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The map label for this gene is tatA [H]

Identifier: 85372853

GI number: 85372853

Start: 39756

End: 40934

Strand: Direct

Name: tatA [H]

Synonym: ELI_00130

Alternate gene names: 85372853

Gene position: 39756-40934 (Clockwise)

Preceding gene: 85372852

Following gene: 85372854

Centisome position: 1.3

GC content: 64.12

Gene sequence:

>1179_bases
ATGCTCGAAGCCCTCGAACCGCAAGCCCCCGACGCGCTGCTGGCGCTGATCAAGCTCTTCGCCTCCGACGACCGCGACGA
AAAGATCGACCTCGGCGTCGGCGTCTATCGCACGGATGATGGCGCGACGCCGGTTTTCAAGGCCATCAAGCAGGCCGAAC
AGAAGCTGGTCGATATCCAGGAATCGAAGGGCTATCTCGGTCCGGAAGGCGATATCGGCTTCGTCCACGCCCTGATGCCG
CGCATCTTCGGCAAGAACGCCACGATGAACGGTCATATCGAAGGCATGCAGACACCCGGCGGCACCGGCGCTTGCCGACT
GGCCTTCGCCCTGGCGCAGAAGGCGGGCGTCGGGCGCGTTTTGATGGGCGTGCCAAGCTGGCCCAATCATGCCCAGATCC
TCGCCGATGTCGGCCTCGAGGTGATGACCTTCGAACATGCCAAGCCCGATGGGACCGCCAATCTCGATGCTCTGCTCGGC
GCGTTGCGCACGGCGGGTGAGGGCGATGCGGTGCTGCTCCATGGCTGCTGCCACAATCCTACTGGCGTGGACTATAGCGC
CGAGGACTGGGCCGCCATAGCCGAAGCGCTGGCGGACAGCCCGGTTCTGCCCGTCATCGATACTGCCTACCATGGCCTGG
GACAGGGGCTGGACGAGGACGTCGCCGGGCTACGCACGGTACTGGCCGCGGTGCCGGAGGCGCTGGTGGCCTATAGCTGC
GACAAGAATTTCGGGCTGTATCGTGACCGTGTCGGGGCATTCTACGTCAAGGCCAAGAGCAGCGAGCAGATGGATGCCAT
CCTGTCCAACGCCAATGCTCTCGCGCGGGCCAATTGGTCGATGCCGCCCGATCACGGCGGTGCGGCCGTACGGCTGGTTC
TGCGCAGCGAGGACATGACCAAGGTCTGGCTCGACGAGCTCGAAAGCATGCGCAAGCGCCTGCGCTGGGTGCGCGACCGC
CTGGCGCAGGCGGACAATGAAGTGCCCGGTCTCGATCTGGCACCTCTGGGTCGCCAGAACGGCATGTTCGCCATGCTGCC
CCTCGACAAAGACCAGATCCAGAAATTGCGCGACGACCACGCGGTCTACATGGCAGGCTCGGGCCGCATCAATGTCGCAG
GTCTGACCAAAGGCAATATGGACAAGTTCATCGGCGCACTGGCGGATGTCACCGGCTGA

Upstream 100 bases:

>100_bases
CCCTTCTAGTCGCACGGTCGCTCCAAGGGTCGCAAAAAGGCCCGGCGGTCATACGAATTCCGGTTGCGGGCGCCGCGCAG
CGCAGGCAATAGCTGCGGCC

Downstream 100 bases:

>100_bases
CCTCGACCGCCAGCCTATCCTCGAGGGGGAGGCGCTGCGCCTTCGGCCATTGGGCTTGGAGGATTTCGACGCGCTCTTCG
CGGTCGCTGCCGATCCCCTC

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: TAT; L-tyrosine:2-oxoglutarate aminotransferase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MLEALEPQAPDALLALIKLFASDDRDEKIDLGVGVYRTDDGATPVFKAIKQAEQKLVDIQESKGYLGPEGDIGFVHALMP
RIFGKNATMNGHIEGMQTPGGTGACRLAFALAQKAGVGRVLMGVPSWPNHAQILADVGLEVMTFEHAKPDGTANLDALLG
ALRTAGEGDAVLLHGCCHNPTGVDYSAEDWAAIAEALADSPVLPVIDTAYHGLGQGLDEDVAGLRTVLAAVPEALVAYSC
DKNFGLYRDRVGAFYVKAKSSEQMDAILSNANALARANWSMPPDHGGAAVRLVLRSEDMTKVWLDELESMRKRLRWVRDR
LAQADNEVPGLDLAPLGRQNGMFAMLPLDKDQIQKLRDDHAVYMAGSGRINVAGLTKGNMDKFIGALADVTG

Sequences:

>Translated_392_residues
MLEALEPQAPDALLALIKLFASDDRDEKIDLGVGVYRTDDGATPVFKAIKQAEQKLVDIQESKGYLGPEGDIGFVHALMP
RIFGKNATMNGHIEGMQTPGGTGACRLAFALAQKAGVGRVLMGVPSWPNHAQILADVGLEVMTFEHAKPDGTANLDALLG
ALRTAGEGDAVLLHGCCHNPTGVDYSAEDWAAIAEALADSPVLPVIDTAYHGLGQGLDEDVAGLRTVLAAVPEALVAYSC
DKNFGLYRDRVGAFYVKAKSSEQMDAILSNANALARANWSMPPDHGGAAVRLVLRSEDMTKVWLDELESMRKRLRWVRDR
LAQADNEVPGLDLAPLGRQNGMFAMLPLDKDQIQKLRDDHAVYMAGSGRINVAGLTKGNMDKFIGALADVTG
>Mature_392_residues
MLEALEPQAPDALLALIKLFASDDRDEKIDLGVGVYRTDDGATPVFKAIKQAEQKLVDIQESKGYLGPEGDIGFVHALMP
RIFGKNATMNGHIEGMQTPGGTGACRLAFALAQKAGVGRVLMGVPSWPNHAQILADVGLEVMTFEHAKPDGTANLDALLG
ALRTAGEGDAVLLHGCCHNPTGVDYSAEDWAAIAEALADSPVLPVIDTAYHGLGQGLDEDVAGLRTVLAAVPEALVAYSC
DKNFGLYRDRVGAFYVKAKSSEQMDAILSNANALARANWSMPPDHGGAAVRLVLRSEDMTKVWLDELESMRKRLRWVRDR
LAQADNEVPGLDLAPLGRQNGMFAMLPLDKDQIQKLRDDHAVYMAGSGRINVAGLTKGNMDKFIGALADVTG

Specific function: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate [H]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=391, Percent_Identity=31.2020460358056, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4504067, Length=390, Percent_Identity=31.7948717948718, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI117414139, Length=380, Percent_Identity=23.9473684210526, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1787159, Length=395, Percent_Identity=40.253164556962, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1790488, Length=396, Percent_Identity=34.3434343434343, Blast_Score=231, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI71981858, Length=392, Percent_Identity=32.9081632653061, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI25147133, Length=389, Percent_Identity=31.1053984575836, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17569539, Length=380, Percent_Identity=29.7368421052632, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17569537, Length=398, Percent_Identity=24.6231155778894, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI25147136, Length=191, Percent_Identity=32.9842931937173, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17550384, Length=241, Percent_Identity=26.5560165975104, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323055, Length=408, Percent_Identity=31.3725490196078, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6322743, Length=430, Percent_Identity=28.6046511627907, Blast_Score=171, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24580970, Length=391, Percent_Identity=32.9923273657289, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI19920542, Length=391, Percent_Identity=32.9923273657289, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24580972, Length=391, Percent_Identity=32.9923273657289, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI19922362, Length=399, Percent_Identity=31.328320802005, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24654046, Length=399, Percent_Identity=31.328320802005, Blast_Score=182, Evalue=3e-46,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.5 [H]

Molecular weight: Translated: 41953; Mature: 41953

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEALEPQAPDALLALIKLFASDDRDEKIDLGVGVYRTDDGATPVFKAIKQAEQKLVDIQ
CCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECEEEEECCCCCCHHHHHHHHHHHHHHHHH
ESKGYLGPEGDIGFVHALMPRIFGKNATMNGHIEGMQTPGGTGACRLAFALAQKAGVGRV
HCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEE
LMGVPSWPNHAQILADVGLEVMTFEHAKPDGTANLDALLGALRTAGEGDAVLLHGCCHNP
EECCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCC
TGVDYSAEDWAAIAEALADSPVLPVIDTAYHGLGQGLDEDVAGLRTVLAAVPEALVAYSC
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
DKNFGLYRDRVGAFYVKAKSSEQMDAILSNANALARANWSMPPDHGGAAVRLVLRSEDMT
CCCCCHHHHCCCEEEEEECCCHHHHHHHHCCCHHEECCCCCCCCCCCCEEEEEEECCCHH
KVWLDELESMRKRLRWVRDRLAQADNEVPGLDLAPLGRQNGMFAMLPLDKDQIQKLRDDH
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCC
AVYMAGSGRINVAGLTKGNMDKFIGALADVTG
EEEEECCCEEEEEECCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MLEALEPQAPDALLALIKLFASDDRDEKIDLGVGVYRTDDGATPVFKAIKQAEQKLVDIQ
CCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECEEEEECCCCCCHHHHHHHHHHHHHHHHH
ESKGYLGPEGDIGFVHALMPRIFGKNATMNGHIEGMQTPGGTGACRLAFALAQKAGVGRV
HCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEE
LMGVPSWPNHAQILADVGLEVMTFEHAKPDGTANLDALLGALRTAGEGDAVLLHGCCHNP
EECCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCC
TGVDYSAEDWAAIAEALADSPVLPVIDTAYHGLGQGLDEDVAGLRTVLAAVPEALVAYSC
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
DKNFGLYRDRVGAFYVKAKSSEQMDAILSNANALARANWSMPPDHGGAAVRLVLRSEDMT
CCCCCHHHHCCCEEEEEECCCHHHHHHHHCCCHHEECCCCCCCCCCCCEEEEEEECCCHH
KVWLDELESMRKRLRWVRDRLAQADNEVPGLDLAPLGRQNGMFAMLPLDKDQIQKLRDDH
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCC
AVYMAGSGRINVAGLTKGNMDKFIGALADVTG
EEEEECCCEEEEEECCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2019560; 8096210; 11481430 [H]