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The map label for this gene is galK [H]

Identifier: 85373527

GI number: 85373527

Start: 721713

End: 722753

Strand: Reverse

Name: galK [H]

Synonym: ELI_03500

Alternate gene names: 85373527

Gene position: 722753-721713 (Counterclockwise)

Preceding gene: 85373528

Following gene: 85373524

Centisome position: 23.68

GC content: 67.44

Gene sequence:

>1041_bases
ATGACCGCCTTCACCGCAACGGTACCGGGCAGGGTCAACCTGATCGGCGAGCATACCGACTACAATGGCGGCATGGTGCT
GCCTGCGGCGCTGTCGGTAAGCCTGACCGCCACGCTGATCCCTCGCGAGGACCGGCGCGTTGGCGTTTCGGCCCGGGGCT
ATCCCGGATCGGCCGAGCGGAGCCTCGACGAAGCGGCTCAGGGGCATTGGTCCGACCCGGCGGTCGGCGCGGTGCGGGAG
GCCAACGCACTGGGCCTGCTTCACGGCGGCGCGAGCCTCTCGATCCGCTCGACCATCCCCGCAGGATCGGGCCTGTCGTC
ATCGGCGGCCCTGATCGTCGCCATCCTCAAAGCTGCGCGCGAGGCGGCGGAAAGCGATATCCCGGATCTCGATCTCGCGG
TCGCGGCCCGCCGGGTGGAGAACGATTATATCGGCGTGCCGTGCGGGATCATGGACCAGGTCGCGGTCGCAGTCGCCCGA
CCTGGCGAGGCCATCGCGCTCGATACCGCGACGCTCGAGTATTCCCTGGTCACGCTCCCCGACAGCCATTCCATGATCGT
GATCCATTCCGGCTATTCCCGCAAGCTGACCGACGGCCGCTACAAGGCACGCAAGGAAGAATGCGACGCGGCCCGGCTGG
CGTTCGGGCGCGAGGCTATCTGCACACTCGACCCGTCAGAGATCGAAGCGGCAACCGGCATCGATGAAACCATCCGCAGG
CGGGCGCGGCACTGCGCCACCGAACATCGGCGCGTCATCGCCGCCCGGGAGGCGATCGACCGCGGCGACATGGCCGTATT
CGGCGCGCTGATGAACGCCAGTCACATTTCCATGCGCGACGATTTCGAGATGTCGACCCCGCCGATCGACGCACTTGTGG
CCGACGCCGTGGAACTCGGTTCCACGGGTGCGCGTCTCACCGGCGGCGGCTTTGGTGGCTGCATCGTCGCCTGCGTCTCG
TCCCGGCAGCGCGAGGAATGGCAGGCACGCCTTGTCGAACGCCATCCCAAGGCGCGATACATCGCTCATATCGGCGGATG
A

Upstream 100 bases:

>100_bases
GACCGCGTCAAATATCTGGCCTCGGTCGAGCAGCACACCGGCGTGATGACGGTCGATGTCATGCCTGAGGCGGCCGCTGC
CGCGCTGCGCGAGGTCTGAC

Downstream 100 bases:

>100_bases
CGGCTAAGCCGCGATAGCCGAAGCCAGACCCAGGAACTGCTGCATCATCCAGTCGACCGGCGGGCCGACCGTCTTTTCGA
TGACGCCCAGTTCCGGTGCG

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MTAFTATVPGRVNLIGEHTDYNGGMVLPAALSVSLTATLIPREDRRVGVSARGYPGSAERSLDEAAQGHWSDPAVGAVRE
ANALGLLHGGASLSIRSTIPAGSGLSSSAALIVAILKAAREAAESDIPDLDLAVAARRVENDYIGVPCGIMDQVAVAVAR
PGEAIALDTATLEYSLVTLPDSHSMIVIHSGYSRKLTDGRYKARKEECDAARLAFGREAICTLDPSEIEAATGIDETIRR
RARHCATEHRRVIAAREAIDRGDMAVFGALMNASHISMRDDFEMSTPPIDALVADAVELGSTGARLTGGGFGGCIVACVS
SRQREEWQARLVERHPKARYIAHIGG

Sequences:

>Translated_346_residues
MTAFTATVPGRVNLIGEHTDYNGGMVLPAALSVSLTATLIPREDRRVGVSARGYPGSAERSLDEAAQGHWSDPAVGAVRE
ANALGLLHGGASLSIRSTIPAGSGLSSSAALIVAILKAAREAAESDIPDLDLAVAARRVENDYIGVPCGIMDQVAVAVAR
PGEAIALDTATLEYSLVTLPDSHSMIVIHSGYSRKLTDGRYKARKEECDAARLAFGREAICTLDPSEIEAATGIDETIRR
RARHCATEHRRVIAAREAIDRGDMAVFGALMNASHISMRDDFEMSTPPIDALVADAVELGSTGARLTGGGFGGCIVACVS
SRQREEWQARLVERHPKARYIAHIGG
>Mature_345_residues
TAFTATVPGRVNLIGEHTDYNGGMVLPAALSVSLTATLIPREDRRVGVSARGYPGSAERSLDEAAQGHWSDPAVGAVREA
NALGLLHGGASLSIRSTIPAGSGLSSSAALIVAILKAAREAAESDIPDLDLAVAARRVENDYIGVPCGIMDQVAVAVARP
GEAIALDTATLEYSLVTLPDSHSMIVIHSGYSRKLTDGRYKARKEECDAARLAFGREAICTLDPSEIEAATGIDETIRRR
ARHCATEHRRVIAAREAIDRGDMAVFGALMNASHISMRDDFEMSTPPIDALVADAVELGSTGARLTGGGFGGCIVACVSS
RQREEWQARLVERHPKARYIAHIGG

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=329, Percent_Identity=37.3860182370821, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1786972, Length=339, Percent_Identity=36.5781710914454, Blast_Score=218, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI71989053, Length=378, Percent_Identity=28.042328042328, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 36562; Mature: 36431

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAFTATVPGRVNLIGEHTDYNGGMVLPAALSVSLTATLIPREDRRVGVSARGYPGSAER
CCEEEEECCCEEEEEECCCCCCCCEEEEEHEEEEEEEEECCCCCCEECCCCCCCCCHHHH
SLDEAAQGHWSDPAVGAVREANALGLLHGGASLSIRSTIPAGSGLSSSAALIVAILKAAR
HHHHHHCCCCCCCCHHHHHCCCEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
EAAESDIPDLDLAVAARRVENDYIGVPCGIMDQVAVAVARPGEAIALDTATLEYSLVTLP
HHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEEEEEEECC
DSHSMIVIHSGYSRKLTDGRYKARKEECDAARLAFGREAICTLDPSEIEAATGIDETIRR
CCCCEEEEECCCCCCCCCCHHHHHHHHCCHHHHHCCCCEEEECCHHHHHHHCCHHHHHHH
RARHCATEHRRVIAAREAIDRGDMAVFGALMNASHISMRDDFEMSTPPIDALVADAVELG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
STGARLTGGGFGGCIVACVSSRQREEWQARLVERHPKARYIAHIGG
CCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
>Mature Secondary Structure 
TAFTATVPGRVNLIGEHTDYNGGMVLPAALSVSLTATLIPREDRRVGVSARGYPGSAER
CEEEEECCCEEEEEECCCCCCCCEEEEEHEEEEEEEEECCCCCCEECCCCCCCCCHHHH
SLDEAAQGHWSDPAVGAVREANALGLLHGGASLSIRSTIPAGSGLSSSAALIVAILKAAR
HHHHHHCCCCCCCCHHHHHCCCEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
EAAESDIPDLDLAVAARRVENDYIGVPCGIMDQVAVAVARPGEAIALDTATLEYSLVTLP
HHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEEEEEEECC
DSHSMIVIHSGYSRKLTDGRYKARKEECDAARLAFGREAICTLDPSEIEAATGIDETIRR
CCCCEEEEECCCCCCCCCCHHHHHHHHCCHHHHHCCCCEEEECCHHHHHHHCCHHHHHHH
RARHCATEHRRVIAAREAIDRGDMAVFGALMNASHISMRDDFEMSTPPIDALVADAVELG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
STGARLTGGGFGGCIVACVSSRQREEWQARLVERHPKARYIAHIGG
CCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA