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The map label for this gene is dtd

Identifier: 85060203

GI number: 85060203

Start: 3874675

End: 3875112

Strand: Reverse

Name: dtd

Synonym: SG2225

Alternate gene names: 85060203

Gene position: 3875112-3874675 (Counterclockwise)

Preceding gene: 85060204

Following gene: 85060196

Centisome position: 92.9

GC content: 61.42

Gene sequence:

>438_bases
ATGATAGCCTTGATACAACGGGTCACGCAGGCCAGGGTCACCATCGACAATGAGGTGGCGGGCGCGATAGGTCCGGGGCT
CCTGATCCTGCTGGGTGTTGAGCGGCAGGACGATGAACAGAAGGCGGCCAAATTGTGTGAACGCGTGCTGGCTTACCGTA
TATTCAGCGATGAGCAGGGTAAGATGAACTTGAATGTGCGCCAGTCGGGAGGGAGAGTACTGGTCGTGTCCCAGTTTACT
CTGGCGGTGGACACCGATCGGGGCCTGCGTCCGGGGTTTTCCCGCGGTGCGGCGCCGGCGGATGCCCGGCGGCTGTATGA
TGACTTTACCGACCGCTGCCGGCAAACCGGTATTCGGACCGAAACCGGCCGATTCGGCGCTGATATGCAGGTGGCGCTGG
TCAACGACGGGCCGGTAACCTTCTGGCTGCAGGTCTGA

Upstream 100 bases:

>100_bases
AGCTGGTGCATTGTATTATTGGGGGCGGAGATCACGGCGTCGCTCAGCGAGCACCGACAGGCCGCCGCGCATCACGCCGC
CCAGATTGTAAGGGATACTG

Downstream 100 bases:

>100_bases
ACGGCCGGACGGCATATTTAATTAAGAGAGATCGGTATGTATCACTTGCGCGTTCCGGAAACTGAACAGGAGCTTCAACA
ATACTATCAGTTCCGCTGGG

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 145; Mature: 145

Protein sequence:

>145_residues
MIALIQRVTQARVTIDNEVAGAIGPGLLILLGVERQDDEQKAAKLCERVLAYRIFSDEQGKMNLNVRQSGGRVLVVSQFT
LAVDTDRGLRPGFSRGAAPADARRLYDDFTDRCRQTGIRTETGRFGADMQVALVNDGPVTFWLQV

Sequences:

>Translated_145_residues
MIALIQRVTQARVTIDNEVAGAIGPGLLILLGVERQDDEQKAAKLCERVLAYRIFSDEQGKMNLNVRQSGGRVLVVSQFT
LAVDTDRGLRPGFSRGAAPADARRLYDDFTDRCRQTGIRTETGRFGADMQVALVNDGPVTFWLQV
>Mature_145_residues
MIALIQRVTQARVTIDNEVAGAIGPGLLILLGVERQDDEQKAAKLCERVLAYRIFSDEQGKMNLNVRQSGGRVLVVSQFT
LAVDTDRGLRPGFSRGAAPADARRLYDDFTDRCRQTGIRTETGRFGADMQVALVNDGPVTFWLQV

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=148, Percent_Identity=38.5135135135135, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1790320, Length=145, Percent_Identity=73.1034482758621, Blast_Score=223, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI115533292, Length=143, Percent_Identity=37.7622377622378, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319982, Length=146, Percent_Identity=35.6164383561644, Blast_Score=100, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281361569, Length=146, Percent_Identity=38.3561643835616, Blast_Score=100, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_SODGM (Q2NQS5)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455905.1
- HSSP:   O66742
- ProteinModelPortal:   Q2NQS5
- SMR:   Q2NQS5
- STRING:   Q2NQS5
- GeneID:   3868809
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG2225
- NMPDR:   fig|343509.6.peg.4901
- eggNOG:   COG1490
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- PhylomeDB:   Q2NQS5
- ProtClustDB:   PRK05273
- BioCyc:   SGLO343509:SG2225-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 15996; Mature: 15996

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALIQRVTQARVTIDNEVAGAIGPGLLILLGVERQDDEQKAAKLCERVLAYRIFSDEQG
CHHHHHHHHHHHEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCC
KMNLNVRQSGGRVLVVSQFTLAVDTDRGLRPGFSRGAAPADARRLYDDFTDRCRQTGIRT
CEEEEEECCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
ETGRFGADMQVALVNDGPVTFWLQV
CCCCCCCCEEEEEECCCCEEEEEEC
>Mature Secondary Structure
MIALIQRVTQARVTIDNEVAGAIGPGLLILLGVERQDDEQKAAKLCERVLAYRIFSDEQG
CHHHHHHHHHHHEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCC
KMNLNVRQSGGRVLVVSQFTLAVDTDRGLRPGFSRGAAPADARRLYDDFTDRCRQTGIRT
CEEEEEECCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
ETGRFGADMQVALVNDGPVTFWLQV
CCCCCCCCEEEEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA