATCAAAAAAGCGAAGGCGGCAGAGCGCCCATACAAGCTTGCGGATGGGGAGGGTCTATT
CCTCCTTGTTCAAAAGAACGGCTCGAAGCTCTGGCGGCTGAAATACCGTTACCACGGTAAGGAGAAGCTGCTTTCTTTCG
GCGCCTATCCCGAAGTAGGAATAGCGGCAGCAAGAGAACTCAAGAAAGTTGCCAAAGGTGTGCTGGCTGAGGGCAGGGAC
CCGATGGTCCACAAACCGGGTCGGGACTTCGAAGAGGCCAAGACCTTCAGGGCGATCGCCACCATGTGGCATCAGAACAG
AGCAAGTAGTCTCGATCCCGCGCATGCGAAGCGTGTCTGGTCACGCATGGACCAGGATGTGTTTCCTGACTTGGGCGAGC
TCATGATGCATGAGATCACTCCACCAGAAGTGCTAAAGGTCATTCGGAAAATCGAAGAGCGCGGCGCGCTCGACATCAGT
CGGCGGGCAAAGCAATGTATTGGACAGGTGTTCCAGTTCGCTATTGCCAGCGGCCTTTGTGATTCCGACCCTACTGCGCA
TCTTCGCGGGGCACTGAAGCCACGGCCTCGGGTCAAGCATATGGCGAAGCTACCTCTCGCGCAGCTACCCGAGCTGATGA
TTAAGATCGGGCAATATCAAGAAGAGGGTGAGAGACGCTCCGAGATTACCCGGGCAGCATTGAATTTCGCTCTTCTTACA
TGGGTGCGGACGAAGGAGCTTCGATTCGCCAAGAAGCACGAGTTCGAAGATATGGGTGGACCTTCACCAGTATGGCGCAT
TGGCGCTGACCGGATGAAAATGGGCCGCGAGCATATCGTGCCACTGTCGCGACAAGCCGCTTCTCTTGCTCAGGATTTGA
TCAGCAAGTCCGAAGGTAAATACGTCTTTCCAGGCCAGAAGCCCAAGATGCCGCTCTCAGAGAATACGATGATCTATGGC
CTCTATCGGCTCGGTTACCACGGGCGGCAAACTGTTCACGGCTTCAGGGGTCTGGCGAGCACCTGGGCGAATGAGCAGCT
TGTCGAGGTCGGCGATCCCCCGATGTGGATCCGTCGATATCATGAAGACTGGGTCGAACTGCAATTGGCACACAGCGAAG
AAAACGAAGTTCGCGGAGCATACAATGCTGCCGAATATCTCGCTCCTCGGCGTGCAATGTTGCAGGATTGGGCAGACTTC
CTCGACTCCATCGGCGGCAAGCCGCAAAACATTGCGGTCTTGAGGGCCGCTTGA

Upstream 100 bases:

>100_bases
GCGTCCGCTTGCGTGCGCTTGCATTCGCTTGAAGCCGGATTTGGTGTGGGGGTATTTTGGGGGTATTTTCCGGGGGTAGC
GAAAAGGAGCGATACCCCCA

Downstream 100 bases:

>100_bases
CCTGCTCCTAAGCGGACACCTGACCAAGCCATTCGACGCGAAGCCGGTCGAACCCGACGACAATACCCTCTGCGGTAACT
TCAAATCCGAAGTCATCGTT

Product: cp4-like integrase protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MALSEIQIKKAKAAERPYKLADGEGLFLLVQKNGSKLWRLKYRYHGKEKLLSFGAYPEVGIAAARELKKVAKGVLAEGRD
PMVHKPGRDFEEAKTFRAIATMWHQNRASSLDPAHAKRVWSRMDQDVFPDLGELMMHEITPPEVLKVIRKIEERGALDIS
RRAKQCIGQVFQFAIASGLCDSDPTAHLRGALKPRPRVKHMAKLPLAQLPELMIKIGQYQEEGERRSEITRAALNFALLT
WVRTKELRFAKKHEFEDMGGPSPVWRIGADRMKMGREHIVPLSRQAASLAQDLISKSEGKYVFPGQKPKMPLSENTMIYG
LYRLGYHGRQTVHGFRGLASTWANEQLVEVGDPPMWIRRYHEDWVELQLAHSEENEVRGAYNAAEYLAPRRAMLQDWADF
LDSIGGKPQNIAVLRAA

Sequences:

>Translated_417_residues
MALSEIQIKKAKAAERPYKLADGEGLFLLVQKNGSKLWRLKYRYHGKEKLLSFGAYPEVGIAAARELKKVAKGVLAEGRD
PMVHKPGRDFEEAKTFRAIATMWHQNRASSLDPAHAKRVWSRMDQDVFPDLGELMMHEITPPEVLKVIRKIEERGALDIS
RRAKQCIGQVFQFAIASGLCDSDPTAHLRGALKPRPRVKHMAKLPLAQLPELMIKIGQYQEEGERRSEITRAALNFALLT
WVRTKELRFAKKHEFEDMGGPSPVWRIGADRMKMGREHIVPLSRQAASLAQDLISKSEGKYVFPGQKPKMPLSENTMIYG
LYRLGYHGRQTVHGFRGLASTWANEQLVEVGDPPMWIRRYHEDWVELQLAHSEENEVRGAYNAAEYLAPRRAMLQDWADF
LDSIGGKPQNIAVLRAA
>Mature_416_residues
ALSEIQIKKAKAAERPYKLADGEGLFLLVQKNGSKLWRLKYRYHGKEKLLSFGAYPEVGIAAARELKKVAKGVLAEGRDP
MVHKPGRDFEEAKTFRAIATMWHQNRASSLDPAHAKRVWSRMDQDVFPDLGELMMHEITPPEVLKVIRKIEERGALDISR
RAKQCIGQVFQFAIASGLCDSDPTAHLRGALKPRPRVKHMAKLPLAQLPELMIKIGQYQEEGERRSEITRAALNFALLTW
VRTKELRFAKKHEFEDMGGPSPVWRIGADRMKMGREHIVPLSRQAASLAQDLISKSEGKYVFPGQKPKMPLSENTMIYGL
YRLGYHGRQTVHGFRGLASTWANEQLVEVGDPPMWIRRYHEDWVELQLAHSEENEVRGAYNAAEYLAPRRAMLQDWADFL
DSIGGKPQNIAVLRAA

Specific function: Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome [H]

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1788974, Length=407, Percent_Identity=35.6265356265356, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI145693166, Length=411, Percent_Identity=36.0097323600973, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1788690, Length=405, Percent_Identity=34.5679012345679, Blast_Score=217, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR023109 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 47365; Mature: 47234

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSEIQIKKAKAAERPYKLADGEGLFLLVQKNGSKLWRLKYRYHGKEKLLSFGAYPEVG
CCCCHHHHHHHHHHCCCCEEECCCCEEEEEECCCCCEEEEEEECCCHHHHHHCCCCCCHH
IAAARELKKVAKGVLAEGRDPMVHKPGRDFEEAKTFRAIATMWHQNRASSLDPAHAKRVW
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
SRMDQDVFPDLGELMMHEITPPEVLKVIRKIEERGALDISRRAKQCIGQVFQFAIASGLC
HHHCHHCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
DSDPTAHLRGALKPRPRVKHMAKLPLAQLPELMIKIGQYQEEGERRSEITRAALNFALLT
CCCCHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WVRTKELRFAKKHEFEDMGGPSPVWRIGADRMKMGREHIVPLSRQAASLAQDLISKSEGK
HHHHHHHHHHHHHCHHHCCCCCCHHHCCHHHHHCCHHHCCCCHHHHHHHHHHHHHCCCCC
YVFPGQKPKMPLSENTMIYGLYRLGYHGRQTVHGFRGLASTWANEQLVEVGDPPMWIRRY
EECCCCCCCCCCCCCCEEEEHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHH
HEDWVELQLAHSEENEVRGAYNAAEYLAPRRAMLQDWADFLDSIGGKPQNIAVLRAA
HHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure 
ALSEIQIKKAKAAERPYKLADGEGLFLLVQKNGSKLWRLKYRYHGKEKLLSFGAYPEVG
CCCHHHHHHHHHHCCCCEEECCCCEEEEEECCCCCEEEEEEECCCHHHHHHCCCCCCHH
IAAARELKKVAKGVLAEGRDPMVHKPGRDFEEAKTFRAIATMWHQNRASSLDPAHAKRVW
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
SRMDQDVFPDLGELMMHEITPPEVLKVIRKIEERGALDISRRAKQCIGQVFQFAIASGLC
HHHCHHCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
DSDPTAHLRGALKPRPRVKHMAKLPLAQLPELMIKIGQYQEEGERRSEITRAALNFALLT
CCCCHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WVRTKELRFAKKHEFEDMGGPSPVWRIGADRMKMGREHIVPLSRQAASLAQDLISKSEGK
HHHHHHHHHHHHHCHHHCCCCCCHHHCCHHHHHCCHHHCCCCHHHHHHHHHHHHHCCCCC
YVFPGQKPKMPLSENTMIYGLYRLGYHGRQTVHGFRGLASTWANEQLVEVGDPPMWIRRY
EECCCCCCCCCCCCCCEEEEHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHH
HEDWVELQLAHSEENEVRGAYNAAEYLAPRRAMLQDWADFLDSIGGKPQNIAVLRAA
HHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7511583; 9278503; 9205837; 7524073 [H]