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The map label for this gene is ilvD

Identifier: 85060372

GI number: 85060372

Start: 4102690

End: 4104540

Strand: Reverse

Name: ilvD

Synonym: SG2394

Alternate gene names: 85060372

Gene position: 4104540-4102690 (Counterclockwise)

Preceding gene: 85060373

Following gene: 85060371

Centisome position: 98.4

GC content: 59.43

Gene sequence:

>1851_bases
ATGCCTAAGTACCGTTCCGCTACCACCACGCACGGCCGAAATATGGCCGGTGCACGCGCCCTGTGGCGCGCCACGGGAAT
GACCGACGACGATTTTGGCAAACCGATTATCGCCGTGGTCAACTCCTTTACCCAGTTTGTGCCGGGCCACGTCCATCTGC
GCGATTTGGGTAAACTGGTCGCCGAACAGATCGAAGCGTCCGGCGGCGTCGCGAAGGAGTTCAACACCATTGCGGTGGAC
GACGGTATTGCGATGGGGCACGGCGGCATGCTGTACTCTCTGCCCTCGCGCGAGCTTATCGCCGATTCGGTGGAATACAT
GGTGAATGCCCACTGTGCCGACGCCATGGTATGTATTTCCAACTGCGATAAAATCACTCCCGGCATGCTGATGGCGTCCT
TGCGCCTGAACATACCGGTCATCTTTGTCTCTGGCGGCCCGATGGAAGCCGGGAAAACCAAGCTGTTGGACAAAATCATC
AAGCTGGACCTGATAGACGCCATGATTCAAGGCGCTAATCCCGACGTCTCGGATGAAGATAGCAACCAGATCGAGCGTTC
CGCCTGTCCGACCTGTGGATCGTGCTCGGGGATGTTTACCGCCAACTCGATGAACTGTCTCACCGAGGCGCTCGGCCTTT
CGCAGCCGGGCAATGGTTCACTGCTGGCGACCCACGCCGACCGCAAGCAGCTGTTCTTGAACGCCGGCGAGCGTATCGTC
GGCTTAGCCAAACGCTATTATGAACAAGATGATACCAGCGCGTTGCCGCGCAGTATCGCCAGCAAAGCGGCGTTTGAAAA
CGCCATGACCCTGGATATCGCCATGGGCGGCTCGACCAACACTGTGCTCCATCTGCTTGCCGCGGCGCAGGAAGGCGAAG
TGGACTTTACCATGGCGGATATCGATCGCCTGTCGCGCAAAGTGCCGCACTTATGCAAGGTTGCGCCCAGCACCCAAAAG
TATCATATGGAAGATGTACACCGCTCCGGCGGCGTTATCGGCATTCTCGGCGAGCTGGGCCGCAGCGGGCTGCTTAATGG
CGATGTGCACAATGTGCTCGGTTTGTCGCTGCCGGAAACCCTGGCGCGCTATGATGTCATGGTGAGCGATGACGCGGCGG
TAAAAAGCATGTATGCCGCGGGGCCTGCGGGCATTCGTACCACACAGGCGTTTTCCCAGGATTGTCGCTGGCCGTCGCTG
GACACCGACCGTCAGGAAGGCTGTATCCGCGCCCGTGAATTCGCCTACAGCCAGGACGGTGGGCTGGCGGTGCTGTACGG
CAACATTGCCGAAGACGGCTGTATAGTGAAAACCGCCGGCGTTGACAAAGGTAGCCTGGTATTCCGCGGTCCGGCCAAAG
TATATGAAAGTCAGGAAGCCGCGTCGGAGGCGATTCTTGGCGGTAAGGTGGTTGCCGGCGATGTAGTCGTTATTCGCTAC
GAAGGCCCGAAAGGCGGTCCGGGGATGCAGGAAATGCTCTATCCGACTACCTTCCTTAAATCCGTGGGACTGGGTAAAAG
CTGCGCTCTGATTACCGATGGCCGCTTTTCTGGCGGTACTTCGGGACTGTCTATCGGCCATGTGTCGCCAGAAGCCGCCA
GCGGCGGCCTGATCGGGCTGGTGCGCGATGGCGATATTATCGATATCAATATCGCCGGCCGCGGTATTGTGCTGGATGTG
GCCGACAGCGAACTGGCGGCACGGCGCGAGACCGAACTGGCGCGCGGTGCTGCGGCCTGGACGCCGGTCGCGCGTGAACG
GCAGGTGTCGTTCGCCCTGAAAGCCTATGCCAGTTTGGCGACCAGTGCAGACAAAGGCGCGGTGCGCGATAAAGCCAAGT
TGGGAGGATAA

Upstream 100 bases:

>100_bases
ATAAATGGGGCTGGCTGGATCCGGTCAATCAATAACGATAACGCTTTCGTGCCGCGGCGCTGCGGCTGCCCTGGCCATCT
GAATAACTGGAGTTATGAGC

Downstream 100 bases:

>100_bases
GGCACCATGGCTGAGTCTCAACCGTTTTCCGCCGAGCCCTGCCCTGCGGAGTACCTGCGCGCGGCGTTACGCGCGCAGGT
GTATGAAGTGGCCCAGGTGA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 616; Mature: 615

Protein sequence:

>616_residues
MPKYRSATTTHGRNMAGARALWRATGMTDDDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEASGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLLDKII
KLDLIDAMIQGANPDVSDEDSNQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGERIV
GLAKRYYEQDDTSALPRSIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEGEVDFTMADIDRLSRKVPHLCKVAPSTQK
YHMEDVHRSGGVIGILGELGRSGLLNGDVHNVLGLSLPETLARYDVMVSDDAAVKSMYAAGPAGIRTTQAFSQDCRWPSL
DTDRQEGCIRAREFAYSQDGGLAVLYGNIAEDGCIVKTAGVDKGSLVFRGPAKVYESQEAASEAILGGKVVAGDVVVIRY
EGPKGGPGMQEMLYPTTFLKSVGLGKSCALITDGRFSGGTSGLSIGHVSPEAASGGLIGLVRDGDIIDINIAGRGIVLDV
ADSELAARRETELARGAAAWTPVARERQVSFALKAYASLATSADKGAVRDKAKLGG

Sequences:

>Translated_616_residues
MPKYRSATTTHGRNMAGARALWRATGMTDDDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEASGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLLDKII
KLDLIDAMIQGANPDVSDEDSNQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGERIV
GLAKRYYEQDDTSALPRSIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEGEVDFTMADIDRLSRKVPHLCKVAPSTQK
YHMEDVHRSGGVIGILGELGRSGLLNGDVHNVLGLSLPETLARYDVMVSDDAAVKSMYAAGPAGIRTTQAFSQDCRWPSL
DTDRQEGCIRAREFAYSQDGGLAVLYGNIAEDGCIVKTAGVDKGSLVFRGPAKVYESQEAASEAILGGKVVAGDVVVIRY
EGPKGGPGMQEMLYPTTFLKSVGLGKSCALITDGRFSGGTSGLSIGHVSPEAASGGLIGLVRDGDIIDINIAGRGIVLDV
ADSELAARRETELARGAAAWTPVARERQVSFALKAYASLATSADKGAVRDKAKLGG
>Mature_615_residues
PKYRSATTTHGRNMAGARALWRATGMTDDDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEASGGVAKEFNTIAVDD
GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLLDKIIK
LDLIDAMIQGANPDVSDEDSNQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGERIVG
LAKRYYEQDDTSALPRSIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEGEVDFTMADIDRLSRKVPHLCKVAPSTQKY
HMEDVHRSGGVIGILGELGRSGLLNGDVHNVLGLSLPETLARYDVMVSDDAAVKSMYAAGPAGIRTTQAFSQDCRWPSLD
TDRQEGCIRAREFAYSQDGGLAVLYGNIAEDGCIVKTAGVDKGSLVFRGPAKVYESQEAASEAILGGKVVAGDVVVIRYE
GPKGGPGMQEMLYPTTFLKSVGLGKSCALITDGRFSGGTSGLSIGHVSPEAASGGLIGLVRDGDIIDINIAGRGIVLDVA
DSELAARRETELARGAAAWTPVARERQVSFALKAYASLATSADKGAVRDKAKLGG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=616, Percent_Identity=86.8506493506494, Blast_Score=1105, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=569, Percent_Identity=29.5254833040422, Blast_Score=176, Evalue=5e-45,
Organism=Escherichia coli, GI1788157, Length=537, Percent_Identity=28.8640595903166, Blast_Score=173, Evalue=4e-44,
Organism=Escherichia coli, GI1786464, Length=523, Percent_Identity=30.4015296367113, Blast_Score=164, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6322476, Length=615, Percent_Identity=37.3983739837398, Blast_Score=339, Evalue=9e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_SODGM (Q2NQA6)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_456074.1
- STRING:   Q2NQA6
- GeneID:   3868093
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG2394
- NMPDR:   fig|343509.6.peg.5166
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- PhylomeDB:   Q2NQA6
- ProtClustDB:   PRK12448
- BioCyc:   SGLO343509:SG2394-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 64896; Mature: 64764

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKYRSATTTHGRNMAGARALWRATGMTDDDFGKPIIAVVNSFTQFVPGHVHLRDLGKLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AEQIEASGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHCCCCCCCCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLLDKIIKLDLIDAMIQGANPDVSDED
CCCCCCHHHHHHHEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
SNQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGERIV
CHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHCCHHHH
GLAKRYYEQDDTSALPRSIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEGEVDFTMAD
HHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEHHH
IDRLSRKVPHLCKVAPSTQKYHMEDVHRSGGVIGILGELGRSGLLNGDVHNVLGLSLPET
HHHHHHHCCHHHHCCCCCHHHHHHHHHHCCCEEEEHHHCCCCCCCCCCHHHHHCCCHHHH
LARYDVMVSDDAAVKSMYAAGPAGIRTTQAFSQDCRWPSLDTDRQEGCIRAREFAYSQDG
HHHHEEEECCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC
GLAVLYGNIAEDGCIVKTAGVDKGSLVFRGPAKVYESQEAASEAILGGKVVAGDVVVIRY
CEEEEECCCCCCCEEEEECCCCCCCEEEECHHHHHHHHHHHHHHHCCCEEEECCEEEEEE
EGPKGGPGMQEMLYPTTFLKSVGLGKSCALITDGRFSGGTSGLSIGHVSPEAASGGLIGL
CCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
VRDGDIIDINIAGRGIVLDVADSELAARRETELARGAAAWTPVARERQVSFALKAYASLA
EECCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHH
TSADKGAVRDKAKLGG
CCCCCCCCCCHHHCCC
>Mature Secondary Structure 
PKYRSATTTHGRNMAGARALWRATGMTDDDFGKPIIAVVNSFTQFVPGHVHLRDLGKLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AEQIEASGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHCCCCCCCCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLLDKIIKLDLIDAMIQGANPDVSDED
CCCCCCHHHHHHHEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
SNQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGERIV
CHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHCCHHHH
GLAKRYYEQDDTSALPRSIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEGEVDFTMAD
HHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEHHH
IDRLSRKVPHLCKVAPSTQKYHMEDVHRSGGVIGILGELGRSGLLNGDVHNVLGLSLPET
HHHHHHHCCHHHHCCCCCHHHHHHHHHHCCCEEEEHHHCCCCCCCCCCHHHHHCCCHHHH
LARYDVMVSDDAAVKSMYAAGPAGIRTTQAFSQDCRWPSLDTDRQEGCIRAREFAYSQDG
HHHHEEEECCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC
GLAVLYGNIAEDGCIVKTAGVDKGSLVFRGPAKVYESQEAASEAILGGKVVAGDVVVIRY
CEEEEECCCCCCCEEEEECCCCCCCEEEECHHHHHHHHHHHHHHHCCCEEEECCEEEEEE
EGPKGGPGMQEMLYPTTFLKSVGLGKSCALITDGRFSGGTSGLSIGHVSPEAASGGLIGL
CCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
VRDGDIIDINIAGRGIVLDVADSELAARRETELARGAAAWTPVARERQVSFALKAYASLA
EECCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHH
TSADKGAVRDKAKLGG
CCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA