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The map label for this gene is ethA [H]

Identifier: 85372845

GI number: 85372845

Start: 26923

End: 28431

Strand: Reverse

Name: ethA [H]

Synonym: ELI_00090

Alternate gene names: 85372845

Gene position: 28431-26923 (Counterclockwise)

Preceding gene: 85372849

Following gene: 85372844

Centisome position: 0.93

GC content: 60.04

Gene sequence:

>1509_bases
ATGACTATCGCAAATACCGACTTCGACGTGCTGATCGTCGGCGCCGGCATTTCAGGCATCGGCATGGCCGCGCATATGGA
AATGCACTGCCCCGATCATAGTTACGGCATCGTCGAAATGCGCGACAATCTCGGCGGGACCTGGGACCTGTTCCGCTATC
CGGGCATCCGATCCGACAGCGATATGCACACGCTCGGCTTCGTGTTCGAGCCATGGAAGCACGAGAAGAGCATCGCCGAT
GCGCCCGCAATTCTCGACTACCTCAACCGTATCGTCGACGAGCGCGGGATCCGCGAACATATCCGCTACGGCCACCGCGT
GGTCGCCGCCGATTTCGACCGCTCGACCGCCCAATGGACCGTCACTATCCAGACCAAGGACGGCGAGAAGAAGCGGCTTA
CCGCCAATTTCCTCTACCTCGGCTCGGGCTATTACGATTACGACGAACCCTACGATCCTGGCTTCGAATTCGGTGACTTC
AAAGGGCAGGTAATCCACCCGCAGTTCTGGCCGGAAGACTTGGATTATGCCGGTAAGAAGGTGATCGTTATCGGCTCCGG
CGCGACCGCCGTCACCATCGTGCCTTCGATGGCCGACAAGGCTGCGCATGTGACGATGCTCCAACGCACGCCGACATGGA
TGTTCTCGCGACCTGCCAAGGACGGCCTCGCCAATTTCCTGCGCAAGATCCTGCCCGAAGAGACCGCCTACAGGATCACC
CGCTGGAAGAACATCAAGCTGCAGGACATCGGCTTCAAGCGCGCGCGGACCAAGCCCGAGAAGGTCAGGAAGATGCTCTA
CAAGCGCATCGAAAAGGCGCTCGGCAAGGATTACGACAAGGAAGCGTTCACCCCGCCCTACGACCCTTGGGACCAGCGCC
TGTGCCTGGTGCCGGACGACGACCTGTTCGAAGCGATGAATTCGGGCACGGCAAGCGTGAAGACCGGGCGCATCGCGCGC
TTCGTCGAAGGCGGCGTCGAGCTGGAGAGCGGCGAAAGGCTGGAGGCCGACATTATCATCACCGCGACCGGGCTGAAGCT
TGCTGTCGCCGGCAAGATCGACGTCTCGGTCGATGGCGAGCAGATCGATTTCGCACAGCGCTATTACTACAAGGGCTGCA
TGTTCTCGAACCTGCCCAACCTCGCGGTGGTGTTCGGTTATCTCAACGCCAGCTGGACCCTGCGGGCGGATATCAACTCC
GACTATATCTGCCGCGTGTTGAACCGCATGAAAGCGACGGACACGCAGATCGCAGAGCCGGTGCTGACCGAAGCCGGCGA
AGCTGCCCTGGAAGAGGACGACATCTTCGATTTCTCCAGCGGTTATATCCAGCGTGGCAAGGCGATCATGCCGAAGAATG
CTGTCGCTTATCCATGGAGGCTCAACCAGGACTATGTTCTCGACCGCAAGCGCATGGTGGAAGAGCCCGTCGACGATGAC
CTGCTCGCCTTCAAGCGTGCCGGGGCCAATGCACGGGAGCCAGGCGAAATTCTCGAAGCGGCAGAGTAG

Upstream 100 bases:

>100_bases
ATTGGAGCCGCGTCAGCAGCCGAGTTGGAGGGACAGCGCAAGACTCGCCAATCCGTTCCAAATATGCTTATTGGGATCGG
TTGCAGGAGAGGACCGAAAT

Downstream 100 bases:

>100_bases
CCACCTCAGCACCAATCGCTTAGGCAGGCCGCATGACTGTCGCTTCTTCGGACCGAATCTGGACCGCCGGCCTTGTCGTC
ATCGGCGACGAGATTCTGTC

Product: monooxygenase, flavin-binding family protein

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MTIANTDFDVLIVGAGISGIGMAAHMEMHCPDHSYGIVEMRDNLGGTWDLFRYPGIRSDSDMHTLGFVFEPWKHEKSIAD
APAILDYLNRIVDERGIREHIRYGHRVVAADFDRSTAQWTVTIQTKDGEKKRLTANFLYLGSGYYDYDEPYDPGFEFGDF
KGQVIHPQFWPEDLDYAGKKVIVIGSGATAVTIVPSMADKAAHVTMLQRTPTWMFSRPAKDGLANFLRKILPEETAYRIT
RWKNIKLQDIGFKRARTKPEKVRKMLYKRIEKALGKDYDKEAFTPPYDPWDQRLCLVPDDDLFEAMNSGTASVKTGRIAR
FVEGGVELESGERLEADIIITATGLKLAVAGKIDVSVDGEQIDFAQRYYYKGCMFSNLPNLAVVFGYLNASWTLRADINS
DYICRVLNRMKATDTQIAEPVLTEAGEAALEEDDIFDFSSGYIQRGKAIMPKNAVAYPWRLNQDYVLDRKRMVEEPVDDD
LLAFKRAGANAREPGEILEAAE

Sequences:

>Translated_502_residues
MTIANTDFDVLIVGAGISGIGMAAHMEMHCPDHSYGIVEMRDNLGGTWDLFRYPGIRSDSDMHTLGFVFEPWKHEKSIAD
APAILDYLNRIVDERGIREHIRYGHRVVAADFDRSTAQWTVTIQTKDGEKKRLTANFLYLGSGYYDYDEPYDPGFEFGDF
KGQVIHPQFWPEDLDYAGKKVIVIGSGATAVTIVPSMADKAAHVTMLQRTPTWMFSRPAKDGLANFLRKILPEETAYRIT
RWKNIKLQDIGFKRARTKPEKVRKMLYKRIEKALGKDYDKEAFTPPYDPWDQRLCLVPDDDLFEAMNSGTASVKTGRIAR
FVEGGVELESGERLEADIIITATGLKLAVAGKIDVSVDGEQIDFAQRYYYKGCMFSNLPNLAVVFGYLNASWTLRADINS
DYICRVLNRMKATDTQIAEPVLTEAGEAALEEDDIFDFSSGYIQRGKAIMPKNAVAYPWRLNQDYVLDRKRMVEEPVDDD
LLAFKRAGANAREPGEILEAAE
>Mature_501_residues
TIANTDFDVLIVGAGISGIGMAAHMEMHCPDHSYGIVEMRDNLGGTWDLFRYPGIRSDSDMHTLGFVFEPWKHEKSIADA
PAILDYLNRIVDERGIREHIRYGHRVVAADFDRSTAQWTVTIQTKDGEKKRLTANFLYLGSGYYDYDEPYDPGFEFGDFK
GQVIHPQFWPEDLDYAGKKVIVIGSGATAVTIVPSMADKAAHVTMLQRTPTWMFSRPAKDGLANFLRKILPEETAYRITR
WKNIKLQDIGFKRARTKPEKVRKMLYKRIEKALGKDYDKEAFTPPYDPWDQRLCLVPDDDLFEAMNSGTASVKTGRIARF
VEGGVELESGERLEADIIITATGLKLAVAGKIDVSVDGEQIDFAQRYYYKGCMFSNLPNLAVVFGYLNASWTLRADINSD
YICRVLNRMKATDTQIAEPVLTEAGEAALEEDDIFDFSSGYIQRGKAIMPKNAVAYPWRLNQDYVLDRKRMVEEPVDDDL
LAFKRAGANAREPGEILEAAE

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17561948, Length=353, Percent_Identity=24.3626062322946, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17555726, Length=367, Percent_Identity=22.3433242506812, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193202226, Length=213, Percent_Identity=24.8826291079812, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 56702; Mature: 56571

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIANTDFDVLIVGAGISGIGMAAHMEMHCPDHSYGIVEMRDNLGGTWDLFRYPGIRSDS
CCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCEEEEECCCCCCEEEHHCCCCCCCCC
DMHTLGFVFEPWKHEKSIADAPAILDYLNRIVDERGIREHIRYGHRVVAADFDRSTAQWT
CCEEEEEEECCCCCCCHHCCHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEECCCCCEEEE
VTIQTKDGEKKRLTANFLYLGSGYYDYDEPYDPGFEFGDFKGQVIHPQFWPEDLDYAGKK
EEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCE
VIVIGSGATAVTIVPSMADKAAHVTMLQRTPTWMFSRPAKDGLANFLRKILPEETAYRIT
EEEEECCCEEEEEECCCCCCHHEEEEEECCCCCEECCCCHHHHHHHHHHHCCCHHHEEEE
RWKNIKLQDIGFKRARTKPEKVRKMLYKRIEKALGKDYDKEAFTPPYDPWDQRLCLVPDD
EECCCEEECCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCEEEECCCH
DLFEAMNSGTASVKTGRIARFVEGGVELESGERLEADIIITATGLKLAVAGKIDVSVDGE
HHHHHHCCCCCEECCCHHHHHHHCCEEECCCCEEEEEEEEEECCEEEEEEEEEEEEECCC
QIDFAQRYYYKGCMFSNLPNLAVVFGYLNASWTLRADINSDYICRVLNRMKATDTQIAEP
HHHHHHHHHHCCHHHCCCCCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHCCHHHHHHH
VLTEAGEAALEEDDIFDFSSGYIQRGKAIMPKNAVAYPWRLNQDYVLDRKRMVEEPVDDD
HHHHCCHHHCCCCCCCCCCCCHHHCCCEECCCCCEECCEECCCCHHHHHHHHHHCCCCCH
LLAFKRAGANAREPGEILEAAE
HHHHHHCCCCCCCCHHHHHCCC
>Mature Secondary Structure 
TIANTDFDVLIVGAGISGIGMAAHMEMHCPDHSYGIVEMRDNLGGTWDLFRYPGIRSDS
CCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCEEEEECCCCCCEEEHHCCCCCCCCC
DMHTLGFVFEPWKHEKSIADAPAILDYLNRIVDERGIREHIRYGHRVVAADFDRSTAQWT
CCEEEEEEECCCCCCCHHCCHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEECCCCCEEEE
VTIQTKDGEKKRLTANFLYLGSGYYDYDEPYDPGFEFGDFKGQVIHPQFWPEDLDYAGKK
EEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCE
VIVIGSGATAVTIVPSMADKAAHVTMLQRTPTWMFSRPAKDGLANFLRKILPEETAYRIT
EEEEECCCEEEEEECCCCCCHHEEEEEECCCCCEECCCCHHHHHHHHHHHCCCHHHEEEE
RWKNIKLQDIGFKRARTKPEKVRKMLYKRIEKALGKDYDKEAFTPPYDPWDQRLCLVPDD
EECCCEEECCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCEEEECCCH
DLFEAMNSGTASVKTGRIARFVEGGVELESGERLEADIIITATGLKLAVAGKIDVSVDGE
HHHHHHCCCCCEECCCHHHHHHHCCEEECCCCEEEEEEEEEECCEEEEEEEEEEEEECCC
QIDFAQRYYYKGCMFSNLPNLAVVFGYLNASWTLRADINSDYICRVLNRMKATDTQIAEP
HHHHHHHHHHCCHHHCCCCCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHCCHHHHHHH
VLTEAGEAALEEDDIFDFSSGYIQRGKAIMPKNAVAYPWRLNQDYVLDRKRMVEEPVDDD
HHHHCCHHHCCCCCCCCCCCCHHHCCCEECCCCCEECCEECCCCHHHHHHHHHHCCCCCH
LLAFKRAGANAREPGEILEAAE
HHHHHHCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA