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The map label for this gene is asd [H]

Identifier: 85060308

GI number: 85060308

Start: 4005063

End: 4006169

Strand: Reverse

Name: asd [H]

Synonym: SG2330

Alternate gene names: 85060308

Gene position: 4006169-4005063 (Counterclockwise)

Preceding gene: 85060310

Following gene: 85060306

Centisome position: 96.04

GC content: 58.36

Gene sequence:

>1107_bases
ATGAAAAACGTTGGTTTTATCGGCTGGCGCGGTATGGTCGGTTCAGTGCTGATACAGCGCATGACCGAAGAGCGCGATTT
TGACGCCATCCGCCCGGTATTTTTTTCCACTTCCCAGCATGGCCAGCCCGCGCCGGCGGTAAACGGCCAGCAGGGTGTGT
TGCAAGATGCGCGGGATCTGGCGGCGCTCAGCGCGCTGGACATTATTGTTACCTGTCAAGGCGGCGATTATACCAACGAA
ATCTATCCCCAGCTGCGTGAAATTGACTGGCAGGGCTACTGGATTGATGCGGCGTCGTCGCTGCGTATGCGCGATGACGC
GATTATCATCCTGGATCCCGTCAATCAGGCCGTCATCCAGCAAGGGCTGGAACGCGGCATTAAAACCTTTGTCGGCGGTA
ATTGCACTGTGAGTCTGATGCTGATGTCGCTGGGCGGTTTGTTTGCCCAAGATTTGGTGGAATGGGCCTCGGTGGCCACC
TATCAGGCGGCATCCGGCGGCGGCGCGCGCCATATGCGCGAGCTCTTGGTACAAATAGGACAATTACACGGCGCGGTAGC
CAAACCGTTGCAGGATCCGGCTTCGGCCATTTTGGATATCGAGCGTCGGGTCACCGAACTGACCCGCAGCGGTACCCTGC
CGACGGATAATTTTGGCGTACCGCTGGCCGGTAGCCTGATCCCCTGGATCGATAAGCAGCTGGAAAACGGCCAGAGCCGC
GAAGAGTGGAAAGGTCAGGCGGAAACCAACAAGATCCTTAATACCCGCCAGCCGATACCGGTGGACGGGCTGTGCGTGCG
TATAGGCGCTCTGCGCTGCCATAGCCAGGTGTTTACGCTGAAGCTGAAGAAGGATGTACCGCTGGCGGAAATTGAGCAAC
TGCTCGCTACCCATAATGATTGGGTGACCGTGGTGCCCAACGATCGTGAATTGTCGATGCGGGAGCTGACGCCGGCAGCG
GTGACCGGCACACTGAAAACCCCGGTCGGTCGGCTGCGGAAATTGAATATGGGCCCGGAGTATCTTTCGGCCTTTACCGT
CGGCGACCAGCTATTGTGGGGCGCTGCCGAGCCTCTGCGCCGTATGCTGCGCCAATTGGCGCATTAA

Upstream 100 bases:

>100_bases
AACCACATTTTGTAAGGTGGACAAAGTGTTTCCTGCTGAGGCTTCGCAGTAAGAGCACGCGGAATAGTTTGTCCACCCCC
CTACGGCAGGACAGTTAAAC

Downstream 100 bases:

>100_bases
ACGACCCTCGGCGGTTGCCGCCTGCGCTGTGTTTCCGGTTGCCGTTAGCTGCCGCCGACGCATTGTGATGGGGCAGGGGC
CGTTTGTCGCGTGAAGAAAG

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MKNVGFIGWRGMVGSVLIQRMTEERDFDAIRPVFFSTSQHGQPAPAVNGQQGVLQDARDLAALSALDIIVTCQGGDYTNE
IYPQLREIDWQGYWIDAASSLRMRDDAIIILDPVNQAVIQQGLERGIKTFVGGNCTVSLMLMSLGGLFAQDLVEWASVAT
YQAASGGGARHMRELLVQIGQLHGAVAKPLQDPASAILDIERRVTELTRSGTLPTDNFGVPLAGSLIPWIDKQLENGQSR
EEWKGQAETNKILNTRQPIPVDGLCVRIGALRCHSQVFTLKLKKDVPLAEIEQLLATHNDWVTVVPNDRELSMRELTPAA
VTGTLKTPVGRLRKLNMGPEYLSAFTVGDQLLWGAAEPLRRMLRQLAH

Sequences:

>Translated_368_residues
MKNVGFIGWRGMVGSVLIQRMTEERDFDAIRPVFFSTSQHGQPAPAVNGQQGVLQDARDLAALSALDIIVTCQGGDYTNE
IYPQLREIDWQGYWIDAASSLRMRDDAIIILDPVNQAVIQQGLERGIKTFVGGNCTVSLMLMSLGGLFAQDLVEWASVAT
YQAASGGGARHMRELLVQIGQLHGAVAKPLQDPASAILDIERRVTELTRSGTLPTDNFGVPLAGSLIPWIDKQLENGQSR
EEWKGQAETNKILNTRQPIPVDGLCVRIGALRCHSQVFTLKLKKDVPLAEIEQLLATHNDWVTVVPNDRELSMRELTPAA
VTGTLKTPVGRLRKLNMGPEYLSAFTVGDQLLWGAAEPLRRMLRQLAH
>Mature_368_residues
MKNVGFIGWRGMVGSVLIQRMTEERDFDAIRPVFFSTSQHGQPAPAVNGQQGVLQDARDLAALSALDIIVTCQGGDYTNE
IYPQLREIDWQGYWIDAASSLRMRDDAIIILDPVNQAVIQQGLERGIKTFVGGNCTVSLMLMSLGGLFAQDLVEWASVAT
YQAASGGGARHMRELLVQIGQLHGAVAKPLQDPASAILDIERRVTELTRSGTLPTDNFGVPLAGSLIPWIDKQLENGQSR
EEWKGQAETNKILNTRQPIPVDGLCVRIGALRCHSQVFTLKLKKDVPLAEIEQLLATHNDWVTVVPNDRELSMRELTPAA
VTGTLKTPVGRLRKLNMGPEYLSAFTVGDQLLWGAAEPLRRMLRQLAH

Specific function: Second step in the common biosynthetic pathway leading from Asp to the cell wall precursor meso-diaminopimelate, to Lys, to Met, to Ile and to Thr. [C]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789841, Length=367, Percent_Identity=83.3787465940054, Blast_Score=634, Evalue=0.0,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR011534
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 40494; Mature: 40494

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS01103 ASD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVGFIGWRGMVGSVLIQRMTEERDFDAIRPVFFSTSQHGQPAPAVNGQQGVLQDARDL
CCCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
AALSALDIIVTCQGGDYTNEIYPQLREIDWQGYWIDAASSLRMRDDAIIILDPVNQAVIQ
HHHHHEEEEEEECCCCCCHHHHHHHHHCCCCCEEECCCCCCEECCCEEEEECCCCHHHHH
QGLERGIKTFVGGNCTVSLMLMSLGGLFAQDLVEWASVATYQAASGGGARHMRELLVQIG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
QLHGAVAKPLQDPASAILDIERRVTELTRSGTLPTDNFGVPLAGSLIPWIDKQLENGQSR
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCH
EEWKGQAETNKILNTRQPIPVDGLCVRIGALRCHSQVFTLKLKKDVPLAEIEQLLATHND
HHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCC
WVTVVPNDRELSMRELTPAAVTGTLKTPVGRLRKLNMGPEYLSAFTVGDQLLWGAAEPLR
EEEECCCCCCCHHHHCCHHHHCCCHHCCHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHH
RMLRQLAH
HHHHHHCC
>Mature Secondary Structure
MKNVGFIGWRGMVGSVLIQRMTEERDFDAIRPVFFSTSQHGQPAPAVNGQQGVLQDARDL
CCCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
AALSALDIIVTCQGGDYTNEIYPQLREIDWQGYWIDAASSLRMRDDAIIILDPVNQAVIQ
HHHHHEEEEEEECCCCCCHHHHHHHHHCCCCCEEECCCCCCEECCCEEEEECCCCHHHHH
QGLERGIKTFVGGNCTVSLMLMSLGGLFAQDLVEWASVATYQAASGGGARHMRELLVQIG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
QLHGAVAKPLQDPASAILDIERRVTELTRSGTLPTDNFGVPLAGSLIPWIDKQLENGQSR
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCH
EEWKGQAETNKILNTRQPIPVDGLCVRIGALRCHSQVFTLKLKKDVPLAEIEQLLATHND
HHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCC
WVTVVPNDRELSMRELTPAAVTGTLKTPVGRLRKLNMGPEYLSAFTVGDQLLWGAAEPLR
EEEECCCCCCCHHHHCCHHHHCCCHHCCHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHH
RMLRQLAH
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]