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The map label for this gene is ldh [H]

Identifier: 85373597

GI number: 85373597

Start: 796134

End: 797207

Strand: Direct

Name: ldh [H]

Synonym: ELI_03850

Alternate gene names: 85373597

Gene position: 796134-797207 (Clockwise)

Preceding gene: 85373593

Following gene: 85373598

Centisome position: 26.08

GC content: 65.83

Gene sequence:

>1074_bases
ATGAACGCGATGACGGCATTCTGGACCGAAGCGGATTACGACGATCACGAGCTGGTCCAGCTCGTGCGCGATCCCAAATC
GGGCCTGACCGCGATTATCGCGATCCATTCGACCCATCTCGGCCCGGGCGCCGGTGGCACGCGTTTCTGGCACTATCCCG
ATCCCAAGGCAGCGATGCGCGACGCGCTGCGGCTCAGCCGCGGGATGAGCTACAAGAACGCGATGGCCGGCCTGCCGATG
GGCGGCGGCAAGGCCGTGATCCTCGCCGACGAGGATCGCACCAAGTCGCCCGAGATGCTCGCCGCCTTCGGCGATGCGGT
CGAAGCGCTGGGTGGCAAATACGTGACCGCTGAGGACGTCGGCATCAGCGAAGCCGACATGGTCGCCGTTTCGCAGCGCA
CCAGCTATGTTTCGGGCCTGCCGGTCGAGGGCGAAGATTCGGCTGGCGGCGATCCCGGTCCGTTCACTGCCATGGGCATC
TATCACGGCATCAAGGCCGCTGTGGCGCACAAGCTCGGCAAGGACAGCGTCAAGGGCGTCCATGTCGCGGTGCAGGGCAC
CGGCAGCGTCGGCGGCGGCGTTGCGCGCCTGCTGGCCAAGGATGGTGCCAAGCTGACGCTCTCCGACATCCACGAAGACC
GCGCCGAAGCGCTGGCGACCGAGCTTGGCGGCAAGGCCGTCGCGCCCGATGCGATCATGAGCACGGCCTGCGACGTTTTC
AGCCCCAACGCTCTTGGCGCGATCCTCGATGACGAAGGCATTGCGCGGCTCGACTGCGCCATTGTCGCCGGCGGCGCCAA
CAACCAGTTCGCCCGCGCCAAACATGGTGCCATGCTGGCCGAGCGCGATATCCTCTACGCCCCGGATTATGTCATCAATG
CCGGCGGTATCATTAGCGTGGCGCAAGAATATCTCGACCGCCAGCAGGGCGCGTCCGGCGGCATCAACGAAGTCCGCAAG
CGCATCGCCCAGATTCCCGAGCGGCTGGTGCAGATCTGGCAAGAGAGCGAACGCAGCGGCATTTCCGCGGACGTCGTTGC
CGACCGCATGGCCCAGAAGCTCATCGGGCGGTGA

Upstream 100 bases:

>100_bases
GGTTTGTGGTACCGGAGGTCGGGGGTTCGAGACCCCTCGATCGCCCCATTTTCCCCCTCGCAACAGCACACTCTTCCACC
CCACAGCAAGGGCAGGGGCG

Downstream 100 bases:

>100_bases
CGAATAGGCCTTCGGTCTCGCTTGCAGGGGCCTGCCCGCGCGACTAGATTGCAACGCGACACGTCTCATGCACGCTTTCG
CCAATCCCAAACGCTTCCTG

Product: leucine dehydrogenase

Products: NA

Alternate protein names: LeuDH [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MNAMTAFWTEADYDDHELVQLVRDPKSGLTAIIAIHSTHLGPGAGGTRFWHYPDPKAAMRDALRLSRGMSYKNAMAGLPM
GGGKAVILADEDRTKSPEMLAAFGDAVEALGGKYVTAEDVGISEADMVAVSQRTSYVSGLPVEGEDSAGGDPGPFTAMGI
YHGIKAAVAHKLGKDSVKGVHVAVQGTGSVGGGVARLLAKDGAKLTLSDIHEDRAEALATELGGKAVAPDAIMSTACDVF
SPNALGAILDDEGIARLDCAIVAGGANNQFARAKHGAMLAERDILYAPDYVINAGGIISVAQEYLDRQQGASGGINEVRK
RIAQIPERLVQIWQESERSGISADVVADRMAQKLIGR

Sequences:

>Translated_357_residues
MNAMTAFWTEADYDDHELVQLVRDPKSGLTAIIAIHSTHLGPGAGGTRFWHYPDPKAAMRDALRLSRGMSYKNAMAGLPM
GGGKAVILADEDRTKSPEMLAAFGDAVEALGGKYVTAEDVGISEADMVAVSQRTSYVSGLPVEGEDSAGGDPGPFTAMGI
YHGIKAAVAHKLGKDSVKGVHVAVQGTGSVGGGVARLLAKDGAKLTLSDIHEDRAEALATELGGKAVAPDAIMSTACDVF
SPNALGAILDDEGIARLDCAIVAGGANNQFARAKHGAMLAERDILYAPDYVINAGGIISVAQEYLDRQQGASGGINEVRK
RIAQIPERLVQIWQESERSGISADVVADRMAQKLIGR
>Mature_357_residues
MNAMTAFWTEADYDDHELVQLVRDPKSGLTAIIAIHSTHLGPGAGGTRFWHYPDPKAAMRDALRLSRGMSYKNAMAGLPM
GGGKAVILADEDRTKSPEMLAAFGDAVEALGGKYVTAEDVGISEADMVAVSQRTSYVSGLPVEGEDSAGGDPGPFTAMGI
YHGIKAAVAHKLGKDSVKGVHVAVQGTGSVGGGVARLLAKDGAKLTLSDIHEDRAEALATELGGKAVAPDAIMSTACDVF
SPNALGAILDDEGIARLDCAIVAGGANNQFARAKHGAMLAERDILYAPDYVINAGGIISVAQEYLDRQQGASGGINEVRK
RIAQIPERLVQIWQESERSGISADVVADRMAQKLIGR

Specific function: Functions catabolically in the bacterial metabolism of branched-chain L-amino acids. Catalyzes the reversible deamination of these branched-chain L-amino acids to their oxo analogs [H]

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Drosophila melanogaster, GI45549226, Length=332, Percent_Identity=26.8072289156627, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45553475, Length=332, Percent_Identity=26.8072289156627, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR016211
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.9 [H]

Molecular weight: Translated: 37350; Mature: 37350

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAMTAFWTEADYDDHELVQLVRDPKSGLTAIIAIHSTHLGPGAGGTRFWHYPDPKAAMR
CCCCEEEECCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCEECCCHHHHHH
DALRLSRGMSYKNAMAGLPMGGGKAVILADEDRTKSPEMLAAFGDAVEALGGKYVTAEDV
HHHHHHHCCCHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEECCC
GISEADMVAVSQRTSYVSGLPVEGEDSAGGDPGPFTAMGIYHGIKAAVAHKLGKDSVKGV
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEE
HVAVQGTGSVGGGVARLLAKDGAKLTLSDIHEDRAEALATELGGKAVAPDAIMSTACDVF
EEEEEECCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
SPNALGAILDDEGIARLDCAIVAGGANNQFARAKHGAMLAERDILYAPDYVINAGGIISV
CCCCCEEEECCCCCEEEEEEEEECCCCCCHHHHHHCCHHHCCCEEECCCEEECCCCHHHH
AQEYLDRQQGASGGINEVRKRIAQIPERLVQIWQESERSGISADVVADRMAQKLIGR
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNAMTAFWTEADYDDHELVQLVRDPKSGLTAIIAIHSTHLGPGAGGTRFWHYPDPKAAMR
CCCCEEEECCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCEECCCHHHHHH
DALRLSRGMSYKNAMAGLPMGGGKAVILADEDRTKSPEMLAAFGDAVEALGGKYVTAEDV
HHHHHHHCCCHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEECCC
GISEADMVAVSQRTSYVSGLPVEGEDSAGGDPGPFTAMGIYHGIKAAVAHKLGKDSVKGV
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEE
HVAVQGTGSVGGGVARLLAKDGAKLTLSDIHEDRAEALATELGGKAVAPDAIMSTACDVF
EEEEEECCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
SPNALGAILDDEGIARLDCAIVAGGANNQFARAKHGAMLAERDILYAPDYVINAGGIISV
CCCCCEEEECCCCCEEEEEEEEECCCCCCHHHHHHCCHHHCCCEEECCCEEECCCCHHHH
AQEYLDRQQGASGGINEVRKRIAQIPERLVQIWQESERSGISADVVADRMAQKLIGR
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020469 [H]