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The map label for this gene is hyuA [H]

Identifier: 85060111

GI number: 85060111

Start: 3704944

End: 3706506

Strand: Reverse

Name: hyuA [H]

Synonym: SG2133

Alternate gene names: 85060111

Gene position: 3706506-3704944 (Counterclockwise)

Preceding gene: 85060112

Following gene: 85060110

Centisome position: 88.86

GC content: 60.59

Gene sequence:

>1563_bases
ATGAGTTGGTCGTTGGGAATTGATGTCGGCGGCACCCATACGGATGCGGTGTTGCTTGATGCGCAGCAAAGAATTATCGC
TCATAGCAAACAGCCGACCAGCGCTGATGTCATGCAGGGGATTGATCAGGCGATCGCGGCTGTGTTGGCGCAGGTTGAAG
TGGATCGCGGCGCCATACGCCGGGCAATGCTCGGCACCACGCAGTGCACTAATGCTATTGTTGAACATAAAGGCTTGCAG
CCGGTGGCGCATTTCCGTCTCGGCGCGCCGGCCTCGCTGGCGGTGCCGCCGTTAACCGATATGCCGGCCGATTTTCGCGC
GCGTCTGCCGGTACGGCTCTTTACCCTTGCCGGCGGCTATCAATATAACGGCGAGAAATTATCGGCGTTGGATGAACAGG
CCGTACGCCGGCAACTGTTGGCGGTAAGGGGGCAGGTTCGTGCCGTCTCGGTATGCGGTATATTTTCGCCCGTCGTCGCC
GAGCAGGAGCAGCGGGTTGCAGCCCTGGCGCGGGAGATACTGGGGGTGAAAACACCGGTGTCCCTGTCATCTGAAATCGG
TTCCATCGGTCTCCTGGAGCGGGAAAATGCCACTGTGCTTAACGCGGTGCTAAGTGGAGTGGTGCATACCCTTACCGATG
GTTTTCGCCAGACGCTGGCGCGGCAGGGAATTATTGCCGAGCTGTTTTTCGGTCAAAATGACGGTACTCTGATGCCGCTG
CATCAGGCGCAGATGTTCCCGATCCTGACTATCGCCTCCGGTCCGACGAATAGCCTGCGGGGCGCAGCCAGACTCTCCAA
TTTACAAGAGGCCCTGGTGGTCGATGTGGGCGGCACGACTACCGACGTTGGTGCTTTGTGCGGGGGATTTCCCCGGCAAT
CTGCCATGGCGGCTGAGATAGGCGGAGTGCGTACTAACTTCCGCATGCCGGATATTGCGTCTATCGGCCTTGGCGGCGGA
TCGGTGGTAACCGTTAACGCCGACGGTGCTATCAGCGTCGGACCCGAGAGCGTGGGTTATGACTTACCGCAGCGGGCGCT
GGTGTTTGGCGGTGATGCCCTGACGGTCACCGATATCGCGGTGGCCCGTGGCTGGGCGGACATTGGCGATGCCGCTCTGG
TTGCCCATCTGTGTCCTGCAATGGTAACCCGGGCGGCGGAACATTATGTGGCCATGGTTGAAAAATGCCTCGCGCGTATG
AATACCAGCCAGAATGATATGCCGGTTATTCTGGTGGGCGGCGGCGCGGCATTACTTCCCATGCACCTCAAAGGCGCTTC
TGAAGTCATACGCCCGCCCTACGCTGGCGTCGCCAACGCCACCGGTGTCGCCATTGCTCAGGTCAGCGGCAGCGTAGACA
CCATTATTTTACCCGGCGATGAATCTCTGGAGTCCTGCCTGCAGCGGGCGGAACATCAGGCACGGGAGGCGGCTATTGCC
GCCGGGGCGCTGCCTGATACGGTGGCCGTTATTGAGCTGGATTCGTTGCCGCTGGGGTATATGCCCGCAAATGCGGTCAG
GATCCGGGCTCGGGCGGTGGGGACGCTCGCGCCGGAGGGCTAG

Upstream 100 bases:

>100_bases
CGCCGCGGGGAATTGAGGTGTGCGGGCCGAGGTATTTTCACTATCTGGATGACTATACGCCGGTCGAAACGCTGGCGGCC
CGCTGCAGTGAGGAGCGCGT

Downstream 100 bases:

>100_bases
TCGGCGTCCGCTGACCGGGAGAATTCGTGGCGAATATGGCTAAACAGTGGTTAAAAACGCTAAGTATTAACATCCTGTGG
CTGGGCCTAGTTAGTGAAAT

Product: hydantoinase

Products: NA

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MSWSLGIDVGGTHTDAVLLDAQQRIIAHSKQPTSADVMQGIDQAIAAVLAQVEVDRGAIRRAMLGTTQCTNAIVEHKGLQ
PVAHFRLGAPASLAVPPLTDMPADFRARLPVRLFTLAGGYQYNGEKLSALDEQAVRRQLLAVRGQVRAVSVCGIFSPVVA
EQEQRVAALAREILGVKTPVSLSSEIGSIGLLERENATVLNAVLSGVVHTLTDGFRQTLARQGIIAELFFGQNDGTLMPL
HQAQMFPILTIASGPTNSLRGAARLSNLQEALVVDVGGTTTDVGALCGGFPRQSAMAAEIGGVRTNFRMPDIASIGLGGG
SVVTVNADGAISVGPESVGYDLPQRALVFGGDALTVTDIAVARGWADIGDAALVAHLCPAMVTRAAEHYVAMVEKCLARM
NTSQNDMPVILVGGGAALLPMHLKGASEVIRPPYAGVANATGVAIAQVSGSVDTIILPGDESLESCLQRAEHQAREAAIA
AGALPDTVAVIELDSLPLGYMPANAVRIRARAVGTLAPEG

Sequences:

>Translated_520_residues
MSWSLGIDVGGTHTDAVLLDAQQRIIAHSKQPTSADVMQGIDQAIAAVLAQVEVDRGAIRRAMLGTTQCTNAIVEHKGLQ
PVAHFRLGAPASLAVPPLTDMPADFRARLPVRLFTLAGGYQYNGEKLSALDEQAVRRQLLAVRGQVRAVSVCGIFSPVVA
EQEQRVAALAREILGVKTPVSLSSEIGSIGLLERENATVLNAVLSGVVHTLTDGFRQTLARQGIIAELFFGQNDGTLMPL
HQAQMFPILTIASGPTNSLRGAARLSNLQEALVVDVGGTTTDVGALCGGFPRQSAMAAEIGGVRTNFRMPDIASIGLGGG
SVVTVNADGAISVGPESVGYDLPQRALVFGGDALTVTDIAVARGWADIGDAALVAHLCPAMVTRAAEHYVAMVEKCLARM
NTSQNDMPVILVGGGAALLPMHLKGASEVIRPPYAGVANATGVAIAQVSGSVDTIILPGDESLESCLQRAEHQAREAAIA
AGALPDTVAVIELDSLPLGYMPANAVRIRARAVGTLAPEG
>Mature_519_residues
SWSLGIDVGGTHTDAVLLDAQQRIIAHSKQPTSADVMQGIDQAIAAVLAQVEVDRGAIRRAMLGTTQCTNAIVEHKGLQP
VAHFRLGAPASLAVPPLTDMPADFRARLPVRLFTLAGGYQYNGEKLSALDEQAVRRQLLAVRGQVRAVSVCGIFSPVVAE
QEQRVAALAREILGVKTPVSLSSEIGSIGLLERENATVLNAVLSGVVHTLTDGFRQTLARQGIIAELFFGQNDGTLMPLH
QAQMFPILTIASGPTNSLRGAARLSNLQEALVVDVGGTTTDVGALCGGFPRQSAMAAEIGGVRTNFRMPDIASIGLGGGS
VVTVNADGAISVGPESVGYDLPQRALVFGGDALTVTDIAVARGWADIGDAALVAHLCPAMVTRAAEHYVAMVEKCLARMN
TSQNDMPVILVGGGAALLPMHLKGASEVIRPPYAGVANATGVAIAQVSGSVDTIILPGDESLESCLQRAEHQAREAAIAA
GALPDTVAVIELDSLPLGYMPANAVRIRARAVGTLAPEG

Specific function: HyuA and hyuB convert D- and L-substituted hydantoins to corresponding N-carbamyl-amino acids [H]

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=396, Percent_Identity=28.7878787878788, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45550492, Length=402, Percent_Identity=28.6069651741293, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: NA

Molecular weight: Translated: 54000; Mature: 53869

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWSLGIDVGGTHTDAVLLDAQQRIIAHSKQPTSADVMQGIDQAIAAVLAQVEVDRGAIR
CCEEEEECCCCCCCCEEEECHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAMLGTTQCTNAIVEHKGLQPVAHFRLGAPASLAVPPLTDMPADFRARLPVRLFTLAGGY
HHHHCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCEEEEEEECCE
QYNGEKLSALDEQAVRRQLLAVRGQVRAVSVCGIFSPVVAEQEQRVAALAREILGVKTPV
EECCHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SLSSEIGSIGLLERENATVLNAVLSGVVHTLTDGFRQTLARQGIIAELFFGQNDGTLMPL
CHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEE
HQAQMFPILTIASGPTNSLRGAARLSNLQEALVVDVGGTTTDVGALCGGFPRQSAMAAEI
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCCHHHHHHHH
GGVRTNFRMPDIASIGLGGGSVVTVNADGAISVGPESVGYDLPQRALVFGGDALTVTDIA
CCCCCCCCCCCCCEECCCCCCEEEEECCCCEEECCHHCCCCCCCCEEEECCCEEEEHHHH
VARGWADIGDAALVAHLCPAMVTRAAEHYVAMVEKCLARMNTSQNDMPVILVGGGAALLP
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEE
MHLKGASEVIRPPYAGVANATGVAIAQVSGSVDTIILPGDESLESCLQRAEHQAREAAIA
EECCCCHHHHCCCCCCCCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
AGALPDTVAVIELDSLPLGYMPANAVRIRARAVGTLAPEG
CCCCCCEEEEEEECCCCCCCCCCCCEEEEEEEEECCCCCC
>Mature Secondary Structure 
SWSLGIDVGGTHTDAVLLDAQQRIIAHSKQPTSADVMQGIDQAIAAVLAQVEVDRGAIR
CEEEEECCCCCCCCEEEECHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAMLGTTQCTNAIVEHKGLQPVAHFRLGAPASLAVPPLTDMPADFRARLPVRLFTLAGGY
HHHHCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCEEEEEEECCE
QYNGEKLSALDEQAVRRQLLAVRGQVRAVSVCGIFSPVVAEQEQRVAALAREILGVKTPV
EECCHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SLSSEIGSIGLLERENATVLNAVLSGVVHTLTDGFRQTLARQGIIAELFFGQNDGTLMPL
CHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEE
HQAQMFPILTIASGPTNSLRGAARLSNLQEALVVDVGGTTTDVGALCGGFPRQSAMAAEI
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCCHHHHHHHH
GGVRTNFRMPDIASIGLGGGSVVTVNADGAISVGPESVGYDLPQRALVFGGDALTVTDIA
CCCCCCCCCCCCCEECCCCCCEEEEECCCCEEECCHHCCCCCCCCEEEECCCEEEEHHHH
VARGWADIGDAALVAHLCPAMVTRAAEHYVAMVEKCLARMNTSQNDMPVILVGGGAALLP
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEE
MHLKGASEVIRPPYAGVANATGVAIAQVSGSVDTIILPGDESLESCLQRAEHQAREAAIA
EECCCCHHHHCCCCCCCCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
AGALPDTVAVIELDSLPLGYMPANAVRIRARAVGTLAPEG
CCCCCCEEEEEEECCCCCCCCCCCCEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1732229 [H]