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The map label for this gene is accC [H]

Identifier: 85373447

GI number: 85373447

Start: 650656

End: 652005

Strand: Reverse

Name: accC [H]

Synonym: ELI_03100

Alternate gene names: 85373447

Gene position: 652005-650656 (Counterclockwise)

Preceding gene: 85373448

Following gene: 85373443

Centisome position: 21.36

GC content: 63.63

Gene sequence:

>1350_bases
ATGGGTATCCAACGCATCCTTATCGCCAATCGCGGCGAGATCGCGCTGCGCATCCACCGCGCGGCGCACGAAATGGGCAT
CGAGACGGTGGCGGTGCACTCCACCGCCGATAGCGATGCCATGCATGTGCGACTGGCGGACCATGCGGTGTGCATCGGCC
CTCCGCCCGCGACCGACAGCTATCTCAACCAGGCCGCGATCATCTCCGCCGCCGAGGTTTCAGGTTGCGACGCCATCCAC
CCGGGCTACGGCTTTCTCTCCGAAAACGCCAAGTTCGCGGAGATCGTCGAAGCGCACGATATCAAGTGGATCGGCCCCAA
GCCCGAACACATTCGCACCATGGGCGACAAGGTCGCCGCCAAGCAGACCGCGGGTGAGCTTGGCCTGCCGCTTGTGCCGG
GCAGCGAGGGCGCAGTTTCGGACTATGACGAAGCGCGCAAGATTGCCGCCGAAATCGGCTATCCGGTAATCATTAAGGCC
GCCTCGGGCGGCGGCGGTCGCGGGATGAAGGTCTGCGACAGCGCGGAGAAGCTCGAGGGCCTGATGAAGCAGGCTGGTAG
CGAGGCCAAGGCCGCTTTCGGCGATGCGACGGTCTATATCGAGAAATATCTCGGCAATCCGCGCCATATCGAGTTTCAGG
TCTTCGGCGACGGCAATGGCAGCGCGATTCATCTGGGCGAGCGCGACTGTTCGCTGCAGCGCCGCCACCAGAAAGTCCTC
GAGGAAGCGCCCTCCCCCGTGCTCGACAGCGCCGAGCGGCACCGGATGGGCGAAATCTGCGCCGATGCCATGCGCAAGAT
GGCCTATCGCGGCGCGGGAACGATCGAATTCCTGTGGGAAGGCGGCGAGTTCTACTTCATCGAGATGAACACCCGCCTGC
AGGTCGAGCATCCTGTGACCGAGGCCATCACCGGCGTCGACCTGGTGCGCGAACAGATCCGCATCGCCGACGGCAAGCCG
CTCTCGGTCAATCAGGAAGAGATCGCCTTCACCGGCCATGCGATCGAATGCCGCATCAATGCCGAAGACCCGTTCACCTT
CGCGCCGTCACCCGGCAAGGTCAGCCATTACCACCCGGCGGGCGGCATGCACGTGCGCGTCGATTCCGGGCTTTACGCCG
GCTATTCGATCCCGCCCTATTACGACAGTATGATCGCCAAGCTGATCGTCTACGGCCGCAACCGCGAGGGCTGCATCATG
CGCCTGAGGAGGGCGCTGGAGGAGATGGTGGTAGAAGGCGTCAAGACCTCGATCCCGCTGCACCAGGAATTGCTGCGGCA
GGACGACGTCCTCAACGGCGACTACAGTATCAAGTGGCTGGAGGAGTGGCTGGCGACGCGGGAGGCTTAG

Upstream 100 bases:

>100_bases
CACTGCCAACACGAGTGGCACGATCAAGGCGATCCTGGTCGAGAACGCGCAGCCGATCGAATTCGACCAGCCGCTGGTCG
TCATCGCTTAAGGACCGTCC

Downstream 100 bases:

>100_bases
CTTTCAGCAACTTTAGCCTGAACGGAGATGTCTTTGGTTCGAATTTCACCGATAAGTTCAGACACCTGCTCTTCGCTTAA
TCCTTTTGAACTCAAAGCTC

Product: AccC, acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MGIQRILIANRGEIALRIHRAAHEMGIETVAVHSTADSDAMHVRLADHAVCIGPPPATDSYLNQAAIISAAEVSGCDAIH
PGYGFLSENAKFAEIVEAHDIKWIGPKPEHIRTMGDKVAAKQTAGELGLPLVPGSEGAVSDYDEARKIAAEIGYPVIIKA
ASGGGGRGMKVCDSAEKLEGLMKQAGSEAKAAFGDATVYIEKYLGNPRHIEFQVFGDGNGSAIHLGERDCSLQRRHQKVL
EEAPSPVLDSAERHRMGEICADAMRKMAYRGAGTIEFLWEGGEFYFIEMNTRLQVEHPVTEAITGVDLVREQIRIADGKP
LSVNQEEIAFTGHAIECRINAEDPFTFAPSPGKVSHYHPAGGMHVRVDSGLYAGYSIPPYYDSMIAKLIVYGRNREGCIM
RLRRALEEMVVEGVKTSIPLHQELLRQDDVLNGDYSIKWLEEWLATREA

Sequences:

>Translated_449_residues
MGIQRILIANRGEIALRIHRAAHEMGIETVAVHSTADSDAMHVRLADHAVCIGPPPATDSYLNQAAIISAAEVSGCDAIH
PGYGFLSENAKFAEIVEAHDIKWIGPKPEHIRTMGDKVAAKQTAGELGLPLVPGSEGAVSDYDEARKIAAEIGYPVIIKA
ASGGGGRGMKVCDSAEKLEGLMKQAGSEAKAAFGDATVYIEKYLGNPRHIEFQVFGDGNGSAIHLGERDCSLQRRHQKVL
EEAPSPVLDSAERHRMGEICADAMRKMAYRGAGTIEFLWEGGEFYFIEMNTRLQVEHPVTEAITGVDLVREQIRIADGKP
LSVNQEEIAFTGHAIECRINAEDPFTFAPSPGKVSHYHPAGGMHVRVDSGLYAGYSIPPYYDSMIAKLIVYGRNREGCIM
RLRRALEEMVVEGVKTSIPLHQELLRQDDVLNGDYSIKWLEEWLATREA
>Mature_448_residues
GIQRILIANRGEIALRIHRAAHEMGIETVAVHSTADSDAMHVRLADHAVCIGPPPATDSYLNQAAIISAAEVSGCDAIHP
GYGFLSENAKFAEIVEAHDIKWIGPKPEHIRTMGDKVAAKQTAGELGLPLVPGSEGAVSDYDEARKIAAEIGYPVIIKAA
SGGGGRGMKVCDSAEKLEGLMKQAGSEAKAAFGDATVYIEKYLGNPRHIEFQVFGDGNGSAIHLGERDCSLQRRHQKVLE
EAPSPVLDSAERHRMGEICADAMRKMAYRGAGTIEFLWEGGEFYFIEMNTRLQVEHPVTEAITGVDLVREQIRIADGKPL
SVNQEEIAFTGHAIECRINAEDPFTFAPSPGKVSHYHPAGGMHVRVDSGLYAGYSIPPYYDSMIAKLIVYGRNREGCIMR
LRRALEEMVVEGVKTSIPLHQELLRQDDVLNGDYSIKWLEEWLATREA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=49.3212669683258, Blast_Score=417, Evalue=1e-117,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=49.3212669683258, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=49.3212669683258, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI116805327, Length=420, Percent_Identity=46.9047619047619, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=44.5190156599553, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=44.5190156599553, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=44.5190156599553, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI38679977, Length=514, Percent_Identity=30.7392996108949, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679967, Length=514, Percent_Identity=30.7392996108949, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679971, Length=514, Percent_Identity=30.7392996108949, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI134142062, Length=508, Percent_Identity=31.1023622047244, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679974, Length=514, Percent_Identity=30.7392996108949, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI38679960, Length=514, Percent_Identity=30.7392996108949, Blast_Score=229, Evalue=4e-60,
Organism=Escherichia coli, GI1789654, Length=447, Percent_Identity=59.0604026845638, Blast_Score=521, Evalue=1e-149,
Organism=Escherichia coli, GI1786216, Length=244, Percent_Identity=23.7704918032787, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=46.1538461538462, Blast_Score=396, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=45.9276018099548, Blast_Score=380, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17562816, Length=452, Percent_Identity=45.7964601769911, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI133931226, Length=494, Percent_Identity=28.3400809716599, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=26.614481409002, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=26.614481409002, Blast_Score=188, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6319685, Length=426, Percent_Identity=42.9577464788732, Blast_Score=342, Evalue=6e-95,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=43.9732142857143, Blast_Score=339, Evalue=5e-94,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=44.4196428571429, Blast_Score=331, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6324343, Length=519, Percent_Identity=29.0944123314065, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6323863, Length=486, Percent_Identity=29.6296296296296, Blast_Score=212, Evalue=1e-55,
Organism=Drosophila melanogaster, GI281363050, Length=447, Percent_Identity=46.3087248322148, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652224, Length=447, Percent_Identity=46.3087248322148, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652222, Length=447, Percent_Identity=46.3087248322148, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652220, Length=447, Percent_Identity=46.3087248322148, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652218, Length=447, Percent_Identity=46.3087248322148, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652212, Length=447, Percent_Identity=46.3087248322148, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652210, Length=447, Percent_Identity=46.3087248322148, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652214, Length=447, Percent_Identity=46.3087248322148, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI19921944, Length=447, Percent_Identity=46.3087248322148, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652216, Length=447, Percent_Identity=46.3087248322148, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24651757, Length=448, Percent_Identity=42.6339285714286, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI24651759, Length=410, Percent_Identity=41.7073170731707, Blast_Score=321, Evalue=6e-88,
Organism=Drosophila melanogaster, GI161076409, Length=502, Percent_Identity=29.6812749003984, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24586458, Length=502, Percent_Identity=29.6812749003984, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI161076407, Length=502, Percent_Identity=29.6812749003984, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24586460, Length=502, Percent_Identity=29.6812749003984, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI45555749, Length=416, Percent_Identity=21.1538461538462, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24642586, Length=416, Percent_Identity=21.1538461538462, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49080; Mature: 48949

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIQRILIANRGEIALRIHRAAHEMGIETVAVHSTADSDAMHVRLADHAVCIGPPPATDS
CCCEEEEEECCCCEEEEEEHHHHHCCCEEEEEECCCCCCEEEEEEECCEEEECCCCCCHH
YLNQAAIISAAEVSGCDAIHPGYGFLSENAKFAEIVEAHDIKWIGPKPEHIRTMGDKVAA
HHCHHHEEEEHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEECCCCHHHHHHHHHHHHH
KQTAGELGLPLVPGSEGAVSDYDEARKIAAEIGYPVIIKAASGGGGRGMKVCDSAEKLEG
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHCCCHHHHHH
LMKQAGSEAKAAFGDATVYIEKYLGNPRHIEFQVFGDGNGSAIHLGERDCSLQRRHQKVL
HHHHCCCHHHHHCCCCEEEEEHHCCCCEEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPSPVLDSAERHRMGEICADAMRKMAYRGAGTIEFLWEGGEFYFIEMNTRLQVEHPVT
HHCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEEECCEEEECCCHH
EAITGVDLVREQIRIADGKPLSVNQEEIAFTGHAIECRINAEDPFTFAPSPGKVSHYHPA
HHHHHHHHHHHHHHHCCCCCCCCCHHHEEEECCEEEEEECCCCCEEECCCCCCCCEECCC
GGMHVRVDSGLYAGYSIPPYYDSMIAKLIVYGRNREGCIMRLRRALEEMVVEGVKTSIPL
CCEEEEECCCEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
HQELLRQDDVLNGDYSIKWLEEWLATREA
HHHHHHHCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
GIQRILIANRGEIALRIHRAAHEMGIETVAVHSTADSDAMHVRLADHAVCIGPPPATDS
CCEEEEEECCCCEEEEEEHHHHHCCCEEEEEECCCCCCEEEEEEECCEEEECCCCCCHH
YLNQAAIISAAEVSGCDAIHPGYGFLSENAKFAEIVEAHDIKWIGPKPEHIRTMGDKVAA
HHCHHHEEEEHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEECCCCHHHHHHHHHHHHH
KQTAGELGLPLVPGSEGAVSDYDEARKIAAEIGYPVIIKAASGGGGRGMKVCDSAEKLEG
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHCCCHHHHHH
LMKQAGSEAKAAFGDATVYIEKYLGNPRHIEFQVFGDGNGSAIHLGERDCSLQRRHQKVL
HHHHCCCHHHHHCCCCEEEEEHHCCCCEEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPSPVLDSAERHRMGEICADAMRKMAYRGAGTIEFLWEGGEFYFIEMNTRLQVEHPVT
HHCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEEECCEEEECCCHH
EAITGVDLVREQIRIADGKPLSVNQEEIAFTGHAIECRINAEDPFTFAPSPGKVSHYHPA
HHHHHHHHHHHHHHHCCCCCCCCCHHHEEEECCEEEEEECCCCCEEECCCCCCCCEECCC
GGMHVRVDSGLYAGYSIPPYYDSMIAKLIVYGRNREGCIMRLRRALEEMVVEGVKTSIPL
CCEEEEECCCEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
HQELLRQDDVLNGDYSIKWLEEWLATREA
HHHHHHHCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]