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The map label for this gene is czcD [H]

Identifier: 85373060

GI number: 85373060

Start: 270614

End: 271570

Strand: Reverse

Name: czcD [H]

Synonym: ELI_01165

Alternate gene names: 85373060

Gene position: 271570-270614 (Counterclockwise)

Preceding gene: 85373061

Following gene: 85373059

Centisome position: 8.9

GC content: 63.85

Gene sequence:

>957_bases
ATGGGCGCGACACACCCACAACACGGGCATGCCCCCTCGCAAGGGCACGAGCATGGGCTCAGCCATGGCCATAATCATGG
CCATGGGCATCACCACCACGCACCCAAGGATTTCGGTCGCGCGTTCGCGATCGGCGTGGTTCTCAATACCGCTTTTGTCA
TCGTCGAAGCGACTTATGGCTTCCTGTCGGGCTCGATGGCGCTGGTCGCGGATGCCGGGCACAATTTGTCTGACGTGATG
GCGCTTCTGCTCGCCTGGGCCGCGGCCGTGGCTGCGAAGAAGCCGCCGTCCGGACGCTTCACATATGGCTACAAGAGCTC
GACCATCCTTGCCGCGATCGCCAATGCCGCGCTGCTGTTCGTCGCCATCGGCGCCATCCTGTTCGAGACCATGCATCGCC
TGCTCGACCCGCAACCGGTCGAAGGCTGGACCATGATCGTGGTTGCGGGAATCGGGGTGGTCATCAACACAGCGACGGCG
CTGCTGTTCGTGAAGGGCCAGCACGACATCAACATCCGCGGCGCGTTCCTGCATATGGCGGCGGATGCGCTGGTCTCGGT
GGGGGTGGTGATTGCCGGGGCGGCGATCCTGCTGACCGGCATGCTCTGGATCGATCCGGCGACCAGCCTGGTGATCGTCG
CGGTGATCGCCTGGGGCACCTGGGGCCTGGCCAAGGACAGCATCAAGATGGGCCTCAACGCTGTGCCCGACAGCATCTGC
GAGAAGGAAGTGGAAAGCTTCCTGATCGGGCAGCCGGGCGTCTCGCTGGTGCACGACCTCCATATCTGGCCCATGAGCAC
CACGGAAACCGCGCTTACCGCGCATCTCGTCATGCCCGATGGCAGCAATGGTGATGAGTTCCTGACCGCGCTCTCCGCCC
GGCTACGCGAGAGGTTCAAGATCGATCACGCGACGATCCAGATCGAGCGCAGTGCGGACTGCGGGGGCGGCTGTTGA

Upstream 100 bases:

>100_bases
AATCCCGGCGGCTGGCTGCGCCGTCATGGCAATACGATTGCTGCGCGTATCGGCGTCGTGCGGCGTGACGGATTGGATTC
CTGCGTCTACGACTAGGGTA

Downstream 100 bases:

>100_bases
GCGACGATCGCGCCACTGCAGCCCGCGAGAAATTGCGCGCGGCCATGGTGCGGTTGTCCGAAGGCGATCGCGCGGCGCTG
GAAGAGATCTATAGCGCGAC

Product: putative cation efflux system protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MGATHPQHGHAPSQGHEHGLSHGHNHGHGHHHHAPKDFGRAFAIGVVLNTAFVIVEATYGFLSGSMALVADAGHNLSDVM
ALLLAWAAAVAAKKPPSGRFTYGYKSSTILAAIANAALLFVAIGAILFETMHRLLDPQPVEGWTMIVVAGIGVVINTATA
LLFVKGQHDINIRGAFLHMAADALVSVGVVIAGAAILLTGMLWIDPATSLVIVAVIAWGTWGLAKDSIKMGLNAVPDSIC
EKEVESFLIGQPGVSLVHDLHIWPMSTTETALTAHLVMPDGSNGDEFLTALSARLRERFKIDHATIQIERSADCGGGC

Sequences:

>Translated_318_residues
MGATHPQHGHAPSQGHEHGLSHGHNHGHGHHHHAPKDFGRAFAIGVVLNTAFVIVEATYGFLSGSMALVADAGHNLSDVM
ALLLAWAAAVAAKKPPSGRFTYGYKSSTILAAIANAALLFVAIGAILFETMHRLLDPQPVEGWTMIVVAGIGVVINTATA
LLFVKGQHDINIRGAFLHMAADALVSVGVVIAGAAILLTGMLWIDPATSLVIVAVIAWGTWGLAKDSIKMGLNAVPDSIC
EKEVESFLIGQPGVSLVHDLHIWPMSTTETALTAHLVMPDGSNGDEFLTALSARLRERFKIDHATIQIERSADCGGGC
>Mature_317_residues
GATHPQHGHAPSQGHEHGLSHGHNHGHGHHHHAPKDFGRAFAIGVVLNTAFVIVEATYGFLSGSMALVADAGHNLSDVMA
LLLAWAAAVAAKKPPSGRFTYGYKSSTILAAIANAALLFVAIGAILFETMHRLLDPQPVEGWTMIVVAGIGVVINTATAL
LFVKGQHDINIRGAFLHMAADALVSVGVVIAGAAILLTGMLWIDPATSLVIVAVIAWGTWGLAKDSIKMGLNAVPDSICE
KEVESFLIGQPGVSLVHDLHIWPMSTTETALTAHLVMPDGSNGDEFLTALSARLRERFKIDHATIQIERSADCGGGC

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=313, Percent_Identity=23.6421725239617, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI64762489, Length=325, Percent_Identity=25.8461538461538, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI289803013, Length=314, Percent_Identity=26.4331210191083, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI289803009, Length=314, Percent_Identity=26.4331210191083, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI289803007, Length=314, Percent_Identity=26.4331210191083, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI289803003, Length=314, Percent_Identity=26.4331210191083, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI21359890, Length=298, Percent_Identity=25.8389261744966, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI21361112, Length=305, Percent_Identity=25.5737704918033, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI14210520, Length=224, Percent_Identity=23.6607142857143, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI52351208, Length=120, Percent_Identity=30.8333333333333, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786966, Length=280, Percent_Identity=36.0714285714286, Blast_Score=137, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI193210990, Length=339, Percent_Identity=28.023598820059, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17555794, Length=307, Percent_Identity=26.3843648208469, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17555796, Length=327, Percent_Identity=25.9938837920489, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI32564488, Length=296, Percent_Identity=27.3648648648649, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323899, Length=120, Percent_Identity=36.6666666666667, Blast_Score=93, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320411, Length=178, Percent_Identity=36.5168539325843, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324892, Length=120, Percent_Identity=37.5, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24583858, Length=348, Percent_Identity=24.4252873563218, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574430, Length=146, Percent_Identity=30.1369863013699, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24584409, Length=146, Percent_Identity=30.1369863013699, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585900, Length=147, Percent_Identity=29.2517006802721, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24585898, Length=147, Percent_Identity=29.2517006802721, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24585896, Length=147, Percent_Identity=29.2517006802721, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19921672, Length=147, Percent_Identity=29.2517006802721, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24645863, Length=106, Percent_Identity=33.0188679245283, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33444; Mature: 33313

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGATHPQHGHAPSQGHEHGLSHGHNHGHGHHHHAPKDFGRAFAIGVVLNTAFVIVEATYG
CCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEHHH
FLSGSMALVADAGHNLSDVMALLLAWAAAVAAKKPPSGRFTYGYKSSTILAAIANAALLF
HHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHH
VAIGAILFETMHRLLDPQPVEGWTMIVVAGIGVVINTATALLFVKGQHDINIRGAFLHMA
HHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHEEEEEEECCCCCEEEHHHHHHH
ADALVSVGVVIAGAAILLTGMLWIDPATSLVIVAVIAWGTWGLAKDSIKMGLNAVPDSIC
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHH
EKEVESFLIGQPGVSLVHDLHIWPMSTTETALTAHLVMPDGSNGDEFLTALSARLRERFK
HHHHHHHHCCCCCHHHHHEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHC
IDHATIQIERSADCGGGC
CCEEEEEEEECCCCCCCC
>Mature Secondary Structure 
GATHPQHGHAPSQGHEHGLSHGHNHGHGHHHHAPKDFGRAFAIGVVLNTAFVIVEATYG
CCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEHHH
FLSGSMALVADAGHNLSDVMALLLAWAAAVAAKKPPSGRFTYGYKSSTILAAIANAALLF
HHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHH
VAIGAILFETMHRLLDPQPVEGWTMIVVAGIGVVINTATALLFVKGQHDINIRGAFLHMA
HHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHEEEEEEECCCCCEEEHHHHHHH
ADALVSVGVVIAGAAILLTGMLWIDPATSLVIVAVIAWGTWGLAKDSIKMGLNAVPDSIC
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHH
EKEVESFLIGQPGVSLVHDLHIWPMSTTETALTAHLVMPDGSNGDEFLTALSARLRERFK
HHHHHHHHCCCCCHHHHHEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHC
IDHATIQIERSADCGGGC
CCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]