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The map label for this gene is tyrB [H]

Identifier: 85060109

GI number: 85060109

Start: 3700499

End: 3701695

Strand: Reverse

Name: tyrB [H]

Synonym: SG2131

Alternate gene names: 85060109

Gene position: 3701695-3700499 (Counterclockwise)

Preceding gene: 85060110

Following gene: 85060108

Centisome position: 88.75

GC content: 56.47

Gene sequence:

>1197_bases
GTGTTCCGAAATGTTGATGCTTATGCGGGAGATCCTATCCTTACGCTGATGGAAACCTATAAACAGGATCCGCGACCTGA
CAGGGTCAATTTAAGCATCGGCCTTTATTATAATGAACAGGCGATCATTCCCCAACTGCAGGCCGTCGCCGAGGCGCAAG
CCATGCTGCTCGCCCGGGCGACGTCAAGTTCGTCGTCCTATCTGCCGATAGAAGGCTTGTCAACCTACCGCAGCGCCACC
CAGGCGTTGCTATTTGGTGAAGATCATCCGATGCGCAATGCGTTGCGTATCGCCACGATTCAGACCGTGGGCGGGTCAGG
GGCGTTGAAAGTCGGGGCGGATTTTCTCAAATGTTATTTCCCGGATTCGCAGGTCTGGGTCAGCGACCCGACCTGGGAAA
ACCATGTGGCGATTTTTTCCGGCGCCGGATTCCAAGTGAACCGGTACCCTTATTTCGATGATGAGAAGCTGGGTGTTAAC
TTCAGCGCGATGCTGGCCTGTTTCCAGCAATTGCCGCCGCGCAGCATTGTGTTGCTGCATCAGTGTTGCCATAACCCGAC
CGGCTCGGACCTGACACGTTCCGAATGGGAGCAGATTATCGCGGTGGTGGCAGAAAGGCAGCTCATCCCCTTTCTGGATA
TCGCCTACCAGGGGTTTGGCGACGGGTTGGAGGAAGACGCCTTTGCGGTGCGCGAAATGGCGCGGCTGGGCCTGCCTTGC
ATGGTAACTCATTCTTTATCAAAGATTTTCTCTCTTTATAGTGAACGTGTGGGAGAGCTATCGATAGTTTGCGATAGCGC
GAGCGAAGCCGAGCGGGTGCTGAGTCAGCTGAAGGCGACCGTGCGCCGCAACTATTCCAGTCCGCCAAACTTTGGCGCTC
AGGTTGTGGCGCAAGTTCTGAACGAACCGGCGTTGAATACCCTGTGGCGTGAGGAAGTCGCGGCAATGCGCCAGCGTATT
CTGGCAATGCGCCATAGCCTGGTGGCGGCATTGAAAGTCGCGCTGCCGGACCATCAATTCGATTATCTCCTGCGTCAGCG
CGGCATGTTCAGCTACACCGGTCTCAGCCCGGCGCAGGTGGCGGATTTGCGCGATACCTTCGGCGTGTATTTAATCGACA
GTGGCCGGATGTGTCTGGCCGGCCTGAATACCGCCAATGTCGCTAAAGTGGCCGAGGCCTTCGCGGCAGTGCAGTAA

Upstream 100 bases:

>100_bases
TGACGCTTTTTGTTAACTTATTCGCCCTTCAAATCTCTTTATTTGATGTTGTGATGAAGTGGGTGCACTTTTGCACCCGT
AAATCCAGGAGAGCTGCACC

Downstream 100 bases:

>100_bases
TCGCCCTGCCGTGACCGGTTTTCACCTGTTCCCGCGTTGCCACTATACTAAGTGATCAACAAAGGAGCAGGATTACGTGG
CACCAACAGACCCTGAAAGC

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MFRNVDAYAGDPILTLMETYKQDPRPDRVNLSIGLYYNEQAIIPQLQAVAEAQAMLLARATSSSSSYLPIEGLSTYRSAT
QALLFGEDHPMRNALRIATIQTVGGSGALKVGADFLKCYFPDSQVWVSDPTWENHVAIFSGAGFQVNRYPYFDDEKLGVN
FSAMLACFQQLPPRSIVLLHQCCHNPTGSDLTRSEWEQIIAVVAERQLIPFLDIAYQGFGDGLEEDAFAVREMARLGLPC
MVTHSLSKIFSLYSERVGELSIVCDSASEAERVLSQLKATVRRNYSSPPNFGAQVVAQVLNEPALNTLWREEVAAMRQRI
LAMRHSLVAALKVALPDHQFDYLLRQRGMFSYTGLSPAQVADLRDTFGVYLIDSGRMCLAGLNTANVAKVAEAFAAVQ

Sequences:

>Translated_398_residues
MFRNVDAYAGDPILTLMETYKQDPRPDRVNLSIGLYYNEQAIIPQLQAVAEAQAMLLARATSSSSSYLPIEGLSTYRSAT
QALLFGEDHPMRNALRIATIQTVGGSGALKVGADFLKCYFPDSQVWVSDPTWENHVAIFSGAGFQVNRYPYFDDEKLGVN
FSAMLACFQQLPPRSIVLLHQCCHNPTGSDLTRSEWEQIIAVVAERQLIPFLDIAYQGFGDGLEEDAFAVREMARLGLPC
MVTHSLSKIFSLYSERVGELSIVCDSASEAERVLSQLKATVRRNYSSPPNFGAQVVAQVLNEPALNTLWREEVAAMRQRI
LAMRHSLVAALKVALPDHQFDYLLRQRGMFSYTGLSPAQVADLRDTFGVYLIDSGRMCLAGLNTANVAKVAEAFAAVQ
>Mature_398_residues
MFRNVDAYAGDPILTLMETYKQDPRPDRVNLSIGLYYNEQAIIPQLQAVAEAQAMLLARATSSSSSYLPIEGLSTYRSAT
QALLFGEDHPMRNALRIATIQTVGGSGALKVGADFLKCYFPDSQVWVSDPTWENHVAIFSGAGFQVNRYPYFDDEKLGVN
FSAMLACFQQLPPRSIVLLHQCCHNPTGSDLTRSEWEQIIAVVAERQLIPFLDIAYQGFGDGLEEDAFAVREMARLGLPC
MVTHSLSKIFSLYSERVGELSIVCDSASEAERVLSQLKATVRRNYSSPPNFGAQVVAQVLNEPALNTLWREEVAAMRQRI
LAMRHSLVAALKVALPDHQFDYLLRQRGMFSYTGLSPAQVADLRDTFGVYLIDSGRMCLAGLNTANVAKVAEAFAAVQ

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=390, Percent_Identity=40, Blast_Score=302, Evalue=4e-82,
Organism=Homo sapiens, GI4504067, Length=397, Percent_Identity=40.3022670025189, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI117414139, Length=382, Percent_Identity=27.7486910994764, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1790488, Length=397, Percent_Identity=68.2619647355164, Blast_Score=564, Evalue=1e-162,
Organism=Escherichia coli, GI1787159, Length=397, Percent_Identity=41.8136020151133, Blast_Score=337, Evalue=6e-94,
Organism=Caenorhabditis elegans, GI71981858, Length=397, Percent_Identity=37.5314861460957, Blast_Score=303, Evalue=9e-83,
Organism=Caenorhabditis elegans, GI25147133, Length=388, Percent_Identity=38.4020618556701, Blast_Score=284, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI17569539, Length=378, Percent_Identity=37.3015873015873, Blast_Score=261, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI17569537, Length=390, Percent_Identity=29.7435897435897, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17550384, Length=263, Percent_Identity=34.6007604562738, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI25147136, Length=213, Percent_Identity=35.2112676056338, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323055, Length=409, Percent_Identity=36.1858190709046, Blast_Score=275, Evalue=8e-75,
Organism=Saccharomyces cerevisiae, GI6322743, Length=423, Percent_Identity=33.5697399527187, Blast_Score=231, Evalue=1e-61,
Organism=Drosophila melanogaster, GI19922362, Length=386, Percent_Identity=38.3419689119171, Blast_Score=288, Evalue=6e-78,
Organism=Drosophila melanogaster, GI24654046, Length=386, Percent_Identity=38.3419689119171, Blast_Score=288, Evalue=7e-78,
Organism=Drosophila melanogaster, GI19920542, Length=389, Percent_Identity=37.2750642673522, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24580972, Length=398, Percent_Identity=36.9346733668342, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24580970, Length=398, Percent_Identity=36.9346733668342, Blast_Score=276, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 44007; Mature: 44007

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRNVDAYAGDPILTLMETYKQDPRPDRVNLSIGLYYNEQAIIPQLQAVAEAQAMLLARA
CCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
TSSSSSYLPIEGLSTYRSATQALLFGEDHPMRNALRIATIQTVGGSGALKVGADFLKCYF
CCCCCCCCCCCCHHHHHHHHHHHEECCCCCCCHHEEEEEEEECCCCCCHHHHHHHHHEEC
PDSQVWVSDPTWENHVAIFSGAGFQVNRYPYFDDEKLGVNFSAMLACFQQLPPRSIVLLH
CCCCEEECCCCCCCCEEEEECCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHH
QCCHNPTGSDLTRSEWEQIIAVVAERQLIPFLDIAYQGFGDGLEEDAFAVREMARLGLPC
HHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCH
MVTHSLSKIFSLYSERVGELSIVCDSASEAERVLSQLKATVRRNYSSPPNFGAQVVAQVL
HHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
NEPALNTLWREEVAAMRQRILAMRHSLVAALKVALPDHQFDYLLRQRGMFSYTGLSPAQV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEECCCCHHHH
ADLRDTFGVYLIDSGRMCLAGLNTANVAKVAEAFAAVQ
HHHHHCCCEEEEECCCEEEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFRNVDAYAGDPILTLMETYKQDPRPDRVNLSIGLYYNEQAIIPQLQAVAEAQAMLLARA
CCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
TSSSSSYLPIEGLSTYRSATQALLFGEDHPMRNALRIATIQTVGGSGALKVGADFLKCYF
CCCCCCCCCCCCHHHHHHHHHHHEECCCCCCCHHEEEEEEEECCCCCCHHHHHHHHHEEC
PDSQVWVSDPTWENHVAIFSGAGFQVNRYPYFDDEKLGVNFSAMLACFQQLPPRSIVLLH
CCCCEEECCCCCCCCEEEEECCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHH
QCCHNPTGSDLTRSEWEQIIAVVAERQLIPFLDIAYQGFGDGLEEDAFAVREMARLGLPC
HHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCH
MVTHSLSKIFSLYSERVGELSIVCDSASEAERVLSQLKATVRRNYSSPPNFGAQVVAQVL
HHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
NEPALNTLWREEVAAMRQRILAMRHSLVAALKVALPDHQFDYLLRQRGMFSYTGLSPAQV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEECCCCHHHH
ADLRDTFGVYLIDSGRMCLAGLNTANVAKVAEAFAAVQ
HHHHHCCCEEEEECCCEEEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521591; 3907634; 8265357; 9278503; 3308851; 10417420 [H]